DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment arr and Lrp2

DIOPT Version :9

Sequence 1:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	NP_001074557.1	Gene:	Lrp2 / 14725	MGIID:	95794	Length:	4660	Species:	Mus musculus

Alignment Length:	1473	Identity:	450/1473 - (30%)
Similarity:	702/1473 - (47%)	Gaps:	174/1473 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 LLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSAL 153
            |:..:|..|.:.|||..|  ..|..:|:|::..:|:||......|.|:|    ::|  ....||.
Mouse  1439 LVVASRDKIIMDNITAHT--HNIYSLVQDVSFVVALDFDSVTGRVFWSD----LLE--GKTWSAF 1495

  Fly   154 QPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAV 218
            |.  ...|:.|..:||...|.:|:||....|||||.....|||:.:||.::.||...::.:||.:
Mouse  1496 QN--GTDKRVVHDSGLSLTEMIAVDWIGRNIYWTDYTLETIEVSKIDGSHRTVLISKNVTKPRGL 1558

  Fly   219 AVVP--ARKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHH 281
            |:.|  ...::.|:|||.:|:||||||||  ..|..:|:|.::||.||::|..|.|||:.|....
Mouse  1559 ALDPRMGDNVMFWSDWGHHPRIERASMDG--TMRTVIVQEKIYWPCGLSIDYPNRLIYFMDAYLD 1621

  Fly   282 FIDVMRLDGSSRRTIVNN---LKYPFSLTFYDDRLYWTDWQRGS---LNALDLQTRELKELIDTP 340
            :|:....||.:||.::.:   |.:|.:||.::|.::|||  ||:   :.|.....|....::.:.
Mouse  1622 YIEFCDYDGQNRRQVIASDLVLHHPHALTLFEDSVFWTD--RGTHQVMQANKWHGRNQSVVMYSV 1684

  Fly   341 KAPNSVRAWDPSLQPYEDNPCAHNNGNCSHLCLL-ATNSQGFSCACPTGVKLI--SANTCANGSQ 402
            ..|..:.|..||.||...||||  :..||||||| |...:.:|||||:|..|.  |.| |..|.|
Mouse  1685 PQPLGIIAIHPSRQPSSPNPCA--SATCSHLCLLSAQEPRHYSCACPSGWNLSDDSVN-CVRGDQ 1746

  Fly   403 EMMFIVQRTQISKISLD----SPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHA 463
            ..:..|:...|..||||    |.|..:   |:..:::...:::|..|:.|||.: ....|.|...
Mouse  1747 PFLISVRENVIFGISLDPEVKSNDAMV---PISGIQHGYDVEFDDSEQFIYWVE-NPGEIHRVKT 1807

  Fly   464 DGTGVTDFV-TSEVRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTAR--KVLIYEH-----LE 520
            ||:..|.|. .|.:....||||||::||:|:|...:..|||..|.|..|  |.||...     :.
Mouse  1808 DGSNRTAFAPLSLLGSSLGLALDWVSRNIYYTTPASRSIEVLTLRGDTRYGKTLITNDGTPLGVG 1872

  Fly   521 EPRAIAVAPSLGWMFWSDWNERK---PKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWC 582
            .|..|||.|:.|.::|||.....   .|:..|::||:...:|.:.|:.....:.|||:.:.:||.
Mouse  1873 FPVGIAVDPARGKLYWSDHGTDSGVPAKIASANMDGTSLKILFTGNMEHLEVVTLDIQEQKLYWA 1937

  Fly   583 DGKTDKIEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQ 647
            ......||..|:||: .|:::..:|.|.:||.:...:||::|.|...|:|..|.:|:|::|..|.
Mouse  1938 VTSRGVIERGNVDGT-ERMILVHHLAHPWGLVVHGSFLYYSDEQYEVIERVDKSSGSNKVVFRDN 2001

  Fly   648 YPDLMGLKVTRLREVR-GQNACAVRNGGCSHLCLNRPRD-YVCRCAIDYELANDKRTCVVPAAFL 710
            .|.|.||:|...|... ..|.|:.....|..:||..|.. :.|.||..::|:.|.|:|....:|:
Mouse  2002 IPYLRGLRVYHHRNAADSSNGCSNNPNACQQICLPVPGGMFSCACASGFKLSPDGRSCSPYNSFI 2066

  Fly   711 LFSRQEHIGRISIEYNEGNHNDERIPFK-DVRDAHALDVSVAERRIYWTD-----QKSKCIFRAF 769
            :.|....:...|:|.::  |::..:|.. ..|:....||.||...|||.|     :.|..|.|..
Mouse  2067 VVSMLPAVRGFSLELSD--HSEAMVPVAGQGRNVLHADVDVANGFIYWCDFSSSVRSSNGIRRIK 2129

  Fly   770 LNGSYVQRIVDSGLIGPDGI---AVDWLANNIYWSDAEARR--IEVARLDGSSRRVLLWKGVEEP 829
            .|||....||..| ||.:||   ||||:|.|:|:::|....  |||.|::.:.|||||...|:.|
Mouse  2130 PNGSNFTNIVTYG-IGANGIRGVAVDWVAGNLYFTNAFVYETLIEVIRINTTYRRVLLKVSVDMP 2193

  Fly   830 RSLVLEPRRGYMYWTE-SPTDSIRRAAMDGSDLQTIVA-GANHAAGLTFDQETRRLYWATQSRP- 891
            |.:|::|:..|::|.: .....|.|:.:|.::...:|: |.....||..|.:|..:||...|..
Mouse  2194 RHIVVDPKHRYLFWADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAVDHDTGYIYWVDDSLDI 2258

  Fly   892 -AKIESADWDGKKRQIL-VGSDMDEPYAVSLYQDYVYWSDWNTGDIERVHKTTGQN--RSLVHSG 952
             |:|..   ||.:.|:: .||....||.::::.:.:.|.|.|...:.:..|..|..  .:::...
Mouse  2259 IARIHR---DGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLRKVFQASKQPGNTDPPTVIRDS 2320

  Fly   953 MTYITSLLVFNDKRQ------TGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCI 1011
            :..:..:.:|::..|      ...|||..:||||||.|.|.|......|.| ....|..||.:|.
Mouse  2321 INLLRDVTIFDEHVQPLSPAELNNNPCLQSNGGCSHFCFALPELPTPKCGC-AFGTLEDDGKNCA 2384

  Fly  1012 PPR-NYIIFSQRNCFGRLL--PNTTDCPNIPLPVSGKNIRAVDYDPITHHIYW------IEGRSH 1067
            ..| :::|:|..|....|.  |...:.|...:.|.|..| |:|||...:.|::      |.|:..
Mouse  2385 TSREDFLIYSLNNSLRSLHFDPQDHNLPFQAISVEGMAI-ALDYDRRNNRIFFTQKLNPIRGQIS 2448

  Fly  1068 SIKRSLANGTKVSLLANSGQPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPR 1132
            .:.......:...||:|.|....:|.|.|.|.::::...:.:||..:..|.:..||  ....|||
Mouse  2449 YVNLYSGASSPTILLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGSNRAVI--ARVSKPR 2511

  Fly  1133 NIAVHAMKRLLFWTDVGSHQAIIRARVDGNERVELA-YKLEGVTALALDQQSDMIYYAHG--KRI 1194
            .|.:...:..::|||.|::..|.||.:.||.||.:. ..|.....|.||.::|::|:|..  ::|
Mouse  2512 AIVLDPCRGYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPNGLTLDLETDLLYWADASLQKI 2576

  Fly  1195 DAIDINGKNKKTLVSMHISQVINIAALGGFVYWLDDKTGVERI----TVNGERRSAELQRLP-QI 1254
            :...:.|.|::.::|..... ..:...|.::||.|..|  ::|    ..:|....|...||| |.
Mouse  2577 ERSTLTGSNREVVISTAFHS-FGLTVYGQYIYWTDFYT--KKIYRANKYDGSDLIAMTTRLPTQP 2638

  Fly  1255 TDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCP-----------KHLML-- 1306
            :.|..|.....:...| .|......|||||.....|..     |.||           |:.::
Mouse  2639 SGISTVVKTQQQQCSN-PCDQFNGGCSHICAPGPNGAE-----CQCPHEGSWYLANDNKYCVVDT 2697

  Fly  1307 ----------------------LEDKENCG----------AFPACGPDHFTCAAPVSGISDVNKD 1339
                                  .::..:||          ||..|....||||         |..
Mouse  2698 GARCNQFQFTCLNGRCISQDWKCDNDNDCGDGSDELPTVCAFHTCRSTAFTCA---------NGR 2753

  Fly  1340 CIPASWRCDGQKDCPDKSDEVGC--PTCRA-DQFSCQSGECIDKSLVCDGTTNCANG--HDEADC 1399
            |:|..:|||...||.|.|||.||  .:|.: .:|:|.:|.||..|.||:|..||.:.  .||.:|
Mouse  2754 CVPYHYRCDFYNDCGDNSDEAGCLFRSCNSTTEFTCSNGRCIPLSYVCNGINNCHDNDTSDEKNC 2818

  Fly  1400 ----CKRPGEFQCPINKLCISAALLCDGWENCADGADESSDIC 1438
                | :|...:|....:|:..|.||||..:|.||:||:...|
Mouse  2819 PPITC-QPDFAKCQTTNICVPRAFLCDGDNDCGDGSDENPIYC 2860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531	15/38 (39%)
		NHL	168..503	CDD:302697	127/350 (36%)
		NHL repeat	172..237	CDD:271320	24/66 (36%)
		LY	252..293	CDD:214531	15/40 (38%)
		NHL repeat	261..298	CDD:271320	14/36 (39%)
		NHL repeat	303..339	CDD:271320	11/38 (29%)
		NHL repeat	341..419	CDD:271320	34/80 (43%)
		NHL repeat	428..476	CDD:271320	13/48 (27%)
		LY	472..511	CDD:214531	16/39 (41%)
		NHL repeat	477..503	CDD:271320	11/25 (44%)
		Ldl_recept_b	534..573	CDD:278487	9/41 (22%)
		LY	558..599	CDD:214531	12/40 (30%)
		LY	600..641	CDD:214531	13/40 (33%)
		FXa_inhibition	668..703	CDD:291342	11/35 (31%)
		LY	739..773	CDD:214531	13/38 (34%)
		LY	776..818	CDD:214531	19/46 (41%)
		LY	819..860	CDD:214531	14/41 (34%)
		FXa_inhibition	973..1010	CDD:291342	15/36 (42%)
		LY	1122..1164	CDD:214531	15/41 (37%)
		FXa_inhibition	1273..1313	CDD:291342	11/74 (15%)
		LDLa	1319..1362	CDD:238060	17/42 (40%)
		LDLa	1365..1399	CDD:238060	14/36 (39%)
		LDLa	1399..1433	CDD:197566	13/37 (35%)
Lrp2	NP_001074557.1	LDLa	28..62	CDD:238060
		LDLa	67..99	CDD:197566
		LDLa	108..142	CDD:238060
		LDLa	148..179	CDD:238060
		LDLa	183..217	CDD:238060
		LDLa	222..256	CDD:238060
		LDLa	265..299	CDD:238060
		LDL-receptor class B 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	435..477
		LY	460..500	CDD:214531
		LDL-receptor class B 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	478..520
		LY	502..547	CDD:214531
		LDL-receptor class B 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	521..567
		LY	550..590	CDD:214531
		LDL-receptor class B 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	568..612
		FXa_inhibition	662..703	CDD:291342
		LDL-receptor class B 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	752..794
		LY	775..817	CDD:214531
		LDL-receptor class B 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	795..836
		LDL-receptor class B 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	837..880
		Ldl_recept_b	837..877	CDD:278487
		LY	863..903	CDD:214531
		LDL-receptor class B 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	881..924
		FXa_inhibition	980..1012	CDD:291342
		LDLa	1025..1059	CDD:238060
		Ldl_recept_a	1065..1101	CDD:278486
		LDLa	1110..1144	CDD:238060
		LDLa	1150..1184	CDD:238060
		LDLa	1188..1223	CDD:238060
		LDLa	1231..1263	CDD:197566
		LDLa	1272..1306	CDD:238060
		LDLa	1313..1345	CDD:197566
		FXa_inhibition	1354..1389	CDD:291342
		EGF_CA	1391..1430	CDD:214542
		LDL-receptor class B 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1479..1521		15/49 (31%)
		LY	1502..1544	CDD:214531	17/41 (41%)
		LDL-receptor class B 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1522..1564		16/41 (39%)
		LY	1546..1590	CDD:214531	19/45 (42%)
		LDL-receptor class B 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1567..1610		21/44 (48%)
		LY	1592..1633	CDD:214531	15/40 (38%)
		LDL-receptor class B 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1611..1655		13/43 (30%)
		LDL-receptor class B 13. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1656..1696		9/41 (22%)
		LDL-receptor class B 14. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1791..1833		16/42 (38%)
		LDL-receptor class B 15. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1834..1883		18/48 (38%)
		LDL-receptor class B 16. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1884..1931		13/46 (28%)
		Ldl_recept_b	1884..1928	CDD:278487	10/43 (23%)
		LY	1912..1954	CDD:214531	12/42 (29%)
		LDL-receptor class B 17. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1932..1973		12/41 (29%)
		LDL-receptor class B 18. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1974..2014		16/39 (41%)
		FXa_inhibition	2023..2059	CDD:291342	11/35 (31%)
		LDL-receptor class B 19. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2108..2157		21/49 (43%)
		LDL-receptor class B 20. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2158..2202		17/43 (40%)
		LY	2183..2226	CDD:214531	14/42 (33%)
		LDL-receptor class B 21. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2203..2246		10/42 (24%)
		LY	2228..2268	CDD:214531	13/42 (31%)
		LDL-receptor class B 22. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2247..2290		12/45 (27%)
		LDL-receptor class B 23. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2291..2333		6/41 (15%)
		FXa_inhibition	2347..2383	CDD:291342	15/36 (42%)
		LDL-receptor class B 24. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2432..2478		9/45 (20%)
		LY	2460..2501	CDD:214531	11/40 (28%)
		LDL-receptor class B 25. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2479..2519		10/41 (24%)
		LY	2503..2543	CDD:214531	15/41 (37%)
		LDL-receptor class B 26. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2520..2563		15/42 (36%)
		LDL-receptor class B 27. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2564..2605		8/41 (20%)
		LDL-receptor class B 28. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2606..2647		13/42 (31%)
FXa_inhibition	2656..2693	CDD:291342	11/41 (27%)
LDLa	2700..2732	CDD:197566	2/31 (6%)
LDLa	2742..2776	CDD:238060	17/42 (40%)
LDLa	2783..2818	CDD:238060	13/34 (38%)
LDLa	2822..2855	CDD:197566	12/33 (36%)
LDLa	2865..2899	CDD:238060
LDLa	2908..2939	CDD:197566
LDLa	2950..2986	CDD:197566
LDLa	2995..3029	CDD:238060
LDLa	3034..3066	CDD:238060
LDLa	3077..3111	CDD:238060
cEGF	3134..3157	CDD:289433
vWFA	<3149..3192	CDD:294047
LY	3221..3262	CDD:214531
LDL-receptor class B 29. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3241..3283
LY	3264..3306	CDD:214531
Ldl_recept_b	3284..3331	CDD:278487
LDL-receptor class B 30. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3284..3326
LDL-receptor class B 31. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3335..3378
Ldl_recept_b	3335..3375	CDD:278487
LY	3360..3401	CDD:214531
LDL-receptor class B 32. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3379..3421
LY	3406..3443	CDD:214531
LDL-receptor class B 33. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3422..3462
FXa_inhibition	3471..>3500	CDD:291342
LDLa	3514..3548	CDD:238060
LDLa	3555..3586	CDD:197566
LDLa	3595..3627	CDD:197566
LDLa	3636..3668	CDD:197566
LDLa	3684..3716	CDD:238060
LDLa	3723..3756	CDD:238060
LDLa	3761..3795	CDD:238060
LDLa	3800..3834	CDD:238060
LDLa	3844..3876	CDD:238060
LDLa	3887..3917	CDD:197566
LDLa	3930..3964	CDD:238060
EGF_CA	4009..4049	CDD:214542
LY	4143..4178	CDD:214531
LDL-receptor class B 34. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4156..4198
LDL-receptor class B 35. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4199..4242
Ldl_recept_b	4199..4239	CDD:278487
LY	4224..4266	CDD:214531
LDL-receptor class B 36. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4244..4285
SH3-binding. /evidence=ECO:0000255	4454..4463
PxLPxI/L motif 1, mediates interaction with ANKRA2. /evidence=ECO:0000250\|UniProtKB:P98158	4457..4462
PxLPxI/L motif 2, mediates interaction with ANKRA2. /evidence=ECO:0000250\|UniProtKB:P98158	4460..4465
Endocytosis signal. /evidence=ECO:0000255	4522..4527
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4558..4660
Interaction with DAB2. /evidence=ECO:0000250\|UniProtKB:P98164	4597..4610
NPXY motif	4603..4606
SH2-binding. /evidence=ECO:0000255	4606..4609
SH3-binding. /evidence=ECO:0000255	4619..4630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845799
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100345
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.640