DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and Lrp5

DIOPT Version :10

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_032539.2 Gene:Lrp5 / 16973 MGIID:1278315 Length:1614 Species:Mus musculus


Alignment Length:1662 Identity:709/1662 - (42%)
Similarity:993/1662 - (59%) Gaps:139/1662 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    78 PASAFVNTPATLLFTTRHDIQVANITRPTGGPQID--VIVRDLAEAMAIDFYYAKNLVCWTDSGR 140
            ||:|   :| .|||..|.|:::.:    .||.:::  ::...|.:|.|:||.::|..|.|||...
Mouse    27 PAAA---SP-LLLFANRRDVRLVD----AGGVKLESTIVASGLEDAAAVDFQFSKGAVYWTDVSE 83

  Fly   141 EIIECAQTNSSALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQK 205
            |.|:....|.:.      |..|.::.:||..|:|||.||...|:||||.|.||||||.|:|..:|
Mouse    84 EAIKQTYLNQTG------AAAQNIVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRK 142

  Fly   206 VLFWTDLDQPRAVAVVPARKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKN 270
            ||||.|||||||:|:.||...:.||||||.|:||||.|||.  :|..:|...::|||||.:||:.
Mouse   143 VLFWQDLDQPRAIALDPAHGYMYWTDWGEAPRIERAGMDGS--TRKIIVDSDIYWPNGLTIDLEE 205

  Fly   271 ELIYWTDGKHHFIDVMRLDGSSRRTIV-NNLKYPFSLTFYDDRLYWTDWQRGSLNALDLQTRE-L 333
            :.:||.|.|..||....||||.|:.:| .:|.:||:||...|.|||||||..|::|.:..|.| .
Mouse   206 QKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKWTGEQR 270

  Fly   334 KELIDTPKAPNSVRAWDPSLQPYEDNPCAHNNGNCSHLCLLATNSQGFSCACPTGVKL-ISANTC 397
            ||::....:|..::......||....||..:||.|||||||:.....:||||||||:| .:..||
Mouse   271 KEILSALYSPMDIQVLSQERQPPFHTPCEEDNGGCSHLCLLSPREPFYSCACPTGVQLQDNGKTC 335

  Fly   398 ANGSQEMMFIVQRTQISKISLDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAH 462
            ..|::|::.:.:||.:.:||||:||:|...|.:|.:::||||||||:|.::||:|.|...|:||:
Mouse   336 KTGAEEVLLLARRTDLRRISLDTPDFTDIVLQVGDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAY 400

  Fly   463 ADGTGVTDFVTSEVRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAV 527
            .||:|....|.:|:..|||:|:||:|||||||||.||||||.||:||:||:|:.|.|:|||||.:
Mouse   401 LDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIVL 465

  Fly   528 APSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVA 592
            .|.:|.|:|:||.| .||:|.|:|||.:|.|||:.:||||||:|||::...:||.|.|||||||.
Mouse   466 HPVMGLMYWTDWGE-NPKIECANLDGRDRHVLVNTSLGWPNGLALDLQEGKLYWGDAKTDKIEVI 529

  Fly   593 NMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVT 657
            |:||:.|:.::.|.|.|:||.::|.|::||||||||||:|.||:.. :|.|::||.|||||||..
Mouse   530 NIDGTKRKTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKA-SRDVIIDQLPDLMGLKAV 593

  Fly   658 RLREVRGQNACAVRNGGCSHLCLNRPRDYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGRIS 722
            .:.:|.|.|.||..||||||||...||...|.|.|..||.:|.:||::|.|||:|:.:..|.|||
Mouse   594 NVAKVVGTNPCADGNGGCSHLCFFTPRATKCGCPIGLELLSDMKTCIIPEAFLVFTSRATIHRIS 658

  Fly   723 IEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVDSGLIGPD 787
            :   |.|:||..||...|::|.|||..|:...|||||...|.|.|||:|||.|:.:::.||..|:
Mouse   659 L---ETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVIEFGLDYPE 720

  Fly   788 GIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTE-SPTDSI 851
            |:||||:..|:||:|....|||||||||..|:||:|:.::.||||.|:|.:||:|||| .....|
Mouse   721 GMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRI 785

  Fly   852 RRAAMDGSDLQTIVAGANHAAGLTFDQETRRLYWATQSRPAKIESADWDGKKRQILVGSDMDEPY 916
            .||.|||::..|:|.....|..||.|...:|||| |......|||::..|::|.: :..|:..|:
Mouse   786 VRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYW-TDLDTNMIESSNMLGQERMV-IADDLPYPF 848

  Fly   917 AVSLYQDYVYWSDWNTGDIERVHKTTGQNRSLVHSGMTYITSLLVFNDKRQTGVNPCKVNNGGCS 981
            .::.|.||:||:|||...|||..||:|:||:|:...:.::..:|||:..||.|:|.|..:||.|.
Mouse   849 GLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCVHSNGQCG 913

  Fly   982 HLCLAQPGRRGMTCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRLLPNTTDCPNIPLPVSG-K 1045
            .||||.||  |..|.|.:||.|.....:|.||..:::|||:....|::|:....|::.||:.| :
Mouse   914 QLCLAIPG--GHRCGCASHYTLDPSSRNCSPPSTFLLFSQKFAISRMIPDDQLSPDLVLPLHGLR 976

  Fly  1046 NIRAVDYDPITHHIYWIEGRSHSIKRSLANGTKVSLLANSG-------QPFDLAIDIIGRLLFWT 1103
            |::|::|||:...|||::|| .:|||:..:||:.|:|.:..       ||.||:|||..|.||||
Mouse   977 NVKAINYDPLDKFIYWVDGR-QNIKRAKDDGTQPSMLTSPSQSLSPDRQPHDLSIDIYSRTLFWT 1040

  Fly  1104 CSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQA-IIRARVDGNER-VE 1166
            |..:|:|||....|:::||:..||.:|||.|||:|.:..:::|::..|.| |.||.:||.|| |.
Mouse  1041 CEATNTINVHRLDGDAMGVVLRGDRDKPRAIAVNAERGYMYFTNMQDHAAKIERASLDGTEREVL 1105

  Fly  1167 LAYKLEGVTALALDQQSDMIYY--AHGKRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLD 1229
            ....|....||.:|.....:::  |..|||::.|::|.|:.||...:|.|.:.:..||..:||:|
Mouse  1106 FTTGLIRPVALVVDNALGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPVGLTVLGRHLYWID 1170

  Fly  1230 -DKTGVERI-TVNGERRSAELQRLPQITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIA 1292
             .:..:||: ...|::|:....|:..:|.|.||.....:....|.|......|||||||.|:|..
Mouse  1171 RQQQMIERVEKTTGDKRTRVQGRVTHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTP 1235

  Fly  1293 RTRDVCSCPKHLMLLEDKENCGAFPACGPDHFTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKS 1357
            |    ||||.||:||::...||..|.|.||.|.|..     .::  ||||.:|||||..:|.|:|
Mouse  1236 R----CSCPVHLVLLQNLLTCGEPPTCSPDQFACTT-----GEI--DCIPGAWRCDGFPECADQS 1289

  Fly  1358 DEVGCPTCRADQFSCQSGECIDKSLVCDGTTNCANGHDEADC---CKRPGEFQCPINKLCISAAL 1419
            ||.|||.|.|.||.|..|:|:|..|.|||..:|.:..|||:|   | .|.:|:|...: |:....
Mouse  1290 DEEGCPVCSASQFPCARGQCVDLRLRCDGEADCQDRSDEANCDAVC-LPNQFRCTSGQ-CVLIKQ 1352

  Fly  1420 LCDGWENCADGADESSDICLQRRMAPATDKRAFMILIGATMITIFSI-----VYLL---QFCRTR 1476
            .||.:.:||||:||   :..:....|:.|..|....||..:..|.|:     ||.:   ..|:..
Mouse  1353 QCDSFPDCADGSDE---LMCEINKPPSDDIPAHSSAIGPVIGIILSLFVMGGVYFVCQRVMCQRY 1414

  Fly  1477 IGKSRTEPKDDQATDPLSPSTL----------------SKSQRVSKIASVADAVRMSTLNSRNSM 1525
            .|.|...|.:.....|..|...                |||...|          ||.:..|.|:
Mouse  1415 TGASGPFPHEYVGGAPHVPLNFIAPGGSQHGPFPGIPCSKSVMSS----------MSLVGGRGSV 1469

  Fly  1526 NSYDRNHITGASSSTTNGSSMVAYP--INPPPSPAT----------------RSRRPYRHYKIIN 1572
            ..|||||:||||||:::.:....||  :||||||||                .:.||||.|.|..
Mouse  1470 PLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNVDVFYSSGIPATARPYRPYVIRG 1534

  Fly  1573 QPPPPTPCSTDICDESDSNYTSKSNSNNSNGGATKHSSSSAAACLQYGYDSEPYPPPPTPRSHYH 1637
            ..||.||||||:|   ||:|::      |...::|:       .|....||:||||||||.|.|.
Mouse  1535 MAPPTTPCSTDVC---DSDYST------SRWKSSKY-------YLDLNSDSDPYPPPPTPHSQYL 1583

  Fly  1638 SDVRIVPESSCPPSPSSRSSTYFSPLPPPPSPVQSPS 1674
            |     .|.||||||.:..| |....||||||....|
Mouse  1584 S-----AEDSCPPSPGTERS-YCHLFPPPPSPCTDSS 1614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 22/38 (58%)
NHL 168..503 CDD:302697 169/337 (50%)
NHL repeat 172..237 CDD:271320 41/64 (64%)
LY 252..293 CDD:214531 18/40 (45%)
NHL repeat 261..298 CDD:271320 18/37 (49%)
NHL repeat 303..339 CDD:271320 18/36 (50%)
NHL repeat 341..419 CDD:271320 31/78 (40%)
NHL repeat 428..476 CDD:271320 22/47 (47%)
LY 472..511 CDD:214531 27/38 (71%)
NHL repeat 477..503 CDD:271320 19/25 (76%)
Ldl_recept_b 534..574 CDD:459654 24/39 (62%)
LY 558..599 CDD:214531 25/40 (63%)
LY 600..641 CDD:214531 20/40 (50%)
FXa_inhibition 668..703 CDD:464251 18/34 (53%)
YncE <736..886 CDD:442618 73/150 (49%)
LY 776..818 CDD:214531 21/41 (51%)
LY 905..946 CDD:214531 16/40 (40%)
FXa_inhibition 973..1010 CDD:464251 16/36 (44%)
YncE <1047..1191 CDD:442618 61/154 (40%)
LDLa 1319..1362 CDD:238060 19/42 (45%)
LDLa 1365..1399 CDD:238060 16/33 (48%)
LDLa 1399..1433 CDD:197566 12/36 (33%)
Lrp5NP_032539.2 YncE 4..213 CDD:442618 88/201 (44%)
Beta-propeller 1 31..287 115/268 (43%)
LY 101..141 CDD:214531 22/39 (56%)
Ldl_recept_b 162..202 CDD:459654 21/41 (51%)
LY 186..228 CDD:214531 18/41 (44%)
LY 229..270 CDD:214531 18/40 (45%)
LDL-receptor class B 5 247..289 15/41 (37%)
FXa_inhibition 298..335 CDD:464251 19/36 (53%)
Beta-propeller 2 340..601 141/262 (54%)
LY 365..405 CDD:214531 20/39 (51%)
LY 407..449 CDD:214531 27/41 (66%)
LY 450..493 CDD:214531 23/43 (53%)
LY 494..536 CDD:214531 25/41 (61%)
LY 537..570 CDD:214531 17/32 (53%)
FXa_inhibition 604..639 CDD:464251 18/34 (53%)
Beta-propeller 3 643..902 117/263 (44%)
YncE <653..781 CDD:442618 67/130 (52%)
LY 709..751 CDD:214531 21/41 (51%)
LY 798..837 CDD:214531 14/39 (36%)
LY 837..878 CDD:214531 17/41 (41%)
FXa_inhibition 905..940 CDD:464251 16/36 (44%)
Beta-propeller 4 944..1211 95/267 (36%)
LY 969..1008 CDD:214531 17/39 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1002..1025 4/22 (18%)
LY 1059..1102 CDD:214531 18/42 (43%)
LY 1103..1145 CDD:214531 11/41 (27%)
FXa_inhibition 1216..1252 CDD:464251 19/39 (49%)
LDLa 1258..1294 CDD:238060 19/42 (45%)
LDLa 1297..1331 CDD:238060 16/33 (48%)
LDLa 1335..1369 CDD:238060 13/38 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1474..1498 11/23 (48%)
PPPSP motif A 1499..1505 5/5 (100%)
PPPSP motif B 1537..1544 5/6 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1567..1599 21/37 (57%)
PPPSP motif C 1573..1580 6/6 (100%)
PPPSP motif D 1590..1595 4/4 (100%)
PPPSP motif E 1604..1611 6/6 (100%)

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