DRSC/TRiP Functional Genomics Resources

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Protein Alignment SoxN and HMGB2

DIOPT Version :10

Sequence 1:NP_001260269.1 Gene:SoxN / 44275 FlyBaseID:FBgn0029123 Length:761 Species:Drosophila melanogaster
Sequence 2:NP_002120.1 Gene:HMGB2 / 3148 HGNCID:5000 Length:209 Species:Homo sapiens


Alignment Length:104 Identity:28/104 - (26%)
Similarity:49/104 - (47%) Gaps:12/104 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   180 KRPMNAFMVWSRGQRRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEHP 244
            |||.:||.::....|.|:.|::|.:...:.:|:||..|.:.|..:|:|:..:|.:|:..:.|:..
Human    96 KRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIA 160

  Fly   245 DYKYRPRRKTKTLTKTKEKYPMGGLMPGQTVGGGAPGEP 283
            .|            :.|.|...|...||:..|.....||
Human   161 AY------------RAKGKSEAGKKGPGRPTGSKKKNEP 187

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SoxNNP_001260269.1 HMG-box_SoxB 177..252 CDD:438790 20/71 (28%)
HMGB2NP_002120.1 HMG-box_HMGB_rpt1 8..76 CDD:438794
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 52..150 17/53 (32%)
HMG-box_HMGB_rpt2 93..163 CDD:438795 20/78 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 162..209 9/38 (24%)
Required for chemotactic activity. /evidence=ECO:0000269|PubMed:19811285 165..180 5/14 (36%)
Blue background indicates that the domain is not in the aligned region.

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