Protein Alignment SoxN and sox18

DIOPT Version :9

• Sequence 1: NP_001260269.1
• Gene: SoxN / 44275
• FlyBaseID: FBgn0029123
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: XP_017209261.1
• Gene: sox18 / 797246
• ZFINID: ZDB-GENE-080725-1
• Length: 431
• Species: Danio rerio
• Alignment Length: 638
• Identity: 136/638 - (21%)
• Similarity: 204/638 - (31%)
• Gaps: 252/638 - (39%)

  Fly    69 ASQSPNPLSSLQS-SMANTLNGSQVGQQQQQQQQQQSSPLHSSS----ELSPTQSSIGSHHMTSP 128
            ||..|:.::...: ..:::..|.:.|....:.:..:.:|:..|.    ..:..::..||...|.|
Zfish    12 ASSQPSQVAERGTWGASSSTPGPERGHGFDRSRTTELAPVPGSGTRTVSRTAAEARTGSPDSTRP 76

  Fly   129 VSHQQHTQQQQHGQQQHLGAGSALSSLTGGSSNNNNNSATANKNQQHADRVKRPMNAFMVWSRGQ 193
                                    .:||.|||...:...:         |::|||||||||::.:
Zfish    77 ------------------------GALTLGSSEGKSGGES---------RIRRPMNAFMVWAKDE 108

  Fly   194 RRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEHPDYKYRPRRKTKTLT 258
            |:::|..||.:||:.:||.||..||.||..:||||::||:|||..|:::||:|||||||| |...
Zfish   109 RKRLAIQNPDLHNAVLSKMLGQSWKALSTLDKRPFVEEAERLRLQHLQDHPNYKYRPRRK-KQPK 172

  Fly   259 KTKEKYPMGGLMPGQTVGGGAPGEPVTPTRVQGQPGQNQSLNGSGGSAAAAAAAAAAAAQQARQD 323
            |.|...| |.|:.|...||  ||:..:|.|
Zfish   173 KMKRVEP-GLLLQGLAHGG--PGDAYSPHR----------------------------------- 199

  Fly   324 MYQMNAPNGYMPNGYMMHADPAGAAAYQTSYMGQHYAAQRYDMGHMYNNGYAMYQTVSGGQTSPY 388
                :|.:...|.|:.....|:||
Zfish   200 ----HAHHLLPPLGHFRDLHPSGA----------------------------------------- 219

  Fly   389 GSSLQQPGSPSPYGGSSLQQQPGSPTPYGGGGGGGGQVSCQSHSPSDSSIKSEPVSPSPSAIALN 453
             ..|:..|.|:|      :..|.....    .|||..|....|...|..:.|.
Zfish   220 -PELESFGLPTP------EMSPLDVLE----EGGGDSVFFPPHMQEDVGLSSW------------ 261

  Fly   454 NNNNINNNHIMKREYSSAAAAAAAAAAAAAAGGGELNHLMNMYHLPDEQRHLLHYQTDSPDLQQQ 518
                ||                                    ||
Zfish   262 ----IN------------------------------------YH--------------------- 265

  Fly   519 HQSMQQQQQHLPQQHLSQQHQQIPQQHHTMQQQQQQHHLQHQQSLRAMAPLAHMXEMASAYGAAG 583
                 |...|.|..|          .||.....|..|...:|:|..|..||.....:..:....|
Zfish   266 -----QHPNHQPGHH----------PHHNSHNLQHSHPHLNQKSPLACLPLQEKCLVVESPNPGG 315

  Fly   584 SSVSVSPPLPPYMPTAPQQQQQQQQQQQQLLNG--RPSPTASGSSGGRS-SAHSSGHTAAHSPAL 645
                    |.|.| |.|:..:.....|   :.|  :|.|..:...|..| ...:|.......|:|
Zfish   316 --------LYPNM-TLPESSKAGYYGQ---IYGSSQPQPAFTSHLGQLSPPPETSAVAQVAPPSL 368

  Fly   646 AAAYQLTPSA----------------ATSSATSAAAAAATAAAVAAAAAAGSS 682
            .|..||.|||                |:.:..|.:|....::|:.:|.:..||
Zfish   369 DAVDQLGPSAEFWGEVDRIEFDQYLSASRTRVSRSAPCEESSALISALSDASS 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	SOX-TCF_HMG-box	178..249	CDD:238684	38/70 (54%)
sox18	XP_017209261.1	SOX-TCF_HMG-box	93..164	CDD:238684	38/70 (54%)
		Sox_C_TAD	207..429	CDD:288887	62/367 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	142	1.000	Inparanoid score	I4455
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.960