DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment arr and Nid1

DIOPT Version :9

Sequence 1:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	NP_035047.2	Gene:	Nid1 / 18073	MGIID:	97342	Length:	1245	Species:	Mus musculus

Alignment Length:	403	Identity:	119/403 - (29%)
Similarity:	179/403 - (44%)	Gaps:	81/403 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 APNSVRAWDPSLQ-----------PYEDNPCAHNNGNCSHLCLLATNSQ--------GFSCAC-- 385
            |.....|..|:||           .|....|.|:.|.|  .|:.....:        |....|
Mouse   857 AAGGADAQRPTLQGMFVPQCDEYGHYVPTQCHHSTGYC--WCVDRDGRELEGSRTPPGMRPPCLS 919

  Fly   386 -------------------PTGVKLISANTCANGSQEMMFIVQRTQISKISLDSPDYTIF-PLPL 430
                               |.|..|:.|.|   |.      ::|..:.:.::...:...| .:|
Mouse   920 TVAPPIHQGPVVPTAVIPLPPGTHLLFAQT---GK------IERLPLERNTMKKTEAKAFLHIP- 974

  Fly   431 GKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSEVRHPDGLALDWLARNLYWTD 495
              .|..|.:.:|.|::.:||:|:...:|.||...|...|..:..::..|:|:|||.|.|.::|||
Mouse   975 --AKVIIGLAFDCVDKVVYWTDISEPSIGRASLHGGEPTTIIRQDLGSPEGIALDHLGRTIFWTD 1037

  Fly   496 TVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDGSERVVLV 560
            :..|||||.::|||.|:||....|..||.|...|..|.::|:|||...||:|.:.:||:.|.:|.
Mouse  1038 SQLDRIEVAKMDGTQRRVLFDTGLVNPRGIVTDPVRGNLYWTDWNRDNPKIETSHMDGTNRRILA 1102

  Fly   561 SENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWTDW 625
            .:|||.|||:..|..:..:.|.|..|.:.|..|....|||.|: :.|::.|.::.....||:|||
Mouse  1103 QDNLGLPNGLTFDAFSSQLCWVDAGTHRAECLNPAQPGRRKVL-EGLQYPFAVTSYGKNLYYTDW 1166

  Fly   626 QRRSI---DRA----------HKITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAVRNGGCSH 677
            :..|:   |.|          ||.|            .|.|:.:...:..:|.|.|:|.||||:|
Mouse  1167 KTNSVIAMDLAISKEMDTFHPHKQT------------RLYGITIALSQCPQGHNYCSVNNGGCTH 1219

  Fly   678 LCLNRPRDYVCRC 690
            |||..|....|||
Mouse  1220 LCLPTPGSRTCRC 1232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531
		NHL	168..503	CDD:302697	47/201 (23%)
		NHL repeat	172..237	CDD:271320
		LY	252..293	CDD:214531
		NHL repeat	261..298	CDD:271320
		NHL repeat	303..339	CDD:271320
		NHL repeat	341..419	CDD:271320	20/116 (17%)
		NHL repeat	428..476	CDD:271320	13/47 (28%)
		LY	472..511	CDD:214531	18/38 (47%)
		NHL repeat	477..503	CDD:271320	13/25 (52%)
		Ldl_recept_b	534..573	CDD:278487	17/38 (45%)
		LY	558..599	CDD:214531	13/40 (33%)
		LY	600..641	CDD:214531	15/53 (28%)
		FXa_inhibition	668..703	CDD:291342	14/23 (61%)
		LY	739..773	CDD:214531
		LY	776..818	CDD:214531
		LY	819..860	CDD:214531
		FXa_inhibition	973..1010	CDD:291342
		LY	1122..1164	CDD:214531
		FXa_inhibition	1273..1313	CDD:291342
		LDLa	1319..1362	CDD:238060
		LDLa	1365..1399	CDD:238060
		LDLa	1399..1433	CDD:197566
Nid1	NP_035047.2	NIDO	106..269	CDD:214712
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..344
		EGF_3	388..423	CDD:289699
		nidG2	427..658	CDD:238158
		EGF_3	670..706	CDD:289699
		Cell attachment site	700..702
		EGF_CA	708..749	CDD:214542
		EGF_3	760..798	CDD:289699
		EGF_3	809..837	CDD:289699
		Thyroglobulin_1	847..917	CDD:278514	12/61 (20%)
		LDL-receptor class B 1	988..1030		13/41 (32%)
		Ldl_recept_b	990..1027	CDD:278487	11/36 (31%)
		LY	1012..1053	CDD:214531	18/40 (45%)
		LDL-receptor class B 2	1031..1073		20/41 (49%)
		LY	1054..1098	CDD:214531	17/43 (40%)
		LDL-receptor class B 3	1074..1118		19/43 (44%)
		LY	1099..1135	CDD:214531	12/35 (34%)
		LDL-receptor class B 4	1119..1160		11/41 (27%)
		FXa_inhibition	1210..>1234	CDD:291342	14/23 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000