Protein Alignment SoxN and SOX4

DIOPT Version :10

• Sequence 1: NP_001260269.1
• Gene: SoxN / 44275
• FlyBaseID: FBgn0029123
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_003098.1
• Gene: SOX4 / 6659
• HGNCID: 11200
• Length: 474
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 149/589 - (25%)
• Similarity: 216/589 - (36%)
• Gaps: 202/589 - (34%)

  Fly   125 MTSPVSHQQHTQQQQHGQQQHLGAGSAL---SSLTGGSSNNNNNSA-TANKNQQHADRVKRPMNA 185
            |....::.::|:....|:....|||..|   ||.|.||:.:....| ..:..:..:..:||||||
Human     1 MVQQTNNAENTEALLAGESSDSGAGLELGIASSPTPGSTASTGGKADDPSWCKTPSGHIKRPMNA 65

  Fly   186 FMVWSRGQRRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEHPDYKYRP 250
            |||||:.:|||:...:|.|||:|||||||.:||.|.:|:|.|||.||:|||..||.::|||||||
Human    66 FMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHMADYPDYKYRP 130

  Fly   251 RRKTKTLTKTKEKYPMGGLMPGQ---TVGGGAPGEPVTPTRVQGQPGQNQSLNGSGGSAAAAAAA 312
            |:|.|:..............||:   .|||...|.       .|..|...|.|..||...|:...
Human   131 RKKVKSGNANSSSSAAASSKPGEKGDKVGGSGGGG-------HGGGGGGGSSNAGGGGGGASGGG 188

  Fly   313 AAAAAQQARQDMYQMNAPNGYMPNGYMMHADPAGAAAYQTSYMGQHYAAQRYDMGHMYNNGYAMY 377
            |                           ::.|                ||:...|.....|
Human   189 A---------------------------NSKP----------------AQKKSCGSKVAGG---- 206

  Fly   378 QTVSGGQTSPYGSSLQQPGSPSPYGGSSLQQQPGSPTPYGGGGGGGGQVSCQSHSPSDSSIKSEP 442
              ..||.:.|:...:                       ..||||||
Human   207 --AGGGVSKPHAKLI-----------------------LAGGGGGG------------------- 227

  Fly   443 VSPSPSAIALNNNNNINNNHIMKREYSSAAAAAAAAAAAAAAGGGELNHLMNMYHLP---DEQRH 504
                                       .|||||||:.||..||...|        ||   ....|
Human   228 ---------------------------KAAAAAAASFAAEQAGAAAL--------LPLGAAADHH 257

  Fly   505 LLHYQTDSPDLQQQHQSMQQQQQHL--PQQHLSQQHQQIPQQHHTMQQQQQQHHLQHQQSLRAMA 567
            .| |:..:|.......|.......|  |.:||:                        ::.::.:.
Human   258 SL-YKARTPSASASASSAASASAALAAPGKHLA------------------------EKKVKRVY 297

  Fly   568 PLAHMXEMASAYGAAGSSVSVSPPLPPY-------MPTAPQQQQQQQQQQQQLLNGRPSPTASGS 625
            ....:...:|..|..|:....|.||..|       .|.||.            |:|| |..||..
Human   298 LFGGLGTSSSPVGGVGAGADPSDPLGLYEEEGAGCSPDAPS------------LSGR-SSAASSP 349

  Fly   626 SGGRSSAHSSGHTA--AHSPALAAAYQLTPSAATSSATSAAAAAATAAAVAAAAAAGSSFAASAS 688
            :.|||.|...|:.:  |.|||        ||:|.|.|:|:|::.:::::.:.::::...|  ...
Human   350 AAGRSPADHRGYASLRAASPA--------PSSAPSHASSSASSHSSSSSSSGSSSSDDEF--EDD 404

  Fly   689 MLDM 692
            :||:
Human   405 LLDL 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	HMG-box_SoxB	177..252	CDD:438790	47/74 (64%)
SOX4	NP_003098.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..58		13/56 (23%)
		HMG-box_SoxC	58..133	CDD:438838	48/74 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..228		34/224 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..286		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	302..416		35/130 (27%)
		9aaTAD. /evidence=ECO:0000269|PubMed:34342803	426..434