DRSC/TRiP Functional Genomics Resources

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Protein Alignment arr and Lrp6

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_032540.2 Gene:Lrp6 / 16974 MGIID:1298218 Length:1613 Species:Mus musculus


Alignment Length:1658 Identity:716/1658 - (43%)
Similarity:998/1658 - (60%) Gaps:139/1658 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 LLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSAL 153
            ||:..|.|:::.:.|  .|.....::|..|.:|.|:||.:...|:.|:|...|.|:..:.|.:  
Mouse    23 LLYANRRDLRLVDAT--NGKENATIVVGGLEDAAAVDFVFGHGLIYWSDVSEEAIKRTEFNKT-- 83

  Fly   154 QPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAV 218
                 ...|.|:.:||..|:|||.||..:|:||||.|.|||||:.|||..:|||||.:||||||:
Mouse    84 -----ESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAI 143

  Fly   219 AVVPARKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHHFI 283
            |:.|:...:.||||||.||||||.|||.  ||..::...::|||||.:|.:...:||.|.|.:||
Mouse   144 ALDPSSGFMYWTDWGEVPKIERAGMDGS--SRFVIINTEIYWPNGLTLDYQERKLYWADAKLNFI 206

  Fly   284 DVMRLDGSSRRTIV-NNLKYPFSLTFYDDRLYWTDWQRGSLNALDLQTRE-LKELIDTPKAPNSV 346
            ....|||::|:.:| .:|.:||:||.::|.||||||...|:.|.:..|.| |:|:.....:|..:
Mouse   207 HKSNLDGTNRQAVVKGSLPHPFALTLFEDTLYWTDWNTHSILACNKYTGEGLREIHSNIFSPMDI 271

  Fly   347 RAWDPSLQPYEDNPCAHNNGNCSHLCLLATNSQGFSCACPTGVKLI-SANTCANGSQEMMFIVQR 410
            .|:....||...|||..:||.||||||::.....:.|||||||||: :..||.:|:.|::.:.:|
Mouse   272 HAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARR 336

  Fly   411 TQISKISLDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSE 475
            |.:.:||||:||:|...|.|..:::||||||||||.:|||:|.|...|:|:..||:|....||::
Mouse   337 TDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQ 401

  Fly   476 VRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWN 540
            :.||||:|:||:|||||||||.||||||.||:||.||:||.|.|||||||.:.|.:|:|:|:||.
Mouse   402 IAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWG 466

  Fly   541 ERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISD 605
            | .||:|||:||||:|||||:.:||||||:|||.:...|||.|.|||||||.|.||:||||::.|
Mouse   467 E-IPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGRRVLVED 530

  Fly   606 NLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAV 670
            .:.|:||.::|.||:||||||||||:|.||.:. .|.|::||.|||||||.|.:..:.|.|.||.
Mouse   531 KIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSA-EREVIIDQLPDLMGLKATSVHRIIGSNPCAE 594

  Fly   671 RNGGCSHLCLNRPRDYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERI 735
            .|||||||||.||:...|.|.|.:||.:|.:||:||.|||||||:..|.|||:   |.|:|:..|
Mouse   595 DNGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISL---ETNNNNVAI 656

  Fly   736 PFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYW 800
            |...|::|.|||..|.:.||||||...|.|.|||:|||.::.:|:.||..|:|:|||||..|:||
Mouse   657 PLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYW 721

  Fly   801 SDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTE-SPTDSIRRAAMDGSDLQTI 864
            :|....||||::|||..|:||:||.::.||:|.|:|..|:||||| .....|.|||||||:..|:
Mouse   722 ADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTL 786

  Fly   865 VAGANHAAGLTFDQETRRLYWATQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSD 929
            |.....|.|||.|...||||| |......|||:|..|..|:: :..|:..|:.::.||||:||:|
Mouse   787 VPNVGRANGLTIDYAKRRLYW-TDLDTNLIESSDMLGLNREV-IADDLPHPFGLTQYQDYIYWTD 849

  Fly   930 WNTGDIERVHKTTGQNRSLVHSGMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQP-GRRGM 993
            |:...|||.:||:||||:::...:.|:..:|||:..||.|.|.|..:||.|||||||.| |  |.
Mouse   850 WSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHCSHLCLAVPVG--GF 912

  Fly   994 TCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRLLPNTTDCPNIPLPV-SGKNIRAVDYDPITH 1057
            .|.||.||.|..|..:|..|..:::|||::...|::.:....|:|.||: |.:|:||:||||:..
Mouse   913 VCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDK 977

  Fly  1058 HIYWIEGRSHSIKRSLANGTK-VSLLANSG-------QPFDLAIDIIGRLLFWTCSQSNSINVTS 1114
            .:|||:.|.:||:::..:|.: .:::|||.       ||:||:|||..|.::|||..:|.|:||.
Mouse   978 QLYWIDSRQNSIRKAHEDGGQGFNVVANSVANQNLEIQPYDLSIDIYSRYIYWTCEATNVIDVTR 1042

  Fly  1115 FLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQ-AIIRARVDGNERVELAYK-LEGVTAL 1177
            ..|.||||:..|:.::||.|.|:..|..:::|::.... .|.||.:||.||..|.:. |....||
Mouse  1043 LDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIAL 1107

  Fly  1178 ALDQQSDMIYYAHG--KRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLD-DKTGVERITV 1239
            |||.:...:::|..  :||::.|::|.|:..|...:|.|.:.:.....::||:| .:..:|:|.:
Mouse  1108 ALDSKLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDM 1172

  Fly  1240 NGERRSAELQ-RLPQITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCPKH 1303
            .|.....::| |:.|::||.||...:.:..|.|.|......|||||:..|:|..|    ||||.|
Mouse  1173 TGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTR----CSCPMH 1233

  Fly  1304 LMLLEDKENCGAFPACGPDHFTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGCPTCRAD 1368
            |:||:|:.:||..|.|.|..|||..     .|:  ||||.:|||||..:|.|.|||:.||.|...
Mouse  1234 LVLLQDELSCGEPPTCSPQQFTCFT-----GDI--DCIPVAWRCDGFTECEDHSDELNCPVCSES 1291

  Fly  1369 QFSCQSGECIDKSLVCDGTTNCANGHDEADC---CKRPGEFQCPINKLCISAALLCDGWENCADG 1430
            ||.|.||:|||.:|.|:|..||.:..||.:|   | ...:|:| .|..|:.....||...:|:|.
Mouse  1292 QFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLC-LIDQFRC-ANGQCVGKHKKCDHSVDCSDR 1354

  Fly  1431 ADESSDICLQRRMAPATDKRAFMILIGATMITIF---SIVYLLQ--FCRTRIGKSRTEPKDDQAT 1490
            :||......:.....||:....:|   ..::|||   :|.::.|  .|....|...|...|....
Mouse  1355 SDELDCYPTEEPAPQATNTVGSVI---GVIVTIFVSGTIYFICQRMLCPRMKGDGETMTNDYVVH 1416

  Fly  1491 DPLS--------PSTLS-----KSQRVSKIASVADAVRMSTLNSRNSMNSYDRNHITGASSSTTN 1542
            .|.|        ||:||     .|:..|.|:|:       ::...:|...|||.|:||||||:::
Mouse  1417 SPASVPLGYVPHPSSLSGSLPGMSRGKSMISSL-------SIMGGSSGPPYDRAHVTGASSSSSS 1474

  Fly  1543 GSSMVAYP--INPPPSPATR---------------------SRRP--YRHYKIINQPPPPTPCST 1582
            .:....:|  :||||||||.                     |.||  |||:     .||.|||||
Mouse  1475 STKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHF-----APPTTPCST 1534

  Fly  1583 DICDESDSNYTSKSNSNNSNGGATKHSSSSAAACLQY----GYDSEPYPPPPTPRSHYHSDVRIV 1643
            |:|   ||:|            |.....:|.|....|    .|||||.||||||||.|.|    .
Mouse  1535 DVC---DSDY------------APSRRMTSVATAKGYTSDVNYDSEPVPPPPTPRSQYLS----A 1580

  Fly  1644 PES--SCPPSPSSRSSTYFSPLPPPPSPVQSPS 1674
            .|:  ||||||.:..|......||||||....|
Mouse  1581 EENYESCPPSPYTERSYSHHLYPPPPSPCTDSS 1613

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 22/38 (58%)
NHL 168..503 CDD:302697 168/337 (50%)
NHL repeat 172..237 CDD:271320 39/64 (61%)
LY 252..293 CDD:214531 15/40 (38%)
NHL repeat 261..298 CDD:271320 16/37 (43%)
NHL repeat 303..339 CDD:271320 17/36 (47%)
NHL repeat 341..419 CDD:271320 32/78 (41%)
NHL repeat 428..476 CDD:271320 24/47 (51%)
LY 472..511 CDD:214531 28/38 (74%)
NHL repeat 477..503 CDD:271320 20/25 (80%)
Ldl_recept_b 534..573 CDD:278487 26/38 (68%)
LY 558..599 CDD:214531 26/40 (65%)
LY 600..641 CDD:214531 22/40 (55%)
FXa_inhibition 668..703 CDD:291342 19/34 (56%)
LY 739..773 CDD:214531 18/33 (55%)
LY 776..818 CDD:214531 21/41 (51%)
LY 819..860 CDD:214531 22/41 (54%)
FXa_inhibition 973..1010 CDD:291342 20/37 (54%)
LY 1122..1164 CDD:214531 13/42 (31%)
FXa_inhibition 1273..1313 CDD:291342 18/39 (46%)
LDLa 1319..1362 CDD:238060 20/42 (48%)
LDLa 1365..1399 CDD:238060 16/33 (48%)
LDLa 1399..1433 CDD:197566 10/36 (28%)
Lrp6NP_032540.2 Beta-propeller 1 20..275 109/262 (42%)
NHL 55..272 CDD:302697 99/225 (44%)
NHL repeat 55..93 CDD:271320 11/44 (25%)
LY 89..127 CDD:214531 22/37 (59%)
NHL repeat 97..132 CDD:271320 21/34 (62%)
NHL repeat 140..176 CDD:271320 22/37 (59%)
Ldl_recept_b 150..190 CDD:278487 22/41 (54%)
LY 175..216 CDD:214531 15/40 (38%)
NHL repeat 181..217 CDD:271320 15/35 (43%)
NHL repeat 226..253 CDD:271320 13/26 (50%)
LDL-receptor class B 5 236..277 14/40 (35%)
FXa_inhibition 286..323 CDD:291342 18/36 (50%)
Beta-propeller 2 328..589 152/262 (58%)
LY 353..393 CDD:214531 21/39 (54%)
LY 397..437 CDD:214531 28/39 (72%)
LY 438..481 CDD:214531 27/43 (63%)
LY 483..524 CDD:214531 26/40 (65%)
LY 525..558 CDD:214531 19/32 (59%)
FXa_inhibition 592..627 CDD:291342 19/34 (56%)
Beta-propeller 3 631..890 125/263 (48%)
LY 656..694 CDD:214531 20/37 (54%)
LY 697..739 CDD:214531 21/41 (51%)
LY 740..783 CDD:214531 23/42 (55%)
LY 783..825 CDD:214531 18/42 (43%)
LY 827..866 CDD:214531 17/39 (44%)
FXa_inhibition 893..929 CDD:291342 20/37 (54%)
Beta-propeller 4 933..1202 89/268 (33%)
LY 958..998 CDD:214531 17/39 (44%)
LY 1050..1093 CDD:214531 13/42 (31%)
LY 1094..1136 CDD:214531 12/41 (29%)
FXa_inhibition 1207..1243 CDD:291342 18/39 (46%)
LDLa 1249..1285 CDD:238060 20/42 (48%)
LDLa 1288..1322 CDD:238060 16/33 (48%)
LDLa 1326..1360 CDD:238060 11/35 (31%)
PPPSP motif A 1487..1493 5/5 (100%)
PPPSP motif B 1527..1534 5/6 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1556..1613 30/60 (50%)
PPPSP motif C 1568..1575 6/6 (100%)
PPPSP motif D 1588..1593 4/4 (100%)
PPPSP motif E 1603..1610 6/6 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167845807
Domainoid 1 1.000 123 1.000 Domainoid score I5564
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1747
Inparanoid 1 1.050 1327 1.000 Inparanoid score I146
Isobase 1 0.950 - 0 Normalized mean entropy S5302
OMA 1 1.010 - - QHG48457
OrthoDB 1 1.010 - - D121310at2759
OrthoFinder 1 1.000 - - FOG0004181
OrthoInspector 1 1.000 - - otm44191
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3498
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.620

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