DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and Nid2

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_032721.2 Gene:Nid2 / 18074 MGIID:1298229 Length:1403 Species:Mus musculus


Alignment Length:203 Identity:85/203 - (41%)
Similarity:123/203 - (60%) Gaps:2/203 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly   437 IAIDYDPVEEHIYWSDVETYTIKRAHAD-GTGVTDFVTSEVRHPDGLALDWLARNLYWTDTVTDR 500
            :.||||..|..:||:||...||.||..: |......:||.:..|:|||:|...|.:||||:..|:
Mouse  1173 VGIDYDCRERMVYWTDVAGRTISRASLEAGAEPETIITSGLISPEGLAIDHFRRTMYWTDSGLDK 1237

  Fly   501 IEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLG 565
            ||...|||:.||||.:..|..||||.|.|..|.::|:|||...||:|.:||||..|.:|:::::|
Mouse  1238 IERAELDGSERKVLFHTDLVNPRAITVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINKDIG 1302

  Fly   566 WPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSI 630
            .|||:..|..:|.:.|.|..|.|:|....||:||| ||.::|.:.|.:....|:.|.|||:|..:
Mouse  1303 LPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR-VIQNHLNYPFSIVSYADH
FYHTDWRRDGV 1366

  Fly   631 DRAHKITG 638
            ...:|.:|
Mouse  1367 ISVNKDSG 1374

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531
NHL 168..503 CDD:302697 28/66 (42%)
NHL repeat 172..237 CDD:271320
LY 252..293 CDD:214531
NHL repeat 261..298 CDD:271320
NHL repeat 303..339 CDD:271320
NHL repeat 341..419 CDD:271320
NHL repeat 428..476 CDD:271320 16/39 (41%)
LY 472..511 CDD:214531 18/38 (47%)
NHL repeat 477..503 CDD:271320 12/25 (48%)
Ldl_recept_b 534..573 CDD:278487 17/38 (45%)
LY 558..599 CDD:214531 14/40 (35%)
LY 600..641 CDD:214531 13/39 (33%)
FXa_inhibition 668..703 CDD:291342
LY 739..773 CDD:214531
LY 776..818 CDD:214531
LY 819..860 CDD:214531
FXa_inhibition 973..1010 CDD:291342
LY 1122..1164 CDD:214531
FXa_inhibition 1273..1313 CDD:291342
LDLa 1319..1362 CDD:238060
LDLa 1365..1399 CDD:238060
LDLa 1399..1433 CDD:197566
Nid2NP_032721.2 NIDO 108..275 CDD:214712
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..403
EGF_3 511..546 CDD:289699
nidG2 548..780 CDD:294123
EGF_3 786..822 CDD:289699
EGF_CA 824..865 CDD:284955
EGF_3 875..913 CDD:289699
EGF_3 919..952 CDD:289699
Cell attachment site 946..948
TY 967..1028 CDD:238114
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1021..1043
TY 1047..1112 CDD:238114
LY 1162..1200 CDD:214531 13/26 (50%)
LDL-receptor class B 1 1182..1225 16/42 (38%)
LY 1206..1248 CDD:214531 18/41 (44%)
LDL-receptor class B 2 1226..1268 22/41 (54%)
LY 1249..1293 CDD:214531 22/43 (51%)
LDL-receptor class B 3 1269..1313 19/43 (44%)
LY 1294..1336 CDD:214531 14/41 (34%)
LDL-receptor class B 4 1314..1355 15/41 (37%)
LDL-receptor class B 5 1357..1401 7/18 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167845801
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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