DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SoxN and SOX9

DIOPT Version :9

Sequence 1:	NP_001260269.1	Gene:	SoxN / 44275	FlyBaseID:	FBgn0029123	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_000337.1	Gene:	SOX9 / 6662	HGNCID:	11204	Length:	509	Species:	Homo sapiens

Alignment Length:	618	Identity:	151/618 - (24%)
Similarity:	211/618 - (34%)	Gaps:	213/618 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 SQSPNPLSSLQSSMANTLNGSQVGQQQQQQQQQQSSPLHSSSELSPTQSSIGSHHMTSPVSHQQH 134
            |.:|:|..|..|:.:...:||  |...:..:.|:::......:|...     |.....||..::.
Human    19 SGAPSPTMSEDSAGSPCPSGS--GSDTENTRPQENTFPKGEPDLKKE-----SEEDKFPVCIREA 76

  Fly   135 TQQQQHGQQQHLGAGSALSSLTGGSSNNNNNSATANKNQQHADRVKRPMNAFMVWSRGQRRKMAS 199
            ..|...|....|   ..:.....|||          ||:.|   |||||||||||::..|||:|.
Human    77 VSQVLKGYDWTL---VPMPVRVNGSS----------KNKPH---VKRPMNAFMVWAQAARRKLAD 125

  Fly   200 DNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEHPDYKYRPRRKTKTLTKTKE-- 262
            ..|.:||:|:||.||..|:.|:|||||||::||:|||..|.|:||||||:|||:........|
Human   126 QYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKNGQAEAE 190

  Fly   263 ---------------------KYPMGGL----MPGQTVG--GGAPGEPVTPTRVQGQPGQNQSLN 300
                                 .:...|:    .||:..|  .|.|..|.|| :...|||:
Human   191 EATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPPTPPTTP-KTDVQPGK----- 249

  Fly   301 GSGGSAAAAAAAAAAAAQQARQ---------------------DMYQMNAPNGYM-PNGYMMHAD 343
                  |..........:..||                     :.:.:|..:.|: |||:.....
Human   250 ------ADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLPPNGHPGVPA 308

  Fly   344 PAGAAAYQTSYMGQHYAAQRYDMGHMYNNGYAMYQTVSGGQTSPYGSSLQQPGSPSPYGGSSLQQ 408
            ..|...|..||.....||.....||::                   .|.||...|.|      ||
Human   309 THGQVTYTGSYGISSTAATPASAGHVW-------------------MSKQQAPPPPP------QQ 348

  Fly   409 QPGSPTPYGGGGGGGGQVSCQSHSPSDSSIKSEPVSPSPSAIALNNNNNINNNHIMKREYSSAAA 473
            .|.:|                               |:|.|                   .....
Human   349 PPQAP-------------------------------PAPQA-------------------PPQPQ 363

  Fly   474 AAAAAAAAAAAGGGELNHLMNMYHLPDEQRHLLHYQTDSPDLQQQHQSMQQQQQHLPQQ------ 532
            ||.....||.....:.:.|..:...|.:.:. .|.:|:  .|...|.|  :||||.|||
Human   364 AAPPQQPAAPPQQPQAHTLTTLSSEPGQSQR-THIKTE--QLSPSHYS--EQQQHSPQQIAYSPF 423

  Fly   533 ---HLSQQHQQIPQQHHTMQQQQQQHHLQHQQSLRAMAPLAHMXEMASAYG-AAG------SSVS 587
               |.|..:..|        .:.|..:..||.|             :|.|. |||      |:.:
Human   424 NLPHYSPSYPPI--------TRSQYDYTDHQNS-------------SSYYSHAAGQGTGLYSTFT 467

  Fly   588 VSPPL--PPYMPTA--------PQQQQQQQQQQ 610
            ...|.  |.|.|.|        ||....|..:|
Human   468 YMNPAQRPMYTPIADTSGVPSIPQTHSPQHWEQ 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	SOX-TCF_HMG-box	178..249	CDD:238684	44/70 (63%)
SOX9	NP_000337.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		11/54 (20%)
		Sox_N	22..94	CDD:403592	15/81 (19%)
		Dimerization (DIM). /evidence=ECO:0000305\|PubMed:31194875	63..103		11/57 (19%)
		PQA. /evidence=ECO:0000305\|PubMed:31194875	63..103		11/57 (19%)
		SOX-TCF_HMG-box	104..174	CDD:238684	44/72 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..273		30/124 (24%)
		Transactivation domain (TAM). /evidence=ECO:0000269\|PubMed:31194875	224..307		19/94 (20%)
		9aaTAD 1. /evidence=ECO:0000269\|PubMed:31194875	275..284		0/8 (0%)
		9aaTAD 2. /evidence=ECO:0000269\|PubMed:31194875	290..298		1/7 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..415		29/164 (18%)
		Transactivation domain (TAC). /evidence=ECO:0000269\|PubMed:8640233	394..509		34/133 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..509		6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810