Protein Alignment arr and LRP10

DIOPT Version :10

• Sequence 1: NP_524737.2
• Gene: arr / 44279
• FlyBaseID: FBgn0000119
• Length: 1678
• Species: Drosophila melanogaster
• Sequence 2: XP_005267567.1
• Gene: LRP10 / 26020
• HGNCID: 14553
• Length: 721
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 123/518 - (23%)
• Similarity: 175/518 - (33%)
• Gaps: 133/518 - (25%)

  Fly  1226 YWLDDKTGVERITVN------------------GERRSAELQR-LPQITDIRAVWT---PDPKVL 1268
            :||.|.....|:.|.                  |...|:.|.| |...::.:||..   ....|:
Human   229 HWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVV 293

  Fly  1269 RNHTCMHSRTKCSHICIASGEGIART---RDVCSCPKHLMLLEDKENCGAFPACGPDHFTCAAPV 1330
            ..||          :..::|.|...|   |..|        |.....||.....|..
Human   294 SYHT----------VAWSNGRGFNATYHVRGYC--------LPWDRPCGLGSGLGAG-------- 332

  Fly  1331 SGISDVNKDCIPASWRCDGQKDCPDKSDEVGCPTCRADQFSC----QSG--ECIDKSLVCDGTTN 1389
               ..:.:.|...:.||||..||.|.:||..||.|....|.|    .||  .|...:..|:..|.
Human   333 ---EGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTF 394

  Fly  1390 CANGHDEADC--CKRPGEFQCPINKLCISAALLCDGWENCADGADE-SSDICLQRRMAPATDKRA 1451
            ||:|.||..|  | :||.|:|...| |:....:|||..:||||:|| .....|.|::..|.
Human   395 CADGADERRCRHC-QPGNFRCRDEK-CVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAA---- 453

  Fly  1452 FMILIGATMITIFSIVYLLQFCRTRIGKSRTEPKDDQATDPLS-----------PSTLSKSQRVS 1505
               :||:.:..:..::.|  .|..::...||:.....|  |||           |.:..:.....
Human   454 ---VIGSLVCGLLLVIAL--GCTCKLYAIRTQEYSIFA--PLSRMEAEIVQQQAPPSYGQLIAQG 511

  Fly  1506 KIASVADAVRMSTLNSRNSMNSYDRNHITGASSSTTNGSSMVAYPINPPPSPATRSR-------- 1562
            .|..|.|   ..|.|..:       |.:.|...|..   .::...:.|...|..|.|
Human   512 AIPPVED---FPTENPND-------NSVLGNLRSLL---QILRQDMTPGGGPGARRRQRGRLMRR 563

  Fly  1563 --RPYRHYKIINQPPPPTPCSTDICDESDSNYTSKSNSNNSNGGATKHSSSSAAACLQYGYDSEP 1625
              |..|.:.::.:...|...|     |:.|..|..:....:..|.|..:....|.   .|.|.|.
Human   564 LVRRLRRWGLLPRTNTPARAS-----EARSQVTPSAAPLEALDGGTGPAREGGAV---GGQDGEQ 620

  Fly  1626 YPP----PPTPRSHYHSDVRIVPES-----SCPPSPSSRSSTY------FSPLPPPPSPVQSP 1673
            .||    .|.|.:........|||:     |.|..||..|...      ..|...||.|.:||
Human   621 APPLPIKAPLPSASTSPAPTTVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSP 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531
		NHL	168..503	CDD:302697
		NHL repeat	172..237	CDD:271320
		LY	252..293	CDD:214531
		NHL repeat	261..298	CDD:271320
		NHL repeat	303..339	CDD:271320
		NHL repeat	341..419	CDD:271320
		NHL repeat	428..476	CDD:271320
		LY	472..511	CDD:214531
		NHL repeat	477..503	CDD:271320
		Ldl_recept_b	534..574	CDD:459654
		LY	558..599	CDD:214531
		LY	600..641	CDD:214531
		FXa_inhibition	668..703	CDD:464251
		YncE	<736..886	CDD:442618
		LY	776..818	CDD:214531
		LY	905..946	CDD:214531
		FXa_inhibition	973..1010	CDD:464251
		YncE	<1047..1191	CDD:442618
		LDLa	1319..1362	CDD:238060	11/42 (26%)
		LDLa	1365..1399	CDD:238060	13/39 (33%)
		LDLa	1399..1433	CDD:197566	15/35 (43%)
LRP10	XP_005267567.1	CUB	34..134	CDD:238001
		LDLa	148..182	CDD:238060
		CUB	200..310	CDD:238001	17/90 (19%)
		LDLa	<338..361	CDD:238060	10/22 (45%)
		LDLa	407..441	CDD:238060	16/35 (46%)
		PRK04654	<581..683	CDD:135173	26/109 (24%)