DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and Lrp2

DIOPT Version :10

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_110454.2 Gene:Lrp2 / 29216 RGDID:68407 Length:4660 Species:Rattus norvegicus


Alignment Length:1490 Identity:443/1490 - (29%)
Similarity:694/1490 - (46%) Gaps:208/1490 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 LLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSAL 153
            |:..:|..|.|.|||..|  ..:..:|:|::..:|:||......|.|:|                
  Rat  1439 LVVASRDKIIVDNITAHT--HNLYSLVQDVSFVVALDFDSVTGRVFWSD---------------- 1485

  Fly   154 QPLLRAPKQTVISTGLDK----------PEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLF 208
              ||:....:|...|.||          .|.:|:||....:||||.....|||:.:||.::.||.
  Rat  1486 --LLQGKTWSVFQNGTDKRVVHDSGLSVTEMIAVDWIGRNLYWTDYALETIEVSKIDGSHRTVLI 1548

  Fly   209 WTDLDQPRAVAVVP--ARKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNE 271
            ..::.:||.:|:.|  ...::.|:|||.:|:||||||||  ..|..:|:|.::||.||::|..|.
  Rat  1549 SKNVTKPRGLALDPRMGDNVMFWSDWGHHPRIERASMDG--TMRTVIVQEKIYWPCGLSIDYPNR 1611

  Fly   272 LIYWTDGKHHFIDVMRLDGSSRRTIVNN---LKYPFSLTFYDDRLYWTD-----------WQRGS 322
            |||:.|....:|:....||.:||.::.:   |.:|.:||.::|.:||||           |..|:
  Rat  1612 LIYFMDAYLDYIEFCDYDGHNRRQVIASDLVLHHPHALTLFEDFVYWTDRGTRQVMQANKWHGGN 1676

  Fly   323 LNALDLQTRELKELIDTPKAPNSVRAWDPSLQPYEDNPCAHNNGNCSHLCLLATNS-QGFSCACP 386
            .:.:.....:          |..:.|..||.||...||||  :.:|||||||:..: :.:|||||
  Rat  1677 QSVVMYSVHQ----------PLGITAIHPSRQPPSRNPCA--SASCSHLCLLSAQAPRHYSCACP 1729

  Fly   387 TGVKLI--SANTCANGSQEMMFIVQRTQISKISLD----SPDYTIFPLPLGKVKYAIAIDYDPVE 445
            :|..|.  |.| |..|.|..:..|:...|..||||    |.|..:   |:..:::...:::|..|
  Rat  1730 SGWNLSDDSVN-CVRGDQPFLMSVRDNIIFGISLDPEVKSNDAMV---PISGIQHGYDVEFDDSE 1790

  Fly   446 EHIYWSDVETYTIKRAHADGTGVTDFV-TSEVRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGT 509
            :.|||.: ....|.|...||:..|.|. .|.:....||||||::||:|:|...:..|||..|.|.
  Rat  1791 QFIYWVE-NPGEIHRVKTDGSNRTVFAPLSLLGSSLGLALDWVSRNIYYTTPASRSIEVLTLKGD 1854

  Fly   510 AR--KVLIYEH-----LEEPRAIAVAPSLGWMFWSDWNERK---PKVERASLDGSERVVLVSENL 564
            .|  |.||...     :..|..|||.|:.|.::|||.....   .|:..|::||:...:|.:.||
  Rat  1855 TRYGKTLIANDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASANMDGTSLKILFTGNL 1919

  Fly   565 GWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRS 629
            .....:.|||:.:.:||.......||..|:||: .|:::..:|.|.:||.:...:||::|.|...
  Rat  1920 QHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGT-ERMILVHHLAHPWGLVVYGSFLYYSDEQYEV 1983

  Fly   630 IDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVR-GQNACAVRNGGCSHLCLNRPRD-YVCRCAI 692
            |:|..|.:|||::|:.|..|.|.||:|...|... ..|.|:.....|..:||..|.. :.|.||.
  Rat  1984 IERVDKSSGNNKVVLRDNVPYLRGLRVYHRRNAADSSNGCSNNPNACQQICLPVPGGMFSCACAS 2048

  Fly   693 DYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERIPFK-DVRDAHALDVSVAERRIY 756
            .::|:.|.|:|....:|::.|....:...|:|.::  |::..:|.. ..|:....||.||...||
  Rat  2049 GFKLSPDGRSCSPYNSFMVVSMLPAVRGFSLELSD--HSEAMVPVAGQGRNVLHADVDVANGFIY 2111

  Fly   757 WTD-----QKSKCIFRAFLNGSYVQRIVDSGLIGPDGI---AVDWLANNIYWSDAEARR--IEVA 811
            |.|     :.|..|.|...:||....:|..| ||.:||   |:||.|.|:|:::|....  |||.
  Rat  2112 WCDFSSSVRSSNGIRRIKPDGSNFTNVVTYG-IGANGIRGVALDWAAGNLYFTNAFVYETLIEVL 2175

  Fly   812 RLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTE-SPTDSIRRAAMDGSDLQTIVA-GANHAAGL 874
            |::.:.|||||...|:.||.::::|:..|::|.: .....|.|:.:|.::...:|: |.....||
  Rat  2176 RINTTYRRVLLKVSVDMPRHIIVDPKHRYLFWADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGL 2240

  Fly   875 TFDQETRRLYWATQSRPAKIESADWDGKKRQIL-VGSDMDEPYAVSLYQDYVYWSDWNTGDIERV 938
            ..|.:|..:||...|... |.....||.:.|:: .||....||.::::.:.:.|.|.|...:.:.
  Rat  2241 AMDHDTGYIYWVDDSLDL-IARIHLDGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLKKVFQA 2304

  Fly   939 HKTTGQNRS--LVHSGMTYITSLLVFNDKRQ------TGVNPCKVNNGGCSHLCLAQPGRRGMTC 995
            .|..|....  ::...:..:..:.:|::..|      ...|||..:||||||.|.|.|......|
  Rat  2305 SKQPGNTDPPVVIRDKINLLRDVTIFDEHAQPLSPAELNNNPCLQSNGGCSHFCFALPELPTPRC 2369

  Fly   996 ACPTHYQLAKDGVSCIPPR-NYIIFSQRNCFGRLL--PNTTDCPNIPLPVSGKNIRAVDYDPITH 1057
            .| ....|..||.||...: :::|:|..|....|.  |.....|...:.|:|..| |:|||...:
  Rat  2370 GC-AFGTLGNDGKSCATSQEDFLIYSLNNSLRSLHFDPRDHSLPFQVISVAGTAI-ALDYDRRNN 2432

  Fly  1058 HIYW------IEGRSHSIKRSLANGTKVSLLANSGQPFDLAIDIIGRLLFWTCSQSNSINVTSFL 1116
            .|::      :.|:...:.....:.:...||:|.|....:|.|.|.|.::::...:.:||..:..
  Rat  2433 RIFFTQKLNSLRGQISYVSLYSGSSSPTVLLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAED 2497

  Fly  1117 GESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQAIIRARVDGNERVELA-YKLEGVTALALD 1180
            |.:..||  ....|||.|.:...:..::|||.|::..|.||.:.||.||.:. ..|.....||||
  Rat  2498 GSNRAVI--ARVSKPRAIVLDPCRGYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPNGLALD 2560

  Fly  1181 QQSDMIYYAHG--KRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLDDKTGVERI----TV 1239
            .::|::|:|..  ::|:...:.|.|::.:||..... ..:...|.::||.|..|  .:|    ..
  Rat  2561 LETDLLYWADASLQKIERSTLTGTNREVVVSTAFHS-FGLTVYGQYIYWTDLYT--RKIYRANKY 2622

  Fly  1240 NGERRSAELQRLP-QITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCP-- 1301
            :|....|...||| |.:.|..|.....:...| .|......|||||.....|..     |.||  
  Rat  2623 DGSDLVAMTTRLPTQPSGISTVVKTQRQQCSN-PCDQFNGGCSHICAPGPNGAE-----CQCPHE 2681

  Fly  1302 ---------KHLML------------------------LEDKENCG----------AFPACGPDH 1323
                     |:.::                        .::..:||          ||..|....
  Rat  2682 GNWYLANDNKYCVVDTGTRCNQLQFTCLNGHCINQDWKCDNDNDCGDGSDELPTVCAFHTCRSTA 2746

  Fly  1324 FTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGC--PTCRA-DQFSCQSGECIDKSLVCD 1385
            |||.         |..|:|..:|||...||.|.|||.||  ..|.: .:|:|.:|.||..|.||:
  Rat  2747 FTCG---------NGRCVPYHYRCDYYNDCGDNSDEAGCLFRNCNSTTEFTCSNGRCIPLSYVCN 2802

  Fly  1386 GTTNCANG--HDEADC----CKRPGEF-QCPINKLCISAALLCDGWENCADGADESSDIC 1438
            |..||.:.  .||.:|    |  |.:| :|....:|:..|.||||..:|.||:||:...|
  Rat  2803 GINNCHDNDTSDEKNCPPHTC--PPDFTKCQTTNICVPRAFLCDGDNDCGDGSDENPIYC 2860

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 15/48 (31%)
NHL 168..503 CDD:302697 125/368 (34%)
NHL repeat 172..237 CDD:271320 23/66 (35%)
LY 252..293 CDD:214531 15/40 (38%)
NHL repeat 261..298 CDD:271320 14/36 (39%)
NHL repeat 303..339 CDD:271320 10/46 (22%)
NHL repeat 341..419 CDD:271320 33/80 (41%)
NHL repeat 428..476 CDD:271320 13/48 (27%)
LY 472..511 CDD:214531 16/39 (41%)
NHL repeat 477..503 CDD:271320 11/25 (44%)
Ldl_recept_b 534..574 CDD:459654 11/42 (26%)
LY 558..599 CDD:214531 13/40 (33%)
LY 600..641 CDD:214531 14/40 (35%)
FXa_inhibition 668..703 CDD:464251 11/35 (31%)
YncE <736..886 CDD:442618 53/162 (33%)
LY 776..818 CDD:214531 17/46 (37%)
LY 905..946 CDD:214531 10/41 (24%)
FXa_inhibition 973..1010 CDD:464251 15/36 (42%)
YncE <1047..1191 CDD:442618 43/150 (29%)
LDLa 1319..1362 CDD:238060 16/42 (38%)
LDLa 1365..1399 CDD:238060 14/36 (39%)
LDLa 1399..1433 CDD:197566 14/38 (37%)
Lrp2NP_110454.2 LDLa 28..62 CDD:238060
LDLa 67..103 CDD:238060
LDLa 108..142 CDD:238060
LDLa 148..179 CDD:238060
LDLa 183..217 CDD:238060
LDLa 222..256 CDD:238060
LDLa 265..299 CDD:238060
YncE <427..576 CDD:442618
LDL-receptor class B 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 435..477
LDL-receptor class B 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 478..520
LY 502..547 CDD:214531
LDL-receptor class B 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 521..567
LY 550..590 CDD:214531
LDL-receptor class B 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 568..612
LDL-receptor class B 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 752..794
LY 775..817 CDD:214531
LDL-receptor class B 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 795..836
LDL-receptor class B 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 837..880
Ldl_recept_b 837..878 CDD:459654
LY 863..903 CDD:214531
LDL-receptor class B 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 881..924
FXa_inhibition 980..1012 CDD:464251
LDLa 1025..1059 CDD:238060
Ldl_recept_a 1065..1101 CDD:395011
LDLa 1110..1144 CDD:238060
LDLa 1150..1184 CDD:238060
LDLa 1188..1223 CDD:238060
LDLa 1231..1263 CDD:197566
LDLa 1272..1306 CDD:238060
LDLa 1313..1345 CDD:197566
FXa_inhibition 1354..1389 CDD:464251
EGF_CA 1391..1430 CDD:214542
LDL-receptor class B 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1479..1521 13/59 (22%)
LY 1502..1544 CDD:214531 13/41 (32%)
LDL-receptor class B 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1522..1564 15/41 (37%)
LY 1546..1590 CDD:214531 19/45 (42%)
LDL-receptor class B 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1567..1610 21/44 (48%)
LY 1592..1633 CDD:214531 15/40 (38%)
LDL-receptor class B 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1611..1655 13/43 (30%)
LDL-receptor class B 13. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1656..1696 8/49 (16%)
FXa_inhibition 1710..1741 CDD:464251 16/31 (52%)
LDL-receptor class B 14. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1791..1833 16/42 (38%)
LDL-receptor class B 15. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1834..1883 18/48 (38%)
LDL-receptor class B 16. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1884..1931 14/46 (30%)
Ldl_recept_b 1884..1929 CDD:459654 12/44 (27%)
LY 1912..1954 CDD:214531 13/42 (31%)
LDL-receptor class B 17. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1932..1973 12/41 (29%)
LDL-receptor class B 18. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1974..2014 17/39 (44%)
YncE 2035..2253 CDD:442618 68/220 (31%)
LDL-receptor class B 19. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2108..2157 18/49 (37%)
LDL-receptor class B 20. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2158..2202 16/43 (37%)
LDL-receptor class B 21. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2203..2246 10/42 (24%)
LDL-receptor class B 22. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2247..2290 11/43 (26%)
FXa_inhibition 2347..2383 CDD:464251 15/36 (42%)
LDL-receptor class B 23. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2432..2478 8/45 (18%)
LY 2460..2501 CDD:214531 11/40 (28%)
LDL-receptor class B 24. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2479..2519 10/41 (24%)
LDL-receptor class B 25. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2520..2563 16/42 (38%)
Ldl_recept_b 2520..2560 CDD:459654 14/39 (36%)
LY 2546..2586 CDD:214531 10/39 (26%)
LDL-receptor class B 26. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2564..2605 9/41 (22%)
LY <2595..2626 CDD:214531 7/33 (21%)
LDL-receptor class B 27. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2606..2647 13/42 (31%)
FXa_inhibition 2656..2693 CDD:464251 11/41 (27%)
LDLa 2700..2732 CDD:197566 2/31 (6%)
LDLa 2742..2776 CDD:238060 16/42 (38%)
LDLa 2783..2818 CDD:238060 13/34 (38%)
LDLa 2822..2855 CDD:197566 13/34 (38%)
LDLa 2864..2897 CDD:197566
LDLa 2907..2939 CDD:197566
LDLa 2950..2986 CDD:197566
LDLa 2995..3029 CDD:238060
LDLa 3034..3065 CDD:197566
LDLa 3077..3111 CDD:238060
FXa_inhibition 3124..3152 CDD:464251
EGF_CA 3154..3193 CDD:214542
LY 3221..3263 CDD:214531
LDL-receptor class B 28. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3241..3283
LY 3264..3306 CDD:214531
Ldl_recept_b 3284..3332 CDD:459654
LDL-receptor class B 29. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3284..3326
LDL-receptor class B 30. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3335..3378
Ldl_recept_b 3335..3376 CDD:459654
LY 3360..3401 CDD:214531
LDL-receptor class B 31. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3379..3421
LY 3402..3443 CDD:214531
LDL-receptor class B 32. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3422..3462
FXa_inhibition 3471..>3500 CDD:464251
LDLa 3514..3548 CDD:238060
LDLa 3555..3586 CDD:197566
LDLa 3595..3627 CDD:197566
LDLa 3636..3668 CDD:197566
LDLa 3684..3716 CDD:238060
LDLa 3723..3756 CDD:238060
LDLa 3761..3795 CDD:238060
LDLa 3800..3834 CDD:238060
LDLa 3844..3876 CDD:238060
LDLa 3887..3917 CDD:197566
LDLa 3930..3964 CDD:238060
EGF_CA 4009..4049 CDD:214542
LY 4143..4178 CDD:214531
LDL-receptor class B 33. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4156..4198
LDL-receptor class B 34. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4199..4242
Ldl_recept_b 4199..4240 CDD:459654
LY 4224..4266 CDD:214531
LDL-receptor class B 35. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4244..4285
FXa_inhibition 4340..>4358 CDD:464251
SH3-binding. /evidence=ECO:0000255 4454..4463
PxLPxI/L motif 1, mediates interaction with ANKRA2. /evidence=ECO:0000269|PubMed:22649097 4457..4462
PxLPxI/L motif 2, mediates interaction with ANKRA2. /evidence=ECO:0000269|PubMed:22649097 4460..4465
Endocytosis signal. /evidence=ECO:0000255 4522..4527
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4559..4582
Interaction with DAB2. /evidence=ECO:0000250|UniProtKB:P98164 4597..4610
NPXY motif 4603..4606
SH2-binding. /evidence=ECO:0000255 4606..4609
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4617..4660
SH3-binding. /evidence=ECO:0000255 4619..4630
Blue background indicates that the domain is not in the aligned region.

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