DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SoxN and Sox10

DIOPT Version :9

Sequence 1:	NP_001260269.1	Gene:	SoxN / 44275	FlyBaseID:	FBgn0029123	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_035567.1	Gene:	Sox10 / 20665	MGIID:	98358	Length:	466	Species:	Mus musculus

Alignment Length:	600	Identity:	144/600 - (24%)
Similarity:	206/600 - (34%)	Gaps:	210/600 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 SQVGQQQQQQQQQQSSPLHSSSELSPTQSSIGSHHMTSPVSHQ--QHTQQQQHGQQQH----LGA 148
            |.||.::.:.....|:|     .|.|.....||....||...:  :..::||.|:...    :..
Mouse    13 SPVGSEEPRCLSPGSAP-----SLGPDGGGGGSGLRASPGPGELGKVKKEQQDGEADDDKFPVCI 72

  Fly   149 GSALSSLTGGSS----------NNNNNSATANKNQQHADRVKRPMNAFMVWSRGQRRKMASDNPK 203
            ..|:|.:..|..          |.      |:|::.|   |||||||||||::..|||:|...|.
Mouse    73 REAVSQVLSGYDWTLVPMPVRVNG------ASKSKPH---VKRPMNAFMVWAQAARRKLADQYPH 128

  Fly   204 MHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEHPDYKYRPRRKTKTLTKTKEKYPMGG 268
            :||:|:||.||..|:.|:||:|||||:||:|||..|.|:||||||:|||:..
Mouse   129 LHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKN------------- 180

  Fly   269 LMPGQTVGGGAPGEPVTPTRVQGQPGQNQSLNGSGGSAAAAAAAAAAAAQQARQDMYQMNAPNGY 333
                   |..|.||...|                ||
Mouse   181 -------GKAAQGEAECP----------------GG----------------------------- 193

  Fly   334 MPNGYMMHADPAGAAAYQTSYMGQHYAAQRYDMGHMYNNGYAMYQTVSGGQTSPYGSSLQQPGSP 398
                   .|:..||||.|..|...|...:..:.|...::|            :|...|.|..|.|
Mouse   194 -------EAEQGGAAAIQAHYKSAHLDHRHPEEGSPMSDG------------NPEHPSGQSHGPP 239

  Fly   399 SPYGGSSLQQQPGSPTPYGGG---GGGG-----------GQVSCQSHSPSDSSIKSE-----PVS 444
            :|......:.|.|...|...|   |.||           |::|.:..|..::...:|     |.:
Mouse   240 TPPTTPKTELQSGKADPKRDGRSLGEGGKPHIDFGNVDIGEISHEVMSNMETFDVTELDQYLPPN 304

  Fly   445 PSPSAIALNNNNNINNNHIMKREYSSAAAAAAAAAAAAAAGGGELNHLMNMYHLPDEQRHLLHYQ 509
            ..|..:.               .||:|.....:|.|.|:.....::....: .||
Mouse   305 GHPGHVG---------------SYSAAGYGLGSALAVASGHSAWISKPPGV-ALP---------- 343

  Fly   510 TDSP---DLQQQHQSMQQQQQHLPQQHLSQQHQQIPQQHHTMQQQQQQHHLQHQQSLRAMAPLAH 571
            |.||   |.:.|.::.....|..|              |:|.|....|              :|:
Mouse   344 TVSPPGVDAKAQVKTETTGPQGPP--------------HYTDQPSTSQ--------------IAY 380

  Fly   572 MXEMASAYGAAGSSVSVSP--------PLPPYMPTAPQQQ------QQQQQQQQQLLNGRPSPTA 622
            . .....||:|..|:| .|        |..||...|.|..      ......|:.|......|:.
Mouse   381 TSLSLPHYGSAFPSIS-RPQFDYSDHQPSGPYYGHAGQASGLYSAFSYMGPSQRPLYTAISDPSP 444

  Fly   623 SGSSGGRSSAHSSGH 637
            ||     ..:||..|
Mouse   445 SG-----PQSHSPTH 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	SOX-TCF_HMG-box	178..249	CDD:238684	44/70 (63%)
Sox10	NP_035567.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		14/58 (24%)
		Sox_N	12..93	CDD:403592	17/84 (20%)
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P56693	62..102		6/45 (13%)
		SOX-TCF_HMG-box	103..173	CDD:238684	44/72 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..200		21/111 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..275		15/73 (21%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P56693	228..310		19/81 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..375		10/44 (23%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P56693	353..466		26/135 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..466		6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	150	1.000	Inparanoid score	I4360
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860