Protein Alignment SoxN and Sox9

DIOPT Version :10

• Sequence 1: NP_001260269.1
• Gene: SoxN / 44275
• FlyBaseID: FBgn0029123
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_035578.3
• Gene: Sox9 / 20682
• MGIID: 98371
• Length: 507
• Species: Mus musculus
• Alignment Length: 626
• Identity: 154/626 - (24%)
• Similarity: 224/626 - (35%)
• Gaps: 191/626 - (30%)

  Fly    70 SQSPNPLSSLQSSMANTLNGSQVGQQQQQQQQQQSSPLHSSSELSPTQSSIGSHHMTSPVSHQQH 134
            |.:|:|..|..|:.:...:||  |...:..:.|:::......:|...     |.....||..::.
Mouse    19 SGAPSPTMSEDSAGSPCPSGS--GSDTENTRPQENTFPKGEPDLKKE-----SEEDKFPVCIREA 76

  Fly   135 TQQQQHGQQQHLGAGSALSSLTGGSSNNNNNSATANKNQQHADRVKRPMNAFMVWSRGQRRKMAS 199
            ..|...|....|   ..:.....|||          ||:.|   |||||||||||::..|||:|.
Mouse    77 VSQVLKGYDWTL---VPMPVRVNGSS----------KNKPH---VKRPMNAFMVWAQAARRKLAD 125

  Fly   200 DNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEHPDYKYRPRRKTKTLTKTKEKY 264
            ..|.:||:|:||.||..|:.|:|||||||::||:|||..|.|:||||||:|||:.
Mouse   126 QYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRK---------- 180

  Fly   265 PMGGLMPGQTVGGGAPGEPVT-PTRVQGQPGQNQSLNGSGGSAAAAAAAAAAAAQQARQDMYQMN 328
                    ....|.|..|..| .|.:               |..|...|..|.:..:...|.:::
Mouse   181 --------SVKNGQAEAEEATEQTHI---------------SPNAIFKALQADSPHSSSGMSEVH 222

  Fly   329 APNGYMPNGYMMHADPAGAAAYQTSYMGQHYAAQRYDMGHMYNNGYAMYQTVSGGQTSPYGSSLQ 393
            :|                         |:|                      ||          |
Mouse   223 SP-------------------------GEH----------------------SG----------Q 230

  Fly   394 QPGSPSP--------YGGSSLQQQPGSPTPYGGGGGGGGQVSCQSHSPSD--------------S 436
            ..|.|:|        ..|....::.|.|...||           ...|.|              |
Mouse   231 SQGPPTPPTTPKTDVQAGKVDLKREGRPLAEGG-----------RQPPIDFRDVDIGELSSDVIS 284

  Fly   437 SIKSEPVSPSPSAIALNNNNNINNNHIMKREYSSAAAAAAAAAAAAAAGGGELNHL-MNMYHLPD 500
            :|::..|:.....:..|.:..:...| .:..|:.:...::.|...|.||     |: |:....|
Mouse   285 NIETFDVNEFDQYLPPNGHPGVPATH-GQVTYTGSYGISSTAPTPATAG-----HVWMSKQQAP- 342

  Fly   501 EQRHLLHYQTDSPDLQQQHQSMQQQQQHLPQQHLSQQHQQIPQQH--HTMQQ------QQQQHHL 557
                        |...||.....|..|..|||....|..|.|||.  ||:..      |.|:.|:
Mouse   343 ------------PPPPQQPPQAPQAPQAPPQQQAPPQQPQAPQQQQAHTLTTLSSEPGQSQRTHI 395

  Fly   558 QHQQSLRAMAPLAHMXEMASAYGAAGSSVSVSP-PLPPYMPTAPQQQQQQQQQQQQLLNGRPSPT 621
            :.:|    ::| :|. |...   .:...:|.|| .||.|.|:.|...:.|........:|.....
Mouse   396 KTEQ----LSP-SHYSEQQQ---HSPQQISYSPFNLPHYSPSYPPITRSQYDYADHQNSGSYYSH 452

  Fly   622 ASGSSGGRSSAHSSGHTAAHSPALAAAYQLTPSAATSSATS 662
            |:|...|..|..:     ..:||....|  ||.|.||...|
Mouse   453 AAGQGSGLYSTFT-----YMNPAQRPMY--TPIADTSGVPS 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	HMG-box_SoxB	177..252	CDD:438790	46/74 (62%)
Sox9	NP_035578.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..67		11/54 (20%)
		Sox_N	22..94	CDD:463586	15/81 (19%)
		Dimerization (DIM). /evidence=ECO:0000250|UniProtKB:P48436	63..103		11/57 (19%)
		PQA. /evidence=ECO:0000250|UniProtKB:P48436	63..103		11/57 (19%)
		HMG-box_SoxE	104..178	CDD:438840	47/76 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..250		34/179 (19%)
		Transactivation domain (TAM). /evidence=ECO:0000250|UniProtKB:P48436	224..307		20/150 (13%)
		9aaTAD 1. /evidence=ECO:0000250|UniProtKB:P48436	275..284		0/8 (0%)
		9aaTAD 2. /evidence=ECO:0000250|UniProtKB:P48436	290..298		1/7 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..429		30/114 (26%)
		Transactivation domain (TAC). /evidence=ECO:0000250|UniProtKB:P48436	392..507		28/110 (25%)
		9aaTAD 3. /evidence=ECO:0000250|UniProtKB:P48436	458..466		2/12 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..507		5/10 (50%)