DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SoxN and Sox15

DIOPT Version :9

Sequence 1:	NP_001260269.1	Gene:	SoxN / 44275	FlyBaseID:	FBgn0029123	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_523739.2	Gene:	Sox15 / 36575	FlyBaseID:	FBgn0005613	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	854	Identity:	174/854 - (20%)
Similarity:	289/854 - (33%)	Gaps:	257/854 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LTMESDMKGSLLHATMPPHHTSAALHGHA--ASPYSALAPLMNLGQSHLTHSQLSHHNHHHHHM- 63
            |..||:....:.|......|:|.:||..|  :|.|.         ..||..:.|:.|:|.|..|
  Fly    51 LMHESNSDAGIYHVRQGSEHSSPSLHSPAIQSSGYE---------NEHLNEAVLAAHSHSHSPMP 106

  Fly    64 ---SAHIAASQSPNPL-------------SSLQSSMANTLNGSQVGQQQQQQQQQQSSPLHSSS- 111
               ||::....:...|             |.|...:::...|...|...|.:.....||:.::|
  Fly   107 MVSSAYVGGGTASGSLINSNIPLLGGGGNSVLNKFLSHPHAGMVGGGTGQMEDCTSHSPIEAASM 171

  Fly   112 -------ELSPTQSSIGSHHMTSPVSHQQHTQQQQHGQQQHLGAGSALSSLTGGSSNNNNNSATA 169
                   :|..........|...|..                     |....||         |.
  Fly   172 WSYDYKGDLCAPNCGYLERHKPLPAD---------------------LKYRPGG---------TQ 206

  Fly   170 NKNQQHADRVKRPMNAFMVWSRGQRRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKR 234
            :|:.:.: |::|||||||||::.:|:|:|.:||.:||:::||.||.:|:.|:..::||:::||:|
  Fly   207 SKSAKES-RIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAER 270

  Fly   235 LRAVHMKEHPDYKYRPRRKTKTLTKTKEKYPMGGLMPGQTVGGGAPGEPVTPTRVQGQPGQNQSL 299
            ||.:||.|||:|||||||:.::        .:..:.||                  |:.....|.
  Fly   271 LRVIHMTEHPNYKYRPRRRKQS--------KLRAMQPG------------------GKEQSESSP 309

  Fly   300 N-GSGGS-----AAAAAAAAAAAAQQARQDMYQMNAPNGYMPNGYMMHADPAGAAAYQTSYMGQH 358
            | |:|||     .|....|.|:::.....|....|:.|       ..|........|:.. :...
  Fly   310 NPGTGGSKSNPKLATPPLATASSSYTTPTDESTCNSTN-------QNHGQSTPGGLYEQP-LKPT 366

  Fly   359 YAAQRYDMGHMYNNGYAMYQTVS---------GGQTSPYGSS------LQQPGSPSPYGGSSLQQ 408
            |:....|   .|:|..:..|..|         ..::||.|..      |::...|||...:..:|
  Fly   367 YSPSSVD---CYSNADSTEQIESLAANCPPALLNESSPTGGGYDNSLLLKKLTKPSPSRAAKSRQ 428

  Fly   409 Q---------------------------PGSPTPYGGGGGGGGQVSCQSHSPSD--SSIKS---E 441
            :                           |.:||........|..|:|.:....|  .|:|.   .
  Fly   429 EKLAKSEEKNKGSQSQGQSQQGIYAATYPLAPTSVAVVAARGMYVTCNNRGLLDHGHSVKGTFYP 493

  Fly   442 PVSPSPSAIALNNNNNINNNHIMKREYSSAAAAAAAAAAAAAAGGG------------------- 487
            |||.|..          :|:..|:...|:.........:..::.||
  Fly   494 PVSVSED----------DNSTSMRNSISALQQHCNVVTSTPSSSGGTMPTSEMSSYTVSMADNCG 548

  Fly   488 ----ELNHLMNMYHLPD------EQRHLLHYQTDSPDLQQQHQSMQQQQQHLPQQHLSQQHQQIP 542
                .:|.|....:||.      :....|.||::..|..   .|..:.::........|:..:.|
  Fly   549 NLRLSMNELSGNEYLPSANAYGMQYEDFLRYQSNDMDYS---TSAVEHKETTSDSASGQKCLKYP 610

  Fly   543 QQHHTMQQQQQQHHLQHQQSLRAMAPLAHMXEMASAYGAAGSSVSVSPPLPPYMPTA-PQQQQQQ 606
            ..:......:.:.:      ..||.|            |..:|.....|.||....| |.|....
  Fly   611 DTNQNYDDYEAEAY------SNAMLP------------ATAASYYTQLPYPPTSLAAFPLQLAVP 657

  Fly   607 QQQQQQLLNGRPSPTASGSSGGRSSAHSSGHTAAHSPALAAAYQLTPSAATSSATSAAAAAATAA 671
            .||           |.||:.|.:.......|...:......|.....:.|......|:.:|..:.
  Fly   658 FQQ-----------TTSGAYGAQPIQSGYLHYGNYGGYEGMAQSQPQNQAPVHHQQASHSAPPSL 711

  Fly   672 AVAAAAAAGSSFAASASMLDMQQQHLEEQQQHHHLHYQQQQ----------------QQHYQQQQ 720
            :|.......|:.||.:            .|||||.|:....                :..::|||
  Fly   712 SVPPNQTVTSNSAAIS------------MQQHHHHHFGPAPGMVGVGVGVGVGVGVGEMLFEQQQ 764

  Fly   721 QQQQQLQHL 729
            ::..::.::
  Fly   765 RKDDEISNI 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	SOX-TCF_HMG-box	178..249	CDD:238684	37/70 (53%)
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	37/70 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451313
Domainoid	1	1.000	49	1.000	Domainoid score	I4418
eggNOG	1	0.900	-	-		E1_KOG0527
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840