Protein Alignment arr and LRP1

DIOPT Version :10

• Sequence 1: NP_524737.2
• Gene: arr / 44279
• FlyBaseID: FBgn0000119
• Length: 1678
• Species: Drosophila melanogaster
• Sequence 2: XP_320185.5
• Gene: LRP1 / 1280340
• VectorBaseID: AGAMI1_005394
• Length: 4869
• Species: Anopheles gambiae
• Alignment Length: 1645
• Identity: 437/1645 - (26%)
• Similarity: 701/1645 - (42%)
• Gaps: 327/1645 - (19%)

  Fly    89 LLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLV--CWTDSGREIIECAQTNSS 151
            ::|:.|.:|...::.  |.|  :......|...:|:||.|....|  .|:|...:.|......:.
Mosquito  1421 VIFSNRQEILGVDLN--TLG--VRSFYTSLRNTIALDFLYRNESVQIFWSDVMDDKIYRGTLRND 1481

  Fly   152 ALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPR 216
            .|..:     :.|:.:||...||||:||....|||.|...::||||..:|.:::.|...|:..||
Mosquito  1482 TLSNV-----EAVVQSGLSTAEGLAVDWIGMNIYWIDSNLDQIEVAKTNGSFRRTLVAGDMVNPR 1541

  Fly   217 AVAVVPARKLLIWTDWGE-YPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKH 280
            |:|:.|...:|.||||.| .|::||.:|.|:..:.:..|.....||||:|:|.....:||.|.:.
Mosquito  1542 AIALDPMEGVLFWTDWEEGSPRLERCTMAGENRTVIKYVGSDGGWPNGIALDYIPRRVYWIDARS 1606

  Fly   281 HFIDVMRLDGSSRRTIVNN---LKYPFSLTFYDDRLYWTDWQRGSL------NALDLQTRELKEL 336
            ..|..:..||.....::.:   |.:|||:|.:|:.:|||||:..|:      |..|:..     :
Mosquito  1607 DSIHTITYDGQDHHLVIKDQGVLAHPFSITVFDNYVYWTDWRTYSVIRANKWNGTDVNV-----I 1666

  Fly   337 IDTPKAPNSVRAWDPSLQP-YEDNPCAHNNGNCSHLCLLATNSQGFSCACPTGVKLISANTCANG 400
            ..|...|..::....|.|| .:.||||.|||.|||||||:..|: ..||||..::|.........
Mosquito  1667 QKTQSQPFGIQILHSSRQPNTQPNPCADNNGGCSHLCLLSVGSR-HECACPHVMRLHEDRRQCVP 1730

  Fly   401 SQEMMFIVQRTQISKISLDSP-DYTIFPLP-LGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHA 463
            ::|::..|..|:|..:.|..| .|||..:. ..:|.....:|||.....:||:|::...||.:..
Mosquito  1731 NEEILLFVVLTEIRGVDLQQPAHYTIPTISHQTQVVQPAVLDYDISAARLYWNDIQLNEIKSSGL 1795

  Fly   464 DGTGVTDFVTSEVRHPDGLALDWLARNLYWT--DTVTDRIEVCRLDGTARKVLIYEHLEEPRAIA 526
            ....:...:.:::.:..|.|:||:::.||::  :....||.|..|:|.. ...|.:.|....::.
Mosquito  1796 ATGPIETILDTDISNSLGFAVDWISKLLYFSTGNETHSRIMVSNLNGEF-VTEIADGLSVVNSLV 1859

  Fly   527 VAPSLGWMFWSDWNERKPKVER---ASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDK 588
            |.|:.|.|:::..:| .||:..   :.:|||||.::.:......:.:|||.|...:|:......:
Mosquito  1860 VYPTRGMMYFATMSE-VPKLYELYASRMDGSERQLISNSTFHPIDSLALDFETNRLYYISSNAGE 1923

  Fly   589 IEVANMDGSGRRVVI----SDNLKH-LFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQY 648
            |...:: |||:.:.:    .||  | :..::|..|.:|:.|.....|.|.:|....|.:.|.:..
Mosquito  1924 INYYDI-GSGKIIQVLAPHEDN--HPISTITIYRDSIYYDDNHDGRIMRCNKNLCQNPVSVRNNT 1985

  Fly   649 PDLMGLKVTRLREVRGQNACAVRNG-----GCSHLCLN-RPRDYVCRCAIDYELANDKRT---CV 704
            ..|..:::.......|.|:|..||.     ||.|||:. ..:.:||||||.|.  :|.|.   |:
Mosquito  1986 SGLNAIRMYHPGAQSGTNSCQKRNDKSAGTGCEHLCIPVSAQSHVCRCAIGYR--SDPRNPWRCI 2048

  Fly   705 VPAAFLLFSRQEHIGRISIEYNEGN----HNDERI-PFKDVRDAHALDVSVAERRIYWTDQKSKC 764
            .....|::|....:..|::..::.:    .|.|.: |.:.:..|.::|..||...:|..|.....
Mosquito  2049 GLDDILVYSVGHQLKGIALSSSDESTGSLRNRESLGPLQQISLATSIDFDVAHDYVYIADTDRGS 2113

  Fly   765 IFRAFLNG-------SYVQRIVD-SGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVL 821
            |.|...:|       |..:::|| |.|....|||:||:|.||||:|.:...||||||:|:.|.|:
Mosquito  2114 ITRIKRDGSAREVIISNFEQVVDGSTLDWLGGIAIDWVAENIYWTDQKRNLIEVARLNGTLRYVV 2178

  Fly   822 LWKGVEEPRSLVLEPRRGYMYWTESPTDSIRRAAMDGSDLQTIVAGANHAAGLTFDQETRRLYWA 886
            . ..||.|:.|.::|.:||:::....|  |.|..:|||....:|..::..:.|..|.:.:.:||.
Mosquito  2179 A-SDVESPQLLAIDPIQGYLFYVTRGT--IGRMGLDGSGNFILVNRSSAISDLALDLDNQVVYWC 2240

  Fly   887 TQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSDWNTGDIERVHKTTGQN-RSLVH 950
            ..|... |...|:||..:::|:......|.::.|:.|.:||:| :.|:|.....:...| ||:|.
Mosquito  2241 ETSTDT-IWKVDYDGNLKRLLLNGTSHNPKSLDLFGDSIYWAD-SRGNIYEAGLSNIFNYRSVVE 2303

  Fly   951 S-GMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCL---AQPGRRGMTCACPTHYQLAK-DGVSC 1010
            : .::.:..:.||:.::|:..|.|.|:||||..|||   ..|     .||| :|.:::. |..:|
Mosquito  2304 ALEVSSLKDIKVFSSRKQSKTNACGVSNGGCQELCLFNGTHP-----ICAC-SHGKISSADLKTC 2362

  Fly  1011 IPPRNYIIFSQRNCFGRLLPNTTDCPNIPLPVSG-------KNIRAVDYDPITHHIYWIEGRSHS 1068
            .|..|::|||:::....:  :.||..||..|:..       ||..|:.||.....|::.:....:
Mosquito  2363 EPYENFLIFSRQSAIESI--HMTDANNINGPIPEIKNSSYLKNTIALSYDYEQQLIFYSDIDHST 2425

  Fly  1069 IKRSLANGTKVSLLANSGQPFD-LAIDIIGRLLFWTCS-----QSNSINVTSFLGESVG------ 1121
            |.....|||....:.......: ||.:::.|:||||.:     :|..:|..|....:..
Mosquito  2426 INCVFFNGTNHRRIVTKQLTVEGLAFNVLTRVLFWTSNNEAAIRSLDLNKASLTDPAANAELVQD 2490

  Fly  1122 VIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQAII-RARVDGNERVELAYKLEGV--------TAL 1177
            ||....::|||.|||.....:::||:...|.|.| ||...|       |.||.:        .||
Mosquito  2491 VIKLRATDKPRGIAVEPCLAMVYWTNWNQHAASIQRAYPSG-------YGLESIITSDIQMPNAL 2548

  Fly  1178 ALDQQSDMIYYAHG--KRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLDDKTGVERITVN 1240
            .||.|:..:|:|..  .:::..|.:||::..|..........:|..|..::|.|       :||:
Mosquito  2549 TLDYQARKLYWADALLDKVERTDYDGKHRVVLAHSTPKHPFALAVFGDLLFWTD-------LTVH 2606

  Fly  1241 GERRSAE--------LQR-LPQITDIRAVWTPD-------------------------------- 1264
            ...|:.:        |:| :.|...|.||...|
Mosquito  2607 AVIRANKYSGSDIVLLRRDIAQPMGIVAVQQIDKECSADPCQVMNGFCEDVCLIDAAGKVECHCT 2671

  Fly  1265 ------------PKVL------------------------------------------------- 1268
                        ||.:
Mosquito  2672 QGVLAADGQRCIPKSVSNCSSSEFSCTNGNCIPFHLTCDGVKNCLDGSDELVTFCAHRPCPDGFF 2736

  Fly  1269 --RNHTCMHSRTKCSHI-------------C-------IASGEGIART------------RDVCS 1299
              .|..|:....:|:||             |       ...|:.|.::            .|...
Mosquito  2737 RCNNARCIPKNQQCNHIQNCGDGSDEVGCSCNNATHFRCTDGQCIVKSMRCDYEPDCKDVSDEIG 2801

  Fly  1300 CPKHLMLLEDKENCG-----------------------------AFPACGPDHFTCAAPVSGISD 1335
            ||......|...||.                             |.|.|..|.|.||
Mosquito  2802 CPVMRNCTEGFVNCANTTGCYMPTWRCDGENDCWDNSDEQDCPTAIPTCPEDKFLCA-------- 2858

  Fly  1336 VNKDCIPASWRCDGQKDCPD------KSDEVGC-PTCRADQFSC-QSGECIDKSLVCDGTTNCAN 1392
             |..|||.|||||.:.||.|      .|||:.| ..|:.:||.| .:.|||..|..|||..:||:
Mosquito  2859 -NGRCIPQSWRCDDEDDCTDATGGGLSSDELACVKHCKPNQFKCTNTSECISNSWQCDGHPDCAD 2922

  Fly  1393 GHDEADCCKR----PGEFQCPINKLCISAALLCDGWENCADGADESSDICLQRRMAPATDKRAFM 1453
            |.||.|.|.|    ..|||||....||....:|||..:|  ||.:..::.....|....||.:|.
Mosquito  2923 GSDEGDHCSRRDCPETEFQCPTTNRCIPQKWVCDGEVDC--GATQDDEMGCDEMMVNECDKTSFT 2985

  Fly  1454 ILIGATMITIFSIVYLLQFC 1473
            ...|       ..:.||..|
Mosquito  2986 CKNG-------ECISLLHVC 2998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531	17/38 (45%)
		NHL	168..503	CDD:302697	113/349 (32%)
		NHL repeat	172..237	CDD:271320	28/65 (43%)
		LY	252..293	CDD:214531	13/40 (33%)
		NHL repeat	261..298	CDD:271320	11/36 (31%)
		NHL repeat	303..339	CDD:271320	13/41 (32%)
		NHL repeat	341..419	CDD:271320	28/78 (36%)
		NHL repeat	428..476	CDD:271320	9/48 (19%)
		LY	472..511	CDD:214531	11/40 (28%)
		NHL repeat	477..503	CDD:271320	8/27 (30%)
		Ldl_recept_b	534..574	CDD:459654	11/42 (26%)
		LY	558..599	CDD:214531	8/40 (20%)
		LY	600..641	CDD:214531	10/45 (22%)
		FXa_inhibition	668..703	CDD:464251	17/43 (40%)
		YncE	<736..886	CDD:442618	52/157 (33%)
		LY	776..818	CDD:214531	22/42 (52%)
		LY	905..946	CDD:214531	10/41 (24%)
		FXa_inhibition	973..1010	CDD:464251	15/40 (38%)
		YncE	<1047..1191	CDD:442618	44/164 (27%)
		LDLa	1319..1362	CDD:238060	20/48 (42%)
		LDLa	1365..1399	CDD:238060	16/34 (47%)
		LDLa	1399..1433	CDD:197566	15/37 (41%)
LRP1	XP_320185.5	None