Protein Alignment disp and Ptchd4

DIOPT Version :9

• Sequence 1: NP_524734.2
• Gene: disp / 44274
• FlyBaseID: FBgn0029088
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_001342199.1
• Gene: Ptchd4 / 627626
• MGIID: 1920485
• Length: 904
• Species: Mus musculus
• Alignment Length: 665
• Identity: 122/665 - (18%)
• Similarity: 225/665 - (33%)
• Gaps: 201/665 - (30%)

  Fly   576 VTSLTTAGAFY---ASYSSSITAIKCFGIFAGTVVVTNYLLMITW------LPASVSIMERLFAT 631
            ::..|.||.|:   ..|:|::..|..|.:..||..|  :.|:..|      ||....:.:.....
Mouse   332 ISIATAAGIFFITDGKYNSTLLGIPFFAMGHGTKGV--FELLSGWRRTKENLPFKDRVADAYSDV 394

  Fly   632 RMSCHHPMSIKLI--------HACKKSINRFCQMFEECITKSIMNYAYLWLLIFGALGASSAVIV 688
            .::.....|:..|        ....:::..|||  ..|:: .::||.|    ||...|   :.:|
Mouse   395 MVTYTMTSSLYFITFGMGASPFTNIEAVKIFCQ--NMCVS-ILLNYFY----IFSFFG---SCLV 449

  Fly   689 FWYPGLQLPEKSHFQLFVSKHPFEVYSSLKQQFWFEKPLQAYENFKMHMHFVWGVQAVDDGDY-- 751
            |   ..||.:..:..:|..|.|...|..       .||             ||....:.||..
Mouse   450 F---AGQLEQNRYHSIFCCKIPSAEYLD-------RKP-------------VWFQTVMSDGHQQT 491

  Fly   752 ----TNPNSYGHLHYDNNF----------NVSSRP---------------AQLWILDFCQ----- 782
                |||  |.| |:..:|          |:..:|               ..|.|.|...
Mouse   492 SHHETNP--YQH-HFIQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGASIINLL 553

  Fly   783 ----------SVRQQPF--YKETLGMLLPNCFIENLIDYMKRRCIDDMDSTRKDRSPCCD--AQF 833
                      .|:|:.|  |...:|.     ::...::|..       .|.::|....|.  ...
Mouse   554 ASDSPSVSYAMVQQKYFSNYSPVIGF-----YVYEPLEYWN-------SSVQEDLQRLCSGFTAV 606

  Fly   834 PFEPHIFEYCLPQSISNMYDTTFFRPGVAGPKFAEAPRLE--TEDYLGMSGNESAEYSTNGSFTP 896
            .:....:::....:||....|.|.  .|....|.:.|..:  ..|.:         :|..|.
Mouse   607 SWVEQYYQFLKTSNISANNKTDFI--SVLQSSFLKKPEFQHFRNDII---------FSRAGD--- 657

  Fly   897 LLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQLKTAPPELQGGWFTSDLKF------YNV 955
                      |:|:..|.:|...|...:..:...::..|..|..|     :..::|      :..
Mouse   658 ----------ENNIIASRLYLVARTSRDKQKEVIEVLDKLRPLSL-----SKSIRFIVFNPSFVF 707

  Fly   956 QDTLSHDTFVAICLAMAASLAVLLC---FTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILE 1017
            .|..|....|.:.:|....|.||:.   ..::.|.:.:.:|:|:......:.::.|  |.:: ::
Mouse   708 TDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLGLMTL--WNVD-MD 769

  Fly  1018 SIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRII-------GPTVMAATTTGLAGGI 1075
            .|::     |.:.::|::.|.:....:...:.||:...::.|       |..::...|:.|.|
Mouse   770 CISI-----LCLIYTLNFAIDHCAPLLYTFVLATEHTRTQCIKSSLQEHGTAILQNITSFLIG-- 827

  Fly  1076 MMASNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRVAGP---QHGFLELKWPLW------SKRS 1131
                 :||.:.:...|           ||.|...|.:.|.   .|.|:.|  |::      ||:.
Mouse   828 -----LLPLLFVPSNL-----------TFTLFKCLLLTGGCTLLHCFVIL--PVFLTFFPPSKKH 874

  Fly  1132 SGSSKFYERKPSQVI 1146
            ....|..:||..:.|
Mouse   875 HKKKKRAKRKEREEI 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disp	NP_524734.2	Patched	<444..1111	CDD:280598	110/619 (18%)
		MMPL	457..627	CDD:304422	15/59 (25%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	27/154 (18%)
Ptchd4	NP_001342199.1	Patched	84..870	CDD:355433	116/644 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845392
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840