Protein Alignment SoxN and sox9

DIOPT Version :10

• Sequence 1: NP_001260269.1
• Gene: SoxN / 44275
• FlyBaseID: FBgn0029123
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_001016853.1
• Gene: sox9 / 549607
• XenbaseID: XB-GENE-1034769
• Length: 482
• Species: Xenopus tropicalis
• Alignment Length: 594
• Identity: 141/594 - (23%)
• Similarity: 203/594 - (34%)
• Gaps: 192/594 - (32%)

  Fly    70 SQSPNPLSSLQSSMANTLNGSQVGQQQQQQQQQQSSPLHSSSELSPTQSSIGSHHMTSPVSHQQH 134
            |.:|:|..|..|:.:...:||  |...:..:.|:::......||...     :.....||..::.
 Frog    19 SGAPSPTMSEDSAGSPCPSGS--GSDTENTRPQENTFPKGDPELKKE-----TEDEKFPVCIREA 76

  Fly   135 TQQQQHGQQQHLGAGSALSSLTGGSSNNNNNSATANKNQQHADRVKRPMNAFMVWSRGQRRKMAS 199
            ..|...|....|   ..:.....|||          |::.|   |||||||||||::..|||:|.
 Frog    77 VSQVLKGYDWTL---VPMPVRVNGSS----------KSKPH---VKRPMNAFMVWAQAARRKLAD 125

  Fly   200 DNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEHPDYKYRPRRKTKTLTKTKEKY 264
            ..|.:||:|:||.||..|:.|:|.|||||::||:|||..|.|:||||||:|||: |::...:.:.
 Frog   126 QYPHLHNAELSKTLGKLWRLLNEGEKRPFVEEAERLRIQHKKDHPDYKYQPRRR-KSVKNGQSEQ 189

  Fly   265 PMGGLM----------------------------PGQTVG--GGAPGEPVTPTRVQGQPGQNQSL 299
            ..|...                            ||:..|  .|.|..|.|| :...|||
 Frog   190 EDGAEQTHISPNAIFKALQADSPHSASSMSEVHSPGEHSGQSQGPPTPPTTP-KTDVQPG----- 248

  Fly   300 NGSGGSAAAAAAAAAAAAQQARQDMYQMNAP---NGYMPNGYMMHADPAGAAAYQTSYMGQHYAA 361
                                 :.|:.:...|   :|..|                     .|...
 Frog   249 ---------------------KPDLKREGRPLQESGRQP---------------------PHIDF 271

  Fly   362 QRYDMGHMYNNGYAMYQTVSGGQTSPYGSSLQQPG---SPSPYGGSSLQQQPGSPTPYGGGGGGG 423
            :..|:|.:.:...:..:|....:...|......||   :.:||.||.......|.||    |.|.
 Frog   272 RDVDIGELSSEVISTIETFDVNEFDQYLPPNGHPGVGSTQAPYTGSYGINSTPSATP----GAGP 332

  Fly   424 GQVSCQSHSPSDSSIKSEPVSPSPSAIALNNNNNINNNHIMKREYSSAAAAAAAAAAAAAAGGGE 488
            ..:|.|....     :.:|..|..|...:|:                                 |
 Frog   333 AWMSKQQQQQ-----QQQPQPPQHSLSTINS---------------------------------E 359

  Fly   489 LNHLMNMYHLPDEQRHLLHYQTDSPDLQQQHQSMQQQQQHLPQQHLSQQHQQIPQQHHTMQQQQQ 553
            .:......|:..||....||.    |.||||...|........||.|..:..|        .:.|
 Frog   360 QSQSQQRTHIKTEQLSPSHYS----DQQQQHSPQQLNYSSFNLQHYSSSYPTI--------TRAQ 412

  Fly   554 QHHLQHQQSLRAMAPLAHMXEMASAYGAAG-------SSVSVSPP--LPPYMPTA--------PQ 601
            ..:.:||.|             .|.|..|.       |:.|...|  .|.|.|.|        ||
 Frog   413 YDYTEHQGS-------------NSYYSHASGQNSGLYSNFSYMNPSQRPMYTPIADTTGVPSIPQ 464

  Fly   602 QQQQQQQQQ 610
            ....|..:|
 Frog   465 THSPQHWEQ 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	HMG-box_SoxB	177..252	CDD:438790	45/74 (61%)
sox9	NP_001016853.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..66		11/53 (21%)
		Sox_N	22..94	CDD:463586	15/81 (19%)
		Dimerization (DIM). /evidence=ECO:0000250|UniProtKB:P48436	63..103		9/57 (16%)
		PQA. /evidence=ECO:0000250|UniProtKB:P48436	63..103		9/57 (16%)
		HMG-box_SoxE	104..178	CDD:438840	46/76 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..274		32/162 (20%)
		Transactivation domain (TAM). /evidence=ECO:0000250|UniProtKB:P48436	224..308		22/131 (17%)
		9aaTAD 1. /evidence=ECO:0000250|UniProtKB:P48436	276..285		1/8 (13%)
		9aaTAD 2. /evidence=ECO:0000250|UniProtKB:P48436	291..299		0/7 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..395		30/145 (21%)
		Transactivation domain (TAC). /evidence=ECO:0000250|UniProtKB:P48436	366..482		33/133 (25%)
		9aaTAD 3. /evidence=ECO:0000250|UniProtKB:P48436	433..441		1/7 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	448..482		8/26 (31%)