DRSC/TRiP Functional Genomics Resources

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Protein Alignment arr and Ldlr

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_786938.2 Gene:Ldlr / 300438 RGDID:2998 Length:879 Species:Rattus norvegicus


Alignment Length:431 Identity:134/431 - (31%)
Similarity:207/431 - (48%) Gaps:68/431 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   335 ELIDTPKAPNSV---RAW-DPSLQPYEDNPCAHNNGNCSHLCLLATNSQGFSCACPTGVKLISAN 395
            |.|...|..||.   |.| |..::..:.|.|..|||.|||:|  .....|:.|.||:|.:|:..:
  Rat   289 ECISLDKVCNSARDCRDWSDEPIKECKTNECLDNNGGCSHIC--KDLKIGYECLCPSGFRLVDGH 351

  Fly   396 TC-----------------------------------------ANGSQEMMFIVQRTQISKISLD 419
            .|                                         |.||...:....|.::.|::||
  Rat   352 QCEDIDECQEPDTCSQLCVNLEGSFKCECRAGFHMDPHTRVCKAVGSIGFLLFTNRHEVRKMTLD 416

  Fly   420 SPDYT-IFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHAD-GTGVT--DFVTSEVRHPD 480
            ..:|| :.|    .:|..:|:|.:.....|||||:....|..|..| ||.::  ..::.::..||
  Rat   417 RSEYTSLIP----NLKNVVALDTEVANNRIYWSDLSQRKIYSAVMDQGTSLSYDAIISGDLHAPD 477

  Fly   481 GLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKPK 545
            |||:||:..|:||||:|...:.|....|..|:.|..|....||||.|.|..|:|:|:||. ...|
  Rat   478 GLAVDWIHGNIYWTDSVPGTVSVADTKGVRRRTLFREKGSRPRAIVVDPVHGFMYWTDWG-TPAK 541

  Fly   546 VERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISD--NLK 608
            :::..|:|.:...||:|::.|||||.||:.:..:||.|.|...|...:::|.||:.::.|  .|.
  Rat   542 IKKGGLNGVDIYSLVTEDIQWPNGITLDLPSGRLYWVDSKLHSISSIDVNGGGRKTILEDEKQLA 606

  Fly   609 HLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQY--PDLMGL--KVTRLREVRGQNACA 669
            |.|.|:|.:|.:||||....:|..|:::||::..:|....  |:.:.|  .||:.|.|....|..
  Rat   607 HPFSLAIYEDKVYWTDVLNEAIFSANRLTGSDVNLVAKNLMSPEDIVLFHNV
TQPRGVNWCEATV 671

  Fly   670 VRNGGCSHLCLNRPR------DYVCRCAIDYELANDKRTCV 704
            :.||||.::||..|:      .:.|.|.....||.|.|:|:
  Rat   672 LPNGGCQYMCLPAPQISAHSPKFTCACPDGMLLAKDMRSCL 712

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531
NHL 168..503 CDD:302697 60/216 (28%)
NHL repeat 172..237 CDD:271320
LY 252..293 CDD:214531
NHL repeat 261..298 CDD:271320
NHL repeat 303..339 CDD:271320 2/3 (67%)
NHL repeat 341..419 CDD:271320 27/122 (22%)
NHL repeat 428..476 CDD:271320 13/50 (26%)
LY 472..511 CDD:214531 15/38 (39%)
NHL repeat 477..503 CDD:271320 13/25 (52%)
Ldl_recept_b 534..573 CDD:278487 15/38 (39%)
LY 558..599 CDD:214531 16/40 (40%)
LY 600..641 CDD:214531 15/42 (36%)
FXa_inhibition 668..703 CDD:291342 13/40 (33%)
LY 739..773 CDD:214531
LY 776..818 CDD:214531
LY 819..860 CDD:214531
FXa_inhibition 973..1010 CDD:291342
LY 1122..1164 CDD:214531
FXa_inhibition 1273..1313 CDD:291342
LDLa 1319..1362 CDD:238060
LDLa 1365..1399 CDD:238060
LDLa 1399..1433 CDD:197566
LdlrNP_786938.2 Ldl_recept_a 25..58 CDD:395011
Ldl_recept_a 66..104 CDD:395011
Ldl_recept_a 107..143 CDD:395011
Ldl_recept_a 196..232 CDD:395011
Ldl_recept_a 235..271 CDD:395011
Ldl_recept_a 279..309 CDD:395011 7/19 (37%)
FXa_inhibition 319..353 CDD:405372 14/35 (40%)
EGF_CA 355..389 CDD:214542 0/33 (0%)
LDL-receptor class B 1 398..439 11/44 (25%)
NHL <435..628 CDD:302697 71/193 (37%)
NHL repeat 435..469 CDD:271320 10/33 (30%)
LDL-receptor class B 2 440..485 17/44 (39%)
NHL repeat 476..514 CDD:271320 17/37 (46%)
LDL-receptor class B 3 486..528 17/41 (41%)
LDL-receptor class B 4 529..572 18/43 (42%)
Ldl_recept_b 529..569 CDD:395012 16/40 (40%)
NHL repeat 555..600 CDD:271320 18/44 (41%)
LDL-receptor class B 5 573..615 14/41 (34%)
NHL repeat 606..628 CDD:271320 9/21 (43%)
LDL-receptor class B 6 616..658 12/41 (29%)
Ldl_recept_b 616..655 CDD:395012 11/38 (29%)
FXa_inhibition 674..711 CDD:405372 13/36 (36%)
Clustered O-linked oligosaccharides 717..788
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..797
Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250|UniProtKB:P01130 830..879
NPXY motif. /evidence=ECO:0000250|UniProtKB:P01130 842..847
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166349228
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.830

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