DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and NID2

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:XP_005267462.1 Gene:NID2 / 22795 HGNCID:13389 Length:1402 Species:Homo sapiens


Alignment Length:213 Identity:92/213 - (43%)
Similarity:128/213 - (60%) Gaps:6/213 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly   437 IAIDYDPVEEHIYWSDVETYTIKRAHAD-GTGVTDFVTSEVRHPDGLALDWLARNLYWTDTVTDR 500
            :.||||..|..:||:||...||.||..: |......|.|.:..|:|||:|.:.|.:||||:|.|:
Human  1172 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDK 1236

  Fly   501 IEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLG 565
            ||...|||:.||||.|..|..||||||.|..|.::|:|||...||:|.:||||..|.:|::.::|
Human  1237 IESALLDGSER
KVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIG 1301

  Fly   566 WPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSI 630
            .|||:..|..:|.:.|.|..|.|:|....||:||| ||.:|||:.|.:....|:.|.|||:|..:
Human  1302 LPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGR
R-VIQNNLKYPFSIVSYADHFYHTDWRRDGV 1365

  Fly   631 DRAHKITGNNRIVVVDQY 648
            ...:|.:|.    ..|:|
Human  1366 VSVNKHSGQ----FTDEY 1379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531
NHL 168..503 CDD:302697 29/66 (44%)
NHL repeat 172..237 CDD:271320
LY 252..293 CDD:214531
NHL repeat 261..298 CDD:271320
NHL repeat 303..339 CDD:271320
NHL repeat 341..419 CDD:271320
NHL repeat 428..476 CDD:271320 16/39 (41%)
LY 472..511 CDD:214531 19/38 (50%)
NHL repeat 477..503 CDD:271320 13/25 (52%)
Ldl_recept_b 534..573 CDD:278487 17/38 (45%)
LY 558..599 CDD:214531 14/40 (35%)
LY 600..641 CDD:214531 15/40 (38%)
FXa_inhibition 668..703 CDD:291342
LY 739..773 CDD:214531
LY 776..818 CDD:214531
LY 819..860 CDD:214531
FXa_inhibition 973..1010 CDD:291342
LY 1122..1164 CDD:214531
FXa_inhibition 1273..1313 CDD:291342
LDLa 1319..1362 CDD:238060
LDLa 1365..1399 CDD:238060
LDLa 1399..1433 CDD:197566
NID2XP_005267462.1 NIDO 108..273 CDD:214712
EGF_3 515..550 CDD:289699
G2F 552..784 CDD:214774
EGF_3 790..826 CDD:289699
EGF_CA 828..870 CDD:214542
EGF_3 879..917 CDD:289699
EGF_3 923..956 CDD:289699
TY 966..1032 CDD:238114
TY 1046..1111 CDD:238114
LY 1161..1199 CDD:214531 13/26 (50%)
LY 1205..1247 CDD:214531 19/41 (46%)
LY 1248..1292 CDD:214531 24/43 (56%)
LY 1293..1335 CDD:214531 14/41 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155337
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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