DRSC/TRiP Functional Genomics Resources

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Protein Alignment arr and Lrp1

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:XP_036011543.1 Gene:Lrp1 / 16971 MGIID:96828 Length:4562 Species:Mus musculus


Alignment Length:1613 Identity:466/1613 - (28%)
Similarity:746/1613 - (46%) Gaps:237/1613 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 CQVIDNNEDVTTKATKCTKSNSGVGWRQMLIGFLLICFGISNSWQYKNVHMPSSSSLIASPPASA 81
            ||:    :....|..||::...     |........|:   ..|    |..|...|..:..|...
Mouse  1239 CQI----QSYCAKHLKCSQKCD-----QNKFSVKCSCY---EGW----VLEPDGESCRSLDPFKP 1287

  Fly    82 FVNTPATLLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECA 146
            |:      :|:.||:|:..::.:    ....|:|..|...:|:||:.:::.:.|||    ::|..
Mouse  1288 FI------IFSNRHEIRRIDLHK----GDYSVLVPGLRNTIALDFHLSQSALYWTD----VVEDK 1338

  Fly   147 QTNSSALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTD 211
            ......|........:.||..||..|||||:||....|||.:...::||||.|||..:..|...|
Mouse  1339 IYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGD 1403

  Fly   212 LDQPRAVAVVPARKLLIWTDW-GEYPKIERASMDGDPLSRMTLVKE--HVFWPNGLAVDLKNELI 273
            ::.|||:|:.|...:|.|||| ...|:||.|||.|  ..|.|:.:|  ...|||||.||...:.|
Mouse  1404 IEHPRAIALDPRDGILFWTDWDASLPRIEAASMSG--AGRRTIHRETGSGGWPNGLTVDYLEKRI 1466

  Fly   274 YWTDGKHHFIDVMRLDGSSRRTIVNN---LKYPFSLTFYDDRLYWTDWQRGSLNALDLQTRELKE 335
            .|.|.:...|...|.|||....::..   |.:||::|.|...:|||||:..:|...:..|.....
Mouse  1467 LWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVT 1531

  Fly   336 LID-TPKAPNSVRAWDPSLQPYEDNPCAHNNGN--CSHLCLLATNSQGFSCACPTGVKLISANTC 397
            ::. |...|..::.:.||.||...|||..|.|.  ||||||:..| :..|||||..:||...||.
Mouse  1532 VVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGRGPCSHLCLINYN-RTVSCACPHLMKLHKDNTT 1595

  Fly   398 ANGSQEMMFIVQRTQISKISLDSPDYT-IFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRA 461
            ....::.:...::.:|..:.||:|.|. |....:..:.....:|||..|:.:|||||.|..||||
Mouse  1596 CYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRA 1660

  Fly   462 HADGTGVTDFVTSEVRHPDGLALDWLARNLYWT--DTVTDRIEVCRLDGTARKVLIYEHLEEPRA 524
            ..:||||...|::::.:..|||:||::|||:||  ||...:|.|.||||:.:..:: :.||:|..
Mouse  1661 FINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHG 1724

  Fly   525 IAVAPSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKI 589
            :.|.|..|.::|:|.:    .:..|::|||...:|.|...| |.|:|:|.....:||.......|
Mouse  1725 LVVHPLRGKLYWTDGD----NISMANMDGSNHTLLFSGQKG-PVGLAIDFPESKLYWISSGNHTI 1784

  Fly   590 EVANMDGSGRRVVISDNLKHLFG----LSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPD 650
            ...|:|||...|:  |.::...|    |:|:.|.|:|.|.....:...:|..|:..:|:.:....
Mouse  1785 NRCNLDGSELEVI--DTMRSQLGKATALAIMGDKLWWADQVSEKMGTCNKADGSGSVVLRNSTTL 1847

  Fly   651 LMGLKV---TRLREVRGQNACAVRNGGCSHLCLNRPRDYV---CRCAIDYELANDKRTCVVPAAF 709
            :|.:||   :...|..|.|.|:|.||.||.|||  |....   |.|...|.|.:.::.|....:|
Mouse  1848 VMHMKVYDESIQLEHEGTNPCSVNNGDCSQLCL--PTSETTRSCMCTAGYSLRSGQQACEGVGSF 1910

  Fly   710 LLFSRQEHIGRISIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSY 774
            ||:|..|.|..|.::.|:  .:|..:|......|..:|.......|||.|.....|.||..:.::
Mouse  1911 LLYSVHEGIRGIPLDPND--KSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTW 1973

  Fly   775 VQRIVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRG 839
            .:.:|.:|:...:||||||:|.||||:|.....||||||:||.|.|::.:|:::||::.:.|.:|
Mouse  1974 REDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKG 2038

  Fly   840 YMYWTE-SPTDSIRRAAMDGSDLQTIV-AGANHAAGLTFDQETRRLYWATQSRPAKIESADWD-G 901
            |::||| .....|.|:.:||::...:| ...:...|::.|.:..:|||. .:|..|||..|.: |
Mouse  2039 YLFWTEWGHYPRIERSRLDGTERVVLVNVSISWPNGISVDYQGGKLYWC-DARMDKIERIDLETG 2102

  Fly   902 KKRQILVGSDMDEPYAVSLYQDYVYWSDWN--TGDIERVHKTTGQNRSLVHSGM-TYITSLLVFN 963
            :.|::::.|:..:.::||:::|::||||..  .|.|:|..|....:...:.:|: ..:..:.|||
Mouse  2103 ENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGCKDNATDSVPLRTGIGVQLKDIKVFN 2167

  Fly   964 DKRQTGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRL 1028
            ..||.|.|.|.|.||||..|||.:.|.: ..||| .|..||:||.||.....|:::|:|.....:
Mouse  2168 RDRQKGTNVCAVANGGCQQLCLYRGGGQ-RACAC-AHGMLAEDGASCREYAGYLLYSERTILKSI 2230

  Fly  1029 LPNTTDCPNIPLPVSG-------KNIRAVDYD------PIT-HHIYWIEGRSHSIKRSLANGT-K 1078
              :.:|..|:..||..       ||:.|:.:|      |.| :.|::.:....:|::...:|: :
Mouse  2231 --HLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSGR 2293

  Fly  1079 VSLLANSGQPFDLAIDIIGRLLFWTCSQSNSI--------NVTSFLGESVGVIDTGDSEKPRNIA 1135
            .:::.|.|....||.......|:||...:::|        ...:|..|:| :..:|| :.||...
Mouse  2294 TTIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETV-ITMSGD-DHPRAFV 2356

  Fly  1136 VHAMKRLLFWTDVGS-HQAIIRARVDGNERVELAYK-LEGVTALALDQQSDMIYYAHG--KRIDA 1196
            :...:.|:|||:... |.:|:||.:.|...:.|..| :.....||:|.:::.:|::..  .:|:.
Mouse  2357 LDECQNLMFWTNWNELHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIER 2421

  Fly  1197 IDINGKNKKTLVSMHISQVINIAALGGFVYWLD-DKTGVERIT--VNGERRSAELQRLPQITDIR 1258
            .:.:|.::..::.........:|..|..::|.| .:..|:|..  |..:.:...:....|...|.
Mouse  2422 CEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKYVGSDMKLLRVDIPQQPMGII 2486

  Fly  1259 AVWTPDPKVLRNHTCMHSRTKCSHICI-------------------------------------- 1285
            || ..|........|..:...|..:|:                                      
Mouse  2487 AV-ANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQEDFTCRAVNSSCRAQDEFEC 2550

  Fly  1286 ASGE---------GIARTRD-------VCS---------------CPKHLMLLEDKENCG----A 1315
            |:||         |::..:|       .|:               |..:::.....::||    .
Mouse  2551 ANGECISFSLTCDGVSHCKDKSDEKPSYCNSRRCKKTFRQCNNGRCVSNMLWCNGVDDCGDGSDE 2615

  Fly  1316 FP----ACGPDHFTC--AAPVSGISDVNK--DCIPA----------------------------- 1343
            .|    |||...|.|  .:.:...|..|:  ||..|                             
Mouse  2616 IPCNKTACGVGEFRCRDGSCIGNSSRCNQFVDCEDASDEMNCSTTDCSSYFRLGVKGVLFQPCER 2680

  Fly  1344 -------SWRCDGQKDCPDKSDEVGC-----PTCRADQFSCQSGECIDKSLVCDGTTNCANGHDE 1396
                   ||.|||..||.|.|||..|     |.|..:.|:|.||.||..|..||...:|.||.||
Mouse  2681 TSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCENGEDE 2745

  Fly  1397 ADCCK--RPGEFQCPINKLCISAALLCDGWENCADGADESSDICLQRRMAPAT 1447
            ..|.|  ...:|:|. |..|||...||||.::|.||:||::. |..:...|::
Mouse  2746 THCNKFCSEAQFECQ-NHRCISKQWLCDGSDDCGDGSDEAAH-CEGKTCGPSS 2796

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 19/38 (50%)
NHL 168..503 CDD:302697 133/346 (38%)
NHL repeat 172..237 CDD:271320 29/65 (45%)
LY 252..293 CDD:214531 17/42 (40%)
NHL repeat 261..298 CDD:271320 14/36 (39%)
NHL repeat 303..339 CDD:271320 11/36 (31%)
NHL repeat 341..419 CDD:271320 27/79 (34%)
NHL repeat 428..476 CDD:271320 19/47 (40%)
LY 472..511 CDD:214531 19/40 (48%)
NHL repeat 477..503 CDD:271320 13/27 (48%)
Ldl_recept_b 534..573 CDD:278487 12/38 (32%)
LY 558..599 CDD:214531 14/40 (35%)
LY 600..641 CDD:214531 11/44 (25%)
FXa_inhibition 668..703 CDD:291342 14/37 (38%)
LY 739..773 CDD:214531 9/33 (27%)
LY 776..818 CDD:214531 22/41 (54%)
LY 819..860 CDD:214531 14/41 (34%)
FXa_inhibition 973..1010 CDD:291342 18/36 (50%)
LY 1122..1164 CDD:214531 13/42 (31%)
FXa_inhibition 1273..1313 CDD:291342 10/108 (9%)
LDLa 1319..1362 CDD:238060 20/82 (24%)
LDLa 1365..1399 CDD:238060 15/33 (45%)
LDLa 1399..1433 CDD:197566 15/35 (43%)
Lrp1XP_036011543.1 LDLa 27..60 CDD:197566
LDLa 72..105 CDD:197566
FXa_inhibition 120..149 CDD:405372
FXa_inhibition 159..189 CDD:405372
LY 276..315 CDD:214531
LY 317..359 CDD:214531
LY 362..402 CDD:214531
FXa_inhibition 487..520 CDD:405372
LY 552..594 CDD:214531
LY 595..634 CDD:214531
LY 641..690 CDD:214531
LY <701..734 CDD:214531
FXa_inhibition 808..843 CDD:405372
LDLa 854..886 CDD:197566
LDLa 896..929 CDD:238060
LDLa 936..968 CDD:197566
LDLa 979..1012 CDD:238060
LDLa 1033..1066 CDD:238060
LDLa 1080..1115 CDD:238060
LDLa 1122..1158 CDD:238060
LDLa 1163..1196 CDD:238060
FXa_inhibition 1203..1239 CDD:405372 466/1613 (29%)
LY 1354..1394 CDD:214531 20/39 (51%)
LY 1398..1441 CDD:214531 19/44 (43%)
LY 1442..1486 CDD:214531 17/43 (40%)
LY 1631..1667 CDD:214531 16/35 (46%)
LY 1668..1711 CDD:214531 19/42 (45%)
LY 1715..1752 CDD:214531 12/41 (29%)
LY 1752..1793 CDD:214531 13/41 (32%)
FXa_inhibition 1868..1904 CDD:405372 14/37 (38%)
LY 1934..1974 CDD:214531 10/39 (26%)
LY 1977..2017 CDD:214531 22/39 (56%)
LY 2018..2061 CDD:214531 14/42 (33%)
LY 2063..2105 CDD:214531 12/42 (29%)
FXa_inhibition 2177..2212 CDD:405372 18/36 (50%)
YvrE 2271..2481 CDD:225921 42/211 (20%)
Ldl_recept_b 2362..2403 CDD:395012 13/40 (33%)
LY 2388..2429 CDD:214531 8/40 (20%)
FXa_inhibition 2500..2532 CDD:405372 3/31 (10%)
LDLa 2545..2575 CDD:238060 5/29 (17%)
LDLa 2584..2618 CDD:238060 3/33 (9%)
LDLa 2623..2657 CDD:238060 9/33 (27%)
LDLa <2684..2706 CDD:238060 11/21 (52%)
LDLa 2714..2748 CDD:238060 15/33 (45%)
LDLa 2752..2783 CDD:197566 13/31 (42%)
LDLa 2791..2824 CDD:197566 1/6 (17%)
LDLa 2835..2867 CDD:197566
LDLa 2875..2908 CDD:197566
LDLa 2925..2957 CDD:238060
cEGF 2980..3003 CDD:403760
EGF_CA 3000..>3029 CDD:214542
LY 3067..3111 CDD:214531
LY 3112..3154 CDD:214531
LY 3156..3198 CDD:214531
LY 3200..3241 CDD:214531
LY 3242..3282 CDD:214531
FXa_inhibition 3312..3348 CDD:405372
LDLa 3352..3383 CDD:238060
LDLa 3392..3426 CDD:238060
LDLa 3431..3466 CDD:238060
LDLa 3470..3503 CDD:197566
LDLa 3511..3544 CDD:197566
LDLa 3554..3588 CDD:238060
LDLa 3593..3627 CDD:238060
LDLa 3631..3665 CDD:238060
LDLa 3671..3703 CDD:197566
LDLa 3713..3749 CDD:238060
LDLa 3764..3794 CDD:238060
LY 3973..4010 CDD:214531
Ldl_recept_b 4031..4071 CDD:395012
LY 4055..4096 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167845800
Domainoid 1 1.000 56 1.000 Domainoid score I10969
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.640

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