DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment arr and Vldlr

DIOPT Version :9

Sequence 1:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	NP_037287.2	Gene:	Vldlr / 25696	RGDID:	3963	Length:	873	Species:	Rattus norvegicus

Alignment Length:	453	Identity:	133/453 - (29%)
Similarity:	205/453 - (45%)	Gaps:	67/453 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 ELIDTPKA---PNSVRAW-DPSLQPYEDNPCAHNNGNCSHLC--LLATNSQGFSCACPTGVKLIS 393
            |.||..|.   ....|.| |..|:....|.|..|||.|||:|  |:.    |:.|.|..|.:||.
  Rat   330 ECIDITKVCDQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVI----GYECDCAAGFELID 390

  Fly   394 ANTC-----------------------------------------ANGSQEMMFIVQRTQISKIS 417
            ..||                                         |.|.:..:....|..|.||.
  Rat   391 RKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIG 455

  Fly   418 LDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDF-VTSEVRHPDG 481
            |:..:|...   :.:::..:|:|.|...:.::|:|:....|..|..|......| :...|.:|..
  Rat   456 LERKEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHFKMIDNVYNPAA 517

  Fly   482 LALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKPKV 546
            :|:||:.:.:||||..:..|.|..||||.||.|....|.||.:|||.|..|:::||||.| ..|:
  Rat   518 IAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGE-PAKI 581

  Fly   547 ERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVIS--DNLKH 609
            |:|.::|.:|..||:|::.|||||.||:....:||.|.|...:...:::|..||:|:.  :.|.|
  Rat   582 EKAGMNGFDRRPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAH 646

  Fly   610 LFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKV-TRLREVRGQNACA--VR 671
            ...|:|.:|.:||.|.:..::..|:|.||:....:|:...|...:.: ..|.:..|:|.|.  :.
  Rat   647 PLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIIYHELVQPSGKNWCEEDME 711

  Fly   672 NGGCSHLCLNRPR------DYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEG 728
            ||||.:|||..|:      .|.|.|...|.|..:.|.|...:..:.:|..:.:....|....|
  Rat   712 NGGCEYLCLPAPQINDHSPKYTCSCPNGYNLEENGRECQSTSTPVTYSETKDVNTTDILRTSG 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531
		NHL	168..503	CDD:302697	53/215 (25%)
		NHL repeat	172..237	CDD:271320
		LY	252..293	CDD:214531
		NHL repeat	261..298	CDD:271320
		NHL repeat	303..339	CDD:271320	2/3 (67%)
		NHL repeat	341..419	CDD:271320	29/124 (23%)
		NHL repeat	428..476	CDD:271320	9/48 (19%)
		LY	472..511	CDD:214531	15/38 (39%)
		NHL repeat	477..503	CDD:271320	9/25 (36%)
		Ldl_recept_b	534..573	CDD:278487	18/38 (47%)
		LY	558..599	CDD:214531	15/40 (38%)
		LY	600..641	CDD:214531	14/42 (33%)
		FXa_inhibition	668..703	CDD:291342	15/42 (36%)
		LY	739..773	CDD:214531
		LY	776..818	CDD:214531
		LY	819..860	CDD:214531
		FXa_inhibition	973..1010	CDD:291342
		LY	1122..1164	CDD:214531
		FXa_inhibition	1273..1313	CDD:291342
		LDLa	1319..1362	CDD:238060
		LDLa	1365..1399	CDD:238060
		LDLa	1399..1433	CDD:197566
Vldlr	NP_037287.2	LDLa	33..67	CDD:238060
		LDLa	71..103	CDD:197566
		Ldl_recept_a	111..149	CDD:395011
		Ldl_recept_a	153..188	CDD:395011
		LDLa	192..224	CDD:197566
		Ldl_recept_a	237..273	CDD:395011
		Ldl_recept_a	276..312	CDD:395011
		Ldl_recept_a	320..350	CDD:395011	6/19 (32%)
		FXa_inhibition	360..394	CDD:405372	15/37 (41%)
		EGF_CA	396..426	CDD:214542	0/29 (0%)
		LDL-receptor class B 1	439..480		9/43 (21%)
		LY	461..499	CDD:214531	8/40 (20%)
		LDL-receptor class B 2	481..524		11/42 (26%)
		Ldl_recept_b	481..521	CDD:395012	9/39 (23%)
		LY	508..547	CDD:214531	15/38 (39%)
		LDL-receptor class B 3	525..567		20/41 (49%)
		LDL-receptor class B 4	568..611		21/43 (49%)
		Ldl_recept_b	568..608	CDD:395012	19/40 (48%)
		LY	592..634	CDD:214531	15/41 (37%)
		LDL-receptor class B 5	612..654		12/41 (29%)
		LDL-receptor class B 6	655..697		10/41 (24%)
		Ldl_recept_b	655..694	CDD:395012	10/38 (26%)
		FXa_inhibition	706..749	CDD:405372	15/42 (36%)
		Clustered O-linked oligosaccharides	751..790		3/24 (13%)
		Endocytosis signal. /evidence=ECO:0000255	832..837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349220
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830