Protein Alignment arr and lrp6

DIOPT Version :10

• Sequence 1: NP_524737.2
• Gene: arr / 44279
• FlyBaseID: FBgn0000119
• Length: 1678
• Species: Drosophila melanogaster
• Sequence 2: NP_001128156.2
• Gene: lrp6 / 100003877
• ZFINID: ZDB-GENE-090821-1
• Length: 1619
• Species: Danio rerio
• Alignment Length: 1671
• Identity: 715/1671 - (42%)
• Similarity: 988/1671 - (59%)
• Gaps: 159/1671 - (9%)

  Fly    89 LLFTTRHDIQV-------ANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECA 146
            ||:..|.|:::       ||.|...||         |.:|.|:|:.||:.|:.|:|...|.|:..
Zfish    23 LLYANRRDLRLVDAAHGRANATLVMGG---------LEDAAAVDYIYAQGLIYWSDVSEESIKRT 78

  Fly   147 QTNSSALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTD 211
            ..|.||...:     ||.:.:||..|:|||.||..:|:||||.|.||||||.|||.::|||||.|
Zfish    79 LFNGSAPSGV-----QTTVISGLASPDGLACDWMGNKLYWTDSETNRIEVAELDGTHRKVLFWQD 138

  Fly   212 LDQPRAVAVVPARKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWT 276
            ||||||:|:.|.|..:.||||||.||||||.|||.  .|..:|:..::|||||.:|.:.:.:||.
Zfish   139 LDQPRAIALDPGRGFMYWTDWGEIPKIERAGMDGS--LRSVIVETEIYWPNGLTLDYQQQQLYWA 201

  Fly   277 DGKHHFIDVMRLDGSSRRTIV-NNLKYPFSLTFYDDRLYWTDWQRGSLNALDLQTRE-LKELIDT 339
            |.|.:.|....||||||..:| .:|.:||:||.|:|.|:||||...|:::....|.| .:|:...
Zfish   202 DAKFNCIHRSNLDGSSREVVVKGSLPHPFALTLYEDTLFWTDWNTHSIHSCHKHTGENSREVHSN 266

  Fly   340 PKAPNSVRAWDPSLQPYE-DNPCAHNNGNCSHLCLLATNSQGFSCACPTGVKLISAN-TCANGSQ 402
            ..:|..:..:....||.: .:||:..||.|||||||:.....:.|||||||:|:..: :|.:|..
Zfish   267 IFSPMDIHVYSQQRQPMDVASPCSVRNGGCSHLCLLSPAKPYYQCACPTGVQLLEDHKSCRDGPS 331

  Fly   403 EMMFIVQRTQISKISLDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTG 467
            :::.:.:||.:.:||||:||:|...|....:::||||||||||.||||:|.|...|:|:..||:.
Zfish   332 QLLLLARRTDLRRISLDTPDFTDIVLQAEDIRHAIAIDYDPVEGHIYWTDDEVRAIRRSLLDGSD 396

  Fly   468 VTDFVTSEVRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLG 532
            ....|||:|.||||:|:||:|||||||||.||||||.||:||.||:||.|.|:|||||.:.|..|
Zfish   397 AQLVVTSQVNHPDGIAVDWIARNLYWTDTGTDRIEVTRLNGTMRKILISEDLDEPRAIVLDPVAG 461

  Fly   533 WMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGS 597
            :|:|:||.| .||:|||:||||:|:|:|:.:||||||:|||...:.|||.|.|||.|||..||||
Zfish   462 YMYWTDWGE-VPKIERAALDGSQRMVMVNTSLGWPNGLALDYSERKIYWGDAKTDVIEVMEMDGS 525

  Fly   598 GRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLREV 662
            ||||::.|||.|:||.::|.||:||||||||||:|.|| ....|.|::||.|||||:|.|.:.:.
Zfish   526 GRRVLLEDNLPHVFGFTLLGDYIYWTDWQRRSIERVHK-RSTEREVIIDQLPDLMGIKATFVHQT 589

  Fly   663 RGQNACAVRNGGCSHLCLNRPRDYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNE 727
            .|.|.||..|||||||||.||:...|.|.|..||..|..||:||.|||||||...|.|||:   |
Zfish   590 FGVNPCAWANGGCSHLCLYRPQGVSCACPIGLELMADLSTCIVPEAFLLFSRHTDIRRISL---E 651

  Fly   728 GNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVDSGLIGPDGIAVD 792
            .|:|:..||...|::|.|||..:.:.||||||...|.|.|||:|||.::.:|:.||..|:|:|||
Zfish   652 TNNNNVAIPLTGVKEASALDFDITDNRIYWTDITLKTISRAFMNGSSLEHVVEFGLDYPEGMAVD 716

  Fly   793 WLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTE-SPTDSIRRAAM 856
            ||..|:||:|....|||||:|||..|:||:||.::.||:|.|:|..|:||||| .....|.||||
Zfish   717 WLGKNLYWADTGTNRIEVAKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGRPKIDRAAM 781

  Fly   857 DGSDLQTIVAGANHAAGLTFDQETRRLYWATQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLY 921
            |||...|:|.....|.|||.|...||||| |......|||::..|.:|:: :..|:..|:.::.|
Zfish   782 DGSGRITLVPNVGRANGLTIDYAERRLYW-TDLDTTLIESSNMLGLEREV-IADDLPHPFGLTQY 844

  Fly   922 QDYVYWSDWNTGDIERVHKTTGQNRSLVHSGMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLA 986
            |||:||:||:...|||.:||:||||:::...:.|:..:|||:..||:|.|.|...||.|||||||
Zfish   845 QDYIYWTDWSQRSIERANKTSGQNRTVIQGHLDYVMDILVFHSSRQSGWNACAATNGHCSHLCLA 909

  Fly   987 QPGRRGMTCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRLLPNTTDCPNIPLPV-SGKNIRAV 1050
            .| ....||.||.||.|..|..:|..|.::::|||:....|::.:....|:|.||: |.:|:||:
Zfish   910 VP-VCSFTCGCPAHYSLNTDNKTCSAPTSFLLFSQKTAINRMVMDELQSPDIILPIHSLRNVRAI 973

  Fly  1051 DYDPITHHIYWIEGRSHSIKRSLANGTKVSLLANSG---------QPFDLAIDIIGRLLFWTCSQ 1106
            ||||:..|:|||:.:.:.|:|:..:|.: |:...||         ||:||:|||..|.::||...
Zfish   974 DYDPLDRHLYWIDAKQNVIRRAQEDGNQ-SVTVVSGAVGGSNLGLQPYDLSIDIYSRFIYWTSEL 1037

  Fly  1107 SNSINVTSFLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQ-AIIRARVDGNERVELAY- 1169
            :|.||||...|..|||:..|:.:|||.|||:..:..::::::.... .|.|..:||.||..|.:
Zfish  1038 TNVINVTRTDGSRVGVVLRGEHDKPRAIAVNPERGYMYFSNLQERSPKIERCALDGTEREVLFFS 1102

  Fly  1170 KLEGVTALALDQQSDMIYYAHG--KRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLD-DK 1231
            .|....|||:|.:...:::...  :||::.|::|.|:..:...:|.|.:.:...|.|:||:| .:
Zfish  1103 NLGRPVALAVDNELGKLFWVDMDLRRIESSDLSGANRIVIEDSNILQPVGLTVFGNFLYWIDRQQ 1167

  Fly  1232 TGVERI-TVNGERRSAELQRLPQITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTR 1295
            ..:||| .|..|.|:....|:..::||.||...|.:....|.|......|:||||..|:|..|
Zfish  1168 QMIERIHKVTREGRTKIQARIASLSDIHAVHQLDMQEYSKHPCTSDNGGCTHICIVKGDGTTR-- 1230

  Fly  1296 DVCSCPKHLMLLEDKENCGAFPACGPDHFTCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEV 1360
              ||||.||:||:|:.:||..|.|.|:.|:|   |||    ..||||.:|||||..:|.|.|||.
Zfish  1231 --CSCPIHLVLLQDELSCGEPPTCSPEQFSC---VSG----EVDCIPQAWRCDGFAECDDSSDER 1286

  Fly  1361 GCPTCRADQFSCQSGECIDKSLVCDGTTNCANGHDEADCCKRPGEFQCPI------NKLCISAAL 1419
            .||.|.:.:|.|.|.:|:|.:|.|:|..||.:..||..|     |..||.      |..||....
Zfish  1287 DCPVCSSREFQCDSRQCVDAALRCNGEINCQDRSDENKC-----EVLCPADQFTCSNGQCIGRHK 1346

  Fly  1420 LCDGWENCADGADESSDICLQRRMAPATDKRAFM------ILIGATMIT-IFSIVYLLQFCRTRI 1477
            .||...:|.|.:||..  |.      ||::.:|.      .::|..|:. :...||.:  |:..:
Zfish  1347 KCDNNMDCTDNSDEIG--CY------ATEEPSFAPTNTIGSIVGVVMVLFVVGAVYFV--CQRVL 1401

  Fly  1478 GKSRTEPKDDQATD---------PLS----PSTLSKS-QRVSKIASVADAVRMSTLNSRNSMNSY 1528
            .....:..|....|         ||.    |::||.| ..:|:..||..::   ::...:|...|
Zfish  1402 CPQMKDDADTMTNDFVVHGPPPVPLGYVPHPASLSGSLPGMSRGKSVMGSL---SIMGGSSGPPY 1463

  Fly  1529 DRNHITGASSSTTNGSSMVAYP--INPPPSPAT-RSR--------------------RP--YRHY 1568
            ||.|:||||||:::.:....:|  :|||||||| ||:                    ||  |||:
Zfish  1464 DRAHVTGASSSSSSSTKGAYFPPILNPPPSPATVRSQYTMEFGYSSNSPSTHRSYSYRPYSYRHF 1528

  Fly  1569 KIINQPPPPTPCSTDICDESDSNYTSKSNSNNSNGGATKHSSSSAAA---CLQYGYDSEPYPPPP 1630
                 .||.||||||:|   ||:||.        |....|:||:.||   .....|||||.||||
Zfish  1529 -----APPTTPCSTDVC---DSDYTP--------GRRAPHASSATAAKGYASDLNYDSEPLPPPP 1577

  Fly  1631 TPRSHYHSDVRIVPES--SCPPSPSSRSSTYFSPLPPPPSPVQSPS 1674
            ||||.|.|    ..|:  ||||||.:..|......||||||....|
Zfish  1578 TPRSQYLS----AEENCESCPPSPYTERSYSHQLYPPPPSPCTDSS 1619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
arr	NP_524737.2	LY	162..201	CDD:214531	23/38 (61%)
		NHL	168..503	CDD:302697	167/338 (49%)
		NHL repeat	172..237	CDD:271320	42/64 (66%)
		LY	252..293	CDD:214531	16/40 (40%)
		NHL repeat	261..298	CDD:271320	17/37 (46%)
		NHL repeat	303..339	CDD:271320	15/36 (42%)
		NHL repeat	341..419	CDD:271320	28/79 (35%)
		NHL repeat	428..476	CDD:271320	24/47 (51%)
		LY	472..511	CDD:214531	30/38 (79%)
		NHL repeat	477..503	CDD:271320	20/25 (80%)
		Ldl_recept_b	534..574	CDD:459654	25/39 (64%)
		LY	558..599	CDD:214531	25/40 (63%)
		LY	600..641	CDD:214531	24/40 (60%)
		FXa_inhibition	668..703	CDD:464251	19/34 (56%)
		YncE	<736..886	CDD:442618	77/150 (51%)
		LY	776..818	CDD:214531	22/41 (54%)
		LY	905..946	CDD:214531	17/40 (43%)
		FXa_inhibition	973..1010	CDD:464251	19/36 (53%)
		YncE	<1047..1191	CDD:442618	54/154 (35%)
		LDLa	1319..1362	CDD:238060	21/42 (50%)
		LDLa	1365..1399	CDD:238060	13/33 (39%)
		LDLa	1399..1433	CDD:197566	11/39 (28%)
lrp6	NP_001128156.2	None