DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and yl

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster


Alignment Length:1401 Identity:332/1401 - (23%)
Similarity:518/1401 - (36%) Gaps:447/1401 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   353 LQPYED-----NPCAHNNGNCSHLCLLATNSQGFSCACPTGVKLISAN-TC---ANGSQEMM-FI 407
            |..:||     :.|...:..||..|  ...|.|:.|.|..|..|...| ||   ..||:|.. .:
  Fly   339 LAKFEDKCEDVDECKEQDDLCSQGC--ENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLL 401

  Fly   408 VQRTQISKISL----DSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDV--ETYTIKRAHADGT 466
            :..||::.:.:    |:....::.: .|.:...|.:.||  ..||||:::  |..:|.:|:.||:
  Fly   402 LYTTQMTIMGMHLREDNVRNHVYQV-AGNLSKVIGVAYD--GSHIYWTNIQNEAESIVKANGDGS 463

  Fly   467 GVTDFVTSEVRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSL 531
            .....:||.:..|:.||:|||.:|:|::|.:...|.||..||....||:.:.:.:||::||.|..
  Fly   464 NAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQK 528

  Fly   532 GWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDG 596
            |.|||:||.| ||.:.|||:|||....:||:|:.||||||||:..:.|||.|.|...::....||
  Fly   529 GLMFWTDWGE-KPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDG 592

  Fly   597 SGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITG-NNRIVVVDQ--------YPDLM 652
            :|||.|:...|||.:||:|.:|.|||:||..:|:...||.:| ::||:..|:        :|   
  Fly   593 TGRRTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRTIYAVHIYHP--- 654

  Fly   653 GLKVTRLREVRGQNACAVRNGGCSHLCLNRPRD---YVCRCAIDYELANDKRTCVVPAAFLLFSR 714
                  .::....:.|  .|..||||||....:   :.|.|.....||.|.|.|:     |:..|
  Fly   655 ------AKQPNSPHGC--ENATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRRCM-----LMEKR 706

  Fly   715 QE---HIGRISIEYNE---GNHNDERIPFKDVRDAHALDVSVAE---RRIYWT------DQKSKC 764
            |.   .:|::.:|...   |.|        .|..::.|...:.|   .||..:      ||:...
  Fly   707 QRLFIGLGQVLLEIEHTAFGRH--------QVSKSYTLPCLINEMVYNRINGSLIIADNDQRLIL 763

  Fly   765 IFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVL-LWKGVEE 828
            .|:...:.|.|  :|.|.|.....:|.|.|:.|:||:|.|...|||..|....|.:: .:.|.|.
  Fly   764 EFQPESHESNV--LVRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEV 826

  Fly   829 PRSLVLEPRRGYMYWT-----ESPTDSIRRAAMDGSDLQTIVAG---ANHAAGLTFDQETRRLYW 885
            |..|.:.|..||:|..     .|..|.|   .:.|...|..|..   .:....|..|.||:.::|
  Fly   827 PIGLTVMPAEGYLYVVLKAKRHSHIDKI---PLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFW 888

  Fly   886 ATQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSDWNTGDIERVHKTTGQNRSLVH 950
             :.|...:|..:::.....||..|. :..||::::....::|::..|..|...||:....|.::.
  Fly   889 -SDSDLGRISYSNYRVPHSQIFRGK-LRRPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVID 951

  Fly   951 -------------------SGMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMTCA 996
                               :|:....|..|..:.     :||:..||||||:|:.: |.....|.
  Fly   952 IMEKDDPAAIMPYVPVATPNGIPLAASSPVGQES-----HPCQQQNGGCSHICVGE-GPYHSICL 1010

  Fly   997 CPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRLLPNTTDCPNIPLPVSGKNIRAVDYDPITHHIYW 1061
            ||..:.....|             .|.|...|     ||                          
  Fly  1011 CPAGFVYRDAG-------------NRTCVEAL-----DC-------------------------- 1031

  Fly  1062 IEGRSHS----IKRSLANGTKVSLLANSGQPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGV 1122
             |.|.||    ......||.:               |.:        ..|:.:|.          
  Fly  1032 -EFRCHSGECLTMNHRCNGRR---------------DCV--------DNSDEMNC---------- 1062

  Fly  1123 IDTGDSE---------KPRNIAVHAMKRLLFWTDVGSHQAIIRARVDGNERVELAYKLEGVTALA 1178
                |.|         .|...|.|:.::.                ||...|              
  Fly  1063 ----DEEHRRKPKVLCSPNQFACHSGEQC----------------VDKERR-------------- 1093

  Fly  1179 LDQQSDMIYYAHGKRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLDDKTGVERITVNGER 1243
            .|.:.|...::..:..:..|   |:||..|..|                     |.:    ||: 
  Fly  1094 CDNRKDCHDHSDEQHCEKFD---KSKKCHVHQH---------------------GCD----NGK- 1129

  Fly  1244 RSAELQRLPQITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCPKHLMLLE 1308
                                         |:.|...|        :|   |.|   |..:    .
  Fly  1130 -----------------------------CVDSSLVC--------DG---TND---CGDN----S 1147

  Fly  1309 DKENCGAFPACGPDHFTCAAPVSGISDVNKDCIPASWRCDGQ----------------------- 1350
            |:..|.|...|.|..|.|.   ||      .||..||.|||:                       
  Fly  1148 DELLCEATSRCEPGMFQCG---SG------SCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQ 1203

  Fly  1351 -----------------KDCPDKSDEVGCPT--------CRADQFSCQSG--ECIDKSLVCDGTT 1388
                             .||.|||||:.|.|        |..||:.|.|.  .|:..::.|:|||
  Fly  1204 RCLLGQCLDRSLVCDGHNDCGDKSDELNCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCNGTT 1268

  Fly  1389 NCANGHDEADC---CKRPGEFQCPINKLCISAALLCDGWENCADGADESSDIC-------LQRRM 1443
            .|..|.|||||   |. ..||:|...:.||.....|||.::|.||:||.|  |       .|.::
  Fly  1269 ECPRGEDEADCGDVCS-IYEFKCRSGRECIRREFRCDGQKDCGDGSDELS--CELEKGHHNQSQI 1330

  Fly  1444 AP-ATDKRAFMILIGATMITIFSIVYLLQFCRTRIGKSRTEPKDDQATDPLSPSTLSKSQRVSKI 1507
            .| :|..|:                     ||..:    .:.:|.:..|            :|::
  Fly  1331 QPWSTSSRS---------------------CRPHL----FDCQDGECVD------------LSRV 1358

  Fly  1508 ASVADAVRMSTLNSRNSMNSYDRNHITGASSSTTNGSSMVAYPINPPPSPATRSRRPYRHYKI-- 1570
            .:          |..:..|.:|.......:..:.:|..:..:.....|:.|..|  .:..|::  
  Fly  1359 CN----------NFPDCTNGHDEGPKCATACRSASGRQVCQHKCRATPAGAVCS--CFDGYRLDA 1411

  Fly  1571 -------INQPPPPTPCSTDICDESDSNYTSKSNSN 1599
                   |::.....||: .:|:.:...|..:.:::
  Fly  1412 DQKSCLDIDECQEQQPCA-QLCENTLGGYQCQCHAD 1446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531
NHL 168..503 CDD:302697 47/165 (28%)
NHL repeat 172..237 CDD:271320
LY 252..293 CDD:214531
NHL repeat 261..298 CDD:271320
NHL repeat 303..339 CDD:271320
NHL repeat 341..419 CDD:271320 21/79 (27%)
NHL repeat 428..476 CDD:271320 15/49 (31%)
LY 472..511 CDD:214531 16/38 (42%)
NHL repeat 477..503 CDD:271320 10/25 (40%)
Ldl_recept_b 534..573 CDD:278487 23/38 (61%)
LY 558..599 CDD:214531 18/40 (45%)
LY 600..641 CDD:214531 18/41 (44%)
FXa_inhibition 668..703 CDD:291342 14/37 (38%)
LY 739..773 CDD:214531 8/42 (19%)
LY 776..818 CDD:214531 15/41 (37%)
LY 819..860 CDD:214531 12/46 (26%)
FXa_inhibition 973..1010 CDD:291342 13/36 (36%)
LY 1122..1164 CDD:214531 7/50 (14%)
FXa_inhibition 1273..1313 CDD:291342 8/39 (21%)
LDLa 1319..1362 CDD:238060 20/82 (24%)
LDLa 1365..1399 CDD:238060 15/35 (43%)
LDLa 1399..1433 CDD:197566 13/36 (36%)
ylNP_996433.1 LDLa 90..124 CDD:238060
LDLa 131..166 CDD:238060
LDLa 184..216 CDD:238060
LDLa 227..262 CDD:238060
LDLa 271..302 CDD:238060
FXa_inhibition 352..387 CDD:291342 11/36 (31%)
Ldl_recept_b 442..482 CDD:278487 14/39 (36%)
LY 466..508 CDD:214531 16/41 (39%)
Ldl_recept_b 529..569 CDD:278487 24/40 (60%)
LY 553..595 CDD:214531 18/41 (44%)
LY 596..637 CDD:214531 18/40 (45%)
FXa_inhibition 669..700 CDD:291342 12/30 (40%)
LY 774..815 CDD:214531 16/42 (38%)
LDLa 1032..1062 CDD:238060 8/52 (15%)
LDLa 1074..1109 CDD:238060 8/64 (13%)
LDLa 1118..1152 CDD:238060 13/106 (12%)
LDLa 1157..1189 CDD:197566 13/40 (33%)
LDLa 1198..1232 CDD:238060 7/33 (21%)
LDLa 1243..1279 CDD:238060 15/35 (43%)
LDLa 1283..1318 CDD:238060 15/37 (41%)
LDLa 1340..1371 CDD:197566 7/56 (13%)
FXa_inhibition 1388..1416 CDD:291342 4/29 (14%)
EGF_CA 1418..1452 CDD:214542 5/30 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45461697
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.640

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