DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and sorl1

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:XP_031762503.1 Gene:sorl1 / 100490681 XenbaseID:XB-GENE-995776 Length:2199 Species:Xenopus tropicalis


Alignment Length:1790 Identity:361/1790 - (20%)
Similarity:567/1790 - (31%) Gaps:656/1790 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 FGISNSWQY--KNVHMPSSSSLIASPPASAFV--NTPA--TLLFTTRHDI-----------QV-- 99
            |.|.:.:.:  |.||:..|..   .|....:|  |..|  :..|.|||.|           ||  
 Frog   291 FQIRDKYMFATKTVHLQDSKK---QPSVQLWVSYNRKAMRSAQFVTRHPITEYYIADASEDQVFV 352

  Fly   100 -----ANITR---------------------PTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDS 138
                 .|||.                     ..||...|.:||..:.....|.:..:.:      
 Frog   353 CVSHSNNITNLYISEAEGLRFSLSLENVLYFNPGGAGSDTLVRYFSNEPFADVHRVRGV------ 411

  Fly   139 GREIIECAQTNSSALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVAT----- 198
             |.:......|.|..:..:|    :||:  .||  |...::....:|...|||...|.:.     
 Frog   412 -RGVYIATILNGSFAEENMR----SVIT--FDK--GGTWEFLAAPVYNGYGEKVPCESSRGCSLH 467

  Fly   199 LDGRYQKVLFWTDLDQPRAVAVVP------ARKLLIWTDWGEYPKIERASMDGDPLSRMTLV--- 254
            |..|..::|.:       .:.::|      |..|::.|          .::..|..|:|.:.   
 Frog   468 LAQRLSQLLNF-------QIPIMPILSKESAPGLIVAT----------GTVGTDMASKMNMYVSS 515

  Fly   255 ------KEHVFWPNGLAVDLKNELIYWTDGKHHFIDVMRLDGSSRRTIVNNLKYPFS-----LTF 308
                  :|.:..|:           |:|.|.|..|.|....|..    .|.|||..:     .||
 Frog   516 TAGVRWRESLLGPH-----------YYTWGDHGGILVAIAQGVD----TNQLKYSTNEGETWKTF 565

  Fly   309 -YDDR-------------------LYWTDWQRG------SLNALDLQTRELKELIDTPKAPNSVR 347
             :.|:                   ::.:..:||      .:||.|        ::..|...:..:
 Frog   566 NFSDKAMIVYGLLTEPGEKSTVFTIFGSYTERGHSWIILQINASD--------VLGVPCTDSDYK 622

  Fly   348 AWDPSLQPYEDNPC------------AHN---NG----------NC------------------- 368
            .|.||.:  ..|.|            ||.   ||          ||                   
 Frog   623 LWSPSDE--RGNECLLGRKTVFKRRTAHATCFNGEDFDRPITVSNCSCTREDFECDFGFKLSKDL 685

  Fly   369 -SHLCL----LATNSQGFSCACPTGV--------KLISANTCANG-----------------SQE 403
             |.||:    .|.........||.|.        :.:|.:||:.|                 ..|
 Frog   686 SSELCVPDPEFAGKLYPIPIPCPVGTTYTRTKGYRKVSGDTCSGGDVENRLQGEEVPCPVGEENE 750

  Fly   404 MMFIVQRTQISKISLDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGV 468
            .:....|..|.:..|.|....  .|||..:..|:|:|:|.....:||:||...||:|...:|:..
 Frog   751 FILYAMRNSIYRYDLSSGINE--ELPLKGLHDAVALDFDYQSNCLYWADVTLETIQRLCLNGSSS 813

  Fly   469 TD-FVTSEVRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEH-LEEPRAIAVAPSL 531
            .: .|.:.:...:.||.|.|::.|||.|....:|||...||..|..::... ||.|||:|:.|..
 Frog   814 QEVIVRNGLETIESLAFDPLSQLLYWVDAGMKKIEVASADGDLRLTILNSTVLERPRALALVPKE 878

  Fly   532 GWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDG 596
            |.|||:||.:.:..:.|:.:|||....|:.|.:.|||||.:|  .:.|||.:...|:||..:.:|
 Frog   879 GLMFWTDWGDERHGIYRSEMDGSSVKHLIFEGIKWPNGICVD--EQWIYWTEAYMDRIERIDFNG 941

  Fly   597 SGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLRE 661
            . :|::|.|||.|.:.:::..:.:||.||.:.||.||.|..|.....::.:...:|.:|:....:
 Frog   942 Q-QRMIILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYNGARMEGIIGRLTGVMDMKIFYKDK 1005

  Fly   662 VRGQNACAVRNGGCSHLCLNRPRD-YVCRCAIDYE---LANDKRTCVVPAAFLLFS----RQEHI 718
            ..|.|||.::  .||.|||.:..: .:|||:...:   |::....|..|..:||.:    :||:.
 Frog  1006 ATGHNACVLK--PCSLLCLPKANNSKICRCSEGVKGTPLSSGDIQCDCPQGYLLKNKTCVKQENT 1068

  Fly   719 GRISIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVDSGL 783
             .:..:|...|.|.....::...|....|:| .|:....|....:.:||...:|:.:.......|
 Frog  1069 -CLPSQYRCSNGNCINSIWQCDTDNDCGDMS-DEKNCPTTTCDPEALFRCQGSGACIPLSYKCDL 1131

  Fly   784 IGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTESPT 848
                   .|...:|...|..||.:.:....:.||...:                           
 Frog  1132 -------EDDCGDNSDESHCEAHQCKEDEFNCSSGMCI--------------------------- 1162

  Fly   849 DSIRRAAMDGSDLQTIVAGANHAAGLTFDQETRRLYWATQSRPAKIESADWDGKKRQILVGSDMD 913
                                             ||.|.          .|.|...|.        
 Frog  1163 ---------------------------------RLSWV----------CDGDNDCRD-------- 1176

  Fly   914 EPYAVSLYQDYVYWSDWNTGDIERVHKTTGQNRSLVHSGMTYITSLLVFNDKRQTGVNPCKVNNG 978
                         |||                                            :.|..
 Frog  1177 -------------WSD--------------------------------------------EANCT 1184

  Fly   979 GCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRLLPNTTDCPNIPLPVS 1043
            ..||.|.|            |.:|....  .|| |:.::      |.|     .|||.:      
 Frog  1185 AISHTCEA------------TSFQCHDS--HCI-PQKWV------CDG-----DTDCQD------ 1217

  Fly  1044 GKNIRAVDYDPITHHIYWIEGRSHSIKRSLANGTKVSLLANSGQPFDLAIDIIGRLLFWTCSQSN 1108
                 ..|.|             |||.....||                         :.|...:
 Frog  1218 -----GSDED-------------HSICEKKCNG-------------------------FQCQNGS 1239

  Fly  1109 SINVTSFLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQAIIRARVDGNERVELAYKLEG 1173
            .|       .||...| |.::.|                            ||            
 Frog  1240 CI-------PSVKHCD-GVNDCP----------------------------DG------------ 1256

  Fly  1174 VTALALDQQSDMIYYAHGKRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLDDKTGVERIT 1238
                |.:||.:.:...:      :|...:|::..: .| |.|.:               ||::..
 Frog  1257 ----ADEQQCEPLCTRY------MDFVCRNRQQCL-FH-SMVCD---------------GVKQCR 1294

  Fly  1239 VNGERRSAELQRLPQITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCPKH 1303
             :|.....:.....|..:.:....|...:.:|..|:....||..:     :......|..:|   
 Frog  1295 -DGSDEDPQYAGCSQGPEFQRTCDPHSFLCQNGVCISLVWKCDGM-----DDCGDYSDEANC--- 1350

  Fly  1304 LMLLEDKENCGAFPACGPDH-FTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGC----- 1362
                   ||....|.|...: |.|.         |..|||..|:||.:.||.|.|||..|     
 Frog  1351 -------ENPTDIPTCSRYYQFPCQ---------NGHCIPTRWKCDHENDCGDWSDEKDCGETIP 1399

  Fly  1363 ------PTCRADQFSCQSGECIDKSLVCDGTTNCANGHDEADC-----------------CKRPG 1404
                  .||.::.|.|.:|.||..:.||||..:|.:|.||..|                 |.: .
 Frog  1400 QTTSRPATCPSNHFRCDNGVCILNTWVCDGYKDCIHGSDEEGCPASANKTVVPTILPHGQCSQ-F 1463

  Fly  1405 EFQCPINKLCISAALLCDGWENCADGADE------SSDICLQRRMAPATDKRAFMILIGATMITI 1463
            ||:|...|.||.:...|||..:|.||.||      ...:|:...:....:               
 Frog  1464 EFECKKWKDCIPSWRHCDGNRDCRDGTDELNCPTHKPSLCVNGSLCEDGE--------------- 1513

  Fly  1464 FSIVYLLQFCRTRIGKSRTEPKDDQATDPLSPSTLSKSQRVSKIASVADAVRMSTL--------- 1519
             :.:.||.||...:..|....:::...|.:       .|:|..:...||.....||         
 Frog  1514 -ACIALLDFCDGFLDCSDGSDENNCTDDTI-------VQKVQNLQWTADFTGNITLMWTRPKKMP 1570

  Fly  1520 NSRNSMNSYDRNHITGASS----STTNGSSMVAYPINPPPSPATRS------RRPYRHYKII--- 1571
            .|....|.|.|  |.|.|:    .|.:..::....|..|.:.....      |:.|....||   
 Frog  1571 QSSCVYNIYYR--IVGESTWKSLETHSNKTVYVLKILKPDTTYQAKVQVQCLRKAYNTNDIITLR 1633

  Fly  1572 ---NQPPPPTPCSTDICDESDSN----YTSKSNSN 1599
               ..|.||......|..:...|    :|:.:|::
 Frog  1634 TPEGVPDPPQHLQLSIMKDEFGNIFGSWTAPANAH 1668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 11/43 (26%)
NHL 168..503 CDD:302697 92/460 (20%)
NHL repeat 172..237 CDD:271320 13/75 (17%)
LY 252..293 CDD:214531 9/49 (18%)
NHL repeat 261..298 CDD:271320 8/36 (22%)
NHL repeat 303..339 CDD:271320 8/66 (12%)
NHL repeat 341..419 CDD:271320 25/151 (17%)
NHL repeat 428..476 CDD:271320 16/48 (33%)
LY 472..511 CDD:214531 14/38 (37%)
NHL repeat 477..503 CDD:271320 9/25 (36%)
Ldl_recept_b 534..573 CDD:278487 16/38 (42%)
LY 558..599 CDD:214531 15/40 (38%)
LY 600..641 CDD:214531 16/40 (40%)
FXa_inhibition 668..703 CDD:291342 10/38 (26%)
LY 739..773 CDD:214531 7/33 (21%)
LY 776..818 CDD:214531 7/41 (17%)
LY 819..860 CDD:214531 0/40 (0%)
FXa_inhibition 973..1010 CDD:291342 7/36 (19%)
LY 1122..1164 CDD:214531 5/41 (12%)
FXa_inhibition 1273..1313 CDD:291342 6/39 (15%)
LDLa 1319..1362 CDD:238060 16/43 (37%)
LDLa 1365..1399 CDD:238060 14/33 (42%)
LDLa 1399..1433 CDD:197566 14/50 (28%)
sorl1XP_031762503.1 VPS10 115..744 CDD:214740 94/512 (18%)
LY 777..812 CDD:214531 12/34 (35%)
LY 815..854 CDD:214531 12/38 (32%)
Ldl_recept_b 879..920 CDD:395012 17/40 (43%)
LY 904..944 CDD:214531 15/42 (36%)
LY 944..982 CDD:214531 15/37 (41%)
LDLa 1069..1103 CDD:238060 7/34 (21%)
LDLa 1114..1144 CDD:238060 7/36 (19%)
Ldl_recept_a 1148..1183 CDD:395011 11/169 (7%)
LDLa 1189..1221 CDD:197566 12/68 (18%)
LDLa 1231..1262 CDD:238060 13/107 (12%)
LDLa 1272..1299 CDD:197566 7/44 (16%)
LDLa 1316..1350 CDD:238060 6/38 (16%)
LDLa 1363..1394 CDD:238060 15/39 (38%)
LDLa 1408..1442 CDD:238060 14/33 (42%)
LDLa 1460..1495 CDD:238060 15/35 (43%)
LDLa 1509..1537 CDD:238060 5/43 (12%)
FN3 1546..1617 CDD:214495 15/72 (21%)
FN3 1639..1730 CDD:238020 7/30 (23%)
FN3 1922..2003 CDD:214495
FN3 2013..2100 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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