DRSC/TRiP Functional Genomics Resources

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Protein Alignment arr and LRP12

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_038465.1 Gene:LRP12 / 29967 HGNCID:31708 Length:859 Species:Homo sapiens


Alignment Length:880 Identity:180/880 - (20%)
Similarity:277/880 - (31%) Gaps:335/880 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   876 FD-QETRR--LYWATQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSDWNTGDIER 937
            || |.:||  |.|.|......|||        ....||.:..||..|  ||:: |..:::.|   
Human    95 FDIQGSRRCNLDWLTIETYKNIES--------YRACGSTIPPPYISS--QDHI-WIRFHSDD--- 145

  Fly   938 VHKTTGQNRSLVHSGMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQ 1002
                     ::...|.    .|..|:.|.:                   :|     .|||     
Human   146 ---------NISRKGF----RLAYFSGKSE-------------------EP-----NCAC----- 168

  Fly  1003 LAKDGVSCIPPRNYIIFSQRNC-FGRLLPNTTDCPNIPL--PVSGKNIRAVDYDPITHHIYWIEG 1064
                             .|..| .|:.:|....|.|:..  ..|.:.|.|.:.:|.|...:  :.
Human   169 -----------------DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAF--QP 214

  Fly  1065 RSHSIKRSLANGTKV------SLLANS-------GQPFDLAIDIIGRLLFWTCSQSNSINVTSFL 1116
            .:::..:.|:..|||      ||..:.       |...|..:...|:.|.:.....||.|...|.
Human   215 CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFY 279

  Fly  1117 ---GESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQAIIRARVDGNERVELAYKLEGVTALA 1178
               .....:|||||..|.          :|.:||                     :||:|     
Human   280 PPGSNCTWLIDTGDHRKV----------ILRFTD---------------------FKLDG----- 308

  Fly  1179 LDQQSDMIYYAHGKRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLDDKTGVERITVNGER 1243
                                                    ...|.:|...|   |:|.       
Human   309 ----------------------------------------TGYGDYVKIYD---GLEE------- 323

  Fly  1244 RSAELQRLPQITDIRAVWTPDP-KVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCPKHLMLL 1307
                                :| |:||..|...|.   :.:.:.|..|..|.. .|:        
Human   324 --------------------NPHKLLRVLTAFDSH---APLTVVSSSGQIRVH-FCA-------- 356

  Fly  1308 EDKENCG-AFPA-------CGPDHFTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGCPT 1364
             ||.|.. .|.|       |.|....|..        |..|.....||||...||:..||..|..
Human   357 -DKVNAARGFNATYQVDGFCLPWEIPCGG--------NWGCYTEQQRCDGYWHCPNGRDETNCTM 412

  Fly  1365 CRADQFSC-QSGECIDKSLVCDGTTNCANGHDEADC--CKRPGEFQCPINKLCISAALLCDGWEN 1426
            |:.::|.| ::|.|..:|..|:...:|.||.||.:|  | :||.|.|..|: |:..:.:||..::
Human   413 CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFC-QPGNFHCKNNR-CVFESWVCDSQDD 475

  Fly  1427 CADGADESS-DICLQRRMAPATDKRAFMILIGATMITIFSIVYLLQFCR-------------TRI 1477
            |.||:||.: .:.:..|:..|.       :||:.:..:..::.|...|:             |::
Human   476 CGDGSDEENCPVIVPTRVITAA-------VIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQL 533

  Fly  1478 GKSRTEPKDDQATDPLSPSTLSKSQRVSKI----------ASVADAVRMSTLN-----------S 1521
              ||.|.:..:...|.|...|.....:..:          |||.:.:|::..:           :
Human   534 --SRVEAELLRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMA 596

  Fly  1522 RNSMNSYDR-------NHITGASSSTTNGSSMVAYPINPPPSPATRSRRPYR---HYKIINQPPP 1576
            ..|.|.::|       .|....:..:.:|..:|       ||.:| ||.|.|   |..:.:.   
Human   597 GRSSNIWNRIFNFARSRHSGSLALVSADGDEVV-------PSQST-SREPERNHTHRSLFSV--- 650

  Fly  1577 PTPCSTDICDESDSNYTSKSNSNNSNGGATKHSSSSAAACLQYGYDSEPYPPPPTPRSHYHSDVR 1641
                      |||.  |...|......||    |...||         |.|....|.:...:.|.
Human   651 ----------ESDD--TDTENERRDMAGA----SGGVAA---------PLPQKVPPTTAVEATVG 690

  Fly  1642 IVPESSCPP-----SPSSRSSTYFSPLPPPPSPVQ 1671
            ....||...     :.:.|..|  |..||..||.:
Human   691 ACASSSTQSTRGGHADNGRDVT--SVEPPSVSPAR 723

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531
NHL 168..503 CDD:302697
NHL repeat 172..237 CDD:271320
LY 252..293 CDD:214531
NHL repeat 261..298 CDD:271320
NHL repeat 303..339 CDD:271320
NHL repeat 341..419 CDD:271320
NHL repeat 428..476 CDD:271320
LY 472..511 CDD:214531
NHL repeat 477..503 CDD:271320
Ldl_recept_b 534..573 CDD:278487
LY 558..599 CDD:214531
LY 600..641 CDD:214531
FXa_inhibition 668..703 CDD:291342
LY 739..773 CDD:214531
LY 776..818 CDD:214531
LY 819..860 CDD:214531
FXa_inhibition 973..1010 CDD:291342 4/36 (11%)
LY 1122..1164 CDD:214531 9/41 (22%)
FXa_inhibition 1273..1313 CDD:291342 7/39 (18%)
LDLa 1319..1362 CDD:238060 13/42 (31%)
LDLa 1365..1399 CDD:238060 12/34 (35%)
LDLa 1399..1433 CDD:197566 13/35 (37%)
LRP12NP_038465.1 CUB 47..158 CDD:238001 22/89 (25%)
LDLa 166..200 CDD:238060 10/55 (18%)
LDLa 215..254 CDD:238060 7/38 (18%)
CUB 267..371 CDD:238001 36/222 (16%)
LDLa 375..410 CDD:238060 13/42 (31%)
LDLa 413..448 CDD:238060 12/34 (35%)
LDLa 451..485 CDD:238060 14/35 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..678 22/90 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 693..723 9/31 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..770
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 801..823
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155342
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.830

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