DRSC/TRiP Functional Genomics Resources

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Protein Alignment arr and lrp-1

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_001379135.1 Gene:lrp-1 / 172520 WormBaseID:WBGene00003071 Length:4753 Species:Caenorhabditis elegans


Alignment Length:1557 Identity:418/1557 - (26%)
Similarity:679/1557 - (43%) Gaps:341/1557 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 AMAIDFYYAKNLVCWTDSGREIIECAQTNSSALQPLLRAPKQTV-ISTGLDKPEGLAMDWYTDKI 184
            |:|:.:....:.:.|:|...:.|..|..|.:         ..|| |:.|||..||:|:||....:
 Worm  1514 AIALAWDSLTDRIYWSDIREKKILSANRNGT---------NATVFIADGLDITEGIALDWVGRNL 1569

  Fly   185 YWTDGEKNRIEVATL-DGRYQKVLFWTDLDQPRAVAVVPARKLLIWTDWGEYPKIERASMDGDPL 248
            ||.|...|.||||.| |.:.:.:|...::.|||.:||.|.:.::.|||||:.|.||||||||  .
 Worm  1570 YWVDSSLNTIEVANLEDPKQRTLLVHQNVSQPRGIAVDPRKGVMFWTDWGQNPCIERASMDG--T 1632

  Fly   249 SRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHHFIDVMRLDGSSRRTIVNNLKY---PFSLTFYD 310
            .|..:||..::|||.:|:|...:.:|:.|.|..|||.:..|||.|..::.:.|:   |.:|..::
 Worm  1633 DRQIIVKTKIYWPNTIALDYTTDRVYFADSKLDFIDFVNYDGSGRTQVLASSKFVQHPHALAIFE 1697

  Fly   311 DRLYWTDWQRGSLNALDLQTRELKELIDTPKAPN---------------SVRAWDPSLQP-YEDN 359
            |.:|::|             |.|::|...||.||               .|.|..|.||| .::|
 Worm  1698 DMMYYSD-------------RRLQKLQVYPKYPNGTTSEYPSHTFSKALGVVAVHPVLQPVIKNN 1749

  Fly   360 PCAHNNGNCSHLCLLATNSQGFSCACPTGVKL-ISANTCANGSQEMMFIVQRTQISKISLDSPDY 423
            ||:.|  .||||||| .|...|:|.||.|.|| .|...|.:.::..:.|:|:|.:..|.::|...
 Worm  1750 PCSTN--PCSHLCLL-NNKNTFTCKCPMGEKLDASGKKCIDDAKPFLVIIQKTNVFGIEMNSASE 1811

  Fly   424 TIFP-----LPLGKVKYAIAIDYDPVEEHIYWSDVETY-----------TIKRAHADGTGVTDFV 472
            ...|     :||..:..|....||.:.|.::..:...:           .|.|:..:|...|...
 Worm  1812 KETPVLAGMVPLSGLGNAFDAAYDALSEEMFILEHTNHAKTLAQITTDSAIYRSTVNGGNKTKMF 1876

  Fly   473 TSEVRHPDG---LALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPR------AIAVA 528
            :|.|  ||.   |..||..|||...:.:|..||:.|..|...:.:|..:.:.|.      ||||.
 Worm  1877 SSAV--PDDAYCLGFDWNGRNLVVGNKITQTIEIIRTQGKQYRSVILSNDQSPTAVVTPVAIAVD 1939

  Fly   529 PSLGWMFWSD--WNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEV 591
            ...|::||.|  ......||.||.||||..:|:.|.:|...:.||:|.....:|:.:.|..:|..
 Worm  1940 ADKGYVFWLDRGGGAADAKVARAGLDGSNPLVIASNDLAELDHIAIDTTNTRVYFSEAKAGRISS 2004

  Fly   592 ANMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYP------- 649
            ...||..|..|:||..:...||:...|.|::.|....||:.| .|.|::      |.|       
 Worm  2005 VTYDGQDRHYVLSDGGRQPNGLAFYGDRLFYADSAFDSIEVA-TINGDS------QPPQWTHFKK 2062

  Fly   650 ---DLMGLKVTRLREVRGQNACAVRNGGCSHLCLNRPRDY---VCRCAIDYELANDKRTC-VVPA 707
               :|..:|..:.|.....:.|.:.||.|.|:|:  |..:   .|.||..| :.:.:.:| :...
 Worm  2063 DVENLANIKALQPRASSSGHPCHINNGNCDHICI--PLMFAQRTCTCANGY-VKDGQTSCKLFDE 2124

  Fly   708 AFLLFSRQ------------------EHIGRISIEYNEGNHNDERIPFKDVRDAHALDVSVAERR 754
            :|::.:.:                  |.||.:||...:.::..:.|   .|.:|..::..:.   
 Worm  2125 SFVIVATKTKVIGYPIDETQSKGVAMEPIGGLSITGVDYDYESKTI---YVAEASGINKGIT--- 2183

  Fly   755 IYWTDQKSKCIFRAFLNGSYVQRIVDSGLIGP---DGIAVDWLANNIYW--SDAEARRIEVARLD 814
                         |:..|....|.|....||.   ..:|:||:..|:|:  .|||...|||::||
 Worm  2184 -------------AYTIGESSPRAVIRDSIGSLTIKSLAIDWINYNMYFINHDAERTNIEVSKLD 2235

  Fly   815 GSSRRVLLWKGVEEPRSLVLEPRRGYMYWT---ESPTDSIRRAAMDGSDLQTIV-AGANHAAGLT 875
            |:.|::||....|.|.|:.::|...|:||.   :.||  |:|:.:|||..:.|| :|......|.
 Worm  2236 GTYRKILLTTKTETPSSIAVDPVSRYLYWADQGQKPT--IQRSFLDGSRREVIVSSGIAEPTDLV 2298

  Fly   876 FDQETRRLYWATQSRPAKIESADWDGKKR-------QILVGSDMDEPYAVSLYQDYVYWSDWNTG 933
            .|..::.:||:         .|..||..|       ..||.||:.....|:|:...:||:|   .
 Worm  2299 VDVASKMIYWS---------DAKMDGIYRVRSTGGTPELVRSDIASAAGVALHGQNMYWTD---N 2351

  Fly   934 DIERVHKTTGQ--NRSLVHSGMTYITSL------LVFNDKRQ-TGVNPCKVNN----GGCSHLCL 985
            .:|::.:.|.:  ..||:.|..|...||      .||:...| ...:||::.:    ..|:.||.
 Worm  2352 RLEKLFRATSKPNQTSLLLSPTTVAASLKDIGDVAVFSSNNQPRASSPCQITDNLRKSPCTQLCF 2416

  Fly   986 AQPGRRGMTCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRLLPNTTDCPNI--------PLP- 1041
            |.||.:..||:|.   :....|.:|..|..||:||.    |..:.:....|::        |.| 
 Worm  2417 ATPGTQTPTCSCA---RGVLKGRTCEEPDTYIMFSD----GDKIIDVAIEPDVKASRPLKDPFPE 2474

  Fly  1042 VSGKNIRAVDYD------------PITHHIYWIEGRSHSIKRSLANGTKVSLL-ANSGQPF---- 1089
            :|  |::..|.|            |:..:|.|.         |:.|.....|: ..|.||.    
 Worm  2475 IS--NLQTFDVDVNLRRVYFVVESPVGVNISWF---------SMNNAENPRLVFGASKQPHAKEI 2528

  Fly  1090 ----DLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVG- 1149
                |:.:|.:.:.:::|..:...:......||.:..|.:||....  :|:.....||||:|.| 
 Worm  2529 RHISDMKLDWLTQKIYFTTGRGGKVMAIDTAGEHLSTIASGDWTYA--LAIDPCSGLLFWSDSGY 2591

  Fly  1150 -SHQAIIRARVD------GNERVELAYKLEGVTALALDQQSDMIYYAHGKR--IDAIDINGKNKK 1205
             :...:...|::      |:.:|.::..:....|:|:|.::..||:|...|  |:..|.:|:|:|
 Worm  2592 KTSGGLYEPRIERSNLAGGSRKVIVSESISLPAAIAVDFRNQKIYWADVNRLNIEVADYDGQNRK 2656

  Fly  1206 TLVSMHISQVINI--------AALGGFVYWLDDK--TGVERITVNGERRSAELQRLPQITDIRAV 1260
            .:.|.:.::.::|        ..|...|:.:|.:  :|:|.: |:..|....|:.....:|:|. 
 Worm  2657 VIASGYRAKSLDIWDRWLYMSDPLSNGVFRIDKESGSGLENV-VSDRRIPGALRVFASESDVRT- 2719

  Fly  1261 WTPDPKVLRNHTCMHSRTK--------CSHIC--IASGEGIARTRDVCSCPKHLMLLED------ 1309
                    ||..|....::        |..:|  :|...|:|.::..|||.....|:::      
 Worm  2720 --------RNQVCNALTSQLCKTDNGGCDQLCTVVADDIGLAASKVQCSCNDTYELVQEPGKDYP 2776

  Fly  1310 -------------KE-------------------NCGAFPAC------GPDHF-TCAAPVSGISD 1335
                         ||                   .|.:.|.|      .|::. |.:.|......
 Worm  2777 TQCVLRGSNSEPAKECLPPYNFQCGDGSCILLGATCDSKPDCADASDENPNYCNTRSCPEDYNLC 2841

  Fly  1336 VNKDCIPASWRCDGQKDCPDKSDEVGCPT---CRADQFSCQSGECIDKSLVCDGTTNCANGHDE- 1396
            .|:.||.::.:|:...||.|.|||:.||:   |....|.|.:|.||:::.||||..:|   ||| 
 Worm  2842 TNRRCIDSAKKCNHIDDCGDGSDELDCPSAVACAEGTFPCSNGHCINQTKVCDGHNDC---HDEQ 2903

  Fly  1397 ------ADCCKRPG--------EFQCPINKLCISAALLCDGWENCADGADESSDICLQRRMA 1444
                  |.|   ||        :.:||...:||..|.||||:::|.|.|||:...|:.::.|
 Worm  2904 VSDESLATC---PGLPIDCRGVKVRCPNTNICIQPADLCDGYDDCGDKADENQLFCMNQQCA 2962

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 20/40 (50%)
NHL 168..503 CDD:302697 125/374 (33%)
NHL repeat 172..237 CDD:271320 27/65 (42%)
LY 252..293 CDD:214531 16/40 (40%)
NHL repeat 261..298 CDD:271320 14/36 (39%)
NHL repeat 303..339 CDD:271320 8/35 (23%)
NHL repeat 341..419 CDD:271320 34/94 (36%)
NHL repeat 428..476 CDD:271320 11/58 (19%)
LY 472..511 CDD:214531 15/41 (37%)
NHL repeat 477..503 CDD:271320 10/28 (36%)
Ldl_recept_b 534..573 CDD:278487 16/40 (40%)
LY 558..599 CDD:214531 11/40 (28%)
LY 600..641 CDD:214531 13/40 (33%)
FXa_inhibition 668..703 CDD:291342 11/37 (30%)
LY 739..773 CDD:214531 3/33 (9%)
LY 776..818 CDD:214531 18/46 (39%)
LY 819..860 CDD:214531 15/43 (35%)
FXa_inhibition 973..1010 CDD:291342 11/40 (28%)
LY 1122..1164 CDD:214531 12/49 (24%)
FXa_inhibition 1273..1313 CDD:291342 12/87 (14%)
LDLa 1319..1362 CDD:238060 14/49 (29%)
LDLa 1365..1399 CDD:238060 15/40 (38%)
LDLa 1399..1433 CDD:197566 15/41 (37%)
lrp-1NP_001379135.1 LDLa 53..87 CDD:238060
LDLa 92..131 CDD:238060
LDLa 140..173 CDD:238060
LDLa 182..216 CDD:238060
LDLa 223..257 CDD:238060
LDLa 262..297 CDD:238060
LY 463..505 CDD:214531
LY 507..546 CDD:214531
LY 547..589 CDD:214531
LY 883..925 CDD:214531
exchanger_TraA <1054..1451 CDD:411343
LDLa 1057..1087 CDD:197566
LDLa 1146..1177 CDD:197566
LDLa 1187..1219 CDD:238060
LDLa 1228..1263 CDD:238060
LDLa 1270..1302 CDD:238060
LDLa 1313..1344 CDD:238060
FXa_inhibition 1447..1475 CDD:405372
LY 1511..1545 CDD:214531 7/39 (18%)
LY 1548..1585 CDD:214531 18/36 (50%)
LY 1590..1634 CDD:214531 21/45 (47%)
LY 1635..1677 CDD:214531 16/41 (39%)
Ldl_recept_b 1943..1986 CDD:423042 17/42 (40%)
LY 1971..2012 CDD:214531 11/40 (28%)
LY 2015..2052 CDD:214531 13/37 (35%)
LY 2193..2239 CDD:214531 18/45 (40%)
LY 2240..2283 CDD:214531 16/44 (36%)
LY 2284..2325 CDD:214531 11/49 (22%)
LY 2570..2612 CDD:214531 10/43 (23%)
LY 2613..2655 CDD:214531 11/41 (27%)
LDLa 2794..2824 CDD:197566 3/29 (10%)
LDLa 2834..2868 CDD:238060 11/33 (33%)
LDLa 2874..2907 CDD:197566 14/35 (40%)
LDLa 2961..2994 CDD:238060 1/2 (50%)
LDLa 3012..3038 CDD:238060
LDLa 3048..3088 CDD:197566
LDLa 3099..3131 CDD:197566
LDLa 3140..3174 CDD:238060
LDLa 3186..3218 CDD:197566
FXa_inhibition 3276..3305 CDD:405372
LY 3382..3424 CDD:214531
Ldl_recept_b 3445..3490 CDD:395012
LY 3476..3516 CDD:214531
FXa_inhibition 3586..3623 CDD:405372
LDLa 3627..3660 CDD:197566
LDLa 3671..3705 CDD:238060
LDLa 3792..3825 CDD:197566
LDLa 3837..3868 CDD:238060
LDLa 3878..3912 CDD:238060
LDLa 3917..3951 CDD:238060
LDLa 3958..3990 CDD:197566
LDLa 4049..4083 CDD:238060
FXa_inhibition 4097..>4121 CDD:405372
EGF_CA 4132..4163 CDD:214542
NHL 4219..>4431 CDD:302697
NHL repeat 4219..4257 CDD:271320
NHL repeat 4267..4330 CDD:271320
NHL repeat 4333..4371 CDD:271320
NHL repeat 4373..4410 CDD:271320
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 50 1.000 Domainoid score I7853
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.710

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