DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment arr and lrp6

DIOPT Version :9

Sequence 1:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster
Sequence 2:XP_031754428.1 Gene:lrp6 / 100489328 XenbaseID:XB-GENE-481820 Length:1612 Species:Xenopus tropicalis


Alignment Length:1693 Identity:717/1693 - (42%)
Similarity:1001/1693 - (59%) Gaps:148/1693 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 LIGFLLICFGISNSWQYKNVHMPSSSSLIASPPASAFVNTPATLLFTTRHDIQVANITRPTGGPQ 110
            |:..||||               |.|.|:.:.|         .||:..|.|:::.:.....|.. 
 Frog     4 LLRSLLIC---------------SLSCLLRASP---------LLLYANRRDLRLVDAAGMKGNS- 43

  Fly   111 IDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSALQPLLRAPKQTVISTGLDKPEGL 175
             .|:|..|.:|.|:||.:.:.|:.|:|...|.|:....|.:       .....|:.:||..|:||
 Frog    44 -TVVVSGLEDAAAVDFVFFRGLIYWSDVSEEAIKRIDFNKT-------GSSHDVVISGLLSPDGL 100

  Fly   176 AMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAVAVVPARKLLIWTDWGEYPKIER 240
            |.||..:|:||||.|.|||||:.|||..:|||||.:||||||:|:.|.|..:.|||||:.|||||
 Frog   101 ACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPTRGYMYWTDWGDVPKIER 165

  Fly   241 ASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHHFIDVMRLDGSSRRTIV-NNLKYPF 304
            |.|||.  .|..::...::|||||.:|...:.:||.|.|..||....||||.|:|:: .:|.:||
 Frog   166 AGMDGS--LRSVIIDSDIYWPNGLTLDYDEQKLYWADAKLSFIHKANLDGSHRQTVIKGSLAHPF 228

  Fly   305 SLTFYDDRLYWTDWQRGSLNALDLQTRELKELIDTP-KAPNSVRAWDPSLQPYEDNPCAHNNGNC 368
            :||.:.|.:|||||...|:.|.:..|.|.:..:|:. .:|..:..:....||...||||.:||.|
 Frog   229 ALTLFGDTIYWTDWTTRSILACNKYTGEDRREVDSDIFSPMDIHVFSRLRQPNATNPCAVHNGGC 293

  Fly   369 SHLCLLATNSQGFSCACPTGVKLI-SANTCANGSQEMMFIVQRTQISKISLDSPDYTIFPLPLGK 432
            |||||::.....:.|||||||:|: ....|.:|:.|::.:|:||.:.:||||:||:|...|||..
 Frog   294 SHLCLMSPMEPFYQCACPTGVRLMEDGKMCMHGATELLLLVRRTDLRRISLDTPDFTDIVLPLDD 358

  Fly   433 VKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSEVRHPDGLALDWLARNLYWTDTV 497
            :::||||||||||.:|||:|.|...|:|...||:.....|||:|.||||:|:||:|||||||||.
 Frog   359 IRHAIAIDYDPVEGYIYWTDDEVRAIRRTQIDGSSSQYIVTSQVAHPDGIAVDWVARNLYWTDTG 423

  Fly   498 TDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDGSERVVLVSE 562
            ||||||.||:||.||:||.|.|:|||||.:.|..|:|:|:||.| .||:|||::|||:|::||:.
 Frog   424 TDRIEVTRLNGTMRKILISEDLDEPRAIVLDPMNGYMYWTDWGE-IPKIERAAMDGSDRIILVNT 487

  Fly   563 NLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQR 627
            :||||||:|||.....|||.|.|||||||...||:||||::.|.|.|:||.::|.||:|||||||
 Frog   488 SLGWPNGLALDYAEGKIYWGDAKTDKIEVMTTDGTGRRVLVEDKLPHIFGFTLLGDYVYWTDWQR 552

  Fly   628 RSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAVRNGGCSHLCLNRPRDYVCRCAI 692
            |||:|.||.|| .|.|::||.|||||||.|.:.::.|.|.||..|||||||||.||:...|.|.|
 Frog   553 RSIERVHKRTG-EREVIIDQLPDLMGLKATNIHKMSGTNGCAENNGGCSHLCLFRPQGPRCACPI 616

  Fly   693 DYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYW 757
            ..||.:|.:||:||.|||||||:..|.|||:   |.:::...||...|::|.|||..|.:.||||
 Frog   617 GLELISDMKTCIVPEAFLLFSRRADIRRISL---ETSNSHVAIPLTGVKEASALDFDVTDNRIYW 678

  Fly   758 TDQKSKCIFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLL 822
            ||...|.|.|||:|||.::.:|..||..|:|:|||||..|:||:|....||||::|||..|::|:
 Frog   679 TDVSLKTISRAFMNGSALEHVVQFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQILV 743

  Fly   823 WKGVEEPRSLVLEPRRGYMYWTE-SPTDSIRRAAMDGSDLQTIVAGANHAAGLTFDQETRRLYWA 886
            ||.::.||:|.|:|..|:||||| .....|.|.|||||...|:|.....|.|||.|...||||| 
 Frog   744 WKDLDSPRALALDPAEGFMYWTEWGGKPKIDRTAMDGSGRITLVPDVGRANGLTIDYAERRLYW- 807

  Fly   887 TQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSDWNTGDIERVHKTTGQNRSLVHS 951
            |......|||::..|..| :::..|:..|:.::.||||:||:||:...|||.:||:||||:::.:
 Frog   808 TDLDTNLIESSNMLGLDR-VVIADDLPHPFGLTQYQDYIYWTDWSQRSIERANKTSGQNRTMIQN 871

  Fly   952 GMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCIPPRNY 1016
            .:.|:..:|||:..||.|.|.|..:||.|||||||.| ..|.||.||.|:.|..|..:|.||.::
 Frog   872 DLDYVMDILVFHSSRQAGWNECASSNGHCSHLCLATP-VSGYTCGCPVHHSLNADNKTCSPPSSF 935

  Fly  1017 IIFSQRNCFGRLLPNTTDCPNIPLPVSG-KNIRAVDYDPITHHIYWIEGRSHSIKRSLANGTK-- 1078
            ::|||:|...|::.:....|:|.||:.. :|:||:||||:...:|||:.| .:|:|:..:|::  
 Frog   936 LLFSQKNAINRMVIDEQQSPDIILPIHNLRNVRAIDYDPLEKQLYWIDSR-QNIRRAQEDGSQSM 999

  Fly  1079 ---VSLLANSG---QPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVH 1137
               .|.:.|..   ||:||:||:..||::|||..:|.||||...|.::||:..|:.::||.|.|:
 Frog  1000 TVVASTVPNQNIDMQPYDLSIDVYSRLIYWTCEATNVINVTRLDGRAIGVVLKGEQDRPRAILVN 1064

  Fly  1138 AMKRLLFWTDVGSHQ-AIIRARVDGNERVELAYK-LEGVTALALDQQSDMIYYAHG--KRIDAID 1198
            ..:..:::|::.... .|.||.:||.||..|.:. |....|||||.:...:::|..  :||::.|
 Frog  1065 PERGYMYFTNLQERSPKIERAALDGTEREVLFFTGLSKPVALALDNKMGKLFWADSDLRRIESSD 1129

  Fly  1199 INGKNKKTLVSMHISQVINIAALGGFVYWLD-DKTGVERITVNGERRSAELQ-RLPQITDIRAVW 1261
            ::|.::..|...::.|.:.:...|..:||:| .:..:|||...|.....::| |:|.:|||.||.
 Frog  1130 LSGGHRIVLEDSNVLQPVGLTVFGNHLYWIDRQQQMIERIEKTGRVGRTKIQARIPLLTDIHAVT 1194

  Fly  1262 TPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCPKHLMLL-EDKENCGAFPACGPDHFT 1325
            .......:.|.|......||||||..|:|..|    ||||.||:|| ||:.:||..|.|.|..||
 Frog  1195 ELSMDEYKEHPCSQDNGGCSHICIVKGDGTTR----CSCPMHLVLLQEDELSCGEPPTCSPLQFT 1255

  Fly  1326 CAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGCPTCRADQFSCQSGECIDKSLVCDGTTNC 1390
            |   .:|    ..|||||.|||||..:|.|.|||..||.|...|:.|.||:|||.||.|:|..||
 Frog  1256 C---FTG----EVDCIPAEWRCDGFTECEDHSDEQNCPMCSDTQYQCASGQCIDSSLRCNGEANC 1313

  Fly  1391 ANGHDEADC---CKRPGEFQCPINKLCISAALLCDGWENCADGADESSDICLQRRMAPATDKRAF 1452
            .:..||.:|   | .|.:|.|...: ||.....||...:|:|.:||.:....:....|:|:....
 Frog  1314 QDKSDEKNCNEVC-APDQFHCGSGQ-CIGKHRRCDLSPDCSDSSDEQACYPTEEPPPPSTNTIGS 1376

  Fly  1453 MILIGATMITIFSIVYLLQ--FCRTRIGKSRTEPKD----DQATDPLS----PSTLSKS-QRVSK 1506
            :|.:..|:..:..:.::.|  .||...|...|...|    ..|:.||:    ||:|:.| ..:|:
 Frog  1377 IIGVILTVFVVGGVYFICQRVLCRRMKGDGETMANDYVVHGPASVPLAYVPHPSSLTGSLPGMSR 1441

  Fly  1507 IASVADAVRMSTLNSRNSMNSYDRNHITGASSSTTNGSSMVAYP--INPPPSPATR--------- 1560
            ..||..::   ::.:.:|...|||.|:||||||:::.:....:|  :||||||||.         
 Frog  1442 GKSVISSL---SIMAGSSGPPYDRAHVTGASSSSSSSTKGTYFPPILNPPPSPATERSHYTMEFG 1503

  Fly  1561 ------------SRRP--YRHYKIINQPPPPTPCSTDICDESDSNYTSKSNSNNSNGGATKHSSS 1611
                        |.||  |||:     .||.||||||:|   ||:||            ..|..:
 Frog  1504 YSSNSPSTHRSYSYRPYSYRHF-----APPTTPCSTDVC---DSDYT------------PSHRIT 1548

  Fly  1612 SAAA---CLQYGYDSEPYPPPPTPRSHYHSDVRIVPES--SCPPSPSSRSSTYFSPLPPPPSPVQ 1671
            ||||   .....|||||.||||||||.|.|    ..|:  ||||||.:..|......||||||..
 Frog  1549 SAAAKGYTSDLNYDSEPVPPPPTPRSQYLS----AEENYESCPPSPYTERSYSHHLYPPPPSPCT 1609

  Fly  1672 SPS 1674
            ..|
 Frog  1610 DSS 1612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
arrNP_524737.2 LY 162..201 CDD:214531 21/38 (55%)
NHL 168..503 CDD:302697 167/337 (50%)
NHL repeat 172..237 CDD:271320 39/64 (61%)
LY 252..293 CDD:214531 16/40 (40%)
NHL repeat 261..298 CDD:271320 17/37 (46%)
NHL repeat 303..339 CDD:271320 14/35 (40%)
NHL repeat 341..419 CDD:271320 31/78 (40%)
NHL repeat 428..476 CDD:271320 25/47 (53%)
LY 472..511 CDD:214531 30/38 (79%)
NHL repeat 477..503 CDD:271320 20/25 (80%)
Ldl_recept_b 534..573 CDD:278487 23/38 (61%)
LY 558..599 CDD:214531 24/40 (60%)
LY 600..641 CDD:214531 25/40 (63%)
FXa_inhibition 668..703 CDD:291342 19/34 (56%)
LY 739..773 CDD:214531 18/33 (55%)
LY 776..818 CDD:214531 21/41 (51%)
LY 819..860 CDD:214531 20/41 (49%)
FXa_inhibition 973..1010 CDD:291342 19/36 (53%)
LY 1122..1164 CDD:214531 12/42 (29%)
FXa_inhibition 1273..1313 CDD:291342 20/40 (50%)
LDLa 1319..1362 CDD:238060 21/42 (50%)
LDLa 1365..1399 CDD:238060 16/33 (48%)
LDLa 1399..1433 CDD:197566 11/36 (31%)
lrp6XP_031754428.1 Ldl_recept_b 63..103 CDD:423042 13/46 (28%)
LY 89..127 CDD:214531 22/37 (59%)
Ldl_recept_b 150..190 CDD:395012 20/41 (49%)
LY 175..216 CDD:214531 16/40 (40%)
LY 217..258 CDD:214531 16/40 (40%)
FXa_inhibition 286..323 CDD:405372 18/36 (50%)
LY 353..393 CDD:214531 22/39 (56%)
LY 397..437 CDD:214531 30/39 (77%)
LY 438..481 CDD:214531 25/43 (58%)
LY 483..524 CDD:214531 24/40 (60%)
LY 525..565 CDD:214531 25/40 (63%)
FXa_inhibition 592..627 CDD:405372 19/34 (56%)
LY 656..694 CDD:214531 20/37 (54%)
LY 697..739 CDD:214531 21/41 (51%)
LY 740..783 CDD:214531 21/42 (50%)
LY 783..825 CDD:214531 17/42 (40%)
LY 825..866 CDD:214531 18/41 (44%)
FXa_inhibition 893..929 CDD:405372 19/36 (53%)
LY 958..997 CDD:214531 16/39 (41%)
LY 1093..1135 CDD:214531 12/41 (29%)
FXa_inhibition 1206..1243 CDD:405372 20/40 (50%)
LDLa 1249..1285 CDD:238060 21/42 (50%)
LDLa 1288..1322 CDD:238060 16/33 (48%)
LDLa 1326..1360 CDD:238060 12/35 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 121 1.000 Domainoid score I5631
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H1747
Inparanoid 1 1.050 1328 1.000 Inparanoid score I149
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D121310at2759
OrthoFinder 1 1.000 - - FOG0004181
OrthoInspector 1 1.000 - - otm49363
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3498
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.060

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