Protein Alignment SoxN and SOX11

DIOPT Version :9

• Sequence 1: NP_001260269.1
• Gene: SoxN / 44275
• FlyBaseID: FBgn0029123
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_003099.1
• Gene: SOX11 / 6664
• HGNCID: 11191
• Length: 441
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 139/552 - (25%)
• Similarity: 197/552 - (35%)
• Gaps: 209/552 - (37%)

  Fly   179 VKRPMNAFMVWSRGQRRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEH 243
            :|||||||||||:.:|||:...:|.|||:|||||||.:||.|.:|||.|||.||:|||..||.::
Human    49 IKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADY 113

  Fly   244 PDYKYRPRRKTK-------TLTKTKEKYPMGGLMPGQTVGGGAPGEPVTPTRVQGQPGQNQSLNG 301
            ||||||||:|.|       :.:::.||...||       |||:.|         |..|..::..|
Human   114 PDYKYRPRKKPKMDPSAKPSASQSPEKSAAGG-------GGGSAG---------GGAGGAKTSKG 162

  Fly   302 SGGSAAAAAAAAAAAAQQARQDMYQMNAPNGYMPNGYMMHADPAGAAAYQTSYMGQHYAAQRYDM 366
            |........|.|||.|:..                        ||.||....|.|   |...|.:
Human   163 SSKKCGKLKAPAAAGAKAG------------------------AGKAAQSGDYGG---AGDDYVL 200

  Fly   367 GHMYNNGYAMYQTVSGGQTSPYGSSLQQPGSPSPYGGSSLQQQPGSPTPYGGGGGGGGQVSCQSH 431
            |                       ||:..||                    ||||.|..|.|
Human   201 G-----------------------SLRVSGS--------------------GGGGAGKTVKC--- 219

  Fly   432 SPSDSSIKSEPVSPSPSAIALNNNNNINNNHIMKREYSSAAAAAAAAAAAAAAGGGELNHLMNMY 496
                              :.|:.:::.:::
Human   220 ------------------VFLDEDDDDDDD----------------------------------- 231

  Fly   497 HLPDEQRHLLHYQTDSPDLQQQHQSMQQQQQHLPQQHLSQQHQQIPQQHHTMQQQQQQHHLQHQQ 561
              .||.:..:..:.|..|.:..||.:.|.....|.|.|                  :::::....
Human   232 --DDELQLQIKQEPDEEDEEPPHQQLLQPPGQQPSQLL------------------RRYNVAKVP 276

  Fly   562 SLRAMAPLAHMXEMASAY---------GAAGSS------VSVSPPLPPYMPTAPQQQQQQQQQQQ 611
            :...::..|...|.||.|         ||.|.|      .:::...||  |.|        |...
Human   277 ASPTLSSSAESPEGASLYDEVRAGATSGAGGGSRLYYSFKNITKQHPP--PLA--------QPAL 331

  Fly   612 QLLNGRPSPTASGSSGGRSSAHSSGHTAAHSPALAAAYQLTPSAATSSATSAAAAAATAAAVAAA 676
            ...:.|...|:|.||.| ||:.|||..|..     ..:.|      |...|.:|.:|:...:...
Human   332 SPASSRSVSTSSSSSSG-SSSGSSGEDADD-----LMFDL------SLNFSQSAHSASEQQLGGG 384

  Fly   677 AAAGSSFAASASMLDMQQQHLEEQQQHHHLHY 708
            ||||:   .|.|::|.......|.....|..:
Human   385 AAAGN---LSLSLVDKDLDSFSEGSLGSHFEF 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	SOX-TCF_HMG-box	178..249	CDD:238684	45/69 (65%)
SOX11	NP_003099.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		SOX-TCF_HMG-box	48..119	CDD:238684	45/69 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..216		43/185 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..292		10/69 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	319..359		16/50 (32%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000250|UniProtKB:Q7M6Y2	409..441		1/5 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910