DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment arr and Sorl1

DIOPT Version :9

Sequence 1:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	NP_035566.2	Gene:	Sorl1 / 20660	MGIID:	1202296	Length:	2215	Species:	Mus musculus

Alignment Length:	1952	Identity:	385/1952 - (19%)
Similarity:	603/1952 - (30%)	Gaps:	749/1952 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 FGISNSWQY--KNVHMPSSSSLIASPPASAFVNTP-ATLLFTTRHDIQVANITRPTGGPQIDVIV 115
            |.:.:.:.:  |.||:|.|....:.....:|...| ....|.|:|.|....|. .....|:.|.|
Mouse   300 FQLRDKYMFATKVVHLPGSQQQSSVQLWVSFGRKPMRAAQFVTKHPINEYYIA-DAAEDQVFVCV 363

  Fly   116 RD--------LAEAMAIDFYYA-KNLVCWTDSGREIIECAQTNSSALQPLLRAPKQTVISTGLDK 171
            ..        ::||..:.|..: :|::.::..|                   |...|::....::
Mouse   364 SHSNNSTNLYISEAEGLKFSLSLENVLYYSPGG-------------------AGSDTLVRYFANE 409

  Fly   172 P-------EGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAVAVVPARKLLIW 229
            |       |||...:....|..:..|:|...|.|.|    |...|..|..|            .:
Mouse   410 PFADFHRVEGLQGVYIATLINGSMNEENMRSVITFD----KGGTWEFLQAP------------AF 458

  Fly   230 TDWGE----------------------------YPKIERASMDG-----DPLSRMTLVKEHVFWP 261
            |.:||                            .|.:.:.|..|     ..:.:....|.:|:..
Mouse   459 TGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYIS 523

  Fly   262 NGLAVDLKNEL---IYWTDGKHHFIDVMRLDGSSRRTIVNNLKYP-----------FS------- 305
            :......:..|   .|:|.|.|..|.:....|..    .|.|||.           ||
Mouse   524 SSAGARWREALPGPHYYTWGDHGGIIMAIAQGME----TNELKYSTNEGETWKTFVFSEKPVFVY 584

  Fly   306 --LT-----------FYDDRLYWTDWQRGSLNALDLQTRELKELIDTPKAPNSVRAWDPSLQ--- 354
              ||           |..::.....|....:||.|        .:..|...|..:.|.||.:
Mouse   585 GLLTEPGEKSTVFTIFGSNKESVHSWLILQVNATD--------ALGVPCTENDYKLWSPSDERGN 641

  Fly   355 --------------PYE--------DNPCAHNNGNCS------------------HLCLLATNSQ 379
                          |:.        |.|...:|.:|:                  .:|:......
Mouse   642 ECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFS 706

  Fly   380 G--FS--CACPT--------GVKLISANTCANG---------------SQEMMFIVQRTQISKIS 417
            |  :|  ..||.        |.:.||.:||:.|               ::|..||:...:.|...
Mouse   707 GKPYSPPVPCPVGSSYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAMRKSIYR 771

  Fly   418 LDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADG-TGVTDFVTSEVRHPDG 481
            .|........|||..::.|:|:|:|.....:||||:...||:|...:| ||....:.|.:...:.
Mouse   772 YDLASGATEQLPLSGLRAAVALDFDYERNCLYWSDLALDTIQRLCLNGSTGQEVIINSGLETVEA 836

  Fly   482 LALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEH-LEEPRAIAVAPSLGWMFWSDWNERKPK 545
            ||.:.|::.|||.|....:|||...||..|..::... |:.|||:.:.|..|.|||:||.:.||.
Mouse   837 LAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPG 901

  Fly   546 VERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHL 610
            :.|:.:|||....||||::.|||||::|  ::.|||.|...|.||.....|..|.|:: |:|.|.
Mouse   902 IYRSYMDGSAAYRLVSEDVKWPNGISVD--SQWIYWTDAYLDCIERITFSGQQRSVIL-DSLPHP 963

  Fly   611 FGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAVRNGGC 675
            :.:::..:.:||.||.:.||.||.|.:.:...::..|...||.:||....:..|.|||..:  .|
Mouse   964 YAIAVFKNEIYWDDWSQLSIFRASKHSRSQVEILASQLTGLMDMKVFYKGKNAGSNACVPQ--PC 1026

  Fly   676 SHLCLNRPR-------------------DYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGRI 721
            |.|||.:..                   |.:|.|...|:..|:  |||          :|....:
Mouse  1027 SLLCLPKANNSKSCRCPEGVASSVLPSGDLMCDCPQGYQRKNN--TCV----------KEENTCL 1079

  Fly   722 SIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVDSGLIGP 786
            ..:|...|.|                                ||
Mouse  1080 RNQYRCSNGN--------------------------------CI--------------------- 1091

  Fly   787 DGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTESPTDSI 851
                     |:|:|.|
Mouse  1092 ---------NSIWWCD------------------------------------------------- 1098

  Fly   852 RRAAMDGSDLQTIVAGANHAAGLTFDQETRRLYWATQSRPAKIESADWDGKKRQILVGSDMDEPY 916
                                    ||.:...:   :..|.......|.|.:.|....|:.:...|
Mouse  1099 ------------------------FDNDCGDM---SDERNCPTTVCDADTQFRCQESGTCIPLSY 1136

  Fly   917 AVSLYQDYVYWSDWNTGD-IERVHKTTGQNRS---LVHSGMTYITSLLV--FNDKRQ-------T 968
            ...|..|        .|| .:..|....|.||   ...|||...:|.:.  .||.|.       |
Mouse  1137 KCDLEDD--------CGDNSDESHCEMHQCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANCT 1193

  Fly   969 GV-NPCKVNNGGC--SHLCLAQPGRRGMTCACPTHYQLA----KDGVSCIPPRNYIIFSQRNCFG 1026
            .: :.|:.:|..|  .| |:.|      ..||.......    :|.|||          ::.|.|
Mouse  1194 AIYHTCEASNFQCHNGH-CIPQ------RWACDGDADCQDGSDEDPVSC----------EKKCNG 1241

  Fly  1027 RLLPNTTDCPNIPLPVSGKNIRAVDYDPITHHIYWIEGRSHSIKRSLANGTKVSLLANSGQPFDL 1091
            ...||.|..|      |.|:...:                    |...:|:.    ....:||
Mouse  1242 FHCPNGTCIP------SSKHCDGL--------------------RDCPDGSD----EQHCEPF-- 1274

  Fly  1092 AIDIIGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQAIIR 1156
                ..|.:.:.|..                                .::.||.:.|  ...|::
Mouse  1275 ----CTRFMDFVCKN--------------------------------RQQCLFHSMV--CDGIVQ 1301

  Fly  1157 ARVDGNERVELAYKLEGVTALALDQQSDMIYYAHGKRIDAIDINGKNKKTLVSMHISQVINIAAL 1221
            .| ||::        |........|..:.    | |..|......:|     .:.||.:
Mouse  1302 CR-DGSD--------EDAAFAGCSQDPEF----H-KECDEFGFQCQN-----GVCISLI------ 1341

  Fly  1222 GGFVYWLDDKTGVERITVNGERRSAELQRLPQITDIRAVWTPDPKVLR-------NHTCMHSRTK 1279
                 |..|  |::......:..:.|..            |..|...|       |..|:.:|.|
Mouse  1342 -----WKCD--GMDDCGDYSDEANCENP------------TEAPNCSRYFQFHCENGHCIPNRWK 1387

  Fly  1280 CSHICIASGEGIARTRDVCSCPKHLMLLEDKENCG---AFPA-------CGPDHFTCAAPVSGIS 1334
            |.           |..|   |..    ..|:::||   ..|:       |.|::|.|:   ||.
Mouse  1388 CD-----------REND---CGD----WSDEKDCGDSHVLPSPTPGPSTCLPNYFHCS---SGA- 1430

  Fly  1335 DVNKDCIPASWRCDGQKDCPDKSDEVGCPT---------------CRADQFSC-QSGECIDKSLV 1383
                 |:..:|.|||.:||.|.|||..||:               |...:|.| |..:||.....
Mouse  1431 -----CVMGTWVCDGYRDCADGSDEEACPSLANSTAASTPTQFGQCDRFEFECHQPKKCIPNWKR 1490

  Fly  1384 CDGTTNCANGHDEADC-------CKRPGEFQCPINKLCISAALLCDGWENCADGADE-------- 1433
            |||..:|.:|.|||:|       | ...||:|...:.||..:..|||:.:|:|.:||
Mouse  1491 CDGHQDCQDGQDEANCPTHSTLTC-TSREFKCEDGEACIVLSERCDGFLDCSDESDEKACSDELT 1554

  Fly  1434 -------------SSDICL----QRRMAPATDKRAFMILIGATMITIFSIVY------LLQFCRT 1475
                         |.|:.|    .::|..|:              .::::.|      :.:...|
Mouse  1555 VYKVQNLQWTADFSGDVTLTWMRPKKMPSAS--------------CVYNVYYRVVGESIWKTLET 1605

  Fly  1476 RIGKSRTEPKDDQATDPLSPSTLSKSQ----RVSKIASVADAVRMST--------LNSRNSMNSY 1528
            ...|:.|..|      .|.|.|..:.:    .::|:.:..|.|.:.|        .|.:.|:||.
Mouse  1606 HSNKTSTVLK------VLKPDTTYQVKVQVHCLNKVHNTNDFVTLRTPEGLPDAPRNLQLSLNSE 1664

  Fly  1529 DRNHITG-------------------------------ASSSTTNGSSMVAYPINPPPSPATRSR 1562
            :...|.|                               |:|::|...:::...:......|..||
Mouse  1665 EEGVILGHWAPPVHTHGLIREYIVEYSRSGSKMWASQRAASNSTEIKNLLLNALYTVRVAAVTSR 1729

  Fly  1563 R----------PYRHYKIINQPPPPTPCSTDICDESDSNYT------------------------ 1593
            .          .....|:|..|    ....|..||:..::|
Mouse  1730 GIGNWSDSKSITTIKGKVIQAP----NIHIDSYDENSLSFTLTMDGDIKVNGYVVNLFWSFDAHK 1790

  Fly  1594 -SKSNSNNSNGGATKHSSSSAAACLQY---GYDSEPYPPPPTPRSHYHSDVRIVPESSCPPSPSS 1654
             .|...:...|.|..|..|:..|...|   .:........|....|      |:...|.||:||.
Mouse  1791 QEKKTLSFRGGSALSHRVSNLTAHTSYEISAWAKTDLGDSPLAFEH------ILTRGSSPPAPSL 1849

  Fly  1655 RS 1656
            ::
Mouse  1850 KA 1851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531	10/45 (22%)
		NHL	168..503	CDD:302697	94/479 (20%)
		NHL repeat	172..237	CDD:271320	17/99 (17%)
		LY	252..293	CDD:214531	9/43 (21%)
		NHL repeat	261..298	CDD:271320	7/39 (18%)
		NHL repeat	303..339	CDD:271320	9/66 (14%)
		NHL repeat	341..419	CDD:271320	24/147 (16%)
		NHL repeat	428..476	CDD:271320	18/48 (38%)
		LY	472..511	CDD:214531	13/38 (34%)
		NHL repeat	477..503	CDD:271320	8/25 (32%)
		Ldl_recept_b	534..573	CDD:278487	20/38 (53%)
		LY	558..599	CDD:214531	18/40 (45%)
		LY	600..641	CDD:214531	13/40 (33%)
		FXa_inhibition	668..703	CDD:291342	11/53 (21%)
		LY	739..773	CDD:214531	2/33 (6%)
		LY	776..818	CDD:214531	4/41 (10%)
		LY	819..860	CDD:214531	0/40 (0%)
		FXa_inhibition	973..1010	CDD:291342	10/42 (24%)
		LY	1122..1164	CDD:214531	7/41 (17%)
		FXa_inhibition	1273..1313	CDD:291342	8/39 (21%)
		LDLa	1319..1362	CDD:238060	17/42 (40%)
		LDLa	1365..1399	CDD:238060	14/34 (41%)
		LDLa	1399..1433	CDD:197566	12/40 (30%)
Sorl1	NP_035566.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..84
		VPS10	124..753	CDD:214740	86/500 (17%)
		BNR 1	136..147
		BNR 2	232..243
		BNR 3	441..452		5/14 (36%)
		BNR 4	521..532		0/10 (0%)
		BNR 5	562..573		2/10 (20%)
		Sortilin_C	588..753	CDD:292523	27/172 (16%)
		LY	780..821	CDD:214531	15/40 (38%)
		LDL-receptor class B 1	800..843		13/42 (31%)
		LY	824..866	CDD:214531	13/41 (32%)
		LDL-receptor class B 2	844..887		15/42 (36%)
		LY	868..910	CDD:214531	15/41 (37%)
		LDL-receptor class B 3	888..932		22/45 (49%)
		Ldl_recept_b	890..929	CDD:278487	20/38 (53%)
		LY	913..953	CDD:214531	18/41 (44%)
		LDL-receptor class B 4	933..972		13/39 (33%)
		LDL-receptor class B 5	973..1013		14/39 (36%)
		LDLa	1078..1112	CDD:238060	12/171 (7%)
		LDLa	1117..1153	CDD:238060	9/43 (21%)
		Ldl_recept_a	1157..1192	CDD:278486	10/34 (29%)
		Ldl_recept_a	1198..1230	CDD:278486	8/38 (21%)
		LDLa	1240..1271	CDD:238060	9/60 (15%)
		LDLa	1281..1308	CDD:197566	8/69 (12%)
		LDLa	1325..1359	CDD:238060	7/51 (14%)
		LDLa	1373..1403	CDD:238060	9/47 (19%)
		LDLa	1419..1453	CDD:238060	17/42 (40%)
		LDLa	1471..1506	CDD:238060	14/34 (41%)
		LDLa	1514..1549	CDD:238060	13/35 (37%)
		FN3	1557..1630	CDD:238020	13/92 (14%)
		FN3	1651..1742	CDD:238020	12/90 (13%)
		FN3	1752..1831	CDD:238020	11/78 (14%)
		FN3	1935..2022	CDD:238020
		FN3	2026..2113	CDD:238020
		Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000250\|UniProtKB:Q92673	2162..2165
		Endocytosis signal. /evidence=ECO:0000255	2173..2178
		Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000250\|UniProtKB:Q92673	2191..2215
		Required for interaction with GGA1 and GGA2. /evidence=ECO:0000250\|UniProtKB:Q92673	2202..2215
		DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000250\|UniProtKB:Q92673	2209..2213
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900