Protein Alignment SoxN and Sry

DIOPT Version :10

• Sequence 1: NP_001260269.1
• Gene: SoxN / 44275
• FlyBaseID: FBgn0029123
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_035694.1
• Gene: Sry / 21674
• MGIID: 98660
• Length: 395
• Species: Mus musculus
• Alignment Length: 593
• Identity: 151/593 - (25%)
• Similarity: 196/593 - (33%)
• Gaps: 266/593 - (44%)

  Fly   179 VKRPMNAFMVWSRGQRRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEH 243
            ||||||||||||||:|.|:|..||.|.|:||||:||.:||.|:|:|||||..||:||:.:|.:::
Mouse     5 VKRPMNAFMVWSRGERHKLAQQNPSMQNTEISKQLGCRWKSLTEAEKRPFFQEAQRLKILHREKY 69

  Fly   244 PDYKYRPRRKTKTLTKTKEKYPMGGLMPGQTVGGGAPGEPVTPTRVQG--QPGQNQSLNGSGGSA 306
            |:|||:|.|:.|...::      |.|.|.           |..|::..  |..:|..
Mouse    70 PNYKYQPHRRAKVSQRS------GILQPA-----------VASTKLYNLLQWDRNPH-------- 109

  Fly   307 AAAAAAAAAAAQQARQD------MYQMNAPNGY-----MPNGYMMHADPAGAAAYQTSYMGQHYA 360
                      |...|||      :|..|..:.|     :|.|   |.........|..:...|..
Mouse   110 ----------AITYRQDWSRAAHLYSKNQQSFYWQPVDIPTG---HLQQQQQQQQQQQFHNHHQQ 161

  Fly   361 AQRYDMGHMYNNGYAMYQTVSGGQTSPYGSSLQQPGSPSPYGGSSLQQQPGSPTPYGGGGGGGGQ 425
            .|::                       |....||            |||.              |
Mouse   162 QQQF-----------------------YDHHQQQ------------QQQQ--------------Q 177

  Fly   426 VSCQSHSPSDSSIKSEPVSPSPSAIALNNNNNINNNHIMKREYSSAAAAAAAAAAAAAAGGGELN 490
            ...|.|...                  ......:::|..::::..                   :
Mouse   178 QQQQFHDHH------------------QQKQQFHDHHQQQQQFHD-------------------H 205

  Fly   491 HLMNMYHLPDEQRHLLHYQTDSPDLQQQHQSMQQQQQHLPQQHLSQQHQQIPQ--QHHTMQQQQQ 553
            |    :|..::|.|..|.|      |||....|||||...||.....|||..|  .||..|||||
Mouse   206 H----HHHQEQQFHDHHQQ------QQQFHDHQQQQQQQQQQQFHDHHQQKQQFHDHHHHQQQQQ 260

  Fly   554 QH-HLQHQQSLRAMAPLAHMXEMASAYGAAGSSVSVSPPLPPYMPTAPQQQQQ---QQQQQQQLL 614
            .| |.|.||.........|...                       ..|||:||   ..|||||.
Mouse   261 FHDHQQQQQQFHDHQQQQHQFH-----------------------DHPQQKQQFHDHPQQQQQF- 301

  Fly   615 NGRPSPTASGSSGGRSSAHSSGHTAAHSPALAAAYQLTPSAATSSATSAAAAAATAAAVAAAAAA 679
                              |...|
Mouse   302 ------------------HDHHH------------------------------------------ 306

  Fly   680 GSSFAASASMLDMQQQHLEEQQQHH------HLHYQQQQQ--QHYQQQQQ-----QQQQLQHLPQ 731
                         |||..::...||      |.|:||:||  .|:|||||     ||||.|   |
Mouse   307 -------------QQQQKQQFHDHHQQKQQFHDHHQQKQQFHDHHQQQQQFHDHHQQQQQQ---Q 355

  Fly   732 QQQHQLYH 739
            |||.|.:|
Mouse   356 QQQQQQFH 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	HMG-box_SoxB	177..252	CDD:438790	46/72 (64%)
Sry	NP_035694.1	Sufficient for interaction with KPNB1. /evidence=ECO:0000250|UniProtKB:Q05066	4..81		47/75 (63%)
		HMG-box_SoxA_SoxB_SoxG	4..79	CDD:438837	46/73 (63%)
		Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q05066	6..22		14/15 (93%)
		Sufficient for interaction with EP300. /evidence=ECO:0000250|UniProtKB:Q05066	52..84		15/31 (48%)
		Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q05066	75..81		2/5 (40%)
		Necessary for interaction with ZNF208 isoform KRAB-O. /evidence=ECO:0000269|PubMed:15469996	92..144		14/83 (17%)
		Necessary for interaction with SLC9A3R2 and nuclear accumulation of SLC9A3R2. /evidence=ECO:0000269|PubMed:16166090	94..138		10/61 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..361		85/414 (21%)