DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and lrp2

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:XP_012826499.2 Gene:lrp2 / 100489914 XenbaseID:XB-GENE-486052 Length:4662 Species:Xenopus tropicalis


Alignment Length:1689 Identity:489/1689 - (28%)
Similarity:778/1689 - (46%) Gaps:215/1689 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 LLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSAL 153
            ||..:|:.|...|||  |....|..::||....:||||....|.:.|:|..::.|..|..|.:  
 Frog  1443 LLVASRNQIIADNIT--TQAHNIYPVIRDGRTIVAIDFDSVTNRIFWSDIAQDKIWSAFVNGT-- 1503

  Fly   154 QPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAV 218
                  .::.:..:|:...|.:|:||....:||||.....|||:.|||.::.||...::..||.:
 Frog  1504 ------DRKVIFDSGVTVTESIAVDWVGRNLYWTDYVLETIEVSQLDGTHRTVLISENVTNPRGL 1562

  Fly   219 AVVPA--RKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHH 281
            .:.|.  ..::.|||||..|:||||||||.  .|..:|...::||||||:|..|:.:|:.|....
 Frog  1563 VLDPRTDAHVMFWTDWGRNPRIERASMDGK--MRTVIVSNKIYWPNGLAIDYPNKRLYFADAYLD 1625

  Fly   282 FIDVMRLDGSSRRTIVNN---LKYPFSLTFYDDRLYWTD-WQRGSLNALDLQTRELKELIDTPKA 342
            :||....||::|:..:.:   |::|.::|.::|.:|||| :....:.|..........:|.....
 Frog  1626 YIDYCDYDGNNRKQAMASDLVLQHPHAITIFEDYVYWTDRYTSRVIRANKFHGGNQTVMIYNIHQ 1690

  Fly   343 PNSVRAWDPSLQPYEDNPCAHNNGNCSHLCLLAT-NSQGFSCACPTGVKLISAN-TCANGSQEMM 405
            |..:.|.....||...||||.|  .|||:|||:: ..:.:|||||:|..|:|.: .|....:..:
 Frog  1691 PLGISAVHSVKQPGGVNPCAFN--PCSHICLLSSIGPKFYSCACPSGWTLVSDSVNCQRDEKPFL 1753

  Fly   406 FIVQRTQISKISLDSPDYTIFPL-PLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVT 469
            .:|:.:.|..:||:..|.|...: |:..::....:|:|..|:.|||.: ....|.|..:|||..|
 Frog  1754 VVVRDSIIFGMSLNPDDKTNDAMVPVAGIRNGYDVDFDDSEQMIYWIE-NPGEIHRVKSDGTNRT 1817

  Fly   470 DFVTSE-VRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTA--RKVLIYEHLEE-----PRAIA 526
            .|..:. :..|.||||||::.|||:|:..|..|||.:|.|..  ||.||.....:     |..||
 Frog  1818 VFAPAAIIGAPVGLALDWISGNLYYTNPRTQSIEVIKLRGEVKHRKTLITNDGTQTGAGAPIGIA 1882

  Fly   527 VAPSLGWMFWSDW---NERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDK 588
            |.|:.|.|:|:|.   .....||..|.:|||...||.:.||.....|.:|...:.:||....|..
 Frog  1883 VDPARGKMYWTDQGIDGGTPAKVASADMDGSNPSVLFTNNLDHIEFITIDTAEQKLYWTVTGTGM 1947

  Fly   589 IEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMG 653
            ||..||||: .||.:.::|.|.:|::|.:.:||::|.....|:|..|.||.|::|:.|   ::.|
 Frog  1948 IERGNMDGT-NRVTVVNHLSHPWGIAIHEAFLYYSDRDYEVIERVDKSTGANKVVMRD---NIQG 2008

  Fly   654 LKVTRL----REVRGQNACAVRNGGCSHLCLNRPR-DYVCRCAIDYELANDKRTCVVPAAFLLFS 713
            ||..|:    ......|.|:.....|..||..:|: .:.|.||..:::..|.|||...::|::.|
 Frog  2009 LKCLRVHYRDNSAGSSNGCSNNPDACQQLCFPKPQGQFSCSCATGFKINADNRTCSPYSSFIVVS 2073

  Fly   714 RQEHIGRISIEYNEGNHNDERIPFKD-VRDAHALDVSVAERRIYWTDQKS-----KCIFRAFLNG 772
            ....|...|:|  ..:|::..:|... .|:|..:||.:....|||.|..|     ..|.|...||
 Frog  2074 MLTAIKGFSLE--AADHSEAMVPMAGRGRNALHVDVHMPSGYIYWCDFSSTPGANNGIRRVKPNG 2136

  Fly   773 SYVQRIVDSGL--IGPDGIAVDWLANNIYWSDAEARR--IEVARLDGSSRRVLLWKGVEEPRSLV 833
            |..:.||..|:  .|..||||||:|.|:|:::|....  |||.||:.|.||||:...|:.||.:|
 Frog  2137 SSFRNIVTGGIGRNGIRGIAVDWVAGNLYFTNAFLTETFIEVLRLNTSYRRVLMKTTVDMPRHIV 2201

  Fly   834 LEPRRGYMYWT---ESPTDSIRRAAMDGSDLQTIVA-GANHAAGLTFDQETRRLYWATQSRP--A 892
            ::|:..|::|.   :||  .|.||.:|.::...:|: |.....||..|:....:||...|..  |
 Frog  2202 VDPKNRYIFWADYGQSP--KIERAFLDCTNRTVLVSEGIVTPRGLAVDRTNGYVYWVDDSLDMIA 2264

  Fly   893 KIESADWDGKKRQIL-VGSDMDEPYAVSLYQDYVYWSDWNTGDIERVHK--TTGQNRSLVHSGMT 954
            :::|   :|.:.:|: .||....||.::::::.:.|.|.|...|.:..|  :..:..|::...:.
 Frog  2265 RVKS---EGGETEIVRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPSNSEQPSVIRDNIN 2326

  Fly   955 YITSLLVFNDK------RQTGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSC-IP 1012
            .:..:.||:.:      ::...|||..|||||||||.|.||::...|.| .:..||.||..| |.
 Frog  2327 LLRDVTVFDSRYQPTSPQELNNNPCFQNNGGCSHLCFALPGQQTRKCGC-AYGTLASDGTRCVIS 2390

  Fly  1013 PRNYIIFSQRNCFGRLL--PNTTDCPNIPLPVSGKNIRAVDYDPITHHIYWIE----GRSHSIKR 1071
            ..:|:||:.......||  |.....|..|:.|. :...|:|||.:.:.:|:.:    |||.....
 Frog  2391 TDDYLIFALEGSIRSLLLDPENHSPPFPPVNVF-RTAVALDYDSLDNRVYFTQSSGAGRSRISYF 2454

  Fly  1072 SLA--NGTKVSLLANSGQPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPRNI 1134
            ||:  :|.:.::.::.|.|..:|.|.|.:.::::...:.:||..:..|....||  ...::||.|
 Frog  2455 SLSSPSGPRTTVASDLGAPDGIAFDWIHKRVYYSDYLNQTINSMAVNGSDRTVI--ARVQRPRAI 2517

  Fly  1135 AVHAMKRLLFWTDVGSHQAIIRARVDGNERVELA-YKLEGVTALALDQQSDMIYYAHG--KRIDA 1196
            .:...:..::|||.|::..|.||.:.||.|..:. ..|.....|.||.:.:.:|:|..  ::|:.
 Frog  2518 MLDPCRGYMYWTDWGTNAKIERATLGGNFRTAIVNTSLVWPNGLTLDYEEERLYWADANLQKIER 2582

  Fly  1197 IDINGKNKKTLVSMHISQVINIAALGGFVYWLDDKT-GVERITV-NGERRSAELQRLPQ-ITDIR 1258
            ..:.|.|::.:||..: ....:......:||.|..| .:.|... :|..:...:|.||| ..||.
 Frog  2583 CSLTGTNREVVVSTAV-YPFAMTLYDQHIYWTDWNTRSIYRANKHDGSDQIIMIQNLPQRPMDIH 2646

  Fly  1259 AVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCPK--HLMLLEDKENC-------- 1313
             |.:.:.:...:..|......|||||.....|..     |.||.  ...|..:.::|        
 Frog  2647 -VLSKNKQQQCSSPCDQFNGGCSHICAPGPNGAE-----CQCPASGRWYLANNNKDCIVDNGTRC 2705

  Fly  1314 --GAFPA----CGPDHFTC--------------------AAPVSGISDVNKDCIPASWRCDGQKD 1352
              |.|..    |.|:...|                    ..|.:..:..|..|:|..:|||...|
 Frog  2706 ENGKFTCLNGRCIPERHKCDNDNDCRDGSDELERVCAFHTCPSTSFTCGNGRCVPYHYRCDHYND 2770

  Fly  1353 CPDKSDEVGC--PTCRAD-QFSCQSGECIDKSLVCDGTTNC-ANG-HDEADCCKR---PGEFQCP 1409
            |.|.|||:||  .||..: :|:|.:|.||.::.||:|..|| .|| .||.:|..|   ||..:|.
 Frog  2771 CGDNSDELGCLFRTCDPNTEFTCNNGRCISRAYVCNGVNNCFDNGTSDERNCPDRTCQPGYTKCR 2835

  Fly  1410 INKLCISAALLCDGWENCADGADESSDICLQRRMAPATDKRAFMILIGATMITIFSIVYLLQFCR 1474
            ...:||....||||..:|.|.:|||...|:   ....|:.. |....|..:...:       :|.
 Frog  2836 STNICIPRTYLCDGDNDCGDMSDESPTHCV---TLTCTESE-FRCSSGRCIPGHW-------YCD 2889

  Fly  1475 TRIGKSRTEPKDDQATDPLSPSTLSKSQ------RVSKIASVADAVRMSTLNSRNSMNSYDRNHI 1533
            .  |...::..|:..|......|.|..|      |....:.:.|..     |....|:..|:.| 
 Frog  2890 Q--GVDCSDGSDEPPTCVAHVRTCSSDQFRCDDARCIPASWICDGD-----NDCGDMSDEDQRH- 2946

  Fly  1534 TGASSSTTNGSSMVAYPINPPPSPATRSRRPYRHYKIINQPPPPTPC--STDICD-ESDSNYTSK 1595
                                  :.|.||..| ..:..||..||...|  .:.:|| ::|.     
 Frog  2947 ----------------------NCANRSCAP-TEFTCINNRPPERRCIPQSWVCDGDADC----- 2983

  Fly  1596 SNSNNSNGGATKHSSSSAAACLQYGYDSEPYPPPPTPRSHYHSDVRIVPESSCPPSPSSRSSTY 1659
            |::.:.:...|:.|.||:......|.         ..||::..|.|    :.|......|...|
 Frog  2984 SDAYDEHQNCTRRSCSSSEFACANGL---------CVRSNFRCDRR----NDCGDGSDERGCIY 3034

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 13/38 (34%)
NHL 168..503 CDD:302697 118/344 (34%)
NHL repeat 172..237 CDD:271320 24/66 (36%)
LY 252..293 CDD:214531 15/40 (38%)
NHL repeat 261..298 CDD:271320 14/36 (39%)
NHL repeat 303..339 CDD:271320 9/36 (25%)
NHL repeat 341..419 CDD:271320 27/79 (34%)
NHL repeat 428..476 CDD:271320 14/49 (29%)
LY 472..511 CDD:214531 17/41 (41%)
NHL repeat 477..503 CDD:271320 13/25 (52%)
Ldl_recept_b 534..573 CDD:278487 14/41 (34%)
LY 558..599 CDD:214531 15/40 (38%)
LY 600..641 CDD:214531 14/40 (35%)
FXa_inhibition 668..703 CDD:291342 10/35 (29%)
LY 739..773 CDD:214531 12/39 (31%)
LY 776..818 CDD:214531 20/45 (44%)
LY 819..860 CDD:214531 16/43 (37%)
FXa_inhibition 973..1010 CDD:291342 19/36 (53%)
LY 1122..1164 CDD:214531 14/41 (34%)
FXa_inhibition 1273..1313 CDD:291342 11/41 (27%)
LDLa 1319..1362 CDD:238060 16/62 (26%)
LDLa 1365..1399 CDD:238060 15/36 (42%)
LDLa 1399..1433 CDD:197566 13/36 (36%)
lrp2XP_012826499.2 LDLa 33..67 CDD:238060
LDLa 111..145 CDD:238060
LDLa 151..182 CDD:238060
LDLa 186..220 CDD:238060
LDLa 266..300 CDD:238060
EGF_CA 348..385 CDD:214542
NHL 391..618 CDD:302697
LY 503..548 CDD:214531
LY 551..591 CDD:214531
FXa_inhibition 663..704 CDD:405372
LY 776..818 CDD:214531
Ldl_recept_b 838..878 CDD:395012
LY 864..904 CDD:214531
LDLa 1026..1060 CDD:238060
LDLa 1067..1101 CDD:238060
LDLa 1109..1143 CDD:238060
LDLa 1149..1183 CDD:238060
LDLa 1187..1222 CDD:238060
LDLa 1230..1264 CDD:238060
LDLa 1271..1305 CDD:238060
LDLa 1311..1344 CDD:197566
FXa_inhibition 1358..1393 CDD:405372
EGF_CA 1395..1434 CDD:214542
LY 1466..1505 CDD:214531 12/46 (26%)
LY 1506..1548 CDD:214531 15/41 (37%)
LY 1550..1594 CDD:214531 19/45 (42%)
LY 1596..1637 CDD:214531 15/40 (38%)
FXa_inhibition 1714..1745 CDD:405372 14/30 (47%)
LY 1825..1857 CDD:214531 16/31 (52%)
Ldl_recept_b 1888..1932 CDD:395012 15/43 (35%)
LY 1917..1958 CDD:214531 15/41 (37%)
FXa_inhibition 2027..2063 CDD:405372 10/35 (29%)
LY 2187..2230 CDD:214531 16/44 (36%)
LY 2232..2272 CDD:214531 11/42 (26%)
FXa_inhibition 2351..2387 CDD:405372 19/36 (53%)
LY 2463..2505 CDD:214531 8/41 (20%)
Ldl_recept_b 2524..2564 CDD:395012 12/39 (31%)
LY 2550..2590 CDD:214531 8/39 (21%)
Ldl_recept_b 2608..2647 CDD:423042 12/39 (31%)
FXa_inhibition 2660..2697 CDD:405372 11/41 (27%)
LDLa 2705..2737 CDD:238060 5/31 (16%)
LDLa 2746..2780 CDD:238060 13/33 (39%)
LDLa 2785..2822 CDD:238060 15/36 (42%)
LDLa 2826..2859 CDD:197566 11/32 (34%)
LDLa 2868..2900 CDD:197566 5/41 (12%)
LDLa 2910..2942 CDD:197566 7/36 (19%)
LDLa 2953..2993 CDD:238060 10/45 (22%)
LDLa 2998..3032 CDD:238060 9/46 (20%)
LDLa <3046..3068 CDD:197566
LDLa 3080..3114 CDD:238060
FXa_inhibition 3126..3155 CDD:405372
vWFA <3152..3195 CDD:412136
LY 3224..3265 CDD:214531
LY 3267..3309 CDD:214531
Ldl_recept_b 3338..3378 CDD:395012
LY 3363..3404 CDD:214531
LY 3405..3446 CDD:214531
FXa_inhibition 3474..>3502 CDD:405372
LDLa 3517..3549 CDD:238060
LDLa 3558..3589 CDD:197566
LDLa 3598..3630 CDD:197566
LDLa 3639..3671 CDD:197566
LDLa 3724..3759 CDD:238060
LDLa 3764..3798 CDD:238060
LDLa 3802..3834 CDD:197566
LDLa 3847..3879 CDD:238060
LDLa 3890..3920 CDD:197566
LDLa 3933..3967 CDD:238060
LY 4146..4181 CDD:214531
Ldl_recept_b 4202..4242 CDD:395012
LY 4226..4269 CDD:214531
FXa_inhibition 4344..4371 CDD:405372
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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