DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and Sorl1

DIOPT Version :10

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_035566.2 Gene:Sorl1 / 20660 MGIID:1202296 Length:2215 Species:Mus musculus


Alignment Length:1952 Identity:385/1952 - (19%)
Similarity:603/1952 - (30%) Gaps:749/1952 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 FGISNSWQY--KNVHMPSSSSLIASPPASAFVNTP-ATLLFTTRHDIQVANITRPTGGPQIDVIV 115
            |.:.:.:.:  |.||:|.|....:.....:|...| ....|.|:|.|....|. .....|:.|.|
Mouse   300 FQLRDKYMFATKVVHLPGSQQQSSVQLWVSFGRKPMRAAQFVTKHPINEYYIA-DAAEDQVFVCV 363

  Fly   116 RD--------LAEAMAIDFYYA-KNLVCWTDSGREIIECAQTNSSALQPLLRAPKQTVISTGLDK 171
            ..        ::||..:.|..: :|::.::..|                   |...|::....::
Mouse   364 SHSNNSTNLYISEAEGLKFSLSLENVLYYSPGG-------------------AGSDTLVRYFANE 409

  Fly   172 P-------EGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAVAVVPARKLLIW 229
            |       |||...:....|..:..|:|...|.|.|    |...|..|..|            .:
Mouse   410 PFADFHRVEGLQGVYIATLINGSMNEENMRSVITFD----KGGTWEFLQAP------------AF 458

  Fly   230 TDWGE----------------------------YPKIERASMDG-----DPLSRMTLVKEHVFWP 261
            |.:||                            .|.:.:.|..|     ..:.:....|.:|:..
Mouse   459 TGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYIS 523

  Fly   262 NGLAVDLKNEL---IYWTDGKHHFIDVMRLDGSSRRTIVNNLKYP-----------FS------- 305
            :......:..|   .|:|.|.|..|.:....|..    .|.|||.           ||       
Mouse   524 SSAGARWREALPGPHYYTWGDHGGIIMAIAQGME----TNELKYSTNEGETWKTFVFSEKPVFVY 584

  Fly   306 --LT-----------FYDDRLYWTDWQRGSLNALDLQTRELKELIDTPKAPNSVRAWDPSLQ--- 354
              ||           |..::.....|....:||.|        .:..|...|..:.|.||.:   
Mouse   585 GLLTEPGEKSTVFTIFGSNKESVHSWLILQVNATD--------ALGVPCTENDYKLWSPSDERGN 641

  Fly   355 --------------PYE--------DNPCAHNNGNCS------------------HLCLLATNSQ 379
                          |:.        |.|...:|.:|:                  .:|:......
Mouse   642 ECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFS 706

  Fly   380 G--FS--CACPT--------GVKLISANTCANG---------------SQEMMFIVQRTQISKIS 417
            |  :|  ..||.        |.:.||.:||:.|               ::|..||:...:.|...
Mouse   707 GKPYSPPVPCPVGSSYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAMRKSIYR 771

  Fly   418 LDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADG-TGVTDFVTSEVRHPDG 481
            .|........|||..::.|:|:|:|.....:||||:...||:|...:| ||....:.|.:...:.
Mouse   772 YDLASGATEQLPLSGLRAAVALDFDYERNCLYWSDLALDTIQRLCLNGSTGQEVIINSGLETVEA 836

  Fly   482 LALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEH-LEEPRAIAVAPSLGWMFWSDWNERKPK 545
            ||.:.|::.|||.|....:|||...||..|..::... |:.|||:.:.|..|.|||:||.:.||.
Mouse   837 LAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPG 901

  Fly   546 VERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHL 610
            :.|:.:|||....||||::.|||||::|  ::.|||.|...|.||.....|..|.|:: |:|.|.
Mouse   902 IYRSYMDGSAAYRLVSEDVKWPNGISVD--SQWIYWTDAYLDCIERITFSGQQRSVIL-DSLPHP 963

  Fly   611 FGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAVRNGGC 675
            :.:::..:.:||.||.:.||.||.|.:.:...::..|...||.:||....:..|.|||..:  .|
Mouse   964 YAIAVFKNEIYWDDWSQLSIFRASKHSRSQVEILASQLTGLMDMKVFYKGKNAGSNACVPQ--PC 1026

  Fly   676 SHLCLNRPR-------------------DYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGRI 721
            |.|||.:..                   |.:|.|...|:..|:  |||          :|....:
Mouse  1027 SLLCLPKANNSKSCRCPEGVASSVLPSGDLMCDCPQGYQRKNN--TCV----------KEENTCL 1079

  Fly   722 SIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVDSGLIGP 786
            ..:|...|.|                                ||                     
Mouse  1080 RNQYRCSNGN--------------------------------CI--------------------- 1091

  Fly   787 DGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTESPTDSI 851
                     |:|:|.|                                                 
Mouse  1092 ---------NSIWWCD------------------------------------------------- 1098

  Fly   852 RRAAMDGSDLQTIVAGANHAAGLTFDQETRRLYWATQSRPAKIESADWDGKKRQILVGSDMDEPY 916
                                    ||.:...:   :..|.......|.|.:.|....|:.:...|
Mouse  1099 ------------------------FDNDCGDM---SDERNCPTTVCDADTQFRCQESGTCIPLSY 1136

  Fly   917 AVSLYQDYVYWSDWNTGD-IERVHKTTGQNRS---LVHSGMTYITSLLV--FNDKRQ-------T 968
            ...|..|        .|| .:..|....|.||   ...|||...:|.:.  .||.|.       |
Mouse  1137 KCDLEDD--------CGDNSDESHCEMHQCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANCT 1193

  Fly   969 GV-NPCKVNNGGC--SHLCLAQPGRRGMTCACPTHYQLA----KDGVSCIPPRNYIIFSQRNCFG 1026
            .: :.|:.:|..|  .| |:.|      ..||.......    :|.|||          ::.|.|
Mouse  1194 AIYHTCEASNFQCHNGH-CIPQ------RWACDGDADCQDGSDEDPVSC----------EKKCNG 1241

  Fly  1027 RLLPNTTDCPNIPLPVSGKNIRAVDYDPITHHIYWIEGRSHSIKRSLANGTKVSLLANSGQPFDL 1091
            ...||.|..|      |.|:...:                    |...:|:.    ....:||  
Mouse  1242 FHCPNGTCIP------SSKHCDGL--------------------RDCPDGSD----EQHCEPF-- 1274

  Fly  1092 AIDIIGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQAIIR 1156
                ..|.:.:.|..                                .::.||.:.|  ...|::
Mouse  1275 ----CTRFMDFVCKN--------------------------------RQQCLFHSMV--CDGIVQ 1301

  Fly  1157 ARVDGNERVELAYKLEGVTALALDQQSDMIYYAHGKRIDAIDINGKNKKTLVSMHISQVINIAAL 1221
            .| ||::        |........|..:.    | |..|......:|     .:.||.:      
Mouse  1302 CR-DGSD--------EDAAFAGCSQDPEF----H-KECDEFGFQCQN-----GVCISLI------ 1341

  Fly  1222 GGFVYWLDDKTGVERITVNGERRSAELQRLPQITDIRAVWTPDPKVLR-------NHTCMHSRTK 1279
                 |..|  |::......:..:.|..            |..|...|       |..|:.:|.|
Mouse  1342 -----WKCD--GMDDCGDYSDEANCENP------------TEAPNCSRYFQFHCENGHCIPNRWK 1387

  Fly  1280 CSHICIASGEGIARTRDVCSCPKHLMLLEDKENCG---AFPA-------CGPDHFTCAAPVSGIS 1334
            |.           |..|   |..    ..|:::||   ..|:       |.|::|.|:   ||. 
Mouse  1388 CD-----------REND---CGD----WSDEKDCGDSHVLPSPTPGPSTCLPNYFHCS---SGA- 1430

  Fly  1335 DVNKDCIPASWRCDGQKDCPDKSDEVGCPT---------------CRADQFSC-QSGECIDKSLV 1383
                 |:..:|.|||.:||.|.|||..||:               |...:|.| |..:||.....
Mouse  1431 -----CVMGTWVCDGYRDCADGSDEEACPSLANSTAASTPTQFGQCDRFEFECHQPKKCIPNWKR 1490

  Fly  1384 CDGTTNCANGHDEADC-------CKRPGEFQCPINKLCISAALLCDGWENCADGADE-------- 1433
            |||..:|.:|.|||:|       | ...||:|...:.||..:..|||:.:|:|.:||        
Mouse  1491 CDGHQDCQDGQDEANCPTHSTLTC-TSREFKCEDGEACIVLSERCDGFLDCSDESDEKACSDELT 1554

  Fly  1434 -------------SSDICL----QRRMAPATDKRAFMILIGATMITIFSIVY------LLQFCRT 1475
                         |.|:.|    .::|..|:              .::::.|      :.:...|
Mouse  1555 VYKVQNLQWTADFSGDVTLTWMRPKKMPSAS--------------CVYNVYYRVVGESIWKTLET 1605

  Fly  1476 RIGKSRTEPKDDQATDPLSPSTLSKSQ----RVSKIASVADAVRMST--------LNSRNSMNSY 1528
            ...|:.|..|      .|.|.|..:.:    .::|:.:..|.|.:.|        .|.:.|:||.
Mouse  1606 HSNKTSTVLK------VLKPDTTYQVKVQVHCLNKVHNTNDFVTLRTPEGLPDAPRNLQLSLNSE 1664

  Fly  1529 DRNHITG-------------------------------ASSSTTNGSSMVAYPINPPPSPATRSR 1562
            :...|.|                               |:|::|...:::...:......|..||
Mouse  1665 EEGVILGHWAPPVHTHGLIREYIVEYSRSGSKMWASQRAASNSTEIKNLLLNALYTVRVAAVTSR 1729

  Fly  1563 R----------PYRHYKIINQPPPPTPCSTDICDESDSNYT------------------------ 1593
            .          .....|:|..|    ....|..||:..::|                        
Mouse  1730 GIGNWSDSKSITTIKGKVIQAP----NIHIDSYDENSLSFTLTMDGDIKVNGYVVNLFWSFDAHK 1790

  Fly  1594 -SKSNSNNSNGGATKHSSSSAAACLQY---GYDSEPYPPPPTPRSHYHSDVRIVPESSCPPSPSS 1654
             .|...:...|.|..|..|:..|...|   .:........|....|      |:...|.||:||.
Mouse  1791 QEKKTLSFRGGSALSHRVSNLTAHTSYEISAWAKTDLGDSPLAFEH------ILTRGSSPPAPSL 1849

  Fly  1655 RS 1656
            ::
Mouse  1850 KA 1851

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 10/45 (22%)
NHL 168..503 CDD:302697 94/479 (20%)
NHL repeat 172..237 CDD:271320 17/99 (17%)
LY 252..293 CDD:214531 9/43 (21%)
NHL repeat 261..298 CDD:271320 7/39 (18%)
NHL repeat 303..339 CDD:271320 9/66 (14%)
NHL repeat 341..419 CDD:271320 24/147 (16%)
NHL repeat 428..476 CDD:271320 18/48 (38%)
LY 472..511 CDD:214531 13/38 (34%)
NHL repeat 477..503 CDD:271320 8/25 (32%)
Ldl_recept_b 534..574 CDD:459654 20/39 (51%)
LY 558..599 CDD:214531 18/40 (45%)
LY 600..641 CDD:214531 13/40 (33%)
FXa_inhibition 668..703 CDD:464251 11/53 (21%)
YncE <736..886 CDD:442618 8/149 (5%)
LY 776..818 CDD:214531 4/41 (10%)
LY 905..946 CDD:214531 8/41 (20%)
FXa_inhibition 973..1010 CDD:464251 10/42 (24%)
YncE <1047..1191 CDD:442618 15/143 (10%)
LDLa 1319..1362 CDD:238060 17/42 (40%)
LDLa 1365..1399 CDD:238060 14/34 (41%)
LDLa 1399..1433 CDD:197566 12/40 (30%)
Sorl1NP_035566.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 59..84
VPS10 124..753 CDD:214740 86/500 (17%)
BNR 1 136..147
BNR 2 232..243
BNR 3 441..452 5/14 (36%)
BNR 4 521..532 0/10 (0%)
BNR 5 562..573 2/10 (20%)
LY 780..821 CDD:214531 15/40 (38%)
LDL-receptor class B 1 800..843 13/42 (31%)
LY 824..866 CDD:214531 13/41 (32%)
LDL-receptor class B 2 844..887 15/42 (36%)
LY 868..910 CDD:214531 15/41 (37%)
LDL-receptor class B 3 888..932 22/45 (49%)
Ldl_recept_b 890..929 CDD:459654 20/38 (53%)
LY 913..953 CDD:214531 18/41 (44%)
LDL-receptor class B 4 933..972 13/39 (33%)
LY 953..987 CDD:214531 12/34 (35%)
LDL-receptor class B 5 973..1013 14/39 (36%)
LDLa 1078..1112 CDD:238060 12/171 (7%)
LDLa 1117..1153 CDD:238060 9/43 (21%)
Ldl_recept_a 1157..1192 CDD:395011 10/34 (29%)
Ldl_recept_a 1198..1230 CDD:395011 8/38 (21%)
LDLa 1240..1271 CDD:238060 9/60 (15%)
LDLa 1281..1308 CDD:197566 8/69 (12%)
LDLa 1325..1359 CDD:238060 7/51 (14%)
LDLa 1373..1403 CDD:238060 9/47 (19%)
LDLa 1419..1453 CDD:238060 17/42 (40%)
LDLa 1471..1506 CDD:238060 14/34 (41%)
LDLa 1514..1549 CDD:238060 13/35 (37%)
FN3 1557..1630 CDD:238020 13/92 (14%)
FN3 1651..1742 CDD:238020 12/90 (13%)
FN3 1690..>2100 CDD:442628 28/172 (16%)
Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000250|UniProtKB:Q92673 2162..2165
Endocytosis signal. /evidence=ECO:0000255 2173..2178
Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000250|UniProtKB:Q92673 2191..2215
Required for interaction with GGA1 and GGA2. /evidence=ECO:0000250|UniProtKB:Q92673 2202..2215
DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000250|UniProtKB:Q92673 2209..2213
Blue background indicates that the domain is not in the aligned region.

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