DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SoxN and Meiosin

DIOPT Version :9

Sequence 1:	NP_001260269.1	Gene:	SoxN / 44275	FlyBaseID:	FBgn0029123	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_001357740.1	Gene:	Meiosin / 243866	MGIID:	3647482	Length:	589	Species:	Mus musculus

Alignment Length:	194	Identity:	38/194 - (19%)
Similarity:	76/194 - (39%)	Gaps:	51/194 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 HIAASQSPNPLSSLQSSMANTLNGSQVGQQQ-----------------QQQQQQQSSP--LHSSS 111
            :::.|::...||:..||..:|...|..||::                 |....||::|  |.:||
Mouse   372 YLSLSENVKVLSNCGSSSESTDTESLWGQEEVRGVATYPRRTGVFSLAQPSVLQQANPEGLQTSS 436

  Fly   112 E------LSPTQSSIGSHHMTSPVSHQQHTQQQQHGQQQHLGAGSALSSLTGGSSNNNNNSATAN 170
            :      .:||..|.|....:..:...|.:|                    |.....::..|...
Mouse   437 DEDRDYTWTPTGQSSGLPVASKKIKKVQASQ--------------------GPVKPKDSRKACPG 481

  Fly   171 KNQQHADRVKRPMNAFMVWSRGQRRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKR 234
            :.:      |:.:|.|:::.|..|::.....|...::..:|.|...|:.::..||:|:..:|:|
Mouse   482 QVK------KKCVNGFIMFCRMNRKQYIRACPGTASTAATKDLAQLWRGMTLEEKKPYCTKARR 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	SOX-TCF_HMG-box	178..249	CDD:238684	14/57 (25%)
Meiosin	NP_001357740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	14..27
		bHLH_SF	24..73	CDD:412148
		Helix-loop-helix motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	28..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..191
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..363
		NHP6B	416..>539	CDD:227935	28/148 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..457		10/34 (29%)
		HMG-box	484..539	CDD:238037	13/60 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	544..566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900