DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and lrp-2

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_491270.2 Gene:lrp-2 / 171981 WormBaseID:WBGene00003072 Length:4858 Species:Caenorhabditis elegans


Alignment Length:2586 Identity:466/2586 - (18%)
Similarity:748/2586 - (28%) Gaps:1210/2586 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly   167 TGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDG-RYQKVLFWTDLDQPRAVAVVPARKLLIWT 230
            ||:...||:|.|:.:|.:|.||..:..|.|..|.. ..|||:...::..|||:|:..|:..|.|.
 Worm   668 TGIMNCEGMAYDFTSDNLYMTDQRRKIITVQRLSNLSIQKVVVSGNMSNPRAIAIHIAKSYLFWG 732

  Fly   231 DWGE-------YP-KIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHHFIDVMR 287
            .|.|       .| .|||:.:||.  .|.|||.::..|.|||.:||||:.:||.|...:.|:.:|
 Worm   733 SWNEDNNDDEKIPAMIERSKLDGS--ERKTLVSKNAMWINGLTLDLKNDYLYWCDAYRNVIERIR 795

  Fly   288 LDGSSRRTIV---NNLKYPFSLTFYDDRLYWTDWQRGSLNALDLQTRELKELIDTPKAPNSVRAW 349
            .:|:.|..:|   :.:.:|:.|.|:|:.:::|::::|::..::         :|.|.....|..:
 Worm   796 WNGADREVVVHGADKISHPYGLAFFDNHIFYTEFKKGAVKRVN---------VDFPDDVQEVFQY 851

  Fly   350 DPSL---------QPYEDNPCAHNNGNCSHLCLLATNSQG------FSCACPTGVKL-------- 391
            ..::         .|...:||:.::..|.|.| .|::.:|      ..|.|..|:|:        
 Worm   852 SATVFELLVFKNSNPETTSPCSTSSNICEHFC-FASSCKGSVGCEPVKCGCADGMKVLKNGKCVK 915

  Fly   392 ----ISANTCAN---------------------------GSQE---------------------- 403
                :..|.|.|                           ||.|                      
 Worm   916 DEEWVDPNACDNEIEFTCLNSKKCVPKSNLCDGDDDCGDGSDEDANGICKDYKCVGNKFQCDGTT 980

  Fly   404 ---MMFI---------------------------------------------------------- 407
               |.||                                                          
 Worm   981 CLPMEFICDGKSDCYDGTDELEKICKKAPIVKCSVSQFQCSKTKCIIKSKRCNGVQECDNGADEE 1045

  Fly   408 --------------------VQRTQI--------------------------------------- 413
                                ::::|:                                       
 Worm  1046 DCPRSKLCDPDEFRCGTGLCIKQSQVCDGKMQCLDGLDEEHCNEEEKCLQGRQFRCANGKSTCLD 1110

  Fly   414 ----------------------------------------------------------------- 413
                                                                             
 Worm  1111 LIFRCDGVADCEDSSDESDEFCKGNSSSTCGKMNQFMCADGKCLRSFQLCDGFPDCLTGEDETEC 1175

  Fly   414 -----------------------------------------SKISLD-------SPDY------- 423
                                                     ::|.||       ||.|       
 Worm  1176 PPSMCDSTTHLSCLNGQKCISKQLECDGVDDCGDNSDEKHCTEIRLDEAALRCQSPMYQCDGPNF 1240

  Fly   424 ---------------------------------------TIFPLPLGKV---------------- 433
                                                   |..|.|:|.:                
 Worm  1241 KCISDKHLCDGTNDCEEGDDEGLWCTFNCTDADDLGCSHTCRPTPVGPICSCPDDHYLDKNGVTC 1305

  Fly   434 --------------------------------------------------------------KY- 435
                                                                          || 
 Worm  1306 SKKDPCRFGQCSQYCSPHGSSHFCYCEDSFKLGADRSSCISDDPRKPFLIYSNRHEIRMIQSKYP 1370

  Fly   436 -----------AIAIDYDPVEEH------IYWSDVETYTIKRAHADGTGVTD---------FVTS 474
                       |||:|:   :.|      |||:|:....|.      ||:.|         .|:.
 Worm  1371 GSLPMITNLVNAIALDF---KYHQNGSVSIYWTDLSADKIY------TGLVDQRTILYQRTIVSY 1426

  Fly   475 EVRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDW 539
            .|.:.:|:|:||::.|:||.|:..|.|:|...|||.|..:|.:::...|::|:....|:|||:||
 Worm  1427 GVFNAEGIAVDWISGNIYWIDSFLDTIQVVSEDGTKRATVINQNMGNARSLAIDVEEGFMFWTDW 1491

  Fly   540 NERKPKVERASLDGSERVVL--VSE--NLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRR 600
            .|..|::|||||.|:.|.::  :|.  ..|||||||||..||.:||.|.|:|.|.....||....
 Worm  1492 EESNPRIERASLAGNNRAIIWKISNIAQAGWPNGIALDTIAKRVYWADAKSDSIHTITYDGRDHV 1556

  Fly   601 VVISD--NLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVR 663
            :|..|  .|.|.||:.:.:.::|::||:..:|.:..|..|:|..::.........||:....:.:
 Worm  1557 IVFRDPERLGHCFGIDVYEGHVYFSDWRTNTISKVDKWFGSNVSIIERVATQPFSLKIVHRSKQK 1621

  Fly   664 GQ--NACAVRNG-GCSHLCLNRPRD-YVCRCAIDYELANDKRTCV-------------------- 704
            .|  |:|   :| .|:.:|||..:: ..|:|.......:|  .||                    
 Worm  1622 MQIKNSC---DGFKCNGICLNNGKNKATCQCTNLQSTTDD--GCVDIQQVLLVATKNGVRGFSTD 1681

  Fly   705 --VPAAFLLFSRQE----------------------HIGRI------------------------ 721
              .|.||.|.|.::                      ||..:                        
 Worm  1682 PPHPHAFPLVSGKQYENIRAVGSFNNRLQVLDDYTTHIATVNLTGTADDGVLATGSDLYGVSGMA 1746

  Fly   722 ------------------SIEYNEGNHNDERI--------PFKDVRDAHALDVSV---------- 750
                              |:|....:....|:        |.|..||...::..:          
 Worm  1747 VDPVVGSTYITLSIDGVGSVEVISADGKSRRVLAESSSSNPMKLPRDILFMNTKLFWFEDSTSPP 1811

  Fly   751 -----------------------------AER---RIYWT--------DQKSKCI---------- 765
                                         .:|   :|||.        |.||:.:          
 Worm  1812 SIFSMSAAGDDLKKLKVNSTLLNKFYNPTVDRFYSKIYWISQGKVIQFDPKSEVVQEIQIPGGDG 1876

  Fly   766 ------------------FRAFLNGSYVQRIVDSGLIGPDGI----------------------- 789
                              |....|.:.::|:   |:.|...|                       
 Worm  1877 NVSSIAVDMTNGDILIGEFIRIANQTTIRRL---GMKGTKAIQRGSVMLVPLHSSIKFFLSTVDI 1938

  Fly   790 --------------------------------------------------------AVDWLAN-- 796
                                                                    :|.|..|  
 Worm  1939 TAKNVPDECKKCPSLCLRSSDKKFQCVCSQGFELVNGKCRSPDKRVFFATDDGSLHSVGWYKNSK 2003

  Fly   797 ----------------------------------------NIYWSDA------------EARRIE 809
                                                    |..|..|            .:.||.
 Worm  2004 TGDLIQKYRAHSLHSDIGKKRILKLVADAKNDLVYVVTRQNEVWKCATNGSFAHIVYSTNSHRIA 2068

  Fly   810 VARLDG-------SSRRVLLWKG------------------VEE----PRSLVLEPRRGYMYWTE 845
            ...||.       |:|..:..||                  ||:    |..:.::|.:|.::|..
 Worm  2069 AITLDRVTGYLLVSARESISPKGFIVLIDPDRHSEAIHQVIVEDEDKIPYEIAVDPPKGKLFWAS 2133

  Fly   846 SPTDSIRRAAMDGSDLQTIVAGANHAAGLTFDQETRRLYWATQSRPAKIESADWDGKKRQILVGS 910
            |  ..|:.:...|::.:.||:.::.:| :..|:...||.: ..|..|.::..|::|...|..|..
 Worm  2134 S--SCIKSSNYYGTEAKCIVSKSSISA-IAIDENRSRLCF-VDSEKAAVDCVDYNGNNEQRNVAM 2194

  Fly   911 DMDEPYA--VSLY--QDYVYWSDW--NTGDIER-----------------VHKTTGQNRSLVHSG 952
            ...:|..  |||.  .|.:|:.|.  ::|.|.|                 ||..  |...::...
 Worm  2195 FKAQPMGDIVSLVFNGDEMYFFDKFNSSGSIVRGLVQQDGSVVLKDSLVKVHPR--QKIRVIDFD 2257

  Fly   953 MTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMT----CACPTHYQLAKDGVSCIPP 1013
            :..:.|.::|        ..|..|||||.|||:..|.....|    |.|....:|  |..||...
 Worm  2258 VMDVKSSVLF--------TACSNNNGGCEHLCITTPSENSPTVRKECLCVHSTRL--DNGSCGSS 2312

  Fly  1014 RNYIIFSQRNC--FGRLLPNTTDCPNIPLPVSG---KNIRAVDYDPITHHIYWIEGRSHSIKRSL 1073
            .::|.|::...  |....|.....||..:..:|   ..|.||..|.....||:.:.....|....
 Worm  2313 DSFIAFTRFTSIEFLSTKPGDLTSPNKQITSNGCVMSKIGAVTADATRGRIYFADYDKFRITAVN 2377

  Fly  1074 ANGTKVSLLANS-GQPFDLAIDIIGRLLFWTCSQSNSI--------NVTSFLGESVGVIDTGDSE 1129
            .:||...::|.. |....:|.|.:...|::..:...||        |:.|:..|...|:.....:
 Worm  2378 FDGTGCVVIAEDVGVVPSMAYDEVHTELYFVRANPASIWRINVADNNLESYPTEPKIVLTLTVRD 2442

  Fly  1130 KPRNIAVHAMKRLLFWTD---VGSHQAIIRARVDGNERVELAYK-LEGVTALALDQQSDMIYYAH 1190
            :||:||:|..:.|||:|:   .||  .|.|....|.:|.::..: |..:..|.:|..|:.:|::.
 Worm  2443 RPRHIAIHPCRMLLFFTNNAITGS--VIERVYFSGFKRDQIVQEDLHDLRGLTIDLDSEKLYFSD 2505

  Fly  1191 GK--RIDAIDINGKNKKTLV-------------SMHISQVINIAALGGFVYWL-DDKTGVERITV 1239
            .|  :|...|.:|.:::.:|             |::..::|       |..|: ....||.:||.
 Worm  2506 SKDFKISRCDFDGSHRELVVSNTDIPSIHPFELSIYDDEII-------FTDWVRRSVVGVNKITG 2563

  Fly  1240 NGERRSAELQRLPQITDI----------RAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIART 1294
            :..|      .:.:.||:          |...|.|       .|..:..||...|.....|.|. 
 Worm  2564 SDNR------NINRATDVPVGLVVVDTKREYCTSD-------ACADNELKCEDYCRLMANGQAS- 2614

  Fly  1295 RDVCSCPKHLMLLEDKENC-GAFP----------------------------------------- 1317
               |:|.....|..|...| |.|.                                         
 Worm  2615 ---CACNGERRLNSDNRTCTGEFDGKKCAENEFKCLHSDRCIRYEDTCDRYNDCPMFDDEDTKYC 2676

  Fly  1318 ---ACGPDHFTC----AAPVSGISDVNKD-----------------------CIPASWRCDGQKD 1352
               .|.|.:|.|    ..|...:.:...|                       |||:..||:..:|
 Worm  2677 STRVCRPGYFNCGNGLCIPEQKVCNRINDCANFADESNCTCNENEFRCQSGACIPSKARCNHMQD 2741

  Fly  1353 CPDKSDEVGCP--TCRA-DQF------SC-QSGECIDKSLVCDGTTNCANGHDEADC-------- 1399
            |.|.|||:|||  .|.| ::|      :| .:.:||..|..||||.:|.:|.||.||        
 Worm  2742 CNDASDEIGCPFRNCSALNEFGMTGLINCATTSQCIHPSWKCDGTNDCYDGSDEKDCFVEFDATG 2806

  Fly  1400 --------CKRPGEFQCPINKLCISAALLCDGWENCADGAD----------------ESSDICLQ 1440
                    |....:|.|...:.|:.....|||..:||||:|                |||..|:.
 Worm  2807 GSVSAPRSCDAKTQFACLATRTCMPKHWQCDGQPDCADGSDEKNCDAKKCTSFEFSCESSKKCIP 2871

  Fly  1441 -------RRMAP-ATDKRAFMILIGATMITIFSIVYLLQFCRTRIGKS----------------- 1480
                   ||..| ..|:..                     |.|.....                 
 Worm  2872 LEQKCDGRRDCPDGEDEHQ---------------------CETECDSKGGNATFRCTNHRCIPMA 2915

  Fly  1481 -RTEPKDDQATDPLS-----------------PSTLSKSQRV---SKIASVADAVR--------- 1515
             |.:..||...:..|                 ||..:....|   ...|.:.|.::         
 Worm  2916 WRCDGTDDCMDNAKSLGSDEVDCAAGRTSFHVPSRCADETCVVACELTAVLCDGIQDCSDGFDEK 2980

  Fly  1516 -MSTLNSRNSMNSY--------DRNHITGASSSTTNGSS--MVAYPINPPPSPATRS-------- 1561
             .::|:.:...|.:        |...:..||....:||.  :....::.||.....|        
 Worm  2981 NCASLDRQCKPNEWMCDSGQCIDSGRLCDASVDCVDGSDEWVEICSLSEPPRRGCPSGWSCLLTN 3045

  Fly  1562 --------------RRPYRHYKIINQPPPPTPCSTDI---CDESDSNYTSKSNSNNSNGGATKHS 1609
                          ||               .|.:.|   ||....|.:|..||.:......:|:
 Worm  3046 GTIGCLQEQQLCDGRR---------------DCMSGIDEQCDNPQGNCSSTRNSCDQTWNCQRHA 3095

  Fly  1610 SSSAAACLQYGYDSEPYP------PPPTPR---SHYHSDVRIV-PESSCPP 1650
            ...:.:| ..||...||.      .|..|:   ||:..|.|.| .:..|.|
 Worm  3096 GFESCSC-DDGYHLSPYDKKTCLRSPSCPKANCSHFCIDRRDVGHQCFCAP 3145

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 13/33 (39%)
NHL 168..503 CDD:302697 118/806 (15%)
NHL repeat 172..237 CDD:271320 24/73 (33%)
LY 252..293 CDD:214531 17/40 (43%)
NHL repeat 261..298 CDD:271320 15/39 (38%)
NHL repeat 303..339 CDD:271320 6/35 (17%)
NHL repeat 341..419 CDD:271320 24/379 (6%)
NHL repeat 428..476 CDD:271320 18/152 (12%)
LY 472..511 CDD:214531 16/38 (42%)
NHL repeat 477..503 CDD:271320 10/25 (40%)
Ldl_recept_b 534..573 CDD:278487 22/42 (52%)
LY 558..599 CDD:214531 20/44 (45%)
LY 600..641 CDD:214531 12/42 (29%)
FXa_inhibition 668..703 CDD:291342 9/36 (25%)
LY 739..773 CDD:214531 11/111 (10%)
LY 776..818 CDD:214531 15/181 (8%)
LY 819..860 CDD:214531 11/62 (18%)
FXa_inhibition 973..1010 CDD:291342 15/40 (38%)
LY 1122..1164 CDD:214531 15/44 (34%)
FXa_inhibition 1273..1313 CDD:291342 10/39 (26%)
LDLa 1319..1362 CDD:238060 17/69 (25%)
LDLa 1365..1399 CDD:238060 15/41 (37%)
LDLa 1399..1433 CDD:197566 13/65 (20%)
lrp-2NP_491270.2 LDLa 80..119 CDD:197566
LDLa 130..162 CDD:197566
LY 668..702 CDD:214531 13/33 (39%)
LY 707..758 CDD:214531 17/52 (33%)
LY 759..801 CDD:214531 17/41 (41%)
LDLa 968..1000 CDD:197566 3/31 (10%)
LDLa 1013..1047 CDD:238060 0/33 (0%)
LDLa 1053..1087 CDD:238060 1/33 (3%)
LDLa 1098..1129 CDD:238060 0/30 (0%)
LDLa 1144..1175 CDD:238060 0/30 (0%)
LDLa 1182..1216 CDD:238060 0/33 (0%)
FXa_inhibition 1276..1305 CDD:291342 4/28 (14%)
LY 1421..1463 CDD:214531 16/41 (39%)
LY 1465..1508 CDD:214531 17/42 (40%)
LY 1521..1555 CDD:214531 19/33 (58%)
LY 2480..2521 CDD:214531 9/40 (23%)
LDLa 2681..2715 CDD:238060 6/33 (18%)
LDLa 2717..2751 CDD:238060 11/33 (33%)
LDLa <2774..2798 CDD:238060 11/23 (48%)
LDLa 2819..2851 CDD:238060 11/31 (35%)
LDLa 2856..2891 CDD:238060 8/55 (15%)
LDLa 2904..2938 CDD:238060 4/33 (12%)
LDLa 2988..3020 CDD:197566 6/31 (19%)
LY 3231..3270 CDD:214531
Ldl_recept_b 3296..3336 CDD:278487
LY 3319..3362 CDD:214531
LY 3363..3404 CDD:214531
LDLa 3481..3514 CDD:197566
LDLa 3574..3609 CDD:238060
LDLa 3614..3649 CDD:197566
LDLa 3659..3693 CDD:238060
LDLa 3881..3912 CDD:238060
LY 4084..4125 CDD:214531
LY 4139..4181 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.710

Return to query results.
Submit another query.