DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and egg-1

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_498237.2 Gene:egg-1 / 175804 WormBaseID:WBGene00015083 Length:551 Species:Caenorhabditis elegans


Alignment Length:272 Identity:81/272 - (29%)
Similarity:115/272 - (42%) Gaps:51/272 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly  1208 VSMHISQVINIAALGGFVYWLDDKTGVERITVNGERRSAELQRL-PQITDIRAVWTPDPKVLRN- 1270
            ||:.:..|:.:...||.:.:|     |..:|.:.::.||:...: ||.......|.|..|:..: 
 Worm    47 VSITVCLVLLVLIFGGAIVYL-----VMSLTSSAQKMSADSMDISPQAIRHPKFWPPTDKIRFDD 106

  Fly  1271 --------------HTCMHSRTKCS---HICIASGEGIARTRDVCSCPKHLMLLEDKENCGAFPA 1318
                          .||......|:   |:.|.|.:.....||   |...    .|:|||....:
 Worm   107 LNGIPMTSLFPQNVSTCSGFGFACTGAVHMVIPSSKRCDGRRD---CEDG----SDEENCKECQS 164

  Fly  1319 CGPDHFTC------AAPVSGISDVNKD--CIPASWRCDGQKDCPDKSDEVGC-PTCRADQFSCQ- 1373
            .    |:|      .:...|.|.|...  |:.|...||..::|||.|||..| .:|..|||.|. 
 Worm   165 V----FSCKLRPEEESKKKGRSTVQPTLICLTAQHLCDNVENCPDGSDEAVCKSSCSKDQFKCPG 225

  Fly  1374 SGECIDKSLVCDGTTNCANGHDEADCCK-RPGEFQCPINKLCISAALLCDGWENCADGADESSDI 1437
            |..|:..|..|||..:||:..||.:|.| :....:|  .|.||.|:.:|||...||||:||....
 Worm   226 SNACLPLSAKCDGINDCADASDEKNCSKCQNNAHKC--GKQCIKASHVCDGVAQCADGSDEQQCD 288

  Fly  1438 CLQRRMAPATDK 1449
            | ||  ...|||
 Worm   289 C-QR--CSGTDK 297

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531
NHL 168..503 CDD:302697
NHL repeat 172..237 CDD:271320
LY 252..293 CDD:214531
NHL repeat 261..298 CDD:271320
NHL repeat 303..339 CDD:271320
NHL repeat 341..419 CDD:271320
NHL repeat 428..476 CDD:271320
LY 472..511 CDD:214531
NHL repeat 477..503 CDD:271320
Ldl_recept_b 534..573 CDD:278487
LY 558..599 CDD:214531
LY 600..641 CDD:214531
FXa_inhibition 668..703 CDD:291342
LY 739..773 CDD:214531
LY 776..818 CDD:214531
LY 819..860 CDD:214531
FXa_inhibition 973..1010 CDD:291342
LY 1122..1164 CDD:214531
FXa_inhibition 1273..1313 CDD:291342 10/42 (24%)
LDLa 1319..1362 CDD:238060 15/50 (30%)
LDLa 1365..1399 CDD:238060 15/34 (44%)
LDLa 1399..1433 CDD:197566 14/34 (41%)
egg-1NP_498237.2 LDLa 123..159 CDD:238060 10/42 (24%)
LDLa 216..251 CDD:238060 15/34 (44%)
LDLa 254..287 CDD:238060 14/34 (41%)
LDLa 300..327 CDD:238060
LDLa <391..413 CDD:238060
LDLa 425..455 CDD:238060
LDLa 458..493 CDD:238060
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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