DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SoxN and sox8a

DIOPT Version :9

Sequence 1:	NP_001260269.1	Gene:	SoxN / 44275	FlyBaseID:	FBgn0029123	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_001271361.1	Gene:	sox8a / 102216265	ZFINID:	ZDB-GENE-130530-719	Length:	401	Species:	Danio rerio

Alignment Length:	280	Identity:	96/280 - (34%)
Similarity:	133/280 - (47%)	Gaps:	64/280 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 KNQQHADRVKRPMNAFMVWSRGQRRKMASDNPKMHNSEISKRLGAQWKDLSESEKRPFIDEAKRL 235
            |::.|   |||||||||||::..|||:|...|.:||:|:||.||..|:.|||||||||::||:||
Zfish    81 KDKPH---VKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERL 142

  Fly   236 RAVHMKEHPDYKYRPRRK--------------TKTLTKTKEKYPM-GGL--MPGQTVGG----GA 279
            |..|.|::|||||:|||:              .|.|..|...|.. .|:  |..||:.|    |.
Zfish   143 RLQHKKDYPDYKYQPRRRKSLKPGQNEAEAGAEKNLHHTDPIYKTEAGMRAMHHQTIHGVQPHGP 207

  Fly   280 PGEPVTPTRVQGQ------PGQNQSLNGSGGSAAAAAAAAAAAAQQARQDMYQMNAPNGYMP-NG 337
            |..|.||...|.|      ....|:::.|....:..::....:..|     :.:...:.|:| ||
Zfish   208 PTPPTTPKSDQHQSMKRLSENARQNIDFSNVDISELSSDVIGSISQ-----FDVREFDQYLPLNG 267

  Fly   338 YMMHADPAGAAAYQTSYMGQHYAAQRYDMGHMYNNGYAMYQTVSGGQTSPYGSSLQQPG------ 396
               |.:..|         |||.:...:.....:::|.:.:...||   ||..||..|..
Zfish   268 ---HTESGG---------GQHSSPGCFSTSFHHHSGASAWNKPSG---SPSTSSANQQRPLIKTE 317

  Fly   397 --SPSPYGGSSLQQQPGSPT 414
              |||.||     |..||||
Zfish   318 QLSPSHYG-----QSHGSPT 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	SOX-TCF_HMG-box	178..249	CDD:238684	44/70 (63%)
sox8a	NP_001271361.1	Sox_N	<40..73	CDD:372113
sox8a	NP_001271361.1	SOX-TCF_HMG-box	85..155	CDD:238684	44/72 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910