DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and Lrp5

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_001099791.2 Gene:Lrp5 / 293649 RGDID:1309329 Length:1600 Species:Rattus norvegicus


Alignment Length:1693 Identity:706/1693 - (41%)
Similarity:991/1693 - (58%) Gaps:168/1693 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 QMLIGFLLICFGISNSWQYKNVHMPSSSSLIASPPASAFVNTPATLLFTTRHDIQVANITRPTGG 108
            |.|:..|.:|..:          :|::    |||          .|||..|.|:::.:    .||
  Rat    14 QPLLLLLALCCSL----------VPAA----ASP----------LLLFANRRDVRLVD----AGG 50

  Fly   109 PQID--VIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSALQPLLRAPKQTVISTGLDK 171
            .:::  ::...|.:|.|:||.::|..|.|||...|.|:....|.:.      |..|.::.:||..
  Rat    51 VKLESTIVASGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTG------AAAQNIVISGLVS 109

  Fly   172 PEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAVAVVPARKLLIWTDWGEYP 236
            |:|||.||...|:||||.|.||||||.|:|..:|||||.|||||||:|:.||...:.||||||.|
  Rat   110 PDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGEAP 174

  Fly   237 KIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHHFIDVMRLDGSSRRTIV-NNL 300
            :||||.|||.  :|..:|...::|||||.:||:.:.:||.|.|..||....||||.|:.:| .:|
  Rat   175 RIERAGMDGS--TRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSL 237

  Fly   301 KYPFSLTFYDDRLYWTDWQRGSLNALDLQTRE-LKELIDTPKAPNSVRAWDPSLQPYEDNPCAHN 364
            .:||:||...|.|||||||..|::|.:..|.| .||::....:|..::......||....||...
  Rat   238 THPFALTLSGDTLYWTDWQTRSIHACNKWTGEKRKEILSALYSPMDIQVLSQERQPPFHTPCEEG 302

  Fly   365 NGNCSHLCLLATNSQGFSCACPTGVKL-ISANTCANGSQEMMFIVQRTQISKISLDSPDYTIFPL 428
            ||.|||||||:.....:||||||||:| .:..||..|::|::.:.:||.:.:||||:||:|...|
  Rat   303 NGGCSHLCLLSPREPFYSCACPTGVQLQDNGKTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVL 367

  Fly   429 PLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSEVRHPDGLALDWLARNLYW 493
            .:|.:::||||||||:|.::||:|.|...|:||:.||:|....|.:|:..|||:|:||:||||||
  Rat   368 QVGDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYW 432

  Fly   494 TDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDGSERVV 558
            |||.||||||.||:||:||:|:.|.|:|||||.:.|.:|.|:|:||.| .||:|.|:|||.:|.|
  Rat   433 TDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIVLHPVMGLMYWTDWGE-NPKIECANLDGRDRHV 496

  Fly   559 LVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWT 623
            ||:.:||||||:|||::...:||.|.|||||||.|:||:.|:.::.|.|.|:||.::|.|::|||
  Rat   497 LVNTSLGWPNGLALDLQEGKLYWGDAKTDKIEVINIDGTKRQTLLEDKLPHIFGFTLLGDFIYWT 561

  Fly   624 DWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAVRNGGCSHLCLNRPRDYVC 688
            |||||||:|.||:.. :|.|::||.|||||||...:.:|.|.|.||..||||||||...|....|
  Rat   562 DWQRRSIERVHKVKA-SRDVIIDQLPDLMGLKAVNVAKVVGTNPCADGNGGCSHLCFFTPHATKC 625

  Fly   689 RCAIDYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERIPFKDVRDAHALDVSVAER 753
            .|.|..||.:|.:||::|.|||:|:.:..|.|||:   |.|:||..||...|::|.|||..|:..
  Rat   626 GCPIGLELLSDMKTCIIPEAFLVFTSRATIHRISL---ETNNNDVAIPLTGVKEASALDFDVSNN 687

  Fly   754 RIYWTDQKSKCIFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSR 818
            .|||||...|.|.|||:|||.|:.:::.||..|:|:||||:..|:||:|....|||||||||..|
  Rat   688 HIYWTDVSLKTISRAFMNGSSVEHVIEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFR 752

  Fly   819 RVLLWKGVEEPRSLVLEPRRGYMYWTE-SPTDSIRRAAMDGSDLQTIVAGANHAAGLTFDQETRR 882
            :||:|:.::.||||.|:|.:||:|||| .....|.||.|||::..|:|.....|..||.|...:|
  Rat   753 QVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQR 817

  Fly   883 LYWATQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSDWNTGDIERVHKTTGQNRS 947
            ||| |......|||::..|::|.: :..|:..|:.::.|.||:||:|||...|||..||:|:||:
  Rat   818 LYW-TDLDTNMIESSNMLGQERMV-IADDLPYPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRT 880

  Fly   948 LVHSGMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCIP 1012
            |:...:.::..:|||:..||.|:|.|..:||.|..||||.||  |..|.|.:||.|.....:|.|
  Rat   881 LIQGHLDFVMDILVFHSSRQDGLNDCVHSNGQCGQLCLAIPG--GHRCGCASHYTLDPSSRNCSP 943

  Fly  1013 PRNYIIFSQRNCFGRLLPNTTDCPNIPLPVSG-KNIRAVDYDPITHHIYWIEGRSHSIKRSLANG 1076
            |..:::|||:....|::|:....|::.||:.| :|::|::|||:...|||::|| .:|||:..:|
  Rat   944 PSTFLLFSQKFAISRMIPDDQLSPDLILPLHGLRNVKAINYDPLDKFIYWVDGR-QNIKRAKDDG 1007

  Fly  1077 TKVSLLANSG-------QPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPRNI 1134
            |:.|:|.:..       ||.||:|||..|.|||||..:|:|||....|:::||:..||.::||.|
  Rat  1008 TQPSMLTSPSQSLSPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLDGDAMGVVLRGDRDRPRAI 1072

  Fly  1135 AVHAMKRLLFWTDVGSHQA-IIRARVDGNER-VELAYKLEGVTALALDQQSDMIYY--AHGKRID 1195
            ||:|.:..:::|::..|.| |.||.:||.|| |.....|....||.:|.....:::  |..|||:
  Rat  1073 AVNAERGYMYFTNMQDHAAKIERASLDGTEREVLFTTGLIRPVALVVDNALGKLFWVDADLKRIE 1137

  Fly  1196 AIDINGKNKKTLVSMHISQVINIAALGGFVYWLD-DKTGVERI-TVNGERRSAELQRLPQITDIR 1258
            :.|::|.|:.||...:|.|.:.:..||..:||:| .:..:||: ...|::|:....|:..:|.|.
  Rat  1138 SCDLSGANRLTLEDANIVQPVGLTVLGRHLYWIDRQQQMIERVEKTTGDKRTRVQGRVTHLTGIH 1202

  Fly  1259 AVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCPKHLMLLEDKENCGAFPACGPDH 1323
            ||.....:....|.|......|||||||.|:|..|    ||||.||:||::...||..|.|.||.
  Rat  1203 AVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPR----CSCPVHLVLLQNLLTCGEPPTCSPDQ 1263

  Fly  1324 FTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGCPTCRADQFSCQSGECIDKSLVCDGTT 1388
            |.||.     .::  ||||.:|||||..:|.|:|||.|||.|.|.||.|..|:|:|..|.||   
  Rat  1264 FACAT-----GEI--DCIPGAWRCDGFPECADQSDEEGCPVCSASQFPCARGQCVDLRLRCD--- 1318

  Fly  1389 NCANGHDEADCCKRPGEFQCPINKLCISAALLCDGWENCADGADESSDICLQRRMAPATDKRAFM 1453
                    |.|.  |.:|:|...: |:.....||.:.:||||:||   :..:....|:.|..|..
  Rat  1319 --------AVCL--PNQFRCASGQ-CVLIKQQCDSFPDCADGSDE---LMCEINKPPSDDVPAHS 1369

  Fly  1454 ILIGATMITIFSI-----VYLL---QFCRTRIGKSRTEPKDDQATDPLSPSTL------------ 1498
            ..||..:..|.|:     ||.:   ..|:...|.|...|.:.....|..|...            
  Rat  1370 SAIGPVIGIILSLFVMGGVYFVCQRVMCQRYTGASGPFPHEYVGGTPHVPLNFIAPGGSQHGPFP 1434

  Fly  1499 ----SKSQRVSKIASVADAVRMSTLNSRNSMNSYDRNHITGASSSTTNGSSMVAYP--INPPPSP 1557
                |||...|          :|.:..|.|:..|||||:||||||:::.:....||  :||||||
  Rat  1435 GIPCSKSMMSS----------VSLVGGRGSVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSP 1489

  Fly  1558 AT----------------RSRRPYRHYKIINQPPPPTPCSTDICDESDSNYTSKSNSNNSNGGAT 1606
            ||                .:.||||.|.|....||.||||||:|   ||:|::      |....:
  Rat  1490 ATDPSLYNMDMFYSSNIPSTARPYRPYIIRGMAPPTTPCSTDVC---DSDYST------SRWKTS 1545

  Fly  1607 KHSSSSAAACLQYGYDSEPYPPPPTPRSHYHSDVRIVPESSCPPSPSSRSSTYFSPLPPPPSPVQ 1671
            |:       .|....||:||||||||.|.|.|     .|.||||||.:..| |....||||||..
  Rat  1546 KY-------YLDLNSDSDPYPPPPTPHSQYLS-----AEDSCPPSPVTERS-YCHLFPPPPSPCT 1597

  Fly  1672 SPS 1674
            ..|
  Rat  1598 DSS 1600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 22/38 (58%)
NHL 168..503 CDD:302697 169/337 (50%)
NHL repeat 172..237 CDD:271320 41/64 (64%)
LY 252..293 CDD:214531 18/40 (45%)
NHL repeat 261..298 CDD:271320 18/37 (49%)
NHL repeat 303..339 CDD:271320 18/36 (50%)
NHL repeat 341..419 CDD:271320 31/78 (40%)
NHL repeat 428..476 CDD:271320 22/47 (47%)
LY 472..511 CDD:214531 27/38 (71%)
NHL repeat 477..503 CDD:271320 19/25 (76%)
Ldl_recept_b 534..573 CDD:278487 23/38 (61%)
LY 558..599 CDD:214531 25/40 (63%)
LY 600..641 CDD:214531 20/40 (50%)
FXa_inhibition 668..703 CDD:291342 17/34 (50%)
LY 739..773 CDD:214531 17/33 (52%)
LY 776..818 CDD:214531 21/41 (51%)
LY 819..860 CDD:214531 21/41 (51%)
FXa_inhibition 973..1010 CDD:291342 16/36 (44%)
LY 1122..1164 CDD:214531 17/42 (40%)
FXa_inhibition 1273..1313 CDD:291342 19/39 (49%)
LDLa 1319..1362 CDD:238060 20/42 (48%)
LDLa 1365..1399 CDD:238060 12/33 (36%)
LDLa 1399..1433 CDD:197566 11/33 (33%)
Lrp5NP_001099791.2 NHL <37..>169 CDD:302697 58/141 (41%)
NHL repeat 65..104 CDD:271320 14/44 (32%)
LY 102..142 CDD:214531 22/39 (56%)
NHL repeat 107..148 CDD:271320 25/40 (63%)
Ldl_recept_b 163..203 CDD:278487 21/41 (51%)
LY 187..229 CDD:214531 18/41 (44%)
LY 230..271 CDD:214531 18/40 (45%)
FXa_inhibition 299..336 CDD:291342 19/36 (53%)
LY 366..406 CDD:214531 20/39 (51%)
LY 408..450 CDD:214531 27/41 (66%)
LY 451..494 CDD:214531 23/43 (53%)
LY 495..537 CDD:214531 25/41 (61%)
LY 538..571 CDD:214531 17/32 (53%)
FXa_inhibition 605..640 CDD:291342 17/34 (50%)
NHL 685..878 CDD:302697 89/194 (46%)
LY 710..752 CDD:214531 21/41 (51%)
NHL repeat 720..756 CDD:271320 21/35 (60%)
NHL repeat 763..802 CDD:271320 20/38 (53%)
NHL repeat 808..843 CDD:271320 13/36 (36%)
NHL repeat 847..871 CDD:271320 11/23 (48%)
FXa_inhibition 906..941 CDD:291342 16/36 (44%)
LY 1060..1103 CDD:214531 17/42 (40%)
LY 1104..1146 CDD:214531 11/41 (27%)
FXa_inhibition 1217..1253 CDD:291342 19/39 (49%)
LDLa 1259..1295 CDD:238060 20/42 (48%)
LDLa 1321..1355 CDD:238060 13/39 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 119 1.000 Domainoid score I5658
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1327 1.000 Inparanoid score I135
OMA 1 1.010 - - QHG48457
OrthoDB 1 1.010 - - D121310at2759
OrthoFinder 1 1.000 - - FOG0004181
OrthoInspector 1 1.000 - - otm46284
orthoMCL 1 0.900 - - OOG6_100345
Panther 1 1.100 - - LDO PTHR46513
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X3498
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.840

Return to query results.
Submit another query.