DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and Lrp2

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:XP_038960355.1 Gene:Lrp2 / 29216 RGDID:68407 Length:4665 Species:Rattus norvegicus


Alignment Length:1490 Identity:443/1490 - (29%)
Similarity:694/1490 - (46%) Gaps:208/1490 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 LLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSAL 153
            |:..:|..|.|.|||..|  ..:..:|:|::..:|:||......|.|:|                
  Rat  1444 LVVASRDKIIVDNITAHT--HNLYSLVQDVSFVVALDFDSVTGRVFWSD---------------- 1490

  Fly   154 QPLLRAPKQTVISTGLDK----------PEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLF 208
              ||:....:|...|.||          .|.:|:||....:||||.....|||:.:||.::.||.
  Rat  1491 --LLQGKTWSVFQNGTDKRVVHDSGLSVTEMIAVDWIGRNLYWTDYALETIEVSKIDGSHRTVLI 1553

  Fly   209 WTDLDQPRAVAVVP--ARKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNE 271
            ..::.:||.:|:.|  ...::.|:|||.:|:||||||||  ..|..:|:|.::||.||::|..|.
  Rat  1554 SKNVTKPRGLALDPRMGDNVMFWSDWGHHPRIERASMDG--TMRTVIVQEKIYWPCGLSIDYPNR 1616

  Fly   272 LIYWTDGKHHFIDVMRLDGSSRRTIVNN---LKYPFSLTFYDDRLYWTD-----------WQRGS 322
            |||:.|....:|:....||.:||.::.:   |.:|.:||.::|.:||||           |..|:
  Rat  1617 LIYFMDAYLDYIEFCDYDGHNRRQVIASDLVLHHPHALTLFEDFVYWTDRGTRQVMQANKWHGGN 1681

  Fly   323 LNALDLQTRELKELIDTPKAPNSVRAWDPSLQPYEDNPCAHNNGNCSHLCLLATNS-QGFSCACP 386
            .:.:.....:          |..:.|..||.||...||||  :.:|||||||:..: :.:|||||
  Rat  1682 QSVVMYSVHQ----------PLGITAIHPSRQPPSRNPCA--SASCSHLCLLSAQAPRHYSCACP 1734

  Fly   387 TGVKLI--SANTCANGSQEMMFIVQRTQISKISLD----SPDYTIFPLPLGKVKYAIAIDYDPVE 445
            :|..|.  |.| |..|.|..:..|:...|..||||    |.|..:   |:..:::...:::|..|
  Rat  1735 SGWNLSDDSVN-CVRGDQPFLMSVRDNIIFGISLDPEVKSNDAMV---PISGIQHGYDVEFDDSE 1795

  Fly   446 EHIYWSDVETYTIKRAHADGTGVTDFV-TSEVRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGT 509
            :.|||.: ....|.|...||:..|.|. .|.:....||||||::||:|:|...:..|||..|.|.
  Rat  1796 QFIYWVE-NPGEIHRVKTDGSNRTVFAPLSLLGSSLGLALDWVSRNIYYTTPASRSIEVLTLKGD 1859

  Fly   510 AR--KVLIYEH-----LEEPRAIAVAPSLGWMFWSDWNERK---PKVERASLDGSERVVLVSENL 564
            .|  |.||...     :..|..|||.|:.|.::|||.....   .|:..|::||:...:|.:.||
  Rat  1860 TRYGKTLIANDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASANMDGTSLKILFTGNL 1924

  Fly   565 GWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRS 629
            .....:.|||:.:.:||.......||..|:||: .|:::..:|.|.:||.:...:||::|.|...
  Rat  1925 QHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGT-ERMILVHHLAHPWGLVVYGSFLYYSDEQYEV 1988

  Fly   630 IDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVR-GQNACAVRNGGCSHLCLNRPRD-YVCRCAI 692
            |:|..|.:|||::|:.|..|.|.||:|...|... ..|.|:.....|..:||..|.. :.|.||.
  Rat  1989 IERVDKSSGNNKVVLRDNVPYLRGLRVYHRRNAADSSNGCSNNPNACQQICLPVPGGMFSCACAS 2053

  Fly   693 DYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERIPFK-DVRDAHALDVSVAERRIY 756
            .::|:.|.|:|....:|::.|....:...|:|.::  |::..:|.. ..|:....||.||...||
  Rat  2054 GFKLSPDGRSCSPYNSFMVVSMLPAVRGFSLELSD--HSEAMVPVAGQGRNVLHADVDVANGFIY 2116

  Fly   757 WTD-----QKSKCIFRAFLNGSYVQRIVDSGLIGPDGI---AVDWLANNIYWSDAEARR--IEVA 811
            |.|     :.|..|.|...:||....:|..| ||.:||   |:||.|.|:|:::|....  |||.
  Rat  2117 WCDFSSSVRSSNGIRRIKPDGSNFTNVVTYG-IGANGIRGVALDWAAGNLYFTNAFVYETLIEVL 2180

  Fly   812 RLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTE-SPTDSIRRAAMDGSDLQTIVA-GANHAAGL 874
            |::.:.|||||...|:.||.::::|:..|::|.: .....|.|:.:|.::...:|: |.....||
  Rat  2181 RINTTYRRVLLKVSVDMPRHIIVDPKHRYLFWADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGL 2245

  Fly   875 TFDQETRRLYWATQSRPAKIESADWDGKKRQIL-VGSDMDEPYAVSLYQDYVYWSDWNTGDIERV 938
            ..|.:|..:||...|... |.....||.:.|:: .||....||.::::.:.:.|.|.|...:.:.
  Rat  2246 AMDHDTGYIYWVDDSLDL-IARIHLDGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLKKVFQA 2309

  Fly   939 HKTTGQNRS--LVHSGMTYITSLLVFNDKRQ------TGVNPCKVNNGGCSHLCLAQPGRRGMTC 995
            .|..|....  ::...:..:..:.:|::..|      ...|||..:||||||.|.|.|......|
  Rat  2310 SKQPGNTDPPVVIRDKINLLRDVTIFDEHAQPLSPAELNNNPCLQSNGGCSHFCFALPELPTPRC 2374

  Fly   996 ACPTHYQLAKDGVSCIPPR-NYIIFSQRNCFGRLL--PNTTDCPNIPLPVSGKNIRAVDYDPITH 1057
            .| ....|..||.||...: :::|:|..|....|.  |.....|...:.|:|..| |:|||...:
  Rat  2375 GC-AFGTLGNDGKSCATSQEDFLIYSLNNSLRSLHFDPRDHSLPFQVISVAGTAI-ALDYDRRNN 2437

  Fly  1058 HIYW------IEGRSHSIKRSLANGTKVSLLANSGQPFDLAIDIIGRLLFWTCSQSNSINVTSFL 1116
            .|::      :.|:...:.....:.:...||:|.|....:|.|.|.|.::::...:.:||..:..
  Rat  2438 RIFFTQKLNSLRGQISYVSLYSGSSSPTVLLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAED 2502

  Fly  1117 GESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQAIIRARVDGNERVELA-YKLEGVTALALD 1180
            |.:..||  ....|||.|.:...:..::|||.|::..|.||.:.||.||.:. ..|.....||||
  Rat  2503 GSNRAVI--ARVSKPRAIVLDPCRGYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPNGLALD 2565

  Fly  1181 QQSDMIYYAHG--KRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLDDKTGVERI----TV 1239
            .::|::|:|..  ::|:...:.|.|::.:||..... ..:...|.::||.|..|  .:|    ..
  Rat  2566 LETDLLYWADASLQKIERSTLTGTNREVVVSTAFHS-FGLTVYGQYIYWTDLYT--RKIYRANKY 2627

  Fly  1240 NGERRSAELQRLP-QITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCP-- 1301
            :|....|...||| |.:.|..|.....:...| .|......|||||.....|..     |.||  
  Rat  2628 DGSDLVAMTTRLPTQPSGISTVVKTQRQQCSN-PCDQFNGGCSHICAPGPNGAE-----CQCPHE 2686

  Fly  1302 ---------KHLML------------------------LEDKENCG----------AFPACGPDH 1323
                     |:.::                        .::..:||          ||..|....
  Rat  2687 GNWYLANDNKYCVVDTGTRCNQLQFTCLNGHCINQDWKCDNDNDCGDGSDELPTVCAFHTCRSTA 2751

  Fly  1324 FTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGC--PTCRA-DQFSCQSGECIDKSLVCD 1385
            |||.         |..|:|..:|||...||.|.|||.||  ..|.: .:|:|.:|.||..|.||:
  Rat  2752 FTCG---------NGRCVPYHYRCDYYNDCGDNSDEAGCLFRNCNSTTEFTCSNGRCIPLSYVCN 2807

  Fly  1386 GTTNCANG--HDEADC----CKRPGEF-QCPINKLCISAALLCDGWENCADGADESSDIC 1438
            |..||.:.  .||.:|    |  |.:| :|....:|:..|.||||..:|.||:||:...|
  Rat  2808 GINNCHDNDTSDEKNCPPHTC--PPDFTKCQTTNICVPRAFLCDGDNDCGDGSDENPIYC 2865

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 15/48 (31%)
NHL 168..503 CDD:302697 125/368 (34%)
NHL repeat 172..237 CDD:271320 23/66 (35%)
LY 252..293 CDD:214531 15/40 (38%)
NHL repeat 261..298 CDD:271320 14/36 (39%)
NHL repeat 303..339 CDD:271320 10/46 (22%)
NHL repeat 341..419 CDD:271320 33/80 (41%)
NHL repeat 428..476 CDD:271320 13/48 (27%)
LY 472..511 CDD:214531 16/39 (41%)
NHL repeat 477..503 CDD:271320 11/25 (44%)
Ldl_recept_b 534..573 CDD:278487 10/41 (24%)
LY 558..599 CDD:214531 13/40 (33%)
LY 600..641 CDD:214531 14/40 (35%)
FXa_inhibition 668..703 CDD:291342 11/35 (31%)
LY 739..773 CDD:214531 12/38 (32%)
LY 776..818 CDD:214531 17/46 (37%)
LY 819..860 CDD:214531 13/41 (32%)
FXa_inhibition 973..1010 CDD:291342 15/36 (42%)
LY 1122..1164 CDD:214531 15/41 (37%)
FXa_inhibition 1273..1313 CDD:291342 11/74 (15%)
LDLa 1319..1362 CDD:238060 16/42 (38%)
LDLa 1365..1399 CDD:238060 14/36 (39%)
LDLa 1399..1433 CDD:197566 14/38 (37%)
Lrp2XP_038960355.1 LDLa 28..62 CDD:238060
LDLa 67..103 CDD:238060
LDLa 108..142 CDD:238060
LDLa 148..179 CDD:238060
LDLa 183..217 CDD:238060
LDLa 222..256 CDD:238060
LDLa 265..299 CDD:238060
LY 460..500 CDD:214531
LY 502..547 CDD:214531
LY 550..590 CDD:214531
LY 775..817 CDD:214531
Ldl_recept_b 837..877 CDD:423042
LY 863..903 CDD:214531
LDLa 1025..1059 CDD:238060
Ldl_recept_a 1065..1101 CDD:395011
LDLa 1110..1144 CDD:238060
LDLa 1150..1184 CDD:238060
LDLa 1188..1223 CDD:238060
LDLa 1231..1263 CDD:197566
LDLa 1272..1306 CDD:238060
LDLa 1313..1345 CDD:197566
FXa_inhibition 1359..1394 CDD:405372
EGF_CA 1396..1435 CDD:214542
LY 1507..1549 CDD:214531 13/41 (32%)
LY 1551..1595 CDD:214531 19/45 (42%)
LY 1597..1638 CDD:214531 15/40 (38%)
FXa_inhibition 1715..1746 CDD:405372 16/31 (52%)
Ldl_recept_b 1889..1933 CDD:395012 11/43 (26%)
LY 1917..1959 CDD:214531 13/42 (31%)
FXa_inhibition 2028..2064 CDD:405372 11/35 (31%)
YncE 2115..>2307 CDD:225926 60/193 (31%)
LY 2188..2231 CDD:214531 13/42 (31%)
LY 2233..2273 CDD:214531 12/40 (30%)
FXa_inhibition 2352..2388 CDD:405372 15/36 (42%)
LY 2465..2506 CDD:214531 11/40 (28%)
Ldl_recept_b 2525..2565 CDD:395012 14/39 (36%)
LY 2551..2591 CDD:214531 10/39 (26%)
LY <2600..2631 CDD:214531 7/33 (21%)
FXa_inhibition 2661..2698 CDD:405372 11/41 (27%)
LDLa 2705..2737 CDD:197566 2/31 (6%)
LDLa 2747..2781 CDD:238060 16/42 (38%)
exchanger_TraA <2748..3136 CDD:411343 48/129 (37%)
LDLa 2912..2944 CDD:197566
LDLa 3000..3034 CDD:238060
LDLa 3039..3070 CDD:197566
LDLa 3082..3116 CDD:238060
cEGF 3139..3162 CDD:403760
EGF_CA 3159..3198 CDD:214542
LY 3226..3268 CDD:214531
LY 3269..3311 CDD:214531
Ldl_recept_b 3340..3380 CDD:395012
LY 3365..3406 CDD:214531
LY 3407..3448 CDD:214531
FXa_inhibition 3476..>3505 CDD:405372
LDLa 3519..3553 CDD:238060
LDLa 3560..3591 CDD:197566
LDLa 3600..3632 CDD:197566
LDLa 3641..3673 CDD:197566
LDLa 3689..3721 CDD:238060
LDLa 3728..3761 CDD:238060
LDLa 3766..3800 CDD:238060
LDLa 3805..3839 CDD:238060
LDLa 3849..3881 CDD:238060
LDLa 3892..3922 CDD:197566
LDLa 3935..3969 CDD:238060
EGF_CA 4014..4054 CDD:214542
LY 4148..4183 CDD:214531
Ldl_recept_b 4204..4244 CDD:395012
LY 4229..4271 CDD:214531
FXa_inhibition 4345..>4363 CDD:405372
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166349217
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.740

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