DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment arr and Lrp6

DIOPT Version :9

Sequence 1:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	XP_017448147.1	Gene:	Lrp6 / 312781	RGDID:	1304749	Length:	1613	Species:	Rattus norvegicus

Alignment Length:	1658	Identity:	715/1658 - (43%)
Similarity:	994/1658 - (59%)	Gaps:	139/1658 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 LLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSAL 153
            ||:..|.|:::.:.|  .|.....::|..|.:|.|:||.:...|:.|:|...|.|:..:.|.:
  Rat    23 LLYANRRDLRLVDAT--NGKENATIVVGGLEDAAAVDFVFGHGLIYWSDVSEEAIKRTEFNKT-- 83

  Fly   154 QPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAV 218
                 ...|.|:.:||..|:|||.||..:|:||||.|.|||||:.|||..:|||||.:||||||:
  Rat    84 -----ESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAI 143

  Fly   219 AVVPARKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHHFI 283
            |:.|:...:.||||||.||||||.|||.  ||..::...::|||||.:|.:...:||.|.|.:||
  Rat   144 ALDPSSGFMYWTDWGEVPKIERAGMDGS--SRFVIINTEIYWPNGLTLDYEERKLYWADAKLNFI 206

  Fly   284 DVMRLDGSSRRTIV-NNLKYPFSLTFYDDRLYWTDWQRGSLNALDLQTRE-LKELIDTPKAPNSV 346
            ....|||::|:.:| .:|.:||:||.::|.||||||...|:.|.:..|.| |:|:.....:|..:
  Rat   207 HKSNLDGTNRQAVVKGSLPHPFALTLFEDTLYWTDWNTHSILACNKYTGEGLREIHSNIFSPMDI 271

  Fly   347 RAWDPSLQPYEDNPCAHNNGNCSHLCLLATNSQGFSCACPTGVKLI-SANTCANGSQEMMFIVQR 410
            .|:....||...|||..:||.||||||::.....:.|||||||||: |..||.:|:.|::.:.:|
  Rat   272 HAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLESGKTCKDGATELLLLARR 336

  Fly   411 TQISKISLDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSE 475
            |.:.:||||:||:|...|.|..:::||||||||||.::||:|.|...|:|:..||:|....||::
  Rat   337 TDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYVYWTDDEVRAIRRSFIDGSGSQFVVTAQ 401

  Fly   476 VRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWN 540
            :.||||:|:||:|||||||||.||||||.||:||.||:||.|.|||||||.:.|..|:|:|:||.
  Rat   402 IAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMAGYMYWTDWG 466

  Fly   541 ERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISD 605
            | .||:|||:||||:|||||:.:||||||:|||.:...|||.|.|||||||.|.||:||||::.|
  Rat   467 E-IPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGRRVLVED 530

  Fly   606 NLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAV 670
            .:.|:||.::|.||:||||||||||:|.||.:. .|.|::||.|||||||.|.:..|.|.|.||.
  Rat   531 KIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSA-EREVIIDQLPDLMGLKATSVHRVIGSNPCAE 594

  Fly   671 RNGGCSHLCLNRPRDYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERI 735
            .|||||||||.||:...|.|.|.:||.:|.:||:||.|||||||:..|.|||:   |.|:|:..|
  Rat   595 ENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISL---ETNNNNVAI 656

  Fly   736 PFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYW 800
            |...|::|.|||..|.:.||||||...|.|.|||:|||.::.:|:.||..|:|:|||||..|:||
  Rat   657 PLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYW 721

  Fly   801 SDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTE-SPTDSIRRAAMDGSDLQTI 864
            :|....||||::|||..|:||:||.::.||:|.|:|..|:||||| .....|.|||||||:..|:
  Rat   722 ADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTL 786

  Fly   865 VAGANHAAGLTFDQETRRLYWATQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSD 929
            |.....|.|||.|...||||| |......|||::..|..|:: :..|:..|:.::.||||:||:|
  Rat   787 VPNVGRANGLTIDYAKRRLYW-TDLDTNLIESSNMLGLNREV-IADDLPHPFGLTQYQDYIYWTD 849

  Fly   930 WNTGDIERVHKTTGQNRSLVHSGMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQP-GRRGM 993
            |:...|||.:||:||||:::...:.|:..:|||:..||.|.|.|..:||.|||||||.| |  |.
  Rat   850 WSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHCSHLCLAVPVG--GF 912

  Fly   994 TCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRLLPNTTDCPNIPLPV-SGKNIRAVDYDPITH 1057
            .|.||.||.|..|..:|..|..:::|||::...|::.:....|:|.||: |.:|:||:||||:..
  Rat   913 VCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDK 977

  Fly  1058 HIYWIEGRSHSIKRSLANGTK-----VSLLANSG---QPFDLAIDIIGRLLFWTCSQSNSINVTS 1114
            .:|||:.|.:.|:::..:|.:     ||.:.|..   ||:||:|||..|.::|||..:|.|:||.
  Rat   978 QLYWIDSRQNMIRKAQEDGGQGFTVVVSSVPNQNLEIQPYDLSIDIYSRYIYWTCEATNVIDVTR 1042

  Fly  1115 FLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQ-AIIRARVDGNERVELAYK-LEGVTAL 1177
            ..|.||||:..|:.::||.|.|:..|..:::|::.... .|.||.:||.||..|.:. |....||
  Rat  1043 LDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPVAL 1107

  Fly  1178 ALDQQSDMIYYAHG--KRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLD-DKTGVERITV 1239
            |||.:...:::|..  :||::.|::|.|:..|...:|.|.:.:.....::||:| .:..:|:|.:
  Rat  1108 ALDSKLSRLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDM 1172

  Fly  1240 NGERRSAELQ-RLPQITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCPKH 1303
            .|.....::| |:.|::||.||...:.:..|.|.|......|||||:..|:|..|    ||||.|
  Rat  1173 TGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTR----CSCPMH 1233

  Fly  1304 LMLLEDKENCGAFPACGPDHFTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGCPTCRAD 1368
            |:||:|:.:||..|.|.|..|||..     .|:  ||||.:|||||..:|.|.|||:.||.|...
  Rat  1234 LVLLQDELSCGEPPTCSPQQFTCFT-----GDI--DCIPVAWRCDGFTECEDHSDELNCPVCSES 1291

  Fly  1369 QFSCQSGECIDKSLVCDGTTNCANGHDEADC---CKRPGEFQCPINKLCISAALLCDGWENCADG 1430
            ||.|.||:|||.:|.|:|..||.:..||.:|   | ...:|:| .|..|:.....||...:|:|.
  Rat  1292 QFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLC-LIDQFRC-ANGQCVGKHKKCDHNVDCSDR 1354

  Fly  1431 ADESSDICLQRRMAPATDKRAFMILIGATMITIF---SIVYLLQ--FCRTRIGKSRTEPKDDQAT 1490
            :||......:.....||:....:|   ..::|||   :|.::.|  .|....|...|...|....
  Rat  1355 SDELDCYPTEEPAPQATNTVGSVI---GVIVTIFVSGTIYFICQRMLCPRMKGDGETMTNDYVVH 1416

  Fly  1491 DPLS--------PSTLS-----KSQRVSKIASVADAVRMSTLNSRNSMNSYDRNHITGASSSTTN 1542
            .|.|        ||:||     .|:..|.|:|:       ::...:|...|||.|:||||||:::
  Rat  1417 GPASVPLGYVPHPSSLSGSLPGMSRGKSMISSL-------SIMGGSSGPPYDRAHVTGASSSSSS 1474

  Fly  1543 GSSMVAYP--INPPPSPATR---------------------SRRP--YRHYKIINQPPPPTPCST 1582
            .:....:|  :||||||||.                     |.||  |||:     .||.|||||
  Rat  1475 STKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHF-----APPTTPCST 1534

  Fly  1583 DICDESDSNYTSKSNSNNSNGGATKHSSSSAAACLQY----GYDSEPYPPPPTPRSHYHSDVRIV 1643
            |:|   ||:|            |.....:|.|....|    .|||||.||||||||.|.|    .
  Rat  1535 DVC---DSDY------------APSRRMTSVATAKGYTSDLNYDSEPVPPPPTPRSQYLS----A 1580

  Fly  1644 PES--SCPPSPSSRSSTYFSPLPPPPSPVQSPS 1674
            .|:  ||||||.:..|......||||||....|
  Rat  1581 EENYESCPPSPYTERSYSHHLYPPPPSPCTDSS 1613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531	22/38 (58%)
		NHL	168..503	CDD:302697	168/337 (50%)
		NHL repeat	172..237	CDD:271320	39/64 (61%)
		LY	252..293	CDD:214531	15/40 (38%)
		NHL repeat	261..298	CDD:271320	16/37 (43%)
		NHL repeat	303..339	CDD:271320	17/36 (47%)
		NHL repeat	341..419	CDD:271320	33/78 (42%)
		NHL repeat	428..476	CDD:271320	23/47 (49%)
		LY	472..511	CDD:214531	28/38 (74%)
		NHL repeat	477..503	CDD:271320	20/25 (80%)
		Ldl_recept_b	534..573	CDD:278487	26/38 (68%)
		LY	558..599	CDD:214531	26/40 (65%)
		LY	600..641	CDD:214531	22/40 (55%)
		FXa_inhibition	668..703	CDD:291342	19/34 (56%)
		LY	739..773	CDD:214531	18/33 (55%)
		LY	776..818	CDD:214531	21/41 (51%)
		LY	819..860	CDD:214531	22/41 (54%)
		FXa_inhibition	973..1010	CDD:291342	20/37 (54%)
		LY	1122..1164	CDD:214531	13/42 (31%)
		FXa_inhibition	1273..1313	CDD:291342	18/39 (46%)
		LDLa	1319..1362	CDD:238060	20/42 (48%)
		LDLa	1365..1399	CDD:238060	16/33 (48%)
		LDLa	1399..1433	CDD:197566	10/36 (28%)
Lrp6	XP_017448147.1	NHL	55..272	CDD:302697	99/225 (44%)
		NHL repeat	55..93	CDD:271320	11/44 (25%)
		LY	89..127	CDD:214531	22/37 (59%)
		NHL repeat	97..132	CDD:271320	21/34 (62%)
		NHL repeat	140..176	CDD:271320	22/37 (59%)
		Ldl_recept_b	150..190	CDD:278487	22/41 (54%)
		LY	175..216	CDD:214531	15/40 (38%)
		NHL repeat	181..217	CDD:271320	15/35 (43%)
		NHL repeat	226..253	CDD:271320	13/26 (50%)
		FXa_inhibition	286..323	CDD:291342	19/36 (53%)
		LY	353..393	CDD:214531	20/39 (51%)
		LY	397..437	CDD:214531	28/39 (72%)
		LY	438..481	CDD:214531	27/43 (63%)
		LY	483..524	CDD:214531	26/40 (65%)
		LY	525..558	CDD:214531	19/32 (59%)
		FXa_inhibition	592..627	CDD:291342	19/34 (56%)
		LY	656..694	CDD:214531	20/37 (54%)
		LY	697..739	CDD:214531	21/41 (51%)
		LY	740..783	CDD:214531	23/42 (55%)
		LY	783..825	CDD:214531	17/42 (40%)
		LY	827..866	CDD:214531	17/39 (44%)
		FXa_inhibition	893..929	CDD:291342	20/37 (54%)
		LY	958..998	CDD:214531	16/39 (41%)
		LY	1001..1048	CDD:214531	19/46 (41%)
		Ldl_recept_b	1069..1110	CDD:278487	13/40 (33%)
		LY	1094..1136	CDD:214531	12/41 (29%)
		FXa_inhibition	1207..1243	CDD:291342	18/39 (46%)
		LDLa	1249..1285	CDD:238060	20/42 (48%)
		LDLa	1288..1322	CDD:238060	16/33 (48%)
		LDLa	1326..1360	CDD:238060	11/35 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349225
Domainoid	1	1.000	119	1.000	Domainoid score	I5658
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1747
Inparanoid	1	1.050	1327	1.000	Inparanoid score	I135
OMA	1	1.010	-	-		QHG48457
OrthoDB	1	1.010	-	-		D121310at2759
OrthoFinder	1	1.000	-	-		FOG0004181
OrthoInspector	1	1.000	-	-		otm46284
orthoMCL	1	0.900	-	-		OOG6_100345
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3498
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.710