Protein Alignment disp and DISP2

DIOPT Version :10

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_277045.1
• Gene: DISP2 / 85455
• HGNCID: 19712
• Length: 1401
• Species: Homo sapiens
• Alignment Length: 1235
• Identity: 353/1235 - (28%)
• Similarity: 543/1235 - (43%)
• Gaps: 245/1235 - (19%)

  Fly    12 YYHVLARRPYLVVVSIAVYCVA----CIIVALVLNKLPDFSDPTLGFETRGTKIGERLTAWYNLL 72
            |..::|..|    |::.:.|:|    |.:..|:..:|||||.|.||||.|.|.||.:|..|..|.
Human   161 YSQLIAEWP----VAVLMLCLAVIFLCTLAGLLGARLPDFSKPLLGFEPRDTDIGSKLVVWRALQ 221

  Fly    73 QETDHHGALFSNPSDLWERRRVEQGYVETKLHPNHRRRKNKHKNRNKNKRRKEQNQSSHEHHDVA 137
            ..|.....||.:| ||                                    |.|.||..:
Human   222 ALTGPRKLLFLSP-DL------------------------------------ELNSSSSHN---- 245

  Fly   138 QKMMQFKKRLKATSSPSPNLGFDTWIGDSGVFRDYEITNDSASSSLEPTRRTEQIEYGHNTTSVD 202
                        |..|:|.                   ..:..|::.|.|..|.:|
Human   246 ------------TLRPAPR-------------------GSAQESAVRPRRMVEPLE--------- 270

  Fly   203 EEEHQQRVQTKKSTWRLLKQAATLPTDGWADMHRRQPIEGFFCDSSPRKEYSHFVVQRIGPNATD 267
                                            .|||  |.||| ..|.|.|:..|..   ..::.
Human   271 --------------------------------DRRQ--ENFFC-GPPEKSYAKLVFM---STSSG 297

  Fly   268 SLFDLNGLLAMCQL-QDQITEVPSYRAFCEPEMLTTECCRPWSLPNYAAMLANKSSCFDLTTEDV 331
            ||::|:.:.:||:: ||||....|:.|.|: .....:||..|||.||.|:|:|:|||.|.|..|.
Human   298 SLWNLHAIHSMCRMEQDQIRSHTSFGALCQ-RTAANQCCPSWSLGNYLAVLSNRSSCLDTTQADA 361

  Fly   332 TSLHTLLLGCYEYFHDLKMDNHC-----NEIPHC-RAPEECKRLNIVFNVLNFLTDFSFI--KSN 388
            .....||..|..|:|...:...|     |:.|.| :.|.:|.:.:.::.:|:||.|..|:  ::.
Human   362 ARTLALLRTCALYYHSGALVPSCLGPGQNKSPRCAQVPTKCSQSSAIYQLLHFLLDRDFLSPQTT 426

  Fly   389 DSNV-YLKYAMIFIPVAQSNRLLPLFHE-----WEDVELINELVEVVAMDLGLENELFNELLLTD 447
            |..| .|||:::|:|..:...|:.::.:     |   .|.:....|..|||||:.||....|:.|
Human   427 DYQVPSLKYSLLFLPTPKGASLMDIYLDRLATPW---GLADNYTSVTGMDLGLKQELLRHFLVQD 488

  Fly   448 VWLVSLGGTFVMASVWLYTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIG 512
            .....|....:...:.||..|.|:|||..:.:..||.:|:|.|.:.....:||::||.|::::..
Human   489 TVYPLLALVAIFFGMALYLRSLFLTLMVLLGVLGSLLVAFFLYQVAFRMAYFPFVNLAALLLLSS 553

  Fly   513 IGADDVFLFLKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVT 577
            :.|:...:|..:|..               |:|.||       :..|...:..||.|....:.|:
Human   554 VCANHTLIFFDLWRL---------------SKSQLP-------SGGLAQRVGRTMHHFGYLLLVS 596

  Fly   578 SLTTAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSIMERLFAT--------RMS 634
            .|||:.||||||.|.:.|::|..:|.||.|:.:..|.:.|||||..:.||..|.        |..
Human   597 GLTTSAAFYASYLSRLPAVRCLALFMGTAVLVHLALTLVWLPASAVLHERYLARGCARRARGRWE 661

  Fly   635 CHHPMSIKL-IHACKKSINRFCQ-----MFEECITKSIMNYAYLWLLIFGALGASSAVIVFWYPG 693
            ...|..:.| :|...:.:.|...     :|:..:...::.:.|:|:..|.||.|..|.|....|.
Human   662 GSAPRRLLLALHRRLRGLRRAAAGTSRLLFQRLLPCGVIKFRYIWICWFAALAAGGAYIAGVSPR 726

  Fly   694 LQLP--EKSHFQLFVSKHPFEVY-SSLKQQFWFEKPLQAYENFKMHMHFVWGVQAVDDGDYTNPN 755
            |:||  .....|:|...||||.: :..:|.|.||: |...|...|.:..||||..||.||..:|.
Human   727 LRLPTLPPPGGQVFRPSHPFERFDAEYRQLFLFEQ-LPQGEGGHMPVVLVWGVLPVDTGDPLDPR 790

  Fly   756 SYGHLHYDNNFNVSSRPAQLWILDFCQSVRQQPFYKETLGMLLPN-CFIENLIDYMKRRCIDDMD 819
            |...|..|..|:.|...||.|:|..|...|.|.|: :||....|. ||:|.|     :|.::...
Human   791 SNSSLVRDPAFSASGPEAQRWLLALCHRARNQSFF-DTLQEGWPTLCFVETL-----QRWMESPS 849

  Fly   820 STRKDRSPCC-DAQFPFEPHIFEYCLPQSISNMYDTTFFRPGVAGPKFAEAPRLETEDYLGMSGN 883
            ..|.....|| .:.||:.|..|.:||.......           ||.       .|:| ||:
Human   850 CARLGPDLCCGHSDFPWAPQFFLHCLKMMALEQ-----------GPD-------GTQD-LGL--- 892

  Fly   884 ESAEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQLKTAPPELQGGWFTS 948
               .:..:||     :.|||::|::|...|..|...:.||..|.||...:|..|||.|:.|||||
Human   893 ---RFDAHGS-----LAALVLQFQTNFRNSPDYNQTQLFYNEVSHWLAAELGMAPPGLRRGWFTS 949

  Fly   949 DLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQL 1013
            .|:.|::|.:||.:..|.:.||:|.:.|.||..|.|:.:|:::|..|:.::..||.:|:||.|||
Human   950 RLELYSLQHSLSTEPAVVLGLALALAFATLLLGTWNVPLSLFSVAAVAGTVLLTVGLLVLLEWQL 1014

  Fly  1014 NILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMA 1078
            |..|::.:|.::||:|||:::|.|.|.:.|..:||:...|.|.:....|.:.|.....||.:|:.
Human  1015 NTAEALFLSASVGLSVDFTVNYCISYHLCPHPDRLSRVAFSLRQTSCATAVGAAALFAAGVLMLP 1079

  Fly  1079 SNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRVAGPQHGFLELKWPL----WSKRSS--GSSKF 1137
            :.:|.|.::|:.|::|..||..:|:||..||....||:....::.||.    |...:.  |..|.
Human  1080 ATVLLYRKLGIILMMVKCVSCGFASFFFQSLCCFFGPEKNCGQILWPCAHLPWDAGTGDPGGEKA 1144

  Fly  1138 YERKPSQVIASEQLLTPTSSAIVELANSETHELESL---NSNSLIKTISGIESAHALSSLPRDFE 1199
            ...:|..|..     .|.|.       ||.:||:.|   .|.|...:.:..:.:|..|.|..|.:
Human  1145 GRPRPGSVGG-----MPGSC-------SEQYELQPLARRRSPSFDTSTATSKLSHRPSVLSEDLQ 1197

  Fly  1200  1199
            Human  1198  1197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	MMPL	<395..1115	CDD:440656	230/743 (31%)
DISP2	NP_277045.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..91
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..138
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	241..264		7/57 (12%)
		Sterol-sensing	<574..639	CDD:463544	25/71 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1169..1192		4/22 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1229..1337
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1352..1401