DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SoxN and HMGXB4

DIOPT Version :9

Sequence 1:	NP_001260269.1	Gene:	SoxN / 44275	FlyBaseID:	FBgn0029123	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_006724164.1	Gene:	HMGXB4 / 10042	HGNCID:	5003	Length:	603	Species:	Homo sapiens

Alignment Length:	281	Identity:	59/281 - (20%)
Similarity:	109/281 - (38%)	Gaps:	55/281 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 QSHLTHSQLSHHNHHHHHMS----------AHIAASQSPN-PLSSLQ-------SSMANTLNGSQ 91
            ||.|..::..|.:....|.|          :..|.|.|.| .||.|:       ||....|...:
Human   285 QSFLKTARKKHKSSSDAHSSPGPEGCGSDASQFAESHSANLDLSGLEPILVESDSSSGGELEAGE 349

  Fly    92 V-----------GQQQQQQQQQQSSPLHSSSELSPTQSSIGSHHMTSPVSHQQHTQQQQHGQQQH 145
            :           .::.::.::::....|.....|.::.|:|...:  ||.....|.    |....
Human   350 LVIDDSYREIKKKKKSKKSKKKKDKEKHKEKRHSKSKRSLGLSAV--PVGEVTVTS----GPPPS 408

  Fly   146 LG-AGSALSSL------TGGSSNNNNNSATANKNQQHADRVKRP-MNAFMVWSRGQRRKMASDNP 202
            :. ||:|...|      |.|.|.........:|.::..::.|:. |:|:.|:.:..|..:.:|:|
Human   409 IPYAGAAAPPLPLPGLHTDGHSEKKKKKEEKDKERERGEKPKKKNMSAYQVFCKEYRVTIVADHP 473

  Fly   203 KMHNSEISKRLGAQWKDLSESEKRPFIDEAKRLRAVHMKEHPDYKYRPRRKTKTLTKTKEKYPMG 267
            .:...|:||:|...||.|.|.:|..:..:|:.|           :::..:...|..|.|.....|
Human   474 GIDFGELSKKLAEVWKQLPEKDKLIWKQKAQYL-----------QHKQNKAEATTVKRKASSSEG 527

  Fly   268 GL-MPGQTVGGGAPGEPVTPT 287
            .: :...:||..:|.:...||
Human   528 SMKVKASSVGVLSPQKKSPPT 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SoxN	NP_001260269.1	SOX-TCF_HMG-box	178..249	CDD:238684	18/71 (25%)
HMGXB4	XP_006724164.1	DUF4171	150..268	CDD:290491
HMGXB4	XP_006724164.1	HMG-box	450..513	CDD:238037	18/73 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1641977at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920