DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SoxN and sox17b.1

DIOPT Version :9

Sequence 1:	NP_001260269.1	Gene:	SoxN / 44275	FlyBaseID:	FBgn0029123	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_988849.1	Gene:	sox17b.1 / 394440	XenbaseID:	XB-GENE-484865	Length:	376	Species:	Xenopus tropicalis

Alignment Length:	362	Identity:	94/362 - (25%)
Similarity:	153/362 - (42%)	Gaps:	84/362 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 IGSHHMTSPVSHQQHTQQQQHGQQQHLGAGSALSSLTGGSSNNNNNSATANKNQQHADRVKRPMN 184
            :|.:..|.|::..|..:.::.       ||||          |:...|.|        |::||||
Frog    24 MGQYEWTDPLTMFQDAKTKKE-------AGSA----------NSRGKAEA--------RIRRPMN 63

  Fly   185 AFMVWSRGQRRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEHPDYKYR 249
            |||||::.:|:::|..||.:||:|:||.||..||.|:.:.||||::||:|||..|::::||||||
Frog    64 AFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKSLTLASKRPFVEEAERLRVQHIQDYPDYKYR 128

  Fly   250 PRRK--TKTLTKTKEKYPMGGLMPGQTVGGGAPGEPVTPTRVQGQPGQNQSLNGSGGSAAAAAAA 312
            ||||  .|.:.:.:|.:.....:||..|.|           .....|||..:..||.::..:...
Frog   129 PRRKKQVKRMKREEEGFLPSADIPGPQVMG-----------CNAMVGQNYKMQYSGQNSQQSQIT 182

  Fly   313 AAAAAQQARQDMYQ---MNAPNGYMPNGYMMHADPAGAAAYQTSYMGQHYAAQRYDMGHMYNNGY 374
            .|...:......|.   .|.|..||.....:...|.....||.             :.:.:|:.|
Frog   183 PAGYFEDHNPVGYYYRGYNVPEYYMSQNSSVTCGPPAQGEYQA-------------LSYNFNSSY 234

  Fly   375 AMYQTVSGGQTSPYGSSLQQPGSPSPYGGSSLQQQPG--------SPTPYGGGGGGGGQVSCQSH 431
            ..||         ..:|....|.......:.:|:.|.        ||..|.|          |.:
Frog   235 IPYQ---------QNASAPAMGKQMAVKENIIQESPEHGIMGCQVSPQMYNG----------QMY 280

  Fly   432 SPSDSSIKSEPVSPSPSAIALNNNNN-INNNHIMKRE 467
            .|  ...|:.||:.:....:|:.:.. :..|::..::
Frog   281 VP--ECAKTHPVAQTEQHSSLHQSQQMVTQNYLPSQQ 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	SOX-TCF_HMG-box	178..249	CDD:238684	38/70 (54%)
sox17b.1	NP_988849.1	SOX-TCF_HMG-box	57..128	CDD:238684	38/70 (54%)
		PABP-1234	<80..250	CDD:130689	58/202 (29%)
		Required for transcriptional activity and interaction with ctnnb1. /evidence=ECO:0000250\|UniProtKB:O42601	327..331
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1641977at2759
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020