Protein Alignment disp and Disp1

DIOPT Version :10

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_036009284.1
• Gene: Disp1 / 68897
• MGIID: 1916147
• Length: 1557
• Species: Mus musculus
• Alignment Length: 1210
• Identity: 377/1210 - (31%)
• Similarity: 596/1210 - (49%)
• Gaps: 234/1210 - (19%)

  Fly    12 YYHVLARRPYLVVVSIAVYCVACIIVALVLNKLPDFSDPTLGFETRGTKIGERLTAWYNLLQETD 76
            |..:||..|.:|:....:..|.|.:|.:::.:|||||||.||||.|||.||:||..|.|:::.|.
Mouse   216 YAALLADWPVVVLGMCTLLIVVCALVGVLVPELPDFSDPLLGFEPRGTTIGQRLVTWNNMMRNTG 280

  Fly    77 HHGALFSNPSDLWERRRVEQGYVETKLHPNHRRRKNKHKNRNKNKRRKEQNQSSHEHHDVAQKMM 141
            :...|.:.|                                  .|..:||.:|   |.|
Mouse   281 YKATLANYP----------------------------------YKYAEEQARS---HRD------ 302

  Fly   142 QFKKRLKATSSPSPNLGFDTWIGDSGVFRDYEITNDSASSSLEPTRRTEQIEYGHNTTSVDEEEH 206
                              |.|                                        .::|
Mouse   303 ------------------DRW----------------------------------------SDDH 309

  Fly   207 QQRVQTKKSTWRLLKQAATLPTDGWADMHRRQPIEGFFCDSSPRKEYSHFVVQRIGPNATDSLFD 271
            .:| :.::..|...|                   :.|||| .|...||..|....|   .::|::
Mouse   310 HER-ERREVDWNFQK-------------------DSFFCD-VPSDGYSRVVFASAG---GETLWN 350

  Fly   272 LNGLLAMCQLQD-QITEVPSYRAFCEPEMLTTECCRPWSLPNYAAMLANKSSCFDLTTEDVTSLH 335
            |..:.:||.:.: :|...|.:...|: ......||..|:|.||.|:|.|:|||..:...||:...
Mouse   351 LPAIKSMCDVDNSRIRSHPQFSDLCQ-RTTAVSCCPSWTLGNYIAILNNRSSCQKIVERDVSHTL 414

  Fly   336 TLLLGCYEYFHDLKMDNHC--------NEIPHCRAPEECKRLNIVFNVLNFLTDFSFI--KSNDS 390
            .||..|.:::.:..:...|        :::.....|.:|.:.|.|:.:|::|.|..|:  |:.|.
Mouse   415 KLLRTCAKHYQNGTLGPDCWDKAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMTPKTADY 479

  Fly   391 NV-YLKYAMIFIPVAQSNRLLPL----FHEWEDVELINELVEVVAMDLGLENELFNELLLTDVWL 450
            .| .|||:|:|.|..:...::.:    |..|...:   .:..|..::.|:::.||.:.||.|...
Mouse   480 AVPALKYSMLFSPTEKGESMMNIYLDNFENWNSSD---GITTVTGIEFGIKHSLFQDYLLMDTVY 541

  Fly   451 VSLGGTFVMASVWLYTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGA 515
            .::....|:..:.:||.|.|||||:..||..||.::||.|.:|..|||||:|||.|:::::||||
Mouse   542 PAIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFNFEFFPFMNLTALIILVGIGA 606

  Fly   516 DDVFLFLKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLT 580
            ||.|:...:|:....::               |..|.|:       .:::|::|||.||||||.|
Mouse   607 DDAFVLCDVWNYTKFDK---------------PRAETSE-------AVSVTLQHAALSMFVTSFT 649

  Fly   581 TAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSIMERLFATRMSC-HHPMSIKLI 644
            ||.||||:|.|:||||:|||::|||.::.||:||:|||||.:.:.||......:| ..|......
Mouse   650 TAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERYLLNIFTCFRKPQPQAYD 714

  Fly   645 HACKKSINRFCQ------------MFEECITKSIMNYAYLWLLIFGALGASSAVIVFWYPGLQLP 697
            .:|...:.:.|:            .||:.:...::.:.||||:.|.||....|.||...|.::||
Mouse   715 KSCWAVLCQKCRRVLFAVSEASRIFFEKVLPCIVIKFRYLWLIWFLALTVGGAYIVCVNPKMKLP 779

  Fly   698 --EKSHFQLFVSKHPFEVY-SSLKQQFWFEKPLQAYENFKMHMHF--VWGVQAVDDGDYTNPNSY 757
              |.|.||:|.|.||||.| :..|:.|.||:   .:...::||..  :|||...|.||..||.|.
Mouse   780 SLELSEFQVFRSSHPFERYDAEFKKLFMFER---VHHGEELHMPITVIWGVSPEDSGDPLNPKSK 841

  Fly   758 GHLHYDNNFNVSSRPAQLWILDFCQSVRQQPFYKETLGMLLPNCFIENLIDYMKRRCIDDMDSTR 822
            |.|..|:.||::|..:|.|||.|||.:|.|.|:.:|......:||||....:|     ::.|...
Mouse   842 GELTLDSTFNIASPASQAWILHFCQKLRNQTFFHQTEQQDFTSCFIETFKQWM-----ENQDCDE 901

  Fly   823 KDRSPCCD-AQFPFEPHIFEYCLPQSISNMYDTTFFR-----PGVAGPKFAEAPRLETEDYLGMS 881
            ....|||. ..||::..:||.|:.::|..:..:|.:.     ||         ||.:..|
Mouse   902 PALYPCCSHCSFPYKQEVFELCIKKAIMELDRSTGYHLNNKTPG---------PRFDIND----- 952

  Fly   882 GNESAEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQLKTAPPELQGGWF 946
                            .::|:|:||:|...::..|..::|||:.|:.|...:|.:||..|..|||
Mouse   953 ----------------TIRAVVLEFQSTFLFTLAYEKMQQFYKEVDSWISHELSSAPEGLSRGWF 1001

  Fly   947 TSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGW 1011
            .|:|:||::||:||..|.:|:.|::|.:.:|:|..|.||:||:||:::::.:||.||..|:||||
Mouse  1002 VSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGW 1066

  Fly  1012 QLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIM 1076
            :||:|||:.:|.|:||:|||::|||:.||::|..:|.....|.|||:.....|||.||.:||.:|
Mouse  1067 ELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMM 1131

  Fly  1077 MASNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRVAGPQHGFLELKWPLWSKRS----SGSSKF 1137
            |.|.:|.|.|:|.|:::||.|||.:||||...|.|..|||....::.:|...:.|    :.|::.
Mouse  1132 MPSTVLAYTQLGTFMMLVMCVSWAFATFFFQCLCRCLGPQGTCGQIPFPTKLQCSPFSHTLSARP 1196

  Fly  1138 YERKPSQVIASEQLLTPTSSAIVELANSETHELESLNSNS 1177
            .:|.||:..|:............:|.: |.:||:.|.|:|
Mouse  1197 GDRGPSKTHAASAYSVDARGQKSQLEH-EFYELQPLASHS 1235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	MMPL	<395..1115	CDD:440656	271/747 (36%)
Disp1	XP_036009284.1	MMPL	<531..1170	CDD:440656	261/698 (37%)