DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment arr and Lrp12

DIOPT Version :9

Sequence 1:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	XP_006520965.1	Gene:	Lrp12 / 239393	MGIID:	2443132	Length:	859	Species:	Mus musculus

Alignment Length:	891	Identity:	172/891 - (19%)
Similarity:	260/891 - (29%)	Gaps:	358/891 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   885 WATQSRPAKI-----ESADWDGKKRQIL----------------VGSDMDEPYAVSLYQDYVYWS 928
            |..::.|.:|     :..|..|.:|..|                .||.:..||..|  ||:| |.
Mouse    78 WLIRANPGEIITISFQDFDIQGSRRCTLDWLTIETYKNIESYRACGSTIPPPYISS--QDHV-WI 139

  Fly   929 DWNTGDIERVHKTTGQNRSLVHSGMTYITSLLVFN-----------DKRQTGVNPCKVNNGGCSH 982
            .:::.|            |:...|.    .|..|:           |:.:.|...|......|:.
Mouse   140 RFHSDD------------SVSRKGF----RLAYFSAGKSEQPDCACDQFRCGNGKCIPEAWKCNS 188

  Fly   983 LCLAQPGRRGMTCACPTHYQLAKDGVSCIPPRNYII----FSQRNCFGRL------LPNTTDCPN 1037
            :...........||...|           ||.....    ::|..|..|.      ||.:..|..
Mouse   189 MDECGDSSDEEVCASDAH-----------PPTTTAFQPCAYNQFQCLSRFTKVYTCLPESLKCDG 242

  Fly  1038 IPLPVSGKNIRAVDYDPITHHIYWIEGRSHSIKRSLANGTKVSLLANSGQPFDLAIDIIGRLLFW 1102
                    ||..:|.                                 |...|..:...|:.|.:
Mouse   243 --------NIDCLDL---------------------------------GDEIDCDMPTCGQWLKY 266

  Fly  1103 TCSQSNSINVTSFL---GESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQAIIRARVDGNER 1164
            .....||.|...|.   .....:|||||..|.          :|.:||
Mouse   267 FYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKV----------ILRFTD----------------- 304

  Fly  1165 VELAYKLEGVTALALDQQSDMIYYAHGKRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLD 1229
                :||:|..           |..:.|..|.::.|.:
Mouse   305 ----FKLDGTG-----------YGDYVKIYDGLEENPR--------------------------- 327

  Fly  1230 DKTGVERITVNGERRSAELQRLPQITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIART 1294
                                                |:||..|...|.   :.:.:.|..|..|.
Mouse   328 ------------------------------------KLLRVLTAFDSH---APLTVVSSSGQIRV 353

  Fly  1295 RDVCSCPKHLMLLEDKENCG-AFPA-------CGPDHFTCAAPVSGISDVNKDCIPASWRCDGQK 1351
            . .|:         ||.|.. .|.|       |.|....|..        |..|.....||||..
Mouse   354 H-FCA---------DKVNAARGFNATYQVDGFCLPWEIPCGG--------NWGCYTEQQRCDGYW 400

  Fly  1352 DCPDKSDEVGCPTCRADQFSC-QSGECIDKSLVCDGTTNCANGHDEADC--CKRPGEFQCPINKL 1413
            .||:..||:.|..|:.::|.| ::|.|..:|..|:...:|.||.||.:|  | :||.|.|..|:
Mouse   401 HCPNGRDEINCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFC-QPGNFHCKNNR- 463

  Fly  1414 CISAALLCDGWENCADGADESS-DICLQRRMAPATDKRAFMILIGATMITIFSIVYLLQFCR--- 1474
            |:..:.:||..::|.||:||.: .:.:..|:..|.       :||:.:..:..::.|...|:
Mouse   464 CVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAA-------VIGSLICGLLLVIALGCTCKLYS 521

  Fly  1475 ----------TRIGKSRTEPKDDQATDPLSPSTLSKSQRVSKI----------ASVADAVRMSTL 1519
                      |::  ||.|.:..:...|.|...|.....:..:          |||.:.:|:: :
Mouse   522 LRMFERRSFETQL--SRVEAELLRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLA-V 583

  Fly  1520 NSRNSMNSYDRNHITGASSSTTN--------------------GSSMVAYPINPPPSPATRSRRP 1564
            .|:....|. |..:||.||:..|                    |..:|     |..|.:..:.|.
Mouse   584 RSQLGFTSI-RLPMTGRSSNIWNRIFNFARSRHSGSLALVSGDGDEVV-----PSQSSSRETERS 642

  Fly  1565 YRHYKIINQPPPPTPCSTDICDESDSNYTSKSNSNNSNGGATKHSSSSAAACLQYGYDSEPYPPP 1629
            ..|..:.:.             |||.  |...|......||    |...||.|       |...|
Mouse   643 RPHRSLFSV-------------ESDD--TDTENERRDTAGA----SGGVAAPL-------PQKVP 681

  Fly  1630 PTPRSHY----------------HSDVRIVPESSCPP-SPSSRSST 1658
            ||.....                |:|.|.|.....|. ||:....|
Mouse   682 PTTAVEATVGSGGNSSAQSTRGGHADGREVSSVEAPSVSPARHQLT 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531
		NHL	168..503	CDD:302697
		NHL repeat	172..237	CDD:271320
		LY	252..293	CDD:214531
		NHL repeat	261..298	CDD:271320
		NHL repeat	303..339	CDD:271320
		NHL repeat	341..419	CDD:271320
		NHL repeat	428..476	CDD:271320
		LY	472..511	CDD:214531
		NHL repeat	477..503	CDD:271320
		Ldl_recept_b	534..573	CDD:278487
		LY	558..599	CDD:214531
		LY	600..641	CDD:214531
		FXa_inhibition	668..703	CDD:291342
		LY	739..773	CDD:214531
		LY	776..818	CDD:214531
		LY	819..860	CDD:214531
		FXa_inhibition	973..1010	CDD:291342	5/36 (14%)
		LY	1122..1164	CDD:214531	9/41 (22%)
		FXa_inhibition	1273..1313	CDD:291342	7/39 (18%)
		LDLa	1319..1362	CDD:238060	13/42 (31%)
		LDLa	1365..1399	CDD:238060	12/34 (35%)
		LDLa	1399..1433	CDD:197566	13/35 (37%)
Lrp12	XP_006520965.1	CUB	47..156	CDD:366096	20/96 (21%)
		LDLa	167..201	CDD:238060	4/33 (12%)
		LDLa	216..255	CDD:238060	10/79 (13%)
		CUB	268..372	CDD:238001	34/221 (15%)
		LDLa	376..411	CDD:238060	13/42 (31%)
		LDLa	414..449	CDD:238060	12/34 (35%)
		LDLa	452..486	CDD:238060	14/35 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845806
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830