DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and LDLRAD3

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_777562.1 Gene:LDLRAD3 / 143458 HGNCID:27046 Length:345 Species:Homo sapiens


Alignment Length:360 Identity:101/360 - (28%)
Similarity:145/360 - (40%) Gaps:76/360 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  1321 PDHFTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGCP----TCRADQFSCQSG-ECIDK 1380
            |.:|.|:         |..|||.:|:|||..||.|||||..||    .|....|.|.|| .||..
Human    32 PGNFMCS---------NGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIG 87

  Fly  1381 SLVCDGTTNCANGHDEADCCKRP-----GEFQCPINKLCISAALLCDGWENCADGADESSDICLQ 1440
            ...|:|..:|.:|.||.:|...|     ..:.|. |.|||..:.:|||..||.|.:||.|  | :
Human    88 RFRCNGFEDCPDGSDEENCTANPLLCSTARYHCK-NGLCIDKSFICDGQNNCQDNSDEES--C-E 148

  Fly  1441 RRMAP------ATDKRAFMILIGATMITI-FSIVYLLQFCRTRIGKSRTEPKDDQATDPL----S 1494
            ....|      .|.:...:.....|...| .|::::|......:.......:::..|.|:    .
Human   149 SSQEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQH 213

  Fly  1495 PSTLSKSQRVSKIASVADAVRMSTLNSRNSMN-SYD-RNHITGASSSTTNGSSMVAYPINPPPSP 1557
            |..||               |:..|:..:..| :|: .|.|...:|.....:|.|..|  |..|.
Human   214 PVLLS---------------RLVVLDHPHHCNVTYNVNNGIQYVASQAEQNASEVGSP--PSYSE 261

  Fly  1558 ATRSRRPYRHYKIINQPPPPTPCSTDICDESD-SNYTSKSNSNNSNGGATKHSSSSAAACLQYGY 1621
            |...:||..:    :.||||....|:..:::| ..|.|:|.|.||       :||.||:.|....
Human   262 ALLDQRPAWY----DLPPPPYSSDTESLNQADLPPYRSRSGSANS-------ASSQAASSLLSVE 315

  Fly  1622 DSEPYPPPPTPRSHYHSDVRIVPESSCPPSPSSRS 1656
            |:...|..|.|:           |.:..|..|..|
Human   316 DTSHSPGQPGPQ-----------EGTAEPRDSEPS 339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531
NHL 168..503 CDD:302697
NHL repeat 172..237 CDD:271320
LY 252..293 CDD:214531
NHL repeat 261..298 CDD:271320
NHL repeat 303..339 CDD:271320
NHL repeat 341..419 CDD:271320
NHL repeat 428..476 CDD:271320
LY 472..511 CDD:214531
NHL repeat 477..503 CDD:271320
Ldl_recept_b 534..573 CDD:278487
LY 558..599 CDD:214531
LY 600..641 CDD:214531
FXa_inhibition 668..703 CDD:291342
LY 739..773 CDD:214531
LY 776..818 CDD:214531
LY 819..860 CDD:214531
FXa_inhibition 973..1010 CDD:291342
LY 1122..1164 CDD:214531
FXa_inhibition 1273..1313 CDD:291342
LDLa 1319..1362 CDD:238060 18/40 (45%)
LDLa 1365..1399 CDD:238060 13/34 (38%)
LDLa 1399..1433 CDD:197566 13/38 (34%)
LDLRAD3NP_777562.1 LDLa 32..64 CDD:238060 18/40 (45%)
LDLa 71..106 CDD:238060 13/34 (38%)
LDLa 113..147 CDD:238060 14/36 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 270..345 25/92 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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