DRSC/TRiP Functional Genomics Resources

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Protein Alignment SoxN and HMGB2

DIOPT Version :9

Sequence 1:NP_001260269.1 Gene:SoxN / 44275 FlyBaseID:FBgn0029123 Length:761 Species:Drosophila melanogaster
Sequence 2:NP_001124160.1 Gene:HMGB2 / 3148 HGNCID:5000 Length:209 Species:Homo sapiens


Alignment Length:104 Identity:28/104 - (26%)
Similarity:49/104 - (47%) Gaps:12/104 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   180 KRPMNAFMVWSRGQRRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEHP 244
            |||.:||.::....|.|:.|::|.:...:.:|:||..|.:.|..:|:|:..:|.:|:..:.|:..
Human    96 KRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIA 160

  Fly   245 DYKYRPRRKTKTLTKTKEKYPMGGLMPGQTVGGGAPGEP 283
            .|            :.|.|...|...||:..|.....||
Human   161 AY------------RAKGKSEAGKKGPGRPTGSKKKNEP 187

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SoxNNP_001260269.1 SOX-TCF_HMG-box 178..249 CDD:238684 20/68 (29%)
HMGB2NP_001124160.1 HMG_box_2 6..78 CDD:401091
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 52..150 17/53 (32%)
HMG_box 95..162 CDD:395407 19/65 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 162..209 9/38 (24%)
Required for chemotactic activity. /evidence=ECO:0000269|PubMed:19811285 165..180 5/14 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1641977at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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