DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and lrp5

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:XP_002941689.1 Gene:lrp5 / 100491803 XenbaseID:XB-GENE-485117 Length:1603 Species:Xenopus tropicalis


Alignment Length:1682 Identity:718/1682 - (42%)
Similarity:1002/1682 - (59%) Gaps:144/1682 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 LLICFGISNSWQYKNVHMPSSSSLIASPPASAFVNTPATLLFTTRHDIQVANITRPTGGPQID-- 112
            ||.|:.:::||              .||          .|||..|.|:::.:    .||.:::  
 Frog     9 LLFCYCLASSW--------------GSP----------LLLFANRRDVRLVD----AGGTKLESV 45

  Fly   113 VIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSALQPLLRAPKQTVISTGLDKPEGLAM 177
            |:|..|.:|.|:||.|::.::.|||...|.|:....|.|       :..|||:.:||..|:|||.
 Frog    46 VVVSGLEDAAAVDFLYSQGVIYWTDVSEESIKQTLYNQS-------SNLQTVVISGLVSPDGLAC 103

  Fly   178 DWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAVAVVPARKLLIWTDWGEYPKIERAS 242
            ||...|:||||.|.|||||..|:|.|:|||||.|||||||:|:.||...:.|||||:.|:||||.
 Frog   104 DWIGKKLYWTDSETNRIEVGNLNGTYRKVLFWQDLDQPRAIALDPAHGYMYWTDWGDTPRIERAG 168

  Fly   243 MDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHHFIDVMRLDGSSRRTIV-NNLKYPFSL 306
            |||.  .|..:|...::|||||.:||..:.:||.|.|..||....||||.|:.:| .:|.:||:|
 Frog   169 MDGS--MRKVIVDTDIYWPNGLTIDLDEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFAL 231

  Fly   307 TFYDDRLYWTDWQRGSLNALDLQTRE-LKELIDTPKAPNSVRAWDPSLQPYEDNPCAHNNGNCSH 370
            |...|.|||||||..|::|.:.:|.| .:|::.:..:|..::.:....|||...||..:||.|||
 Frog   232 TLAGDTLYWTDWQTRSIHACNKRTGEKRREILSSLYSPMDIQVFSKERQPYFPTPCDESNGGCSH 296

  Fly   371 LCLLATNSQGFSCACPTGVKLI-SANTCANGSQEMMFIVQRTQISKISLDSPDYTIFPLPLGKVK 434
            ||||:.....:||.|||||:|. ...||..|:.:::.:.:||.:.:||||.||:|...|.:..::
 Frog   297 LCLLSPREPFYSCTCPTGVQLTQDGKTCKTGADDVLLLARRTDLRRISLDMPDFTDIVLQIDDIR 361

  Fly   435 YAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSEVRHPDGLALDWLARNLYWTDTVTD 499
            :||||||||||.:|||:|.|...|:||:.||:|....||:||:||||:|:||:|||||||||.||
 Frog   362 HAIAIDYDPVEGYIYWTDDEVKAIRRAYLDGSGAQTLVTTEVQHPDGIAVDWVARNLYWTDTGTD 426

  Fly   500 RIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDGSERVVLVSENL 564
            ||||.||:||:||:||.|:|:|||||.:.|..|:|:|:||.| .||:|.|.||||||:|||:.:|
 Frog   427 RIEVTRLNGTSRKILISENLDEPRAIVLHPLTGYMYWTDWGE-NPKIESAYLDGSERMVLVNSSL 490

  Fly   565 GWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRS 629
            |||||:|||::...:||.|.|||||||.|:|||.|:.::.|.|.|:||.::|.||:|||||||||
 Frog   491 GWPNGLALDLQDGKLYWGDAKTDKIEVINVDGSNRKTLLEDKLPHIFGFTLLGDYIYWTDWQRRS 555

  Fly   630 IDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAVRNGGCSHLCLNRPRDYVCRCAIDY 694
            |:|.||:.. :|.:::||.|||||||...:....|.|.||..||||||||...||...|.|.|..
 Frog   556 IERVHKVRA-SREIIIDQLPDLMGLKAASVSNTFGTNPCADNNGGCSHLCFFSPRGVRCSCPIGL 619

  Fly   695 ELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTD 759
            ||.:|.|||::|.|||:|:.:..|.|||:   |.|:||..||...|::|.|||..|::.|:||||
 Frog   620 ELLSDMRTCIIPEAFLVFTSRATIHRISL---ETNNNDVAIPLTGVKEASALDFDVSDNRLYWTD 681

  Fly   760 QKSKCIFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWK 824
            ...|.|.|||:|||.|:.:::.||..|:|:||||:..|:||||....||||:||||..|:||:||
 Frog   682 ITLKTISRAFMNGSSVEHVIEFGLDYPEGMAVDWMGKNLYWSDTGTNRIEVSRLDGLYRQVLVWK 746

  Fly   825 GVEEPRSLVLEPRRGYMYWTE-SPTDSIRRAAMDGSDLQTIVAGANHAAGLTFDQETRRLYWATQ 888
            .::.||||.|:|.:||||||| .....|.||.|||::...:|.....|..||.|...:|||| |.
 Frog   747 DLDNPRSLALDPAKGYMYWTEWGGKPRIVRAYMDGTNSIILVDKVGRANDLTIDYADQRLYW-TD 810

  Fly   889 SRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSDWNTGDIERVHKTTGQNRSLVHSGM 953
            .....|||::..|.:| :::..|:..|:.::.|.||:||:|||...|||..|..|.||:|:...:
 Frog   811 LDTNMIESSNMLGAER-VIIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKLNGNNRTLIQDHL 874

  Fly   954 TYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCIPPRNYII 1018
            .::..:|||:..||.|:|.|..|||.||.||||.|  :|..|:|.:||.|..:..:|.||.|:::
 Frog   875 DFVMDILVFHSSRQDGLNDCMQNNGHCSQLCLAVP--KGYKCSCSSHYTLDSNNRNCSPPSNFLL 937

  Fly  1019 FSQRNCFGRLLPNTTDCPNIPLPVSG-KNIRAVDYDPITHHIYWIEGRSHSIKRSLANGTKVSLL 1082
            |||:....|:|.:....|:|.||:.| :|::||.|||:...|||::||.:.|||:..:||:..::
 Frog   938 FSQKTAINRMLLDEQQSPDITLPIHGLRNVKAVSYDPLDKLIYWVDGRQNIIKRAKDDGTQPFVV 1002

  Fly  1083 ANS--------GQPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVHAM 1139
            .::        .||.||:|||....|:|||..:|:||.....|||:||:..||.:|||.|||:|.
 Frog  1003 VSTPNQSQTPEKQPHDLSIDIYSHTLYWTCEGTNTINANKLNGESIGVVLRGDHDKPRAIAVNAE 1067

  Fly  1140 KRLLFWTDVGSHQ-AIIRARVDGNER-VELAYKLEGVTALALDQQSDMIYY--AHGKRIDAIDIN 1200
            :..|::|::.... .|.||..||.|| |..:..|....||.:|.:...:::  |..|||::.|::
 Frog  1068 RGYLYFTNMQERSPKIERAAFDGTEREVLFSTGLIRPVALVVDNKLGKLFWVDADLKRIESSDLS 1132

  Fly  1201 GKNKKTLVSMHISQVINIAALGGFVYWLD-DKTGVERI-TVNGERRSAELQRLPQITDIRAVWTP 1263
            |.|:.||...:|.|.:.:..||..:||:| .:..:||: ..||.||:....|:...|.|.||.:.
 Frog  1133 GANRVTLEDSNILQPMGLTILGDHLYWIDKQQQMIERVEKTNGIRRTKIQGRIAHPTGIHAVESV 1197

  Fly  1264 DPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCPKHLMLLEDKENCGAFPACGPDHFTCAA 1328
            |......|.|..:...||||||..|:|..|    ||||.||:||::...||..|.|.|:.||||.
 Frog  1198 DMNEFSAHPCSRNNGGCSHICITKGDGTPR----CSCPVHLVLLQNLLTCGEPPTCSPEQFTCAT 1258

  Fly  1329 PVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGCPTCRADQFSCQSGECIDKSLVCDGTTNCANG 1393
                 .|:  ||||.:|||||..:|.|.|||..||.|.::||.|:.|:|||....|:|..:|.:.
 Frog  1259 -----GDI--DCIPMAWRCDGFSECDDNSDEENCPVCSSNQFQCEKGQCIDARQKCNGEIDCQDK 1316

  Fly  1394 HDEADC---CKRPGEFQCPINKLCISAALLCDGWENCADGADESSDICLQRRMAPATDKR-AFMI 1454
            .||.||   | .|.:|:| .|..||..:..||.:.:|:|.:||.  ||.:    |.::|. :...
 Frog  1317 SDELDCDSIC-LPDQFRC-ANGQCIMMSQQCDTFPDCSDSSDEL--ICDK----PPSEKTPSHSS 1373

  Fly  1455 LIGATMITIFSIVYL--LQF------CRTRIGKSRTEPKDDQATDPLSPSTL--SKSQRVSKIAS 1509
            .||..:..|.|:..:  |.|      |....|.:...|.:..:..|..|...  ::|.:.:....
 Frog  1374 AIGPVIGIILSVFVMGGLYFVCQRVVCHRYTGPNGPFPHEYISGTPHVPLNFITTRSSQPNTYTG 1438

  Fly  1510 VADAV----RMSTLNSRNSMNSYDRNHITGASSSTTNGSSMVAYP--INPPPSPAT--------- 1559
            ::...    .||.:...:....|||||:||||||:::.:....||  :||||||||         
 Frog  1439 ISYGKPMIGSMSIMGGSSGAPLYDRNHVTGASSSSSSSTKATLYPQILNPPPSPATDRSLYNTEV 1503

  Fly  1560 -------RSRRPYRHYKIINQPPPPTPCSTDICDESDSNYTSKSNSNNSNGGATKHSSSSAAACL 1617
                   .:.|.||.|.|....||.||||||:|   ||:||:      |...|.|:       .:
 Frog  1504 FYSSNSPSTTRSYRPYLIRGIAPPTTPCSTDVC---DSDYTT------SRWKANKY-------YM 1552

  Fly  1618 QYGYDSEPYPPPPTPRSHYHSDVRIVPESSCPPSPSSRSSTYFSPLPPPPSPVQSPS 1674
            ....||:||||||||||.|.|     .|.||||||::..| ||...||||||....|
 Frog  1553 DLNSDSDPYPPPPTPRSQYMS-----AEESCPPSPTTERS-YFHLYPPPPSPCTDSS 1603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 23/38 (61%)
NHL 168..503 CDD:302697 170/337 (50%)
NHL repeat 172..237 CDD:271320 40/64 (63%)
LY 252..293 CDD:214531 18/40 (45%)
NHL repeat 261..298 CDD:271320 18/37 (49%)
NHL repeat 303..339 CDD:271320 17/36 (47%)
NHL repeat 341..419 CDD:271320 30/78 (38%)
NHL repeat 428..476 CDD:271320 24/47 (51%)
LY 472..511 CDD:214531 30/38 (79%)
NHL repeat 477..503 CDD:271320 20/25 (80%)
Ldl_recept_b 534..573 CDD:278487 25/38 (66%)
LY 558..599 CDD:214531 26/40 (65%)
LY 600..641 CDD:214531 21/40 (53%)
FXa_inhibition 668..703 CDD:291342 19/34 (56%)
LY 739..773 CDD:214531 17/33 (52%)
LY 776..818 CDD:214531 21/41 (51%)
LY 819..860 CDD:214531 23/41 (56%)
FXa_inhibition 973..1010 CDD:291342 17/36 (47%)
LY 1122..1164 CDD:214531 17/42 (40%)
FXa_inhibition 1273..1313 CDD:291342 18/39 (46%)
LDLa 1319..1362 CDD:238060 21/42 (50%)
LDLa 1365..1399 CDD:238060 13/33 (39%)
LDLa 1399..1433 CDD:197566 12/36 (33%)
lrp5XP_002941689.1 LY 88..130 CDD:214531 24/41 (59%)
LY 131..174 CDD:214531 28/44 (64%)
LY 175..217 CDD:214531 18/41 (44%)
LY 218..252 CDD:214531 16/33 (48%)
FXa_inhibition 287..324 CDD:373209 18/36 (50%)
LY 354..394 CDD:214531 21/39 (54%)
LY 396..438 CDD:214531 30/41 (73%)
LY 439..482 CDD:214531 25/43 (58%)
LY 484..525 CDD:214531 26/40 (65%)
LY 526..559 CDD:214531 18/32 (56%)
FXa_inhibition 593..628 CDD:373209 19/34 (56%)
LY 657..697 CDD:214531 21/39 (54%)
LY 698..740 CDD:214531 21/41 (51%)
LY 741..783 CDD:214531 23/41 (56%)
LY 785..826 CDD:214531 14/41 (34%)
LY 826..867 CDD:214531 16/41 (39%)
FXa_inhibition 894..929 CDD:373209 17/36 (47%)
LY 958..998 CDD:214531 18/39 (46%)
LY 1050..1093 CDD:214531 17/42 (40%)
LY 1094..1136 CDD:214531 11/41 (27%)
FXa_inhibition 1207..1243 CDD:373209 18/39 (46%)
LDLa 1249..1285 CDD:238060 21/42 (50%)
LDLa 1288..1322 CDD:238060 13/33 (39%)
LDLa 1326..1360 CDD:238060 13/37 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 121 1.000 Domainoid score I5631
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1328 1.000 Inparanoid score I149
OMA 1 1.010 - - QHG48457
OrthoDB 1 1.010 - - D121310at2759
OrthoFinder 1 1.000 - - FOG0004181
OrthoInspector 1 1.000 - - otm49363
Panther 1 1.100 - - LDO PTHR46513
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3498
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1010.080

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