DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment arr and ldlr

DIOPT Version :9

Sequence 1:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	XP_002942891.1	Gene:	ldlr / 100495826	XenbaseID:	XB-GENE-962372	Length:	894	Species:	Xenopus tropicalis

Alignment Length:	436	Identity:	137/436 - (31%)
Similarity:	216/436 - (49%)	Gaps:	77/436 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 ELIDTPKAPN---SVRAW-DPSLQPYEDNPCAHNNGNCSHLCLLATNSQ--GFSCACPTGVKLI- 392
            |.|...|..|   ..|.| |..::...:|.|..|||.|:|:|    |..  |:.|.|..|.:|:
Frog   288 ECITMDKVCNKKRDCRDWSDEPIKECGENECMRNNGGCAHIC----NDLKIGYECLCNEGYRLVD 348

  Fly   393 -----------SANTCAN-----------------------------GSQEMMFIVQRTQISKIS 417
                       :.|||:.                             |:...:|...|.::.|::
Frog   349 KKRCEDINECENPNTCSQICINLDGGYKCECREGYQMDPVTASCKSIGTVAYLFFTNRHEVRKMT 413

  Fly   418 LDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDV---ETYTIKRAHADGTGVTD-FVTSEVRH 478
            ||..:||.|   :.::|..:|:|.:.....|||||:   :.|:.....||.|...: .::|:::.
Frog   414 LDRSEYTSF---IPRLKNVVALDMEIASNKIYWSDLTQRKIYSASMDKADNTSHHETVISSQIQA 475

  Fly   479 PDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERK 543
            |||:|:||:..|:||||:....|.|...:|:.||.|..:.|.:||.|.|.||.|:|:|:||. ..
Frog   476 PDGIAVDWIHGNIYWTDSKFSTISVANTEGSKRKTLFSDDLAKPRDIVVDPSQGFMYWTDWG-LP 539

  Fly   544 PKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISD--N 606
            .|:|:..|:|.:|..||:||:.|||||.||:..:.:||.|.|...:...::.|..|..||||  :
Frog   540 AKIEKGGLNGVDRYPLVTENIEWPNGITLDLTNQRLYWVDSKLHSLSCIDVTGQNRITVISDETH 604

  Fly   607 LKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMG----LKVTRLREVRGQNA 667
            |.|.|||::.:|.::|||.:..:|..|:::||:|...|.:   ||:.    :....||:.:.:|.
Frog   605 LAHPFGLTVFEDLVFWTDIENEAIFSANRLTGSNITKVAE---DLLSPEDIVLYHNLRQPKAENW 666

  Fly   668 CA---VRNGGCSHLCL------NRPRDYVCRCAIDYELANDKRTCV 704
            |.   :.||||.:|||      :|...:.|.|.....|..|.|:||
Frog   667 CESHHLGNGGCEYLCLPAPLITSRSPKFTCACPDGMHLGADMRSCV 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531
		NHL	168..503	CDD:302697	58/218 (27%)
		NHL repeat	172..237	CDD:271320
		LY	252..293	CDD:214531
		NHL repeat	261..298	CDD:271320
		NHL repeat	303..339	CDD:271320	2/3 (67%)
		NHL repeat	341..419	CDD:271320	26/124 (21%)
		NHL repeat	428..476	CDD:271320	13/51 (25%)
		LY	472..511	CDD:214531	15/38 (39%)
		NHL repeat	477..503	CDD:271320	12/25 (48%)
		Ldl_recept_b	534..573	CDD:278487	18/38 (47%)
		LY	558..599	CDD:214531	16/40 (40%)
		LY	600..641	CDD:214531	17/42 (40%)
		FXa_inhibition	668..703	CDD:291342	14/43 (33%)
		LY	739..773	CDD:214531
		LY	776..818	CDD:214531
		LY	819..860	CDD:214531
		FXa_inhibition	973..1010	CDD:291342
		LY	1122..1164	CDD:214531
		FXa_inhibition	1273..1313	CDD:291342
		LDLa	1319..1362	CDD:238060
		LDLa	1365..1399	CDD:238060
		LDLa	1399..1433	CDD:197566
ldlr	XP_002942891.1	Ldl_recept_a	27..60	CDD:365841
		Ldl_recept_a	68..106	CDD:365841
		LDLa	111..145	CDD:238060
		Ldl_recept_a	149..185	CDD:365841
		Ldl_recept_a	195..231	CDD:365841
		Ldl_recept_a	235..270	CDD:365841
		LDLa	278..308	CDD:381805	6/19 (32%)
		FXa_inhibition	318..352	CDD:373209	13/37 (35%)
		EGF_CA	354..384	CDD:214542	3/29 (10%)
		LY	419..457	CDD:214531	12/40 (30%)
		Ldl_recept_b	439..482	CDD:278487	14/42 (33%)
		Ldl_recept_b	486..525	CDD:278487	15/38 (39%)
		Ldl_recept_b	529..569	CDD:278487	19/40 (48%)
		LY	555..595	CDD:214531	16/39 (41%)
		Ldl_recept_b	616..655	CDD:278487	12/41 (29%)
		FXa_inhibition	674..711	CDD:373209	13/36 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910