DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SoxN and SOX18

DIOPT Version :9

Sequence 1:	NP_001260269.1	Gene:	SoxN / 44275	FlyBaseID:	FBgn0029123	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_060889.1	Gene:	SOX18 / 54345	HGNCID:	11194	Length:	384	Species:	Homo sapiens

Alignment Length:	311	Identity:	96/311 - (30%)
Similarity:	136/311 - (43%)	Gaps:	95/311 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 SATANKNQQHAD--RVKRPMNAFMVWSRGQRRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPF 228
            |......:|.||  |::|||||||||::.:|:::|..||.:||:.:||.||..||:|:.:|||||
Human    70 SPAGRGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPF 134

  Fly   229 IDEAKRLRAVHMKEHPDYKYRPRRKTKTLTKTKEKYPMGGLMPGQTVGGGAPGEP---------- 283
            ::||:|||..|:::||:|||||||| |...|.:.      |.||..:.|.||.:|
Human   135 VEEAERLRVQHLRDHPNYKYRPRRK-KQARKARR------LEPGLLLPGLAPPQPPPEPFPAASG 192

  Fly   284 -------VTPTRVQ----GQPGQNQS-LNGSGGSAAAAAAAAAAAAQQARQDMYQMNAPNGYMPN 336
                   :.|...:    |.|...:| |:|.....||.....||....|   :....||  |.|.
Human   193 SARAFRELPPLGAEFDGLGLPTPERSPLDGLEPGEAAFFPPPAAPEDCA---LRPFRAP--YAPT 252

  Fly   337 GYMMHADPAG------AAAYQTSYMGQHYAAQRYDMGHMYNNGYAMYQTVSGGQTSPYGSSLQQP 395
              .:..||.|      |.|.:|       |.....:..:|                 ||:.
Human   253 --ELSRDPGGCYGAPLAEALRT-------APPAAPLAGLY-----------------YGTL---- 287

  Fly   396 GSPSPYGGSSLQQQPGSPTPYGGGGGGGGQVSCQSHSPSDSSIKSEPVSPS 446
            |:|.||.|      |.||.|              ...|.:|   :||:.|:
Human   288 GTPGPYPG------PLSPPP--------------EAPPLES---AEPLGPA 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	SOX-TCF_HMG-box	178..249	CDD:238684	38/70 (54%)
SOX18	NP_060889.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..88		5/17 (29%)
		SOX-TCF_HMG-box	84..155	CDD:238684	38/70 (54%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P43680	87..100		9/12 (75%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P43680	111..123		6/11 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..218		22/78 (28%)
		Important for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:P43680	166..231		15/70 (21%)
		Sox_C_TAD	193..382	CDD:288887	39/181 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..312		9/41 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910