DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment disp and PTCH2

DIOPT Version :9

Sequence 1:	NP_524734.2	Gene:	disp / 44274	FlyBaseID:	FBgn0029088	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_003729.3	Gene:	PTCH2 / 8643	HGNCID:	9586	Length:	1203	Species:	Homo sapiens

Alignment Length:	1043	Identity:	202/1043 - (19%)
Similarity:	344/1043 - (32%)	Gaps:	333/1043 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 VVQRIGPNATDSLFDLNGLLAMCQLQDQITEVPSY--RAFCEPEMLTTECCRPWSLPNYAAMLAN 319
            :::.:||.|:     |.|..   :|.|:.....:|  |....|:.|  .|  |.|.||:.:..|.
Human   221 LLEELGPFAS-----LEGFR---ELLDKAQVGQAYVGRPCLHPDDL--HC--PPSAPNHHSRQAP 273

  Fly   320 KSSCFDLTTEDVTSLHTLLLGCYEYFHDLKMDNHCNEI---PHCRAPE----ECKRLNIVFNVL- 376
            ..:            |.|..||:.:.|  |..:...|:   ...|.|:    ..:.|...|.::
Human   274 NVA------------HELSGGCHGFSH--KFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMS 324

  Fly   377 ----------NFLT-DFSFIKSNDSNVYLKYAMIFIPVAQSNRLLP-----LFHEWEDVELINEL 425
                      ::.| |..:.:...|.|...:...|:.:||  ..||     ..|.:....|.:.|
Human   325 PRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQ--EALPENASQQIHAFSSTTLDDIL 387

  Fly   426 VEVVAMDLGLENELFNELLLTDVWLVSLGGTFVMASVWLYT----------GSAFI--TLMSCVA 478
                        ..|:|:....|    :||..:|.:....|          ||..:  .|:..:|
Human   388 ------------HAFSEVSAARV----VGGYLLMLAYACVTMLRWDCAQSQGSVGLAGVLLVALA 436

  Fly   479 ICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGADDVFLFLKIWHCVLTERFSNRCTLTTQS 543
            :...|||     ..:|...|......:...:.:|||.|||||        |...|:
Human   437 VASGLGL-----CALLGITFNAATTQVLPFLALGIGVDDVFL--------LAHAFT--------- 479

  Fly   544 QSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVV 608
             .|||       ...|:..|...::....|:.:||:....||..:....|.|::.|.:.|..||.
Human   480 -EALP-------GTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVG 536

  Fly   609 TNYLLMITWLPASVSI-MERLFATRMS---C-HHPMSIKLIHACKKS------------INRFCQ 656
            ..::.::...||.:|: :.|....|:.   | ..|.|.::|....:.            :....|
Human   537 CTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGDGTVPVGIAHLTATVQ 601

  Fly   657 MFEEC----------------------------------ITKSIM-------------------- 667
            .|..|                                  .|:.::
Human   602 AFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTRDLLGQEEETRQKAACKSLPCARW 666

  Fly   668 NYAY-----------------LWLLIFGA-LGASSAVIVFWYPGLQLPE------KSHFQLFVSK 708
            |.|:                 :.|::||| ||.|.........||.|.:      |.|..|....
Human   667 NLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQL 731

  Fly   709 HPFEVYS-SLKQQFWFEKPLQAYENFKMHMHF----------------VW---------GVQAVD 747
            ..|.:|. :|..|..|:........|.:|..|                .|         |:||..
Human   732 RYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRNWLQGIQAAF 796

  Fly   748 DGDYTNPNSYGHLHYDNNFNVSSRPAQLWI--------LDFCQSVRQQPFYKETLGMLLPNCFIE 804
            |.|:.:.....| .|.|.....:...:|.|        |||.|...::...:|  |::.|..|..
Human   797 DQDWASGRITRH-SYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDRE--GLIPPELFYM 858

  Fly   805 NLIDYMKRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISNMYDTTFFRPGVAGPKFAEA 869
            .|..::.           .|......:|..|.|.     .|:.:.:.||||           .|.
Human   859 GLTVWVS-----------SDPLGLAASQANFYPP-----PPEWLHDKYDTT-----------GEN 896

  Fly   870 PRLETEDYLGMSGNESAEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQL 934
            .|:.....|     |.|::       |.|::.|              .....|.|::|     ..
Human   897 LRIPPAQPL-----EFAQF-------PFLLRGL--------------QKTADFVEAIE-----GA 930

  Fly   935 KTAPPEL-QGGWFT----SDLKFYNVQDTLSHDTFVAICLAMAASL---AVLLC--FTVNILISI 989
            :.|..|. |.|...    |...|:.....|.....:|:|:.:..:.   |:||.  :|..:::.:
Human   931 RAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLV 995

  Fly   990 YAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFV 1054
            .|::||.|     ..::..||.:|:.:..:.:..::|:.|:|::|..:.:..:.....|.|.. .
Human   996 LAMMTVEL-----FGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAAH-A 1054

  Fly  1055 LSRIIGPTVMAATTTGLAGGIMMASNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRVAGPQHGF 1119
            |.....|....|.:| |.|.:|:|.:...:           ||.:|:|...:::||   |..||.
Human  1055 LEHTFAPVTDGAIST-LLGLLMLAGSHFDF-----------IVRYFFAALTVLTLL---GLLHGL 1104

  Fly  1120 LEL 1122
            :.|
Human  1105 VLL 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	155/817 (19%)
		MMPL	457..627	CDD:304422	40/182 (22%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	31/149 (21%)
PTCH2	NP_003729.3	2A060602	12..1142	CDD:273338	202/1043 (19%)
		Sterol-sensing	418..570	CDD:289145	41/181 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1171..1203
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154919
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930