DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment arr and Lrp12

DIOPT Version :9

Sequence 1:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	NP_001128355.1	Gene:	Lrp12 / 314941	RGDID:	1304943	Length:	858	Species:	Rattus norvegicus

Alignment Length:	883	Identity:	168/883 - (19%)
Similarity:	266/883 - (30%)	Gaps:	343/883 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   885 WATQSRPAKI-----ESADWDGKKRQIL----------------VGSDMDEPYAVSLYQDYVYWS 928
            |..::.|.:|     :..|..|.:|..|                .||.:..||..|  ||:| |.
  Rat    78 WLIRANPGEIITISFQDFDIQGSRRCTLDWLTIETYKNIESYRACGSTIPPPYISS--QDHV-WI 139

  Fly   929 DWNTGDIERVHKTTGQNRSLVHSGMTYITSLLVFNDKRQTGVNPC---KVNNGGCSHLCLAQPGR 990
            .:::.|            |:...|.    .|..|:.|.:.....|   :..||    .|:.:..:
  Rat   140 RFHSDD------------SVSRKGF----RLAYFSGKSEEPHCACDQFRCGNG----KCIPEAWK 184

  Fly   991 RGMTCACPTHYQLAKDGVSCI----PPRNYII----FSQRNCFGRL------LPNTTDCPNIPLP 1041
            ......|..    :.|...|:    ||.....    ::|..|..|.      ||.:..|..
  Rat   185 CNSMDECGD----SSDEEVCVQDAHPPTTTAFQPCAYNQFQCLSRFTKVYTCLPESLKCDG---- 241

  Fly  1042 VSGKNIRAVDYDPITHHIYWIEGRSHSIKRSLANGTKVSLLANSGQPFDLAIDIIGRLLFWTCSQ 1106
                ||..:|.                                 |...|..:...|:.|.:....
  Rat   242 ----NIDCLDL---------------------------------GDEIDCDMPTCGQWLKYFYGT 269

  Fly  1107 SNSINVTSFL---GESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQAIIRARVDGNERVELA 1168
            .:|.|...|.   .....:|||||..|.          :|.:||
  Rat   270 FSSPNYPDFYPPGSNCTWLIDTGDHRKV----------ILRFTD--------------------- 303

  Fly  1169 YKLEGVTALALDQQSDMIYYAHGKRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLDDKTG 1233
            :||:|..           |..:.|..|.::.|.:
  Rat   304 FKLDGTG-----------YGDYVKIYDGLEENPR------------------------------- 326

  Fly  1234 VERITVNGERRSAELQRLPQITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVC 1298
                                            |:||..|...|.   :.:.:.|..|..|.. .|
  Rat   327 --------------------------------KLLRVLTAFDSH---APLTVVSSSGQIRVH-FC 355

  Fly  1299 SCPKHLMLLEDKENCG-AFPA-------CGPDHFTCAAPVSGISDVNKDCIPASWRCDGQKDCPD 1355
            :         ||.|.. .|.|       |.|....|..        |..|.....||||...||:
  Rat   356 A---------DKVNAARGFNATYQVDGFCLPWEIPCGG--------NWGCYTEQQRCDGYWHCPN 403

  Fly  1356 KSDEVGCPTCRADQFSC-QSGECIDKSLVCDGTTNCANGHDEADC--CKRPGEFQCPINKLCISA 1417
            ..||:.|..|:.::|.| ::|.|..:|..|:...:|.||.||.:|  | :||.|.|..|: |:..
  Rat   404 GRDEINCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFC-QPGNFHCKNNR-CVFE 466

  Fly  1418 ALLCDGWENCADGADESS-DICLQRRMAPATDKRAFMILIGATMITIFSIVYLLQFCR------- 1474
            :.:||..::|.||:||.| .:.:..|:..|.       :||:.:..:..::.|...|:
  Rat   467 SWVCDSQDDCGDGSDEESCPVIVPTRVITAA-------VIGSLVCGLLLVIALGCTCKLYSLRMF 524

  Fly  1475 ------TRIGKSRTE-------PKDDQ-----ATDPLSPSTLSKSQRVSKIASVADAVRMS---- 1517
                  |::.:...|       |...|     ...|:....:....:.|.:.::..|||..
  Rat   525 ERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFP 589

  Fly  1518 ------TLNSRNSMN---SYDRNHITGASSSTT-NGSSMVAYPINPPPSPATRSRRPYRHYKIIN 1572
                  |..|||..|   ::.|:..:|:.:..: :|..:|     |..|.:..:.|.:.|..:.:
  Rat   590 SIRLPMTGRSRNIWNRIFNFARSRHSGSLALVSGDGDEVV-----PSQSSSRETERSHPHRSLFS 649

  Fly  1573 QPPPPTPCSTDICDESDSNYTSKSNSNNSNGGATKHSSSSAAACLQYGYDSEPYPPPPTPRSHY- 1636
                           ::|:.|...|......||    |...||.|       |...|||.....
  Rat   650 ---------------AESDDTDTENERRDTAGA----SGGVAAPL-------PQKVPPTTAVEAT 688

  Fly  1637 ---------------HSDVRIVPESSCPP-SPSSRSST 1658
                           |:|.|.|.....|. ||:....|
  Rat   689 VGTGGNSSAQSTRGGHADGREVSSVEAPSVSPARHQLT 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531
		NHL	168..503	CDD:302697
		NHL repeat	172..237	CDD:271320
		LY	252..293	CDD:214531
		NHL repeat	261..298	CDD:271320
		NHL repeat	303..339	CDD:271320
		NHL repeat	341..419	CDD:271320
		NHL repeat	428..476	CDD:271320
		LY	472..511	CDD:214531
		NHL repeat	477..503	CDD:271320
		Ldl_recept_b	534..573	CDD:278487
		LY	558..599	CDD:214531
		LY	600..641	CDD:214531
		FXa_inhibition	668..703	CDD:291342
		LY	739..773	CDD:214531
		LY	776..818	CDD:214531
		LY	819..860	CDD:214531
		FXa_inhibition	973..1010	CDD:291342	6/39 (15%)
		LY	1122..1164	CDD:214531	9/41 (22%)
		FXa_inhibition	1273..1313	CDD:291342	7/39 (18%)
		LDLa	1319..1362	CDD:238060	13/42 (31%)
		LDLa	1365..1399	CDD:238060	12/34 (35%)
		LDLa	1399..1433	CDD:197566	13/35 (37%)
Lrp12	NP_001128355.1	CUB	47..158	CDD:238001	20/98 (20%)
		LDLa	166..200	CDD:238060	6/41 (15%)
		LDLa	215..254	CDD:238060	10/79 (13%)
		CUB	267..371	CDD:238001	33/221 (15%)
		LDLa	375..410	CDD:238060	13/42 (31%)
		LDLa	413..448	CDD:238060	12/34 (35%)
		LDLa	451..485	CDD:238060	14/35 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349224
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830