DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment disp and Ptchd3

DIOPT Version :9

Sequence 1:	NP_524734.2	Gene:	disp / 44274	FlyBaseID:	FBgn0029088	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_083325.1	Gene:	Ptchd3 / 74675	MGIID:	1921925	Length:	906	Species:	Mus musculus

Alignment Length:	861	Identity:	162/861 - (18%)
Similarity:	284/861 - (32%)	Gaps:	322/861 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 EDVTSLHTLLLGCYEYFHDLKMDNHCNEIPHCRAPEECKRLNIVFNVLNFLTDFSFIKSNDSNVY 393
            ||.......|....::|:|:|......||.           .:.|:.|:...:|.
Mouse   290 EDSERSQAWLTHFLDHFNDMKSSLTLEEIE-----------VVYFSSLSRQLEFE---------- 333

  Fly   394 LKYAMIFIPVAQSNRLLPLFHEWEDVELINELVEVVAMDLGLENELFNELLLTDVWLVSLGGTFV 458
                      |.|..::||||....:.::..:|....:|. :.|::          .|::.|.|.
Mouse   334 ----------ATSKTVIPLFHLAYILIILFAVVSCSRLDC-IRNKM----------CVAVFGVFS 377

  Fly   459 MASVWLYTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGADDVFLFLK 523
            :|          ::::|...:...||:.  |..||....|          :|:|:|.||:|:.:.
Mouse   378 VA----------MSVVSGFGLMLHLGVP--FVIIVANSPF----------LILGVGVDDMFIMIS 420

  Fly   524 IWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYAS 588
            .|.            .|:.|:|....|.||             ....|.|:.:|::|...|||..
Mouse   421 AWQ------------KTSLSESIRERLSNS-------------YSKVAVSITITTITNVLAFYTG 460

  Fly   589 YSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSI---------------MERLFATRMSC--- 635
            .:||..:::.|.|:.||.::..|...||...|.:::               .::..:.:.||
Mouse   461 ITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAVMALDGKREVAWSRWLEKPDQKYSSLKKSCCVP 525

  Fly   636 -----------HHPMSIKLIHACKKSINRFCQMFEECITKSIMNYAYLWLLIFGALGASSAVIVF 689
                       :|||::           .|...|...:|.|...:..:.|.||       .:|..
Mouse   526 FGSLIDKHGEDNHPMNL-----------FFRDYFGPFLTTSKAKFIVVLLYIF-------YIISS 572

  Fly   690 WYPGLQLPEKSHFQLFVSKHPF-EVYSSLKQQFWFEKPLQAYENFKMHMHFVWGVQAVDDGDY-- 751
            .|...|:.|....:...|...: ..|.::::.::                          .||
Mouse   573 IYGCFQVQEGLDLRNLASDDSYITPYFNVEEDYF--------------------------SDYGP 611

  Fly   752 ------TNPNSYGHLHYDNNFNVSSRPAQLWILDFCQSVRQQPFYKETLGMLLPNCFIENLIDYM 810
                  |...:|    :||:....        ||.|.:..::..|.:           :||.::.
Mouse   612 RVMVIVTESVNY----WDNDVRQK--------LDKCMTQFEENEYVD-----------KNLTEFW 653

  Fly   811 KRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISNMYDTTFFRPGVAGPKFAEAPRLETE 875
            ....:..|:|                          |.:|..|...|...:||  |.:...:.|.
Mouse   654 LEAYMQYMNS--------------------------SGNNPNDKNTFMNNIAG--FLQFFPIFTY 690

  Fly   876 DYLGMSGNESAEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQLKTAPPE 940
            |....|.||..  |:.|...       :::..|:.....:...:|...|:.|         .|
Mouse   691 DINISSSNEIT--SSRGFIQ-------IVDVSSSSNKKRMLLKLRSIAENCE---------VP-- 735

  Fly   941 LQGGWFTSDLKFYNVQDTLSHDTFVAIC-----LAMAASLAVLLCFTVNILISIYAVLTVSLSIF 1000
                     |..|| |..:..|.:.||.     ..|.||.|:   |.|::|:..:.|    .|::
Mouse   736 ---------LMVYN-QAFIYFDQYAAIIENTVRNVMIASTAM---FIVSLLLIPHPV----CSLW 783

  Fly  1001 NTVAVL-ILLG-------WQLNILESIAVST---AIGLAVDFSLHYGIHYRM------SPVKERL 1048
            .|.|:. :::|       |.:| |:||::..   .||.:.|||.|  |.|..      |..|:.:
Mouse   784 VTFAIASVIVGVTGFMAFWNVN-LDSISMINLVICIGFSFDFSAH--ISYAFVSSTEPSVNKKSI 845

  Fly  1049 AA--------TQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYIQIGVFLVVVMIVSWFYATFF 1105
            .|        .|..:|.|||..|::|..                             ::.:.|||
Mouse   846 EALYLLGYPVLQSAISTIIGVCVLSAAK-----------------------------AYIFRTFF 881

  Fly  1106 -LMSLLRVAGPQHGFL 1120
             :|.|:...|..||.:
Mouse   882 KIMFLVMFFGAAHGLI 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	139/735 (19%)
		MMPL	457..627	CDD:304422	39/184 (21%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	41/175 (23%)
Ptchd3	NP_083325.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70
		Patched	127..906	CDD:280598	162/861 (19%)
		MMPL	363..503	CDD:304422	42/197 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845386
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840