Protein Alignment SoxN and Sox18

DIOPT Version :9

• Sequence 1: NP_001260269.1
• Gene: SoxN / 44275
• FlyBaseID: FBgn0029123
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_033262.2
• Gene: Sox18 / 20672
• MGIID: 103559
• Length: 377
• Species: Mus musculus
• Alignment Length: 292
• Identity: 88/292 - (30%)
• Similarity: 131/292 - (44%)
• Gaps: 82/292 - (28%)

  Fly   173 QQHAD--RVKRPMNAFMVWSRGQRRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRL 235
            :|.||  |::|||||||||::.:|:::|..||.:||:.:||.||..||:|:.:|||||::||:||
Mouse    71 RQTADELRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNTAEKRPFVEEAERL 135

  Fly   236 RAVHMKEHPDYKYRPRRKTKTLTKTKEKYPMGGLMPGQTVGGGAPGEPVTPTRVQGQPGQNQSLN 300
            |..|:::||:|||||||| |...|.:...| |.|:|| .|...||.|
Mouse   136 RVQHLRDHPNYKYRPRRK-KQARKVRRLEP-GLLLPG-LVQPSAPPE------------------ 179

  Fly   301 GSGGSAAAAAAAAAAAAQQARQ--------DMYQMNAPNGYMPNGYMMHADPAGAAAYQTSYMGQ 357
                    |.|||:.:|:..|:        |...:..|.....:|    .:|..|:.:......:
Mouse   180 --------AFAAASGSARSFRELPTLGAEFDGLGLPTPERSPLDG----LEPGEASFFPPPLAPE 232

  Fly   358 HYAAQRYDMGHMYNNGYAMYQTVSGGQTSPYGSSLQQPGSPSPYGGSSLQQ-----QPGSPTP-- 415
            ..|.:.:                    .:||...|.:  .||...|:.|.:     .|.:|..
Mouse   233 DCALRAF--------------------RAPYAPELAR--DPSFCYGAPLAEALRTAPPAAPLAGL 275

  Fly   416 -YGGGGGGGGQVSCQSHSPSDSSIKSEPVSPS 446
             ||..|..|         |..:.:...|.|||
Mouse   276 YYGTLGTPG---------PFPNPLSPPPESPS 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	SOX-TCF_HMG-box	178..249	CDD:238684	38/70 (54%)
Sox18	NP_033262.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76		2/4 (50%)
		SOX-TCF_HMG-box	78..149	CDD:238684	38/70 (54%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:26939885	81..94		9/12 (75%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:26939885	105..117		6/11 (55%)
		Important for transcriptional activation. /evidence=ECO:0000269|PubMed:10742113, ECO:0000269|PubMed:7651823	160..225		20/96 (21%)
		Sox_C_TAD	187..375	CDD:288887	26/147 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910